{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:04:57Z","timestamp":1778889897848,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":468,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26253023"],"award-info":[{"award-number":["26253023"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26110007"],"award-info":[{"award-number":["26110007"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.ajpath.2018.05.016","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T13:34:09Z","timestamp":1530624849000},"page":"2059-2073","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of Peribiliary Gland\u2013Constituting Cells Based on Differential Expression of Trophoblast Cell Surface Protein 2 in Biliary Tract"],"prefix":"10.1016","volume":"188","author":[{"given":"Satoshi","family":"Matsui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Okochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Miyajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2500-7973","authenticated-orcid":false,"given":"Minoru","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2018.05.016_bib1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.stem.2014.04.010","article-title":"Stem\/progenitor cells in liver development, homeostasis, regeneration, and reprogramming","volume":"14","author":"Miyajima","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2018.05.016_bib2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/hep.28326","article-title":"The hepatic, biliary, and pancreatic network of stem\/progenitor cell niches in humans: a new reference frame for disease and regeneration","volume":"64","author":"Lanzoni","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2018.05.016_bib3","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1002\/hep.24590","article-title":"Multipotent stem\/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets","volume":"54","author":"Cardinale","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2018.05.016_bib4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1469-7580.2011.01462.x","article-title":"Biliary tree stem\/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical in situ study yielding evidence of maturational lineages","volume":"220","author":"Carpino","year":"2012","journal-title":"J Anat"},{"key":"10.1016\/j.ajpath.2018.05.016_bib5","first-page":"260","article-title":"Histologic and scanning electron microscopic observations of intrahepatic peribiliary glands in normal human livers","volume":"60","author":"Ishida","year":"1989","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2018.05.016_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1440-1746.1994.tb01220.x","article-title":"Intrahepatic peribiliary glands of humans, I: anatomy, development and presumed functions","volume":"9","author":"Nakanuma","year":"1994","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2018.05.016_bib7","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/(SICI)1097-0029(19970915)38:6<552::AID-JEMT2>3.0.CO;2-H","article-title":"Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply","volume":"38","author":"Nakanuma","year":"1997","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.ajpath.2018.05.016_bib8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.4254\/wjh.v5.i8.425","article-title":"Participation of peribiliary glands in biliary tract pathophysiologies","volume":"5","author":"Igarashi","year":"2013","journal-title":"World J Hepatol"},{"key":"10.1016\/j.ajpath.2018.05.016_bib9","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jhep.2014.02.010","article-title":"Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures","volume":"60","author":"op den Dries","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2018.05.016_bib10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1586\/17474124.2016.1104246","article-title":"Latest advances in the pathological understanding of cholangiocarcinomas","volume":"10","author":"Nakanuma","year":"2016","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2018.05.016_bib11","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1242\/dev.031369","article-title":"Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver","volume":"136","author":"Okabe","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2018.05.016_bib12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/hep.1840180409","article-title":"Extrahepatic peribiliary glands express alpha-amylase isozymes, trypsin and pancreatic lipase: an immunohistochemical analysis","volume":"18","author":"Terada","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2018.05.016_bib13","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/hep.26485","article-title":"Identification of intramural epithelial networks linked to peribiliary glands that express progenitor cell markers and proliferate after injury in mice","volume":"58","author":"DiPaola","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2018.05.016_bib14","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1002\/hep.27685","article-title":"Adaptive remodeling of the biliary architecture underlies liver homeostasis","volume":"61","author":"Kaneko","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2018.05.016_bib15","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/nn.3447","article-title":"SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction","volume":"16","author":"Ke","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ajpath.2018.05.016_bib16","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1242\/jcs.00388","article-title":"Isolation of hepatoblasts based on the expression of Dlk\/Pref-1","volume":"116","author":"Tanimizu","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2018.05.016_bib17","doi-asserted-by":"crossref","first-page":"7589","DOI":"10.1074\/jbc.M113.517243","article-title":"Sry HMG box protein 9-positive (Sox9+) epithelial cell adhesion molecule-negative (EpCAM-) biphenotypic cells derived from hepatocytes are involved in mouse liver regeneration","volume":"289","author":"Tanimizu","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2018.05.016_bib18","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1038\/emboj.2013.204","article-title":"Unlimited