{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:39:09Z","timestamp":1793133549912,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":621,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK096518"],"award-info":[{"award-number":["DK096518"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL123482"],"award-info":[{"award-number":["HL123482"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 DK097820"],"award-info":[{"award-number":["R01 DK097820"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008893","name":"University of Iowa Center for Gene Therapy","doi-asserted-by":"publisher","award":["DK54759"],"award-info":[{"award-number":["DK54759"]}],"id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000292","name":"UK Cystic Fibrosis Trust","doi-asserted-by":"publisher","award":["SRC007"],"award-info":[{"award-number":["SRC007"]}],"id":[{"id":"10.13039\/501100000292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ajp.amjpathol.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.ajpath.2017.12.015","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T13:53:13Z","timestamp":1517406793000},"page":"876-890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets"],"prefix":"10.1016","volume":"188","author":[{"given":"Pavana G.","family":"Rotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananta","family":"Poudel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingshen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliye","family":"Uc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manami","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Engelhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine N.","family":"Gibson-Corley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2017.12.015_bib1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1085\/jgp.200810122","article-title":"CFTR functions as a bicarbonate channel in pancreatic duct cells","volume":"133","author":"Ishiguro","year":"2009","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.ajpath.2017.12.015_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/path.4634","article-title":"Pancreatic pathophysiology in cystic fibrosis","volume":"238","author":"Gibson-Corley","year":"2016","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2017.12.015_bib3","doi-asserted-by":"crossref","first-page":"a009746","DOI":"10.1101\/cshperspect.a009746","article-title":"The cystic fibrosis of exocrine pancreas","volume":"3","author":"Wilschanski","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.ajpath.2017.12.015_bib4","doi-asserted-by":"crossref","first-page":"7258","DOI":"10.3748\/wjg.v19.i42.7258","article-title":"Diagnosis and treatment of pancreatic exocrine insufficiency","volume":"19","author":"Lindkvist","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajpath.2017.12.015_bib5","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.2337\/dc09-0586","article-title":"Cystic fibrosis-related diabetes: current trends in prevalence, incidence, and mortality","volume":"32","author":"Moran","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ajpath.2017.12.015_bib6","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1164\/rccm.201512-2518OC","article-title":"Abnormal glucose tolerance in infants and young children with cystic fibrosis","volume":"194","author":"Yi","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2017.12.015_bib7","first-page":"91","article-title":"Insulin resistance, beta-cell dysfunction and differences in curves of plasma glucose and insulin in the intermediate points of the standard glucose tolerance test in adults with cystic fibrosis","volume":"62","author":"Cano Megias","year":"2015","journal-title":"Endocrinol Nutr"},{"key":"10.1016\/j.ajpath.2017.12.015_bib8","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.2337\/diab.43.8.1020","article-title":"Insulin sensitivity in cystic fibrosis","volume":"43","author":"Moran","year":"1994","journal-title":"Diabetes"},{"key":"10.1016\/j.ajpath.2017.12.015_bib9","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/ppul.22946","article-title":"Increased rate of lung function decline in Australian adolescents with cystic fibrosis","volume":"49","author":"Welsh","year":"2014","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.ajpath.2017.12.015_bib10","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1515\/jpem-2017-0005","article-title":"Cystic-fibrosis related-diabetes (CFRD) is preceded by and associated with growth failure and deteriorating lung function","volume":"30","author":"Terliesner","year":"2017","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2017.12.015_bib11","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MCP.0b013e32834b14c9","article-title":"New animal models of cystic fibrosis: what are they teaching us?","volume":"17","author":"Keiser","year":"2011","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.ajpath.2017.12.015_bib12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1073\/pnas.91.2.479","article-title":"Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-\/-) mice","volume":"91","author":"Clarke","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2017.12.015_bib13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ajpath.2012.04.024","article-title":"Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways","volume":"181","author":"Abu-El-Haija","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2017.12.015_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/CS20140059","article-title":"Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass","volume":"128","author":"Uc","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.ajpath.2017.12.015_bib15","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1172\/JCI43052","article-title":"Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis","volume":"120","author":"Sun","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2017.12.015_bib16","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.ajpath.2014.01.035","article-title":"Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets","volume":"184","author":"Sun","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2017.12.015_bib17","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1172\/JCI60610","article-title":"Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets","volume":"122","author":"Olivier","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2017.12.015_bib18","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1210\/en.2015-1935","article-title":"A