{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:55:17Z","timestamp":1782489317652,"version":"3.54.5"},"reference-count":55,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81220108026"],"award-info":[{"award-number":["81220108026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81430089"],"award-info":[{"award-number":["81430089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673524"],"award-info":[{"award-number":["81673524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371940"],"award-info":[{"award-number":["81371940"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673490"],"award-info":[{"award-number":["81673490"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ajpath.2018.08.008","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T17:44:13Z","timestamp":1538156653000},"page":"2863-2876","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Intrauterine Programming of Glucocorticoid\u2013Insulin-Like Growth Factor-1 Axis\u2013Mediated Developmental Origin of Osteoporosis Susceptibility in Female Offspring Rats with Prenatal Caffeine Exposure"],"prefix":"10.1016","volume":"188","author":[{"given":"Yangfan","family":"Shangguan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxian","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Magdalou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8778-1457","authenticated-orcid":false,"given":"Liaobin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2018.08.008_bib1","first-page":"2","article-title":"Osteoporosis: epidemiology, diagnosis, and treatment","volume":"93","author":"Iqbal","year":"2000","journal-title":"South Med J"},{"issue":"2 Suppl","key":"10.1016\/j.ajpath.2018.08.008_bib2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ajog.2005.08.047","article-title":"Epistemology, etiology, and diagnosis of osteoporosis","volume":"194","author":"Lane","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/s-0031-1275518","article-title":"The long-term effects of prenatal development on growth and metabolism","volume":"29","author":"Godfrey","year":"2011","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.ajpath.2018.08.008_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000439488","article-title":"Development, epigenetics and metabolic programming","volume":"85","author":"Godfrey","year":"2016","journal-title":"Nestle Nutr Inst Workshop Ser"},{"key":"10.1016\/j.ajpath.2018.08.008_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1053\/j.semperi.2007.11.003","article-title":"The IUGR newborn","volume":"3","author":"Rosenberg","year":"2008","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib6","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00198-010-1344-9","article-title":"Does birthweight predict bone mass in adulthood? a systematic review and meta-analysis","volume":"5","author":"Baird","year":"2011","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ajpath.2018.08.008_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nrendo.2014.74","article-title":"Glucocorticoids and fetal programming part 2: mechanisms","volume":"10","author":"Moisiadis","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrendo.2014.73","article-title":"Glucocorticoids and fetal programming part 1: outcomes","volume":"10","author":"Moisiadis","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.15283\/ijsc.2012.5.2.96","article-title":"Effects of growth factors on establishment and propagation of embryonic stem cells from very early stage IVF embryos and their characterization in Buffalo","volume":"5","author":"Puri","year":"2012","journal-title":"Int J Stem Cells"},{"key":"10.1016\/j.ajpath.2018.08.008_bib10","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1002\/stem.1478","article-title":"Insulin and IGFs enhance hepatocyte differentiation from human embryonic stem cells via the PI3K\/AKT pathway","volume":"31","author":"Magner","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.ajpath.2018.08.008_bib11","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4248\/BR201302007","article-title":"IGF-1 signaling is essential for differentiation of mesenchymal stem cells for peak bone mass","volume":"28","author":"Crane","year":"2013","journal-title":"Bone Res"},{"key":"10.1016\/j.ajpath.2018.08.008_bib12","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1210\/en.2007-0303","article-title":"Ontogeny and nutritional programming of the hepatic growth hormone-insulin-like growth factor-prolactin axis in the sheep","volume":"148","author":"Hyatt","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2018.08.008_bib13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1365-2265.2009.03683.x","article-title":"Dexamethasone administration inhibits skeletal muscle expression of the androgen receptor and IGF-1--implications for steroid-induced myopathy","volume":"1","author":"Inder","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ajpath.2018.08.008_bib14","first-page":"624","article-title":"Dexamethasone decreases insulin-like growth factor-I and -II via a glucocorticoid receptor dependent mechanism in developing rat brain","volume":"34","author":"Feng","year":"2013","journal-title":"Neuro Endocrinol Lett"},{"key":"10.1016\/j.ajpath.2018.08.008_bib15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1210\/me.2014-1362","article-title":"Glucocorticoid regulation of lung development: lessons learned from conditional GR knockout mice","volume":"29","author":"Bird","year":"2015","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jcp.10189","article-title":"Development of the fetal intestine in mice lacking