in\u00a0vitro expansion of adult bi-potent pancreas progenitors through the Lgr5\/R-spondin axis","volume":"32","author":"Huch","year":"2013","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2018.05.016_bib19","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nbt.3275","article-title":"Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation","volume":"33","author":"Sampaziotis","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ajpath.2018.05.016_bib20","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1053\/j.gastro.2005.11.031","article-title":"Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice","volume":"130","author":"Fukuda","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2018.05.016_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ng.722","article-title":"Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine","volume":"43","author":"Furuyama","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2018.05.016_bib22","doi-asserted-by":"crossref","first-page":"20882","DOI":"10.1073\/pnas.0811411106","article-title":"Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics","volume":"105","author":"Goldstein","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2018.05.016_bib23","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.jhep.2015.06.018","article-title":"Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis","volume":"63","author":"Carpino","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2018.05.016_bib24","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.dld.2015.07.012","article-title":"Development and functional characterization of extrahepatic cholangiocyte lines from normal rats","volume":"47","author":"Venter","year":"2015","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.ajpath.2018.05.016_bib25","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1053\/gast.2000.18156","article-title":"Molecular identification and functional characterization of Mdr1a in rat cholangiocytes","volume":"119","author":"Gigliozzi","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2018.05.016_bib26","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/nm.4360","article-title":"Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids","volume":"23","author":"Sampaziotis","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2018.05.016_bib27","first-page":"143","article-title":"Endocrine cells in the intrahepatic biliary tree in normal livers and hepatolithiasis","volume":"113","author":"Kurumaya","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.ajpath.2018.05.016_bib28","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1478-3231.2011.02721.x","article-title":"Regeneration of human extrahepatic biliary epithelium: the peribiliary glands as progenitor cell compartment","volume":"32","author":"Sutton","year":"2012","journal-title":"Liver Int"},{"key":"10.1016\/j.ajpath.2018.05.016_bib29","doi-asserted-by":"crossref","first-page":"E3806","DOI":"10.1073\/pnas.1619416114","article-title":"Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands","volume":"114","author":"Nakagawa","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2018.05.016_bib30","doi-asserted-by":"crossref","first-page":"e28607","DOI":"10.1371\/journal.pone.0028607","article-title":"TROP2 expressed in the trunk of the ureteric duct regulates branching morphogenesis during kidney development","volume":"6","author":"Tsukahara","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2018.05.016_bib31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/onc.2012.36","article-title":"Upregulation of Trop-2 quantitatively stimulates human cancer growth","volume":"32","author":"Trerotola","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2018.05.016_bib32","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.celrep.2013.09.005","article-title":"Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium","volume":"5","author":"Mustata","year":"2013","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2018.05.016_bib33","first-page":"1452","article-title":"Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage","volume":"143","author":"Fernandez Vallone","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2018.05.016_bib34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12931-016-0463-z","article-title":"Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease","volume":"17","author":"Liu","year":"2016","journal-title":"Respir Res"},{"key":"10.1016\/j.ajpath.2018.05.016_bib35","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1158\/1535-7163.MCT-07-2003","article-title":"Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers","volume":"7","author":"Wang","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.ajpath.2018.05.016_bib36","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1101\/gad.196451.112","article-title":"Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via beta-catenin signaling","volume":"26","author":"Stoyanova","year":"2012","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2018.05.016_bib37","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.2353\/ajpath.2010.100149","article-title":"Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy","volume":"177","author":"Nakatsukasa","year":"2010","journal-title":"Am J Pathol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401830141X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401830141X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:04:52Z","timestamp":1762081492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000294401830141X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S000294401830141X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2018.05.016","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of Peribiliary Gland\u2013Constituting Cells Based on Differential Expression of Trophoblast Cell Surface Protein 2 in Biliary Tract","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2018.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}