{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:34:07Z","timestamp":1782952447847,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.ajpath.2020.01.021","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T17:26:28Z","timestamp":1584638788000},"page":"1256-1270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease"],"prefix":"10.1016","volume":"190","author":[{"given":"Jesse J.","family":"Balic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-2360","authenticated-orcid":false,"given":"Mohamed I.","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice J.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison C.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"D'Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Deswaerte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Dev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7829-0974","authenticated-orcid":false,"given":"William","family":"Sievert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Gough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithi S.","family":"Bhathal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6817-6211","authenticated-orcid":false,"given":"Richard L.","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7552-4656","authenticated-orcid":false,"given":"Brendan J.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2020.01.021_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jcmgh.2016.12.001","article-title":"The clinical evidence linking Helicobacter pylori to gastric cancer","volume":"3","author":"Moss","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","article-title":"The gastric precancerous cascade","volume":"13","author":"Correa","year":"2012","journal-title":"J Dig Dis"},{"key":"10.1016\/j.ajpath.2020.01.021_bib3","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41577-018-0066-7","article-title":"Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer","volume":"18","author":"Jones","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib4","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1158\/0008-5472.CAN-08-1191","article-title":"Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in\u00a0vitro and in\u00a0vivo","volume":"69","author":"Bronte-Tinkew","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2020.01.021_bib5","doi-asserted-by":"crossref","first-page":"9050715","DOI":"10.1155\/2018\/9050715","article-title":"Activation of signal transduction and activator of transcription 3 signaling contributes to Helicobacter-associated gastric epithelial proliferation and inflammation","volume":"2018","author":"Ishii","year":"2018","journal-title":"Gastroenterol Res Pract"},{"key":"10.1016\/j.ajpath.2020.01.021_bib6","doi-asserted-by":"crossref","first-page":"468","DOI":"10.18632\/oncoscience.62","article-title":"Helicobacter pylori-induced STAT3 activation and signalling network in gastric cancer","volume":"1","author":"Zhao","year":"2014","journal-title":"Oncoscience"},{"key":"10.1016\/j.ajpath.2020.01.021_bib7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/gutjnl-2013-305092","article-title":"Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response","volume":"63","author":"Ericksen","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2020.01.021_bib8","doi-asserted-by":"crossref","first-page":"16042","DOI":"10.1074\/jbc.M110.111054","article-title":"Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2\/ERK and JAK\/STAT signal transduction pathways in gastric epithelial cells","volume":"285","author":"Lee","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2020.01.021_bib9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/hel.12298","article-title":"Helicobacter pylori activates IL-6-STAT3 signaling in human gastric cancer cells: potential roles for reactive oxygen species","volume":"21","author":"Piao","year":"2016","journal-title":"Helicobacter"},{"key":"10.1016\/j.ajpath.2020.01.021_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08977194.2018.1473393","article-title":"STAT3: a multifaceted oncoprotein","volume":"36","author":"Guanizo","year":"2018","journal-title":"Growth Factors"},{"key":"10.1016\/j.ajpath.2020.01.021_bib11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(95)90311-9","article-title":"Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation","volume":"82","author":"Wen","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2020.01.021_bib12","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.7701321","article-title":"Requirement of serine phosphorylation for formation of STAT-promoter complexes","volume":"267","author":"Zhang","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2020.01.021_bib13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1128\/MCB.24.1.407-419.2004","article-title":"Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation","volume":"24","author":"Shen","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib14","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/hr.2012.223","article-title":"Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation","volume":"36","author":"Zouein","year":"2013","journal-title":"Hypertens Res"},{"key":"10.1016\/j.ajpath.2020.01.021_bib15","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.1171721","article-title":"Mitochondrial STAT3 supports Ras-dependent oncogenic transformation","volume":"324","author":"Gough","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2020.01.021_bib16","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1126\/science.1164551","article-title":"Function of mitochondrial Stat3 in cellular respiration","volume":"323","author":"Wegrzyn","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2020.01.021_bib17","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1182\/blood-2013-02-484196","article-title":"STAT3 supports experimental K-RasG12D\u2013induced murine myeloproliferative neoplasms dependent on serine phosphorylation","volume":"124","author":"Gough","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2020.01.021_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cyto.2016.05.019","article-title":"Mitochondrial STAT3: powering up a potent factor","volume":"87","author":"Garama","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.ajpath.2020.01.021_bib19","first-page":"gmr7358","article-title":"Role of the IL-11\/STAT3 signaling pathway in human chronic atrophic gastritis and gastric cancer","volume":"15","author":"Wang","year":"2016","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.ajpath.2020.01.021_bib20","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/jir.2018.0065","article-title":"Interplay between Helicobacter pylori infection, interleukin-11, and leukemia inhibitory factor in gastric cancer among Egyptian patients","volume":"38","author":"Sabry","year":"2018","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.ajpath.2020.01.021_bib21","first-page":"1727","article-title":"STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumourigenesis in gp130 receptor mutant mice","volume":"118","author":"Ernst","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2020.01.021_bib22","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1074\/mcp.M600170-MCP200","article-title":"Identification of protein expression signatures associated with Helicobacter pylori infection and gastric adenocarcinoma using recombinant antibody