{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:55:32Z","timestamp":1788404132229,"version":"build-2803163510"},"reference-count":80,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI108400"],"award-info":[{"award-number":["R01AI108400"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI095004"],"award-info":[{"award-number":["R21AI095004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI135583"],"award-info":[{"award-number":["R21AI135583"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ajpath.2019.12.005","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T11:17:06Z","timestamp":1580901426000},"page":"844-861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Hippo Signaling Pathway Has a Critical Role in Zika Virus Replication and in the Pathogenesis of Neuroinflammation"],"prefix":"10.1016","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-9251","authenticated-orcid":false,"suffix":"Jr.","given":"Gustavo","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayan","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Beshara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Krishnan","family":"Ramanujan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-6141","authenticated-orcid":false,"given":"Arunachalam","family":"Ramaiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1742-5211","authenticated-orcid":false,"given":"Karin","family":"Nielsen-Saines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6905-7940","authenticated-orcid":false,"given":"Melody M.H.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouki","family":"Morizono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6872-5118","authenticated-orcid":false,"given":"Vaithilingaraja","family":"Arumugaswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2019.12.005_bib1","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika virus Outbreak on Yap Island, Federated States of Micronesia","volume":"360","author":"Duffy","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2019.12.005_bib2","doi-asserted-by":"crossref","first-page":"e20181104","DOI":"10.1542\/peds.2018-1104","article-title":"Eye findings in infants with suspected or confirmed antenatal Zika virus exposure","volume":"142","author":"Tsui","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajpath.2019.12.005_bib3","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in Rio de Janeiro","volume":"375","author":"Brasil","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2019.12.005_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/0004-2749.20160002","article-title":"Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection","volume":"79","author":"Ventura","year":"2016","journal-title":"Arquivos Brasileiros de Oftalmologia"},{"key":"10.1016\/j.ajpath.2019.12.005_bib5","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/jamaophthalmol.2017.3595","article-title":"Ocular histopathologic features of congenital Zika syndromeocular histopathologic features of congenital Zika syndrome","volume":"135","author":"Fernandez","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/jamaophthalmol.2016.0267","article-title":"Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil","volume":"134","author":"de Paula Freitas","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib7","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.ophtha.2016.05.001","article-title":"Expanded spectrum of congenital ocular findings in microcephaly with presumed Zika infection","volume":"123","author":"Miranda","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajpath.2019.12.005_bib8","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3390\/v10100530","article-title":"Ocular manifestations of emerging flaviviruses and the blood-retinal barrier","volume":"10","author":"Singh","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.ajpath.2019.12.005_bib9","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0140-6736(16)30058-7","article-title":"Guillain-Barre syndrome associated with Zika virus infection","volume":"387","author":"Brasil","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2019.12.005_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/14787210.2018.1466702","article-title":"Neurological complications of Zika virus infection","volume":"16","author":"Carod-Artal","year":"2018","journal-title":"Expert Rev Anti Infect Therapy"},{"key":"10.1016\/j.ajpath.2019.12.005_bib11","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1016\/j.celrep.2016.08.079","article-title":"Zika virus infection in mice causes panuveitis with shedding of virus in tears","volume":"16","author":"Miner","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2019.12.005_bib12","doi-asserted-by":"crossref","first-page":"e92340","DOI":"10.1172\/jci.insight.92340","article-title":"Zika virus infects cells lining the blood-retinal barrier and causes chorioretinal atrophy in mouse eyes","volume":"2","author":"Singh","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.ajpath.2019.12.005_bib13","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1016\/S0140-6736(16)30776-0","article-title":"Zika: neurological and ocular findings in infant without microcephaly","volume":"387","author":"Ventura","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2019.12.005_bib14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.stem.2016.02.016","article-title":"Zika virus infects human cortical neural progenitors and attenuates their growth","volume":"18","author":"Tang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2019.12.005_bib15","doi-asserted-by":"crossref","first-page":"e02144-16","DOI":"10.1128\/JVI.02144-16","article-title":"Zika virus efficiently replicates in human retinal epithelium and disturbs its permeability","volume":"91","author":"Salinas","year":"2017","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12974-017-0824-7","article-title":"Zika