{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:32:47Z","timestamp":1777357967339,"version":"3.51.4"},"reference-count":68,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001067","name":"Juvenile Diabetes Research Foundation Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ajpath.2020.05.016","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T02:39:58Z","timestamp":1591670398000},"page":"1801-1812","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lung and Eye Disease Develop Concurrently in Supplemental Oxygen\u2013Exposed Neonatal Mice"],"prefix":"10.1016","volume":"190","author":[{"given":"Lakshanie C.","family":"Wickramasinghe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maverick","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devy","family":"Deliyanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-5555","authenticated-orcid":false,"given":"Timothy A.","family":"Gottschalk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8800-7834","authenticated-orcid":false,"given":"Peter","family":"van Wijngaarden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Talia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Wilkinson-Berka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Tsantikos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-6751","authenticated-orcid":false,"given":"Margaret L.","family":"Hibbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2020.05.016_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/ANC.0b013e318206d0c0","article-title":"Oxygen use for preterm infants: factors that may influence clinical decisions surrounding oxygen titration","volume":"11","author":"Johnson","year":"2011","journal-title":"Adv Neonatal Care"},{"key":"10.1016\/j.ajpath.2020.05.016_bib2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000087581","article-title":"Neonatal chronic lung disease in the post-surfactant era","volume":"88","author":"Bland","year":"2005","journal-title":"Neonatology"},{"key":"10.1016\/j.ajpath.2020.05.016_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fmed.2015.00002","article-title":"Bronchopulmonary dysplasia early changes leading to long-term consequences","volume":"2","author":"Hilgendorff","year":"2015","journal-title":"Front Med"},{"key":"10.1016\/j.ajpath.2020.05.016_bib4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/thoraxjnl-2012-202980","article-title":"Lung function after preterm birth: development from mid-childhood to adulthood","volume":"68","author":"Volls\u00e6ter","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.ajpath.2020.05.016_bib5","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1056\/NEJM199204163261603","article-title":"A cohort study of transcutaneous oxygen tension and the incidence and severity of retinopathy of prematurity","volume":"326","author":"Flynn","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2020.05.016_bib6","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2020.05.016_bib7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1001\/archopht.116.5.601","article-title":"Antenatal dexamethasone and decreased severity of retinopathy of prematurity","volume":"116","author":"Higgins","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib8","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3109\/14767058.2012.733778","article-title":"Early neonatal outcomes of volume guaranteed ventilation in preterm infants with respiratory distress syndrome","volume":"26","author":"Guven","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajpath.2020.05.016_bib9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1034\/j.1600-0420.1998.760216.x","article-title":"Neonatal risk factors for retinopathy of prematurity-a population-based study","volume":"76","author":"Holmstr\u00f6m","year":"1998","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.ajpath.2020.05.016_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1515\/med-2018-0012","article-title":"Correlation of retinopathy of prematurity with bronchopulmonary dysplasia","volume":"13","author":"Podraza","year":"2018","journal-title":"Open Med"},{"key":"10.1016\/j.ajpath.2020.05.016_bib11","first-page":"S1","article-title":"The bronchopulmonary dysplasia in infants with retinopathy of prematurity","volume":"24","author":"Kachurina","year":"2014","journal-title":"Iranian J Pediatr"},{"key":"10.1016\/j.ajpath.2020.05.016_bib12","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00417-009-1116-4","article-title":"Kinetics of retinal vaso-obliteration and neovascularisation in the oxygen-induced retinopathy (OIR) mouse model","volume":"247","author":"Lange","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib13","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1242\/bio.017665","article-title":"Impact of bronchopulmonary dysplasia on brain and retina","volume":"5","author":"Poon","year":"2016","journal-title":"Biol Open"},{"key":"10.1016\/j.ajpath.2020.05.016_bib14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/01902140903258904","article-title":"Exposure to cyclic oxygen sufficient for development of oxygen-induced retinopathy does not induce bronchopulmonary dysplasia in rats","volume":"36","author":"Klebe","year":"2010","journal-title":"Exp Lung Research"},{"key":"10.1016\/j.ajpath.2020.05.016_bib15","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/nprot.2009.187","article-title":"Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis","volume":"4","author":"Connor","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ajpath.2020.05.016_bib16","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1089\/ars.2013.5357","article-title":"NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy","volume":"20","author":"Wilkinson-Berka","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ajpath.2020.05.016_bib17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1152\/japplphysiol.01100.2009","article-title":"Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach","volume":"108","author":"Knudsen","year":"2010","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib18","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1165\/rcmb.2004-0092OC","article-title":"Conditional overexpression of bioactive transforming growth factor\u2013\u03b21 in neonatal mouse lung: a new model for bronchopulmonary dysplasia?","volume":"31","author":"Vicencio","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib19","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1369\/jhc.5A6721.2005","article-title":"Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids","volume":"53","author":"Pua","year":"2005","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.ajpath.2020.05.016_bib20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajpath.2020.05.016_bib21","doi-asserted-by":"crossref","first-page":"946","DOI":"10.4049\/jimmunol.1200660","article-title":"Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease","volume":"189","author":"Duan","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib22","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1001\/archopht.1996.01100140419009","article-title":"Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity","volume":"114","author":"Pierce","year":"1996","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib23","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1073\/pnas.92.3.905","article-title":"Vascular