{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:26:59Z","timestamp":1768343219639,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ajpath.2019.05.017","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T23:42:25Z","timestamp":1560814945000},"page":"1775-1785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Involvement of \u03b1-Melanocyte\u2013Stimulating Hormone\u2013Thromboxane A2 System on Itching in Atopic Dermatitis"],"prefix":"10.1016","volume":"189","author":[{"given":"Tsugunobu","family":"Andoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Akasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8732-7457","authenticated-orcid":false,"given":"Jung-Bum","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Yoshihisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadamichi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2019.05.017_bib1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1600-0625.2009.01024.x","article-title":"Atopic eczema or atopiform dermatitis","volume":"19","author":"Bos","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1346-8138.1999.tb02090.x","article-title":"Itch and atopic dermatitis: an overview","volume":"26","author":"Wahlgren","year":"1999","journal-title":"J Dermatol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib3","first-page":"1","article-title":"Itch and atopic dermatitis: clinical and experimental studies","volume":"165","author":"Wahlgren","year":"1991","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"10.1016\/j.ajpath.2019.05.017_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2230.2006.02128.x","article-title":"Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors","volume":"31","author":"Millington","year":"2006","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.mce.2010.07.015","article-title":"Melanocortin receptors and their accessory proteins","volume":"331","author":"Cooray","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1152\/physiolgenomics.2001.5.1.11","article-title":"Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells","volume":"5","author":"Mountjoy","year":"2001","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.ajpath.2019.05.017_bib7","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1038\/sj.jid.5700421","article-title":"Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology","volume":"126","author":"B\u00f6hm","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib8","doi-asserted-by":"crossref","first-page":"E468","DOI":"10.1152\/ajpendo.00434.2002","article-title":"The melanocortin system","volume":"284","author":"Gantz","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2019.05.017_bib9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1600-0625.2009.00988.x","article-title":"Increased alpha-melanocyte-stimulating hormone (alpha-MSH) levels and melanocortin receptors expression associated with pigmentation in an NC\/Nga mouse model of atopic dermatitis","volume":"19","author":"Hiramoto","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib10","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1016\/j.ajpath.2015.07.015","article-title":"Histamine released from epidermal keratinocytes plays a role in \u03b1-melanocyte-stimulating hormone-induced itching in mice","volume":"185","author":"Shimizu","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0923-1811(00)00099-2","article-title":"Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis","volume":"25","author":"Yamaguchi","year":"2001","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.ajpath.2019.05.017_bib12","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1038\/sj.jid.5700810","article-title":"Thromboxane A2 induces itch-associated responses through TP receptors in the skin in mice","volume":"127","author":"Andoh","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-2999(94)00780-B","article-title":"Scratching behavior induced by pruritogenic but not algesiogenic agents in mice","volume":"275","author":"Kuraishi","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib14","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/371799a0","article-title":"Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor","volume":"371","author":"Lu","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2019.05.017_bib15","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/1523-1747.ep12292572","article-title":"Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to \u03b1-melanotropin","volume":"108","author":"Suzuki","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib16","doi-asserted-by":"crossref","first-page":"899","DOI":"10.2340\/00015555-2437","article-title":"Thromboxane A2 is involved in itch-associated responses in mice with atopic dermatitis-like skin lesions","volume":"96","author":"Andoh","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0167-0115(02)00207-0","article-title":"Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues","volume":"110","author":"Li","year":"2003","journal-title":"Regul Pept"},{"key":"10.1016\/j.ajpath.2019.05.017_bib18","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jaci.2004.08.041","article-title":"Prostaglandin E2 suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes","volume":"114","author":"Kanda","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pharep.2017.10.001","article-title":"Involvement of thromboxane A2 in interleukin-31-induced itch-associated response in mice","volume":"70","author":"Andoh","year":"2018","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.ajpath.2019.05.017_bib20","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0091-6749(89)90132-2","article-title":"Eicosanoids in skin of patients with atopic dermatitis: prostaglandin E2 and leukotriene B4 are present in biologically active concentrations","volume":"83","author":"Fogh","year":"1989","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib21","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000056338","article-title":"Scratching behavior in various strains of mice","volume":"14","author":"Inagaki","year":"2001","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib23","doi-asserted-by":"crossref","first-page":"7708","DOI":"10.1073\/pnas.87.19.7708","article-title":"Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937","volume":"87","author":"Clark","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2019.05.017_bib24","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1999.79.4.1193","article-title":"Prostanoid receptors: structures, properties, and functions","volume":"79","author":"Narumiya","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ajpath.2019.05.017_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1083\/jcb.201603042","article-title":"The cell biology of acute itch","volume":"213","author":"Green","year":"2016","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/intimm\/9.3.461","article-title":"Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC\/Nga mice","volume":"9","author":"Matsuda","year":"1997","journal-title":"Int Immunol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.intimp.2008.12.013","article-title":"Dermatophagoides farinae extract induces severe atopic dermatitis in NC\/Nga mice, which is effectively suppressed by the administration of tacrolimus ointment","volume":"9","author":"Oshio","year":"2009","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1254\/jphs.08332FP","article-title":"Involvement of tryptase and proteinase-activated receptor-2 in spontaneous itch-associated response in mice with atopy-like dermatitis","volume":"109","author":"Tsujii","year":"2009","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.ajpath.2019.05.017_bib29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0167-5699(97)01009-8","article-title":"Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH","volume":"18","author":"Lipton","year":"1997","journal-title":"Immunol Today"},{"key":"10.1016\/j.ajpath.2019.05.017_bib30","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.4049\/jimmunol.163.6.3363","article-title":"Receptor-mediated modulation of murine mast cell function by alpha-melanocyte stimulating hormone","volume":"163","author":"Adachi","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib31","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1046\/j.1440-1711.2001.01022.x","article-title":"In\u00a0vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH)","volume":"79","author":"Taylor","year":"2001","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib32","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1600-0625.2011.01360.x","article-title":"Inducible nitric oxide synthase (iNOS) and \u03b1-melanocyte-stimulating hormones of iNOS origin play important roles in the allergic reactions of atopic dermatitis in mice","volume":"20","author":"Orita","year":"2011","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2019.05.017_bib33","doi-asserted-by":"crossref","first-page":"17P","DOI":"10.1254\/fpj.114.supplement_17","article-title":"Involvement of nitric oxide in itch-scratch response of NC mice","volume":"114","author":"Tsukumo","year":"1999","journal-title":"Nihon Yakurigaku Zasshi"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401831174X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401831174X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:34:08Z","timestamp":1757694848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000294401831174X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S000294401831174X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2019.05.017","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of \u03b1-Melanocyte\u2013Stimulating Hormone\u2013Thromboxane A2 System on Itching in Atopic Dermatitis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2019.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}