{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:33:07Z","timestamp":1790249587205,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["031L0084"],"award-info":[{"award-number":["031L0084"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHN 947\/4-2"],"award-info":[{"award-number":["SCHN 947\/4-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STR 1570\/1-1"],"award-info":[{"award-number":["STR 1570\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010345","name":"B. Braun-Stiftung","doi-asserted-by":"publisher","award":["BBST-D-18-00018"],"award-info":[{"award-number":["BBST-D-18-00018"]}],"id":[{"id":"10.13039\/100010345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ajpath.2018.08.003","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T04:41:26Z","timestamp":1537591286000},"page":"2826-2838","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Loss of Prolyl-Hydroxylase 1 Protects against Biliary Fibrosis via Attenuated Activation of Hepatic Stellate Cells"],"prefix":"10.1016","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-9283","authenticated-orcid":false,"given":"Moritz J.","family":"Strowitzki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kirchberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Tuffs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Schiedeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina S.","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Biller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Harnoss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Lasitschka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-3675","authenticated-orcid":false,"given":"Thomas","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2018.08.003_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2018.08.003_bib2","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1053\/j.gastro.2008.02.028","article-title":"Indications for liver transplantation","volume":"134","author":"O'Leary","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2018.08.003_bib3","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2018.08.003_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1755-1536-6-19","article-title":"Experimental liver fibrosis research: update on animal models, legal issues and translational aspects","volume":"6","author":"Liedtke","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.ajpath.2018.08.003_bib6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2353\/ajpath.2007.061133","article-title":"A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis","volume":"171","author":"Fickert","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1872-034X.2010.00635.x","article-title":"Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic Kupffer cells","volume":"40","author":"Copple","year":"2010","journal-title":"Hepatol Res"},{"key":"10.1016\/j.ajpath.2018.08.003_bib8","doi-asserted-by":"crossref","first-page":"G582","DOI":"10.1152\/ajpgi.90368.2008","article-title":"Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice","volume":"296","author":"Moon","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib9","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1073\/pnas.79.17.5415","article-title":"Periportal and pericentral pyridine nucleotide fluorescence from the surface of the perfused liver: evaluation of the hypothesis that chronic treatment with ethanol produces pericentral hypoxia","volume":"79","author":"Ji","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2018.08.003_bib10","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ajpath.2018.08.003_bib11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol Cell"},{"key":"10.1016\/j.ajpath.2018.08.003_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pathol-012513-104720","article-title":"Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology","volume":"9","author":"Semenza","year":"2014","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/cdd.2008.10","article-title":"Role and regulation of prolyl hydroxylase domain proteins","volume":"15","author":"Fong","year":"2008","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.ajpath.2018.08.003_bib14","first-page":"1","article-title":"Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges","volume":"3","author":"Harnoss","year":"2015","journal-title":"Hypoxia (Auckl)"},{"key":"10.1016\/j.ajpath.2018.08.003_bib15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1600-0463.2007.apm_610.x","article-title":"Hypoxia-inducible factor-1alpha expression in experimental cirrhosis: correlation with vascular endothelial growth factor expression and angiogenesis","volume":"115","author":"Bozova","year":"2007","journal-title":"APMIS"},{"key":"10.1016\/j.ajpath.2018.08.003_bib16","doi-asserted-by":"crossref","first-page":"41038","DOI":"10.1038\/srep41038","article-title":"Reduction of hepatic fibrosis by overexpression of von Hippel-Lindau protein in experimental models of chronic liver disease","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2018.08.003_bib17","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1113\/JP275327","article-title":"The PHD1 oxygen sensor in health and disease","volume":"596","author":"Kennel","year":"2018","journal-title":"J Physiol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib18","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1053\/j.gastro.2009.09.057","article-title":"Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia\/reperfusion injury","volume":"138","author":"Schneider","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2018.08.003_bib19","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00423-012-0998-5","article-title":"Deficiency of the oxygen sensor PHD1 augments liver regeneration after partial hepatectomy","volume":"397","author":"Mollenhauer","year":"2012","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.ajpath.2018.08.003_bib20","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/SLA.0000000000001696","article-title":"Prolyl hydroxylase inhibition enhances liver regeneration without induction of tumor growth","volume":"265","author":"Harnoss","year":"2017","journal-title":"Ann Surg"},{"key":"10.1016\/j.ajpath.2018.08.003_bib21","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.surg.2016.05.018","article-title":"Hypoxia of the growing liver accelerates regeneration","volume":"161","author":"Schadde","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.ajpath.2018.08.003_bib22","series-title":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals; National Research Council: Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"10.1016\/j.ajpath.2018.08.003_bib23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng.2007.62","article-title":"Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism","volume":"40","author":"Aragon\u00e9s","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2018.08.003_bib24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s12253-015-0027-4","article-title":"miRNA