{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:01:36Z","timestamp":1792674096733,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001229","name":"G. Harold and Leila Y. Mathers Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01GM124531"],"award-info":[{"award-number":["R01GM124531"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50CA228991"],"award-info":[{"award-number":["P50CA228991"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["EDRN U01CA200469"],"award-info":[{"award-number":["EDRN U01CA200469"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50GM107632"],"award-info":[{"award-number":["P50GM107632"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA215483"],"award-info":[{"award-number":["R01CA215483"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014008","name":"Ovarian Cancer Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ajpath.2018.11.005","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T12:19:52Z","timestamp":1544703592000},"page":"513-520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Long Interspersed Nuclear Element 1 Retrotransposons Become Deregulated during the Development of Ovarian Cancer Precursor Lesions"],"prefix":"10.1016","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5796-0836","authenticated-orcid":false,"suffix":"II","given":"Thomas R.","family":"Pisanic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Asaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-7234","authenticated-orcid":false,"given":"Shiou-Fu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Tai","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanru","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Bahadirli-Talbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tza-Huei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen H.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ie-Ming","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2018.11.005_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/GCO.0b013e328011a21f","article-title":"The distal fallopian tube: a new model for pelvic serous carcinogenesis","volume":"19","author":"Crum","year":"2007","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ajpath.2015.11.011","article-title":"The dualistic model of ovarian carcinogenesis: revisited, revised, and expanded","volume":"186","author":"Kurman","year":"2016","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib3","article-title":"Genomic landscape and evolutionary trajectories of ovarian cancer early precursor lesions","author":"Wu","year":"2018","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/path.3023","article-title":"TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma: evidence supporting the clonal relationship of the two lesions","volume":"226","author":"Kuhn","year":"2012","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship","volume":"31","author":"Kindelberger","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib6","doi-asserted-by":"crossref","first-page":"6536","DOI":"10.1158\/1078-0432.CCR-18-1199","article-title":"Methylomic analysis of ovarian cancers identifies tumor-specific alterations readily detectable in early precursor lesions","volume":"24","author":"Pisanic","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2018.11.005_bib7","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/IGC.0000000000000196","article-title":"DNA damage signaling and apoptosis in preinvasive tubal lesions of ovarian carcinoma","volume":"25","author":"Chene","year":"2015","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ajpath.2018.11.005_bib8","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.ajpath.2014.01.007","article-title":"Long interspersed element-1 protein expression is a hallmark of many human cancers","volume":"184","author":"Rodi\u0107","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib9","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2018.11.005_bib10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.cell.2012.04.019","article-title":"Human transposon tectonics","volume":"149","author":"Burns Kathleen","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2018.11.005_bib11","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1073\/pnas.0831042100","article-title":"Hot L1s account for the bulk of retrotransposition in the human population","volume":"100","author":"Brouha","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2018.11.005_bib12","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.cell.2010.05.021","article-title":"LINE-1 retrotransposition activity in human genomes","volume":"141","author":"Beck","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2018.11.005_bib13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc.2017.35","article-title":"Transposable elements in cancer","volume":"17","author":"Burns","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ajpath.2018.11.005_bib14","doi-asserted-by":"crossref","first-page":"1251343","DOI":"10.1126\/science.1251343","article-title":"Mobile DNA in cancer: extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes","volume":"345","author":"Tubio","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2018.11.005_bib15","doi-asserted-by":"crossref","first-page":"10488","DOI":"10.1093\/nar\/gku687","article-title":"Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci","volume":"42","author":"Kines","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2018.11.005_bib16","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.jmb.2006.01.089","article-title":"The human LINE-1 retrotransposon creates DNA double-strand breaks","volume":"357","author":"Gasior","year":"2006","journal-title":"J Mol Biol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib17","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1222077","article-title":"Landscape of somatic retrotransposition in human cancers","volume":"337","author":"Lee","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2018.11.005_bib18","doi-asserted-by":"crossref","first-page":"E733","DOI":"10.1073\/pnas.1619797114","article-title":"Human transposon insertion profiling: analysis, visualization and identification of somatic LINE-1 insertions in ovarian cancer","volume":"114","author":"Tang","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2018.11.005_bib19","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1373\/clinchem.2016.257444","article-title":"The human long interspersed element-1 retrotransposon: an emerging biomarker of neoplasia","volume":"63","author":"Ardeljan","year":"2017","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajpath.2018.11.005_bib20","series-title":"Immunodetection of human LINE-1 expression in cultured cells and human tissues. Transposons and Retrotransposons: Methods and Protocols","first-page":"261","author":"Sharma","year":"2016"},{"key":"10.1016\/j.ajpath.2018.11.005_bib21","first-page":"4244s","article-title":"Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors","volume":"46","author":"McCarty","year":"1986","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2018.11.005_bib22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1101\/gad.266098.115","article-title":"p53 Genes function to restrain mobile elements","volume":"30","author":"Wylie","year":"2016","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2018.11.005_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/PGP.0b013e31823b8831","article-title":"Validation of an algorithm for the diagnosis of serous tubal intraepithelial carcinoma","volume":"31","author":"Vang","year":"2012","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1155\/2015\/131547","article-title":"The fine LINE: methylation drawing the cancer landscape","volume":"2015","author":"Miousse","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ajpath.2018.11.005_bib25","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/hmg\/ddr455","article-title":"Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility","volume":"21","author":"Wissing","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajpath.2018.11.005_bib26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1101\/gr.201814.115","article-title":"A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer","volume":"26","author":"Scott","year":"2016","journal-title":"Genome Res"},{"key":"10.1016\/j.ajpath.2018.11.005_bib27","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1093\/nar\/28.8.e32","article-title":"MethyLight: a high-throughput assay to measure DNA methylation","volume":"28","author":"Eads","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2018.11.005_bib28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/PAS.0b013e3181cf3d79","article-title":"The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory","volume":"34","author":"Kurman","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/PGP.0000000000000207","article-title":"Molecular alterations of TP53 are a defining feature of ovarian high-grade serous carcinoma: a rereview of cases lacking TP53 mutations in The Cancer Genome Atlas Ovarian Study","volume":"35","author":"Vang","year":"2016","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib30","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/modpathol.2016.101","article-title":"CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma","volume":"29","author":"Kuhn","year":"2016","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib31","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.humpath.2011.03.003","article-title":"Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer: shifting the paradigm","volume":"42","author":"Kurman","year":"2011","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib32","doi-asserted-by":"crossref","first-page":"11620","DOI":"10.1038\/ncomms11620","article-title":"Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution","volume":"7","author":"Bartlett","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2018.11.005_bib33","doi-asserted-by":"crossref","first-page":"aad2197","DOI":"10.1126\/science.aad2197","article-title":"A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation","volume":"351","author":"Kaufman","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2018.11.005_bib34","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/PAS.0b013e3181dcede7","article-title":"Shortened telomeres in serous tubal intraepithelial carcinoma: an early event in ovarian high-grade serous carcinogenesis","volume":"34","author":"Kuhn","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ajpath.2018.11.005_bib35","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/modpathol.2010.60","article-title":"Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase","volume":"23","author":"Sehdev","year":"2010","journal-title":"Mod Pathol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944018306904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944018306904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:06:54Z","timestamp":1762081614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944018306904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0002944018306904"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2018.11.005","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long Interspersed Nuclear Element 1 Retrotransposons Become Deregulated during the Development of Ovarian Cancer Precursor Lesions","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2018.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}