{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:37:13Z","timestamp":1790743033047,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ajpath.2020.09.002","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T21:20:34Z","timestamp":1599772834000},"page":"2387-2402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["High-Fat Diet\u2013Induced Functional and Pathologic Changes in Lacrimal Gland"],"prefix":"10.1016","volume":"190","author":[{"given":"Xin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaopan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changkai","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kechun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-4523","authenticated-orcid":false,"given":"Peter Sol","family":"Reinach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Quantock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2020.09.002_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00441-004-0877-7","article-title":"Human lacrimal gland mucins","volume":"316","author":"Paulsen","year":"2004","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajpath.2020.09.002_bib2","first-page":"97","article-title":"The lacrimal gland and its veil of tears","volume":"13","author":"Walcott","year":"1998","journal-title":"News Physiol Sci"},{"key":"10.1016\/j.ajpath.2020.09.002_bib3","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3390\/ijms18071398","article-title":"Dry eye management: targeting the ocular surface microenvironment","volume":"18","author":"Zhang","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2020.09.002_bib4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jtos.2017.05.009","article-title":"TFOS DEWS II clinical trial design report","volume":"15","author":"Novack","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajpath.2020.09.002_bib5","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.ophtha.2014.04.018","article-title":"Bilateral lacrimal gland disease: clinical features of 97 cases","volume":"121","author":"Tang","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajpath.2020.09.002_bib6","doi-asserted-by":"crossref","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","article-title":"Sj\u00f6gren syndrome","volume":"2","author":"