endothelial growth factor\/vascular permeability factor expression in a mouse model of retinal neovascularization","volume":"92","author":"Pierce","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2020.05.016_bib24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.clp.2013.02.002","article-title":"The biology of retinopathy of prematurity: how knowledge of pathogenesis guides treatment","volume":"40","author":"Smith","year":"2013","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib25","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1242\/dev.126.14.3047","article-title":"Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse","volume":"126","author":"Hellstrom","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2020.05.016_bib26","doi-asserted-by":"crossref","first-page":"L231","DOI":"10.1152\/ajplung.00342.2013","article-title":"Reduced platelet-derived growth factor receptor expression is a primary feature of human bronchopulmonary dysplasia","volume":"307","author":"Popova","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib27","doi-asserted-by":"crossref","first-page":"dev161976","DOI":"10.1242\/dev.161976","article-title":"PDGF-A signaling is required for secondary alveolar septation and controls epithelial proliferation in the developing lung","volume":"145","author":"Gouveia","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2020.05.016_bib28","doi-asserted-by":"crossref","first-page":"L369","DOI":"10.1152\/ajplung.00176.2014","article-title":"Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependent","volume":"309","author":"Datta","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib29","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1089\/ars.2013.5785","article-title":"Role of reactive oxygen species in neonatal pulmonary vascular disease","volume":"21","author":"Wedgwood","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ajpath.2020.05.016_bib30","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00441-016-2545-0","article-title":"Development of the lung","volume":"367","author":"Schittny","year":"2017","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajpath.2020.05.016_bib31","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev.physiol.67.040403.102229","article-title":"Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia","volume":"67","author":"Stenmark","year":"2005","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib32","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3109\/15513819109065482","article-title":"Pulmonary vascular changes in bronchopulmonary dysplasia: a clinicopathologic correlation in short-and long-term survivors","volume":"11","author":"Gorenflo","year":"1991","journal-title":"Pediatr Pathol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib33","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1164\/ajrccm.164.10.2101140","article-title":"Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia","volume":"164","author":"Bhatt","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2020.05.016_bib34","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1165\/ajrcmb.16.5.9160838","article-title":"Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung","volume":"16","author":"Maniscalco","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib35","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1523\/JNEUROSCI.15-07-04738.1995","article-title":"Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia","volume":"15","author":"Stone","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2020.05.016_bib36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ydbio.2007.04.042","article-title":"Epithelial\u2013vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis","volume":"308","author":"Yamamoto","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/(SICI)1097-0177(199803)211:3<215::AID-AJA3>3.0.CO;2-K","article-title":"VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in\u00a0vivo","volume":"211","author":"Zeng","year":"1998","journal-title":"Dev Dyn"},{"key":"10.1016\/j.ajpath.2020.05.016_bib38","doi-asserted-by":"crossref","first-page":"L600","DOI":"10.1152\/ajplung.2000.279.3.L600","article-title":"Inhibition of angiogenesis decreases alveolarization in the developing rat lung","volume":"279","author":"Jakkula","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib39","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000438953","article-title":"Platelet-derived growth factor inhibitors: a potential therapeutic approach for ocular neovascularization","volume":"55","author":"Sadiq","year":"2016","journal-title":"Dev Ophthalmol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib40","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0002-9440(10)63214-2","article-title":"Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy","volume":"164","author":"Wilkinson-Berka","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib41","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0092-8674(00)81270-2","article-title":"PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis","volume":"85","author":"Bostrom","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2020.05.016_bib42","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1242\/dev.124.20.3943","article-title":"Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development","volume":"124","author":"Lindahl","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2020.05.016_bib43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1165\/rcmb.2014-0294TR","article-title":"Platelet-derived growth factor signaling in the lung: from lung development and\u00a0disease to clinical studies","volume":"52","author":"Noskovi\u010dov\u00e1","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib44","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0002-9440(10)65432-6","article-title":"Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor","volume":"154","author":"Hoyle","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib45","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/dvdy.21403","article-title":"TGF-\u03b2 signaling is dynamically regulated during the alveolarization of rodent and human lungs","volume":"237","author":"Alejandre-Alc\u00e1zar","year":"2008","journal-title":"Dev Dyn"},{"key":"10.1016\/j.ajpath.2020.05.016_bib46","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0022-3476(96)70355-4","article-title":"Increase in the concentration of transforming growth factor beta-1 in bronchoalveolar lavage fluid before development of chronic lung disease of prematurity","volume":"128","author":"Kotecha","year":"1996","journal-title":"J Pediatr"},{"key":"10.1016\/j.ajpath.2020.05.016_bib47","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000014219","article-title":"Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation","volume":"77","author":"Lecart","year":"2000","journal-title":"Neonatology"},{"key":"10.1016\/j.ajpath.2020.05.016_bib48","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-1-4419-1399-9_9","article-title":"Increased