{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:43:50Z","timestamp":1792651430979,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.ajpath.2020.07.008","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T21:10:18Z","timestamp":1595279418000},"page":"2282-2289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Association of Neutrophil Extracellular Traps with the Development of Idiopathic Osteonecrosis of the Femoral Head"],"prefix":"10.1016","volume":"190","author":[{"given":"Mayu","family":"Nonokawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miku","family":"Yoshinari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamato","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Nishibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakiko","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utano","family":"Tomaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7084-9734","authenticated-orcid":false,"given":"Akihiro","family":"Ishizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2020.07.008_bib1","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1056\/NEJM199205283262206","article-title":"Nontraumatic necrosis of bone (osteonecrosis)","volume":"326","author":"Mankin","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2020.07.008_bib2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1302\/2058-5241.4.180036","article-title":"Osteonecrosis of the femoral head: pathophysiology and current concepts of treatment","volume":"4","author":"Petek","year":"2019","journal-title":"EFORT Open Rev"},{"key":"10.1016\/j.ajpath.2020.07.008_bib3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jos.2016.03.008","article-title":"Clinical and basic research on steroid-induced osteonecrosis of the femoral head in Japan","volume":"21","author":"Kubo","year":"2016","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.ajpath.2020.07.008_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.gene.2018.05.091","article-title":"The pathogenesis of steroid-induced osteonecrosis of the femoral head: a systematic review of the literature","volume":"671","author":"Wang","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.ajpath.2020.07.008_bib5","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1177\/0300060517700299","article-title":"Role of coagulopathy in glucocorticoid-induced osteonecrosis of the femoral head","volume":"46","author":"Zhang","year":"2018","journal-title":"J Int Med Res"},{"key":"10.1016\/j.ajpath.2020.07.008_bib6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/oxfordjournals.aje.a116706","article-title":"Association of alcohol intake, cigarette smoking, and occupational status with the risk of idiopathic osteonecrosis of the femoral head","volume":"137","author":"Hirota","year":"1993","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajpath.2020.07.008_bib7","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1056\/NEJMoa042480","article-title":"Type II collagen gene variants and inherited osteonecrosis of the femoral head","volume":"352","author":"Liu","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2020.07.008_bib8","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2020.07.008_bib9","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1161\/ATVBAHA.113.301889","article-title":"Footprints of neutrophil extracellular traps as predictors of cardiovascular risk","volume":"33","author":"Doring","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2020.07.008_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fcvm.2019.00085","article-title":"Platelet-neutrophil interplay: insights into neutrophil extracellular trap (NET)-driven coagulation in infection","volume":"6","author":"Zucoloto","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.ajpath.2020.07.008_bib11","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jhep.2018.07.005","article-title":"Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use","volume":"69","author":"Bukong","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2020.07.008_bib12","doi-asserted-by":"crossref","first-page":"9813","DOI":"10.1073\/pnas.0909927107","article-title":"Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis","volume":"107","author":"Hakkim","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2020.07.008_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1538\/expanim.44.181","article-title":"Tissue distribution of deoxyribonuclease I (DNase I) activity level in mice and its sexual dimorphism","volume":"44","author":"Koizumi","year":"1995","journal-title":"Exp Anim"},{"key":"10.1016\/j.ajpath.2020.07.008_bib14","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/cyto.a.23169","article-title":"Measurement of NET formation in\u00a0vitro and in\u00a0vivo by flow cytometry","volume":"91","author":"Masuda","year":"2017","journal-title":"Cytometry A"},{"key":"10.1016\/j.ajpath.2020.07.008_bib15","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1093\/rheumatology\/kez089","article-title":"The presence of anti-neutrophil extracellular trap antibody in patients with microscopic polyangiitis","volume":"58","author":"Hattanda","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ajpath.2020.07.008_bib16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12178-015-9277-8","article-title":"Pathophysiology and risk factors for osteonecrosis","volume":"8","author":"Shah","year":"2015","journal-title":"Curr Rev Musculoskelet Med"},{"key":"10.1016\/j.ajpath.2020.07.008_bib17","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00264-018-3956-1","article-title":"Animal models of steroid-induced osteonecrosis of the femoral head-a comprehensive research review up to 2018","volume":"42","author":"Xu","year":"2018","journal-title":"Int Orthop"},{"key":"10.1016\/j.ajpath.2020.07.008_bib18","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/iep.12035","article-title":"Experimental rat model for alcohol-induced osteonecrosis of the femoral head","volume":"94","author":"Okazaki","year":"2013","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.ajpath.2020.07.008_bib19","doi-asserted-by":"crossref","first-page":"BR97","DOI":"10.12659\/MSM.881708","article-title":"An animal model of femoral head osteonecrosis induced by a single injection of absolute alcohol: an experimental study","volume":"17","author":"Zhu","year":"2011","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.ajpath.2020.07.008_bib20","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.7150\/ijms.6314","article-title":"A canine model of femoral head osteonecrosis induced by an ethanol injection navigated by a novel template","volume":"10","author":"Wang","year":"2013","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.ajpath.2020.07.008_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.lfs.2017.11.022","article-title":"Divergent profile between hypothalamic and plasmatic aminopeptidase activities in WKY and SHR: influence of \u03b2-adrenergic blockade","volume":"192","author":"Prieto","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.ajpath.2020.07.008_bib22","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.2353\/ajpath.2009.080458","article-title":"Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis","volume":"174","author":"Little","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2020.07.008_bib23","first-page":"2800","article-title":"Hypoxia-inducible factors (HIFs) in the articular cartilage: a systematic review","volume":"21","author":"Fernandez-Torres","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.ajpath.2020.07.008_bib24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1538-7836.2011.04544.x","article-title":"Neutrophil extracellular traps promote deep vein thrombosis in mice","volume":"10","author":"Brill","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ajpath.2020.07.008_bib25","doi-asserted-by":"crossref","first-page":"672","DOI":"10.2106\/JBJS.14.01099","article-title":"Anatomical findings in patients undergoing total hip arthroplasty for idiopathic femoral head osteonecrosis","volume":"98","author":"Ollivier","year":"2016","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.ajpath.2020.07.008_bib26","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1189\/jlb.3MA0916-411R","article-title":"Human blood monocytes are able to form extracellular traps","volume":"102","author":"Granger","year":"2017","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ajpath.2020.07.008_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/BOR.0000000000000667","article-title":"Deadliest catch: neutrophil extracellular traps in autoimmunity","volume":"32","author":"Goel","year":"2020","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.ajpath.2020.07.008_bib28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00281-013-0375-7","article-title":"Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity","volume":"35","author":"Carmona-Rivera","year":"2013","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.ajpath.2020.07.008_bib29","doi-asserted-by":"crossref","first-page":"1702590","DOI":"10.1183\/13993003.02590-2017","article-title":"Impaired efferocytosis and neutrophil extracellular trap clearance by macrophages in ARDS","volume":"52","author":"Gregoire","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2020.07.008_bib30","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1681\/ASN.2013060606","article-title":"Enhanced formation and disordered regulation of NETs in myeloperoxidase-ANCA-associated microscopic polyangiitis","volume":"25","author":"Nakazawa","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2020.07.008_bib31","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/intimm\/dxy055","article-title":"Efferocytosis and autoimmune disease","volume":"30","author":"Kawano","year":"2018","journal-title":"Int Immunol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944020303424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944020303424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:37:09Z","timestamp":1757695029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944020303424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0002944020303424"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2020.07.008","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Neutrophil Extracellular Traps with the Development of Idiopathic Osteonecrosis of the Femoral Head","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2020.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}