the glucocorticoid receptor (GR)","volume":"194","author":"Gartner","year":"2003","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ceb.2008.02.002","article-title":"C\/EBPs: recipients of extracellular signals through proteome modulation","volume":"2","author":"Nerlov","year":"2008","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib18","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.fct.2004.05.002","article-title":"Beverage caffeine intake in US consumers and subpopulations of interest: estimates from the Share of Intake Panel survey","volume":"42","author":"Knight","year":"2004","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/eb-2013-101683","article-title":"Higher coffee intake in pregnancy linked to prolonged gestation, and higher caffeine intake linked with babies being small for gestational age","volume":"17","author":"Hollins Martin","year":"2014","journal-title":"Evid Based Nurs"},{"key":"10.1016\/j.ajpath.2018.08.008_bib20","doi-asserted-by":"crossref","first-page":"279.e1","DOI":"10.1016\/j.ajog.2007.10.803","article-title":"Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study","volume":"198","author":"Weng","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib21","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1039\/C5TX00265F","article-title":"Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms","volume":"2","author":"He","year":"2016","journal-title":"Toxicol Res (Camb)"},{"key":"10.1016\/j.ajpath.2018.08.008_bib22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.taap.2012.05.002","article-title":"Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways","volume":"262","author":"Liu","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.toxlet.2012.09.007","article-title":"Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation","volume":"214","author":"Tan","year":"2012","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.ajpath.2018.08.008_bib24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.toxlet.2013.11.006","article-title":"Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring","volume":"224","author":"Wang","year":"2014","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.ajpath.2018.08.008_bib25","doi-asserted-by":"crossref","first-page":"e44497","DOI":"10.1371\/journal.pone.0044497","article-title":"Caffeine-induced activated glucocorticoid metabolism in the hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2018.08.008_bib26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/clr.12360","article-title":"Skeletal site-specific response to ovariectomy in a rat model: change in bone density and microarchitecture","volume":"26","author":"Liu","year":"2015","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.ajpath.2018.08.008_bib27","first-page":"294","article-title":"Bone histomorphometry revisited","volume":"37","author":"Vidal","year":"2012","journal-title":"Acta Reumatol Port"},{"key":"10.1016\/j.ajpath.2018.08.008_bib28","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ajpath.2018.08.008_bib29","first-page":"170","article-title":"Establishment of method to culture osteoblasts from female neonatal rat skull","volume":"39","author":"Na","year":"2013","journal-title":"J Jilin Univ Med Edition"},{"key":"10.1016\/j.ajpath.2018.08.008_bib30","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bone.2006.02.063","article-title":"Osteoblast responses to nucleotides increase during differentiation","volume":"39","author":"Orriss","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.ajpath.2018.08.008_bib31","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s00198-010-1236-z","article-title":"Birth weight and adult bone mass: a systematic literature review","volume":"21","author":"Schlussel","year":"2010","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ajpath.2018.08.008_bib32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1542-2011.2011.00135.x","article-title":"Osteoporosis update","volume":"56","author":"Schuiling","year":"2011","journal-title":"J Midwifery Womens Health"},{"key":"10.1016\/j.ajpath.2018.08.008_bib33","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1359\/JBMR.040109","article-title":"Incidence of hip and other osteoporotic fractures in elderly men and women: Dubbo Osteoporosis Epidemiology Study","volume":"19","author":"Chang","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ajpath.2018.08.008_bib34","first-page":"223","article-title":"Epidemiology of hip fractures and its social and economic impact: an update for 2014","volume":"40","author":"Laires","year":"2015","journal-title":"Acta Reumatol Port"},{"key":"10.1016\/j.ajpath.2018.08.008_bib35","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s00223-015-9991-7","article-title":"Characterising bone material composition and structure in the ovariectomized (OVX) rat model of osteoporosis","volume":"97","author":"Mathavan","year":"2015","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ajpath.2018.08.008_bib36","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.bone.2005.11.019","article-title":"Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption","volume":"38","author":"Zhang","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.ajpath.2018.08.008_bib37","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00198-005-2039-5","article-title":"Review: developmental origins of osteoporotic fracture","volume":"17","author":"Cooper","year":"2006","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ajpath.2018.08.008_bib38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1017\/S2040174409990146","article-title":"Early