expression of TGF-\u03b21 and Smad 4 on oxygen-induced retinopathy in neonatal mice","volume":"664","author":"Yingchuan","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib49","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/01902148.2016.1226448","article-title":"Alteration of TGF-\u03b2-ALK-Smad signaling in hyperoxia-induced bronchopulmonary dysplasia model of newborn rats","volume":"42","author":"Jin","year":"2016","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.ajpath.2020.05.016_bib50","doi-asserted-by":"crossref","first-page":"47082","DOI":"10.18632\/oncotarget.9314","article-title":"Mesenchymal stem cells in combination with erythropoietin repair hyperoxia-induced alveoli dysplasia injury in neonatal mice via inhibition of TGF-\u03b21 signaling","volume":"7","author":"Luan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ajpath.2020.05.016_bib51","article-title":"Expression of transforming growth factor-\u03b21 in neonatal rats with hyperoxia-induced bronchopulmonary dysplasia and its relationship with lung development","volume":"15:gmr8064","author":"Yan","year":"2016","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.ajpath.2020.05.016_bib52","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/S0002-9440(10)63612-7","article-title":"Transfer of the active form of transforming growth factor-\u03b21 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia","volume":"163","author":"Gauldie","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib53","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/ncb826","article-title":"Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-\u03b2","volume":"4","author":"Abreu","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib54","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1203\/PDR.0b013e3180987202","article-title":"Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis","volume":"62","author":"Chen","year":"2007","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajpath.2020.05.016_bib55","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1203\/PDR.0b013e318163a8cc","article-title":"High tidal volume ventilation activates Smad2 and upregulates expression of connective tissue growth factor in newborn rat lung","volume":"63","author":"Wu","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajpath.2020.05.016_bib56","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1755-1536-4-4","article-title":"Cooperative interaction of CTGF and TGF-\u03b2 in animal models of fibrotic disease","volume":"4","author":"Wang","year":"2011","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.ajpath.2020.05.016_bib57","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1203\/PDR.0b013e318211c917","article-title":"Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and up-regulation of p21 in neonatal mouse lung","volume":"69","author":"Londhe","year":"2011","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajpath.2020.05.016_bib58","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/MOP.0000000000000095","article-title":"Disrupted lung development and bronchopulmonary dysplasia: opportunities for lung repair and regeneration","volume":"26","author":"Baker","year":"2014","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.ajpath.2020.05.016_bib59","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.stem.2019.12.014","article-title":"Distinct airway epithelial stem cells hide among club cells but mobilize to promote alveolar regeneration","volume":"26","author":"Kathiriya","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2020.05.016_bib60","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.chest.2017.04.173","article-title":"Bronchopulmonary dysplasia: where have all the stem cells gone? origin and (potential) function of resident lung stem cells","volume":"152","author":"M\u00f6bius","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.ajpath.2020.05.016_bib61","doi-asserted-by":"crossref","first-page":"L488","DOI":"10.1152\/ajplung.00359.2014","article-title":"Neonatal exposure to mild hyperoxia causes persistent increases in oxidative stress and immune cells in the lungs of mice without altering lung structure","volume":"309","author":"Bouch","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib62","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1183\/09031936.00185511","article-title":"Evidence of unexpected oxidative stress in airways of adolescents born very pre-term","volume":"40","author":"Filippone","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2020.05.016_bib63","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1164\/rccm.200902-0296OC","article-title":"NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice","volume":"180","author":"Carnesecchi","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2020.05.016_bib64","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/CS20150660","article-title":"NOX2-dependent regulation of inflammation","volume":"130","author":"Singel","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.ajpath.2020.05.016_bib65","doi-asserted-by":"crossref","first-page":"6238","DOI":"10.1167\/iovs.10-6742","article-title":"Choroidal involution is a key component of oxygen-induced retinopathy","volume":"52","author":"Shao","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2020.05.016_bib66","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1001\/jamaophthalmol.2013.5052","article-title":"Choroidal thickness in patients with a history of retinopathy of prematurity","volume":"131","author":"Wu","year":"2013","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ajpath.2020.05.016_bib67","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1203\/00006450-199608000-00010","article-title":"Increase in interleukin (IL)-1\u03b2 and IL-6 in bronchoalveolar lavage fluid obtained from infants with chronic lung disease of prematurity","volume":"40","author":"Kotecha","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajpath.2020.05.016_bib68","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41467-017-00751-w","article-title":"Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis","volume":"8","author":"Deliyanti","year":"2017","journal-title":"Nat Commun"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294402030287X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294402030287X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:37:51Z","timestamp":1757695071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000294402030287X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":68,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S000294402030287X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2020.05.016","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lung and Eye Disease Develop Concurrently in Supplemental Oxygen\u2013Exposed Neonatal Mice","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2020.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}