{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:08:07Z","timestamp":1791616087911,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011898","name":"Marcus och Amalia Wallenbergs minnesfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011898","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.ajpath.2019.06.015","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T19:36:06Z","timestamp":1565379366000},"page":"1933-1944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Localization and Regulation of Polymeric Ig Receptor in Healthy and Diseased Human Kidney"],"prefix":"10.1016","volume":"189","author":[{"given":"Krzysztof M.","family":"Krawczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hel\u00e9n","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Nystr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lindgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Leandersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Sw\u00e4rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2019.06.015_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nri982","article-title":"Intestinal IgA synthesis: regulation of front-line body defences","volume":"3","author":"Fagarasan","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib2","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1172\/JCI105805","article-title":"Secretory gamma-A in normal urine","volume":"47","author":"Bienenstock","year":"1968","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajpath.2019.06.015_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1084\/jem.129.2.411","article-title":"The human secretory immunoglobulin system: immunohistological localization of gamma A, secretory \u201cpiece,\u201d and lactoferrin in normal human tissues","volume":"129","author":"Tourville","year":"1969","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2019.06.015_bib4","first-page":"318","article-title":"The secretory immune system and renal disease","volume":"21","author":"Dobrin","year":"1975","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.stem.2008.01.014","article-title":"Intrinsic epithelial cells repair the kidney after injury","volume":"2","author":"Humphreys","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2019.06.015_bib6","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.ajpath.2010.10.026","article-title":"Isolation and characterization of progenitor-like cells from human renal proximal tubules","volume":"178","author":"Lindgren","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib7","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1681\/ASN.2006010089","article-title":"Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys","volume":"17","author":"Sagrinati","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/path.4125","article-title":"Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration","volume":"229","author":"Smeets","year":"2013","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib9","doi-asserted-by":"crossref","first-page":"C807","DOI":"10.1152\/ajpcell.00301.2006","article-title":"Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney","volume":"292","author":"Vogetseder","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12882-017-0738-8","article-title":"Injury induced expression of caveolar proteins in human kidney tubules: role of megakaryoblastic leukemia 1","volume":"18","author":"Krawczyk","year":"2017","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib11","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/labinvest.2017.78","article-title":"Papillary renal cell carcinoma-derived chemerin, IL-8, and CXCL16 promote monocyte recruitment and differentiation into foam-cell macrophages","volume":"97","author":"Krawczyk","year":"2017","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2019.06.015_bib12","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","author":"Consortium","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2019.06.015_bib13","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib14","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/mi.2011.37","article-title":"Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity","volume":"4","author":"Johansen","year":"2011","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.0105-2896.2005.00278.x","article-title":"The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces","volume":"206","author":"Kaetzel","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/j.ajpath.2019.06.015_bib16","first-page":"571","article-title":"Secretory immune responses in human kidneys","volume":"125","author":"Abramowsky","year":"1986","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2249.2008.03868.x","article-title":"The level of urinary secretory immunoglobulin A (sIgA) of patients with IgA nephropathy is elevated and associated with pathological phenotypes","volume":"156","author":"Tan","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0090-1229(89)90048-2","article-title":"Secretory immunoglobulin A in urinary tract infection, chronic glomerulonephritis, and renal transplantation","volume":"53","author":"Marx","year":"1989","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/ndt\/5.7.520","article-title":"Urinary secretory immunoglobulin A in acute renal allograft rejection","volume":"5","author":"Marx","year":"1990","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ajpath.2019.06.015_bib20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1590-8658(00)80026-2","article-title":"High serum levels of secretory immunoglobullin A in chronic pancreatitis","volume":"32","author":"Frulloni","year":"2000","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.ajpath.2019.06.015_bib21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000188677","article-title":"Serum secretory IgA and IgM and free secretory component in IgA nephropathy","volume":"71","author":"Mole","year":"1995","journal-title":"Nephron"},{"key":"10.1016\/j.ajpath.2019.06.015_bib22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0168-8278(95)80280-0","article-title":"Serum secretory IgA and secretory component in patients with non-cirrhotic alcoholic liver diseases","volume":"22","author":"Seilles","year":"1995","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4049\/jimmunol.105.1.43","article-title":"Secretory IgA in human serum","volume":"105","author":"Waldman","year":"1970","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/ndt\/gfm492","article-title":"The level of serum secretory IgA of patients with IgA nephropathy is elevated and associated with pathological phenotypes","volume":"23","author":"Zhang","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ajpath.2019.06.015_bib25","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1097\/01.smj.0000243183.87381.c2","article-title":"Minimal change disease: a review","volume":"99","author":"Saha","year":"2006","journal-title":"South Med J"},{"key":"10.1016\/j.ajpath.2019.06.015_bib26","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1053\/j.ajkd.2011.07.024","article-title":"New insights into human minimal change disease: lessons from animal models","volume":"59","author":"Chugh","year":"2012","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ajpath.2019.06.015_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF02725654","article-title":"Elevated levels of secretory immunoglobulin A (sIgA) in urinary tract infections","volume":"71","author":"Deo","year":"2004","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.ajpath.2019.06.015_bib28","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s003450050160","article-title":"The urinary tract response to entry of pathogens","volume":"17","author":"Uehling","year":"1999","journal-title":"World J Urol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib29","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1128\/jvi.69.2.1339-1343.1995","article-title":"Intracellular neutralization of influenza virus by immunoglobulin A anti-hemagglutinin monoclonal antibodies","volume":"69","author":"Mazanec","year":"1995","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib30","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1073\/pnas.89.15.6901","article-title":"Intracellular neutralization of virus by immunoglobulin A antibodies","volume":"89","author":"Mazanec","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2019.06.015_bib31","doi-asserted-by":"crossref","first-page":"10972","DOI":"10.1128\/JVI.76.21.10972-10979.2002","article-title":"Multiple functions of immunoglobulin A in mucosal defense against viruses: an in\u00a0vitro measles virus model","volume":"76","author":"Yan","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib32","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ki.1983.90","article-title":"Does low urinary sIgA predispose to urinary tract infection?","volume":"23","author":"Riedasch","year":"1983","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2019.06.015_bib33","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1128\/iai.22.3.790-797.1978","article-title":"Secretory immunoglobulin A and G antibodies prevent adhesion of Escherichia coli to human urinary tract epithelial cells","volume":"22","author":"Svanborg-Eden","year":"1978","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2019.06.015_bib34","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.it.2004.01.001","article-title":"Transcriptional regulation of the mucosal IgA system","volume":"25","author":"Johansen","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib35","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.smim.2006.04.006","article-title":"BAFF, APRIL and their receptors: structure, function and signaling","volume":"18","author":"Bossen","year":"2006","journal-title":"Semin Immunol"},{"key":"10.1016\/j.ajpath.2019.06.015_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20032000","article-title":"TACI and BAFF-R mediate isotype switching in B cells","volume":"201","author":"Castigli","year":"2005","journal-title":"J Exp Med"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944019306583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944019306583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:06:12Z","timestamp":1762081572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944019306583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0002944019306583"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2019.06.015","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Localization and Regulation of Polymeric Ig Receptor in Healthy and Diseased Human Kidney","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2019.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}