development and osteoporosis and bone health","volume":"1","author":"Dennison","year":"2010","journal-title":"J Dev Orig Health Dis"},{"key":"10.1016\/j.ajpath.2018.08.008_bib39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.taap.2013.02.008","article-title":"Nicotine-induced retardation of chondrogenesis through down-regulation of IGF-1 signaling pathway to inhibit matrix synthesis of growth plate chondrocytes in fetal rats","volume":"269","author":"Deng","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib40","doi-asserted-by":"crossref","first-page":"14711","DOI":"10.1038\/srep14711","article-title":"Prenatal ethanol exposure increases osteoarthritis susceptibility in female rat offspring by programming a low-functioning IGF-1 signaling pathway","volume":"5","author":"Ni","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2018.08.008_bib41","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1111\/bph.13506","article-title":"Mitogen-inducible gene-6 partly mediates the inhibitory effects of prenatal dexamethasone exposure on endochondral ossification in long bones of fetal rats","volume":"173","author":"Zhang","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib42","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1002\/jbmr.2299","article-title":"Fetal and childhood growth patterns associated with bone mass in school-age children: the Generation R study","volume":"29","author":"Heppe","year":"2014","journal-title":"J Bone Mineral Res"},{"key":"10.1016\/j.ajpath.2018.08.008_bib43","first-page":"29","article-title":"Intrauterine programming of physiological systems: causes and consequences","volume":"21","author":"Fowden","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.ajpath.2018.08.008_bib44","first-page":"212","article-title":"Intrauterine programming","volume":"18","author":"Sedaghat","year":"2015","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.ajpath.2018.08.008_bib45","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/carcin\/bgn273","article-title":"C\/EBPbeta regulates body composition, energy balance-related hormones and tumor growth","volume":"30","author":"Staiger","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ajpath.2018.08.008_bib46","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1002\/hep.23875","article-title":"A novel GSK-3 beta-C\/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma","volume":"52","author":"Zeng","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2018.08.008_bib47","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.taap.2015.07.005","article-title":"Prenatal ethanol exposure-induced adrenal developmental abnormality of male offspring rats and its possible intrauterine programming mechanisms","volume":"288","author":"Huang","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib48","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/em.20366","article-title":"Environmental epigenomics in human health and disease","volume":"49","author":"Dolinoy","year":"2008","journal-title":"Environ Mol Mutagen"},{"key":"10.1016\/j.ajpath.2018.08.008_bib49","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1289\/ehp.8700","article-title":"Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome","volume":"114","author":"Dolinoy","year":"2006","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ajpath.2018.08.008_bib50","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1124\/mol.106.032011","article-title":"Maternal cocaine administration causes an epigenetic modification of protein kinase Cepsilon gene expression in fetal rat heart","volume":"71","author":"Zhang","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib51","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1210\/en.2011-2160","article-title":"Prenatal synthetic glucocorticoid treatment changes DNA methylation states in male organ systems: multigenerational effects","volume":"153","author":"Crudo","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2018.08.008_bib52","first-page":"230","article-title":"The World Health Report 2002\u2014reducing risks, promoting healthy life","volume":"16","author":"Guilbert","year":"2003","journal-title":"Educ Health (Abingdon)"},{"key":"10.1016\/j.ajpath.2018.08.008_bib53","doi-asserted-by":"crossref","first-page":"a2332","DOI":"10.1136\/bmj.a2332","article-title":"Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study","volume":"337","author":"Group","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.ajpath.2018.08.008_bib54","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.taap.2015.09.007","article-title":"Prenatal caffeine exposure induced a lower level of fetal blood leptin mainly via placental mechanism","volume":"289","author":"Wu","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.ajpath.2018.08.008_bib55","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017311227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017311227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T21:38:00Z","timestamp":1720647480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944017311227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0002944017311227"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2018.08.008","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrauterine Programming of Glucocorticoid\u2013Insulin-Like Growth Factor-1 Axis\u2013Mediated Developmental Origin of Osteoporosis Susceptibility in Female Offspring Rats with Prenatal Caffeine Exposure","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2018.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}