microarrays","volume":"5","author":"Ellmark","year":"2006","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.ajpath.2020.01.021_bib23","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","article-title":"Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994","volume":"20","author":"Dixon","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/path.2933","article-title":"The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17","volume":"225","author":"Kennedy","year":"2011","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib25","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/jac\/dki199","article-title":"Real-time PCR detection and frequency of 16S rDNA mutations associated with resistance and reduced susceptibility to tetracycline in Helicobacter pylori from England and Wales","volume":"56","author":"Lawson","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ajpath.2020.01.021_bib26","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1182\/blood.V90.6.2148","article-title":"Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis","volume":"90","author":"Nandurkar","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2020.01.021_bib27","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/0016-5085(90)91156-Z","article-title":"A small animal model of human Helicobacter pylori active chronic gastritis","volume":"99","author":"Lee","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2020.01.021_bib28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-1-62703-005-2_20","article-title":"Mouse models of Helicobacter-induced gastric cancer: use of cocarcinogens","volume":"921","author":"Ferrero","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib29","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1053\/j.gastro.2009.02.077","article-title":"Interleukin-17 is a critical mediator of vaccine-induced reduction of Helicobacter infection in the mouse model","volume":"136","author":"Velin","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2020.01.021_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-1-62703-005-2_12","article-title":"Rodent models of Helicobacter infection, inflammation, and disease","volume":"921","author":"Zhang","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib31","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1053\/j.gastro.2005.02.066","article-title":"Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL\/6 mice","volume":"128","author":"Cai","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2020.01.021_bib32","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4049\/jimmunol.163.3.1490","article-title":"Cellular immune responses are essential for the development of Helicobacter felis-associated gastric pathology","volume":"163","author":"Roth","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib33","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1128\/iai.64.1.238-245.1996","article-title":"Role of the host in pathogenesis of Helicobacter-associated gastritis: H. felis infection of inbred and congenic mouse strains","volume":"64","author":"Mohammadi","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2020.01.021_bib34","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.3748\/wjg.14.5962","article-title":"MYC and gastric adenocarcinoma carcinogenesis","volume":"14","author":"Calcagno","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib35","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/0140-6736(93)92879-X","article-title":"De-novo expression of CD44 and survival in gastric cancer","volume":"342","author":"Mayer","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2020.01.021_bib36","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/(SICI)1096-9896(199910)189:2<194::AID-PATH426>3.0.CO;2-P","article-title":"Cyclin D2, but not cyclin D1, overexpression closely correlates with gastric cancer progression and prognosis","volume":"189","author":"Takano","year":"1999","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib37","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ccr.2012.08.010","article-title":"STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation","volume":"22","author":"Tye","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ajpath.2020.01.021_bib38","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.4049\/jimmunol.162.8.4472","article-title":"The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation","volume":"162","author":"Gollob","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib39","doi-asserted-by":"crossref","first-page":"24392","DOI":"10.1074\/jbc.274.34.24392","article-title":"Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner","volume":"274","author":"Jain","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2020.01.021_bib40","doi-asserted-by":"crossref","first-page":"31055","DOI":"10.1074\/jbc.274.43.31055","article-title":"Serine phosphorylation and negative regulation of Stat3 by JNK","volume":"274","author":"Lim","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2020.01.021_bib41","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1021\/bi052490j","article-title":"Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest","volume":"45","author":"Shi","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.ajpath.2020.01.021_bib42","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1128\/MCB.00034-14","article-title":"Signal integration and gene induction by a functionally distinct STAT3 phosphoform","volume":"34","author":"Waitkus","year":"2014","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib43","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1038\/sj.onc.1203481","article-title":"Serine phosphorylation of STATs","volume":"19","author":"Decker","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2020.01.021_bib44","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4291\/wjgp.v5.i3.133","article-title":"Role of Toll-like receptors in Helicobacter pylori infection and immunity","volume":"5","author":"Smith","year":"2014","journal-title":"World J Gastrointest Pathophysiol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib45","doi-asserted-by":"crossref","first-page":"6446","DOI":"10.1128\/IAI.72.11.6446-6454.2004","article-title":"Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4","volume":"72","author":"Mandell","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2020.01.021_bib46","doi-asserted-by":"crossref","first-page":"5964","DOI":"10.1128\/IAI.66.12.5964-5971.1998","article-title":"Local cytokine response in Helicobacter pylori-infected subjects","volume":"66","author":"Lindholm","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2020.01.021_bib47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.molonc.2010.05.001","article-title":"Stem cells and cancer of the stomach and intestine","volume":"4","author":"Vries","year":"2010","journal-title":"Mol Oncol"},{"key":"10.1016\/j.ajpath.2020.01.021_bib48","doi-asserted-by":"crossref","first-page":"e1004663","DOI":"10.1371\/journal.ppat.1004663","article-title":"CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation","volume":"11","author":"Bertaux-Skeirik","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2020.01.021_bib49","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1074\/jbc.M706976200","article-title":"Identification of novel direct Stat3 target genes for control of growth and differentiation","volume":"283","author":"Snyder","year":"2008","journal-title":"J Biol Chem"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944020301346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944020301346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:36:46Z","timestamp":1757695006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944020301346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0002944020301346"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2020.01.021","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2020.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}