virus infection of cellular components of the blood-retinal barriers: implications for viral associated congenital ocular disease","volume":"14","author":"Roach","year":"2017","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.ajpath.2019.12.005_bib17","doi-asserted-by":"crossref","first-page":"12774","DOI":"10.1038\/s41598-018-31149-3","article-title":"Zika virus impairs the development of blood vessels in a mouse model of congenital infection","volume":"8","author":"Garcez","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2019.12.005_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","article-title":"The blood-brain barrier: an overview: structure, regulation, and clinical implications","volume":"16","author":"Ballabh","year":"2004","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.ajpath.2019.12.005_bib19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stem.2016.03.012","article-title":"Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells","volume":"18","author":"Nowakowski Tomasz","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2019.12.005_bib20","doi-asserted-by":"crossref","first-page":"e00952-17","DOI":"10.1128\/mBio.00952-17","article-title":"Zika virus persistently infects and is basolaterally released from primary human brain microvascular endothelial cells","volume":"8","author":"Mladinich","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.ajpath.2019.12.005_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte\u2013endothelial interactions at the blood\u2013brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ajpath.2019.12.005_bib22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3109\/13813455.2010.539616","article-title":"Astrocytes and energy metabolism","volume":"117","author":"Prebil","year":"2011","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.ajpath.2019.12.005_bib23","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","article-title":"Zika virus infection during pregnancy in mice causes placental damage and fetal demise","volume":"165","author":"Miner","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2019.12.005_bib24","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1167\/iovs.17-22016","article-title":"Viral retinopathy in experimental models of Zika infection","volume":"58","author":"Zhao","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2019.12.005_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12640-016-9635-3","article-title":"Zika virus infection and development of a murine model","volume":"30","author":"Shah","year":"2016","journal-title":"Neurotox Res"},{"key":"10.1016\/j.ajpath.2019.12.005_bib26","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.cmet.2019.01.024","article-title":"Differential metabolic reprogramming by Zika virus promotes cell death in human versus mosquito cells","volume":"29","author":"Thaker","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2019.12.005_bib27","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.15252\/embr.201642627","article-title":"Zika virus inhibits type-I interferon production and downstream signaling","volume":"17","author":"Kumar","year":"2016","journal-title":"EMBO Rep"},{"key":"10.1016\/j.ajpath.2019.12.005_bib28","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika virus targets human STAT2 to inhibit type I interferon signaling","volume":"19","author":"Grant","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ajpath.2019.12.005_bib29","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.4049\/jimmunol.1601949","article-title":"Adaptive immune responses to Zika virus are important for controlling virus infection and preventing infection in brain and testes","volume":"198","author":"Winkler","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib30","doi-asserted-by":"crossref","first-page":"e1006004","DOI":"10.1371\/journal.ppat.1006004","article-title":"Zika (PRVABC59) infection is associated with T cell infiltration and neurodegeneration in CNS of immunocompetent neonatal C57Bl\/6 Mice","volume":"12","author":"Manangeeswaran","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2019.12.005_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.chom.2016.12.010","article-title":"Mapping and role of the CD8+ T cell response during primary Zika virus infection in mice","volume":"21","author":"Elong Ngono","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ajpath.2019.12.005_bib32","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1016\/j.celrep.2016.11.070","article-title":"A mouse model of Zika virus sexual transmission and vaginal viral replication","volume":"17","author":"Tang","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2019.12.005_bib33","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.chom.2016.03.010","article-title":"A mouse model of Zika virus pathogenesis","volume":"19","author":"Lazear","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ajpath.2019.12.005_bib34","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00173-19","article-title":"Zika virus infects trabecular meshwork and causes trabeculitis and glaucomatous pathology in mouse eyes","volume":"4","author":"Singh","year":"2019","journal-title":"mSphere"},{"key":"10.1016\/j.ajpath.2019.12.005_bib35","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrc2070","article-title":"The Salvador-Warts-Hippo pathway: an emerging tumour-suppressor network","volume":"7","author":"Harvey","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ajpath.2019.12.005_bib36","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gad.1909210","article-title":"The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2019.12.005_bib37","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2019.12.005_bib38","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.cell.2016.11.005","article-title":"The Hippo pathway kinases LATS1\/2 suppress cancer immunity","volume":"167","author":"Moroishi","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2019.12.005_bib39","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/emboj.2009.82","article-title":"Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes","volume":"28","author":"Katagiri","year":"2009","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2019.12.005_bib40","doi-asserted-by":"crossref","first-page":"37695","DOI":"10.1038\/srep37695","article-title":"Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1\/2 expression to modulate host immune responses","volume":"6","author":"Boro","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2019.12.005_bib41","doi-asserted-by":"crossref","first-page":"e44010","DOI":"10.1371\/journal.pone.0044010","article-title":"Inherited MST1 deficiency underlies susceptibility to EV-HPV infections","volume":"7","author":"Crequer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2019.12.005_bib42","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/ncb3496","article-title":"Hippo signalling governs cytosolic nucleic acid sensing through YAP\/TAZ-mediated TBK1 blockade","volume":"19","author":"Zhang","year":"2017","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib43","series-title":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals; National Research Council: Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"10.1016\/j.ajpath.2019.12.005_bib44","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/hmg\/ddq341","article-title":"Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells","volume":"19","author":"Liao","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajpath.2019.12.005_bib45","doi-asserted-by":"crossref","first-page":"e91416","DOI":"10.1371\/journal.pone.0091416","article-title":"Integrated analysis of DNA methylation and RNA transcriptome during in\u00a0vitro differentiation of human pluripotent stem cells into retinal pigment epithelial cells","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2019.12.005_bib46","doi-asserted-by":"crossref","first-page":"e6529","DOI":"10.1371\/journal.pone.0006529","article-title":"A versatile viral system for expression and depletion of proteins in mammalian cells","volume":"4","author":"Campeau","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2019.12.005_bib47","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1128\/JVI.03287-13","article-title":"Role of phosphatidylserine receptors in enveloped virus infection","volume":"88","author":"Morizono","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib48","first-page":"54767","article-title":"Zika virus infectious cell culture system and the in\u00a0vitro prophylactic effect of interferons","volume":"114","author":"Contreras","year":"2016","journal-title":"J Vis Exp"},{"key":"10.1016\/j.ajpath.2019.12.005_bib49","first-page":"128405","article-title":"Modeling Zika virus congenital eye disease: differential susceptibility of fetal retinal progenitor cells and ipsc-derived retinal stem cells to Zika virus infection","author":"Contreras","year":"2017","journal-title":"bioRxiv"},{"key":"10.1016\/j.ajpath.2019.12.005_bib50","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib51","series-title":"R Core Team: R: a language and environment for statistical computing","year":"2016"},{"key":"10.1016\/j.ajpath.2019.12.005_bib52","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib53","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B Methodol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib54","doi-asserted-by":"crossref","first-page":"e0176334","DOI":"10.1371\/journal.pone.0176334","article-title":"shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics","volume":"12","author":"Khomtchouk","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2019.12.005_bib55","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.celrep.2018.10.001","article-title":"Comprehensive molecular characterization of the Hippo signaling pathway in cancer","volume":"25","author":"Wang","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2019.12.005_bib56","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ccell.2016.05.005","article-title":"YAP\/TAZ at the roots of cancer","volume":"29","author":"Zanconato","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ajpath.2019.12.005_bib57","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ncb3113","article-title":"AMPK modulates Hippo pathway activity to regulate energy homeostasis","volume":"17","author":"Wang","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib58","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ncb3111","article-title":"Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway","volume":"17","author":"Mo","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib59","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance","volume":"66","author":"Garcia","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.ajpath.2019.12.005_bib60","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1194\/jlr.M500438-JLR200","article-title":"Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells","volume":"47","author":"Fediuc","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2019.12.005_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.274027.115","article-title":"Mechanisms of Hippo pathway regulation","volume":"30","author":"Meng","year":"2016","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2019.12.005_bib62","doi-asserted-by":"crossref","first-page":"E1312","DOI":"10.1073\/pnas.1110428108","article-title":"Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance","volume":"108","author":"Zhou","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2019.12.005_bib63","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2217\/epi-2018-0180","article-title":"Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells","volume":"11","author":"Kandilya","year":"2019","journal-title":"Epigenomics"},{"key":"10.1016\/j.ajpath.2019.12.005_bib64","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.4161\/onci.21284","article-title":"Conditional IFNAR1 ablation reveals distinct requirements of type I IFN signaling for NK cell maturation and tumor surveillance","volume":"1","author":"Mizutani","year":"2012","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.ajpath.2019.12.005_bib65","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1089\/scd.2012.0685","article-title":"Mesenchymal stem cell and chondrocyte fates in a multishear microdevice are regulated by Yes-associated protein","volume":"22","author":"Zhong","year":"2013","journal-title":"Stem Cell Dev"},{"key":"10.1016\/j.ajpath.2019.12.005_bib66","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nature20602","article-title":"Integrin-YAP\/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow","volume":"540","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2019.12.005_bib67","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1128\/JVI.02577-12","article-title":"Differential replication of pathogenic and nonpathogenic strains of West Nile virus within astrocytes","volume":"87","author":"Hussmann","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib68","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1080\/13550280500384982","article-title":"Differential responses of human brain cells to West Nile virus infection","volume":"11","author":"Cheeran","year":"2005","journal-title":"J Neurovirol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib69","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1073\/pnas.1618029113","article-title":"Zika virus cell tropism in the developing human brain and inhibition by azithromycin","volume":"113","author":"Retallack","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2019.12.005_bib70","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3390\/ijms20030691","article-title":"Astrocytes in flavivirus infections","volume":"20","author":"Potokar","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2019.12.005_bib71","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1093\/cercor\/bhv292","article-title":"YAP is a critical inducer of SOCS3, preventing reactive astrogliosis","volume":"26","author":"Huang","year":"2016","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.ajpath.2019.12.005_bib72","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1182\/blood-2011-09-378364","article-title":"MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival","volume":"119","author":"Nehme","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2019.12.005_bib73","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/rmv.687","article-title":"Viruses and the fuel sensor: the emerging link between AMPK and virus replication","volume":"21","author":"Mankouri","year":"2011","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib74","doi-asserted-by":"crossref","first-page":"22513","DOI":"10.18632\/oncotarget.15116","article-title":"AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema","volume":"8","author":"Cheng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ajpath.2019.12.005_bib75","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/cmi.12625","article-title":"5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis","volume":"18","author":"Kumar","year":"2016","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib76","doi-asserted-by":"crossref","first-page":"e00360-18","DOI":"10.1128\/AAC.00360-18","article-title":"Direct activation of adenosine monophosphate-activated protein kinase (AMPK) by PF-06409577 inhibits flavivirus infection through modification of host cell lipid metabolism","volume":"62","author":"Jimenez de Oya","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ajpath.2019.12.005_bib77","doi-asserted-by":"crossref","first-page":"e02019-17","DOI":"10.1128\/JVI.02019-17","article-title":"Suppression of Zika virus infection and replication in endothelial cells and astrocytes by PKA inhibitor PKI 14-22","volume":"92","author":"Cheng","year":"2018","journal-title":"J Virol"},{"issue":"Suppl","key":"10.1016\/j.ajpath.2019.12.005_bib78","doi-asserted-by":"crossref","first-page":"50.14","DOI":"10.4049\/jimmunol.200.Supp.50.14","article-title":"AMP-activated kinase (AMPK) promotes innate immunity and antiviral defense against Zika virus induced ocular infection","volume":"200","author":"Kumar","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib79","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ncb2936","article-title":"Metabolic control of YAP and TAZ by the mevalonate pathway","volume":"16","author":"Sorrentino","year":"2014","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2019.12.005_bib80","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.canlet.2016.10.020","article-title":"Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP\/CD44 growth stimulatory axis","volume":"385","author":"Tanaka","year":"2017","journal-title":"Cancer Lett"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944020300201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944020300201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:06:35Z","timestamp":1762081595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944020300201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0002944020300201"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2019.12.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737338954.793570988","asserted-by":"object"}]},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippo Signaling Pathway Has a Critical Role in Zika Virus Replication and in the Pathogenesis of Neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2019.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}