isolation from FFPET specimen: a technical comparison of miRNA and total RNA isolation methods","volume":"22","author":"Nagy","year":"2016","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.ajpath.2018.08.003_bib25","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1002\/pmic.201100157","article-title":"Sample preparation method for isolation of single-cell types from mouse liver for proteomic studies","volume":"11","author":"Liu","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.ajpath.2018.08.003_bib26","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/hep.1840190629","article-title":"Classification of chronic hepatitis: diagnosis, grading and staging","volume":"19","author":"Desmet","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2018.08.003_bib27","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/j.biocel.2009.03.010","article-title":"Hepatic myofibroblasts: a heterogeneous population of multifunctional cells in liver fibrogenesis","volume":"41","author":"Novo","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib28","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1136\/gutjnl-2014-308325","article-title":"CD248\/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism","volume":"65","author":"Wilhelm","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2018.08.003_bib29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2018.08.003_bib30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-2001-17550","article-title":"History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells","volume":"21","author":"Geerts","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.ajpath.2018.08.003_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ajpath.2018.08.003_bib32","doi-asserted-by":"crossref","first-page":"e42490","DOI":"10.1371\/journal.pone.0042490","article-title":"Gene profile of chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9\/10 on liver non-parenchymal cells","volume":"7","author":"Liang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2018.08.003_bib33","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jaut.2010.09.003","article-title":"CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation","volume":"35","author":"Hintermann","year":"2010","journal-title":"J Autoimmun"},{"key":"10.1016\/j.ajpath.2018.08.003_bib34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.bbrc.2016.04.085","article-title":"Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-kappaB-dependent manner","volume":"474","author":"Fitzpatrick","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2018.08.003_bib35","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.jhep.2016.01.010","article-title":"Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers","volume":"64","author":"Lua","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib36","first-page":"919","article-title":"Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation","volume":"38","author":"Vi\u00f1as","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2018.08.003_bib37","first-page":"135","article-title":"Hepatic fibrosis and cirrhosis: the (myo)fibroblastic cell subpopulations involved","volume":"38","author":"Guyot","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib38","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1053\/jhep.2001.23500","article-title":"In\u00a0vitro and in\u00a0vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage-operated calcium channels","volume":"33","author":"Bataller","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2018.08.003_bib39","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","article-title":"Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors","volume":"102","author":"Iredale","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2018.08.003_bib40","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2012.06.036","article-title":"Deactivation of hepatic stellate cells during liver fibrosis resolution in mice","volume":"143","author":"Troeger","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2018.08.003_bib41","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-kappaB in the liver\u2014linking injury, fibrosis and hepatocellular carcinoma","volume":"8","author":"Luedde","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib42","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1089\/104454999314890","article-title":"NF-kappaB inhibits expression of the alpha1(I) collagen gene","volume":"18","author":"Rippe","year":"1999","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib43","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0002-9440(10)62291-2","article-title":"Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury","volume":"166","author":"Oakley","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib44","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cld.2008.07.012","article-title":"Genetic determinants in hepatic fibrosis: from experimental models to fibrogenic gene signatures in humans","volume":"12","author":"Weber","year":"2008","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.ajpath.2018.08.003_bib45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1755-1536-6-18","article-title":"The role of mouse strain differences in the susceptibility to fibrosis: a systematic review","volume":"6","author":"Walkin","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.ajpath.2018.08.003_bib46","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0002-9440(10)64480-X","article-title":"Bile acid-induced Mallory body formation in drug-primed mouse liver","volume":"161","author":"Fickert","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2018.08.003_bib47","doi-asserted-by":"crossref","first-page":"G1076","DOI":"10.1152\/ajpgi.00229.2016","article-title":"Hydroxylases regulate intestinal fibrosis through the suppression of ERK-mediated TGF-beta1 signaling","volume":"311","author":"Manresa","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017306211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017306211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:31:47Z","timestamp":1757694707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944017306211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0002944017306211"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2018.08.003","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of Prolyl-Hydroxylase 1 Protects against Biliary Fibrosis via Attenuated Activation of Hepatic Stellate Cells","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2018.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}