transient metabolic recovery from early life glucose intolerance in cystic fibrosis ferrets occurs during pancreatic remodeling","volume":"157","author":"Yi","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2017.12.015_bib19","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1172\/JCI34599","article-title":"Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets","volume":"118","author":"Sun","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2017.12.015_bib20","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1165\/rcmb.2013-0261OC","article-title":"Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets","volume":"50","author":"Sun","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2017.12.015_bib21","doi-asserted-by":"crossref","first-page":"34049","DOI":"10.1038\/srep34049","article-title":"Stereological analyses of the whole human pancreas","volume":"6","author":"Poudel","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2017.12.015_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/isl.2.3.11815","article-title":"Pancreatic islet plasticity: interspecies comparison of islet architecture and composition","volume":"2","author":"Steiner","year":"2010","journal-title":"Islets"},{"key":"10.1016\/j.ajpath.2017.12.015_bib23","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.cmet.2017.03.015","article-title":"beta Cell aging markers have heterogeneous distribution and are induced by insulin resistance","volume":"25","author":"Aguayo-Mazzucato","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2017.12.015_bib24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00006676-199511000-00012","article-title":"Quantitative immunohistochemical changes in the endocrine pancreas of nonobese diabetic (NOD) mice","volume":"11","author":"Gomez Dumm","year":"1995","journal-title":"Pancreas"},{"key":"10.1016\/j.ajpath.2017.12.015_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/jdi.12424","article-title":"Dynamic pathology of islet endocrine cells in type 2 diabetes: beta-cell growth, death, regeneration and their clinical implications","volume":"7","author":"Yagihashi","year":"2016","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.ajpath.2017.12.015_bib26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2017.12.015_bib27","doi-asserted-by":"crossref","first-page":"19327","DOI":"10.1073\/pnas.0705953104","article-title":"Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway","volume":"104","author":"Sawey","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2017.12.015_bib28","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1172\/JCI0215051","article-title":"Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas","volume":"109","author":"Crawford","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2017.12.015_bib29","doi-asserted-by":"crossref","first-page":"e11499","DOI":"10.1371\/journal.pone.0011499","article-title":"Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes","volume":"5","author":"Marselli","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2017.12.015_bib30","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1900\/RDS.2012.9.407","article-title":"Islet neogenesis: a possible pathway for beta-cell replenishment","volume":"9","author":"Bonner-Weir","year":"2012","journal-title":"Rev Diabet Stud"},{"key":"10.1016\/j.ajpath.2017.12.015_bib31","series-title":"Pancreatic Stem Cells","author":"Murtaugh","year":"2008"},{"key":"10.1016\/j.ajpath.2017.12.015_bib32","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1242\/jcs.065268","article-title":"Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats","volume":"123","author":"Li","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2017.12.015_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1210\/endo.141.1.7263","article-title":"Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in\u00a0vitro study of pancreatic islets from somatostatin receptor 2 knockout mice","volume":"141","author":"Strowski","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2017.12.015_bib34","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1126\/science.aai8792","article-title":"Regeneration of fat cells from myofibroblasts during wound healing","volume":"355","author":"Plikus","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2017.12.015_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1172\/JCI30082","article-title":"The pancreatic stellate cell: a star on the rise in pancreatic diseases","volume":"117","author":"Omary","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2017.12.015_bib36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1369\/jhc.2009.954909","article-title":"Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity","volume":"58","author":"Aye","year":"2010","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.ajpath.2017.12.015_bib37","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0092-8674(02)01079-6","article-title":"Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury","volume":"111","author":"Li","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2017.12.015_bib38","doi-asserted-by":"crossref","first-page":"e30509","DOI":"10.1371\/journal.pone.0030509","article-title":"Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia","volume":"7","author":"Scotti","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2017.12.015_bib39","doi-asserted-by":"crossref","first-page":"19915","DOI":"10.1073\/pnas.0805803105","article-title":"Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth","volume":"105","author":"Inada","year":"2008","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017307289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017307289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T23:56:38Z","timestamp":1617234998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944017307289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0002944017307289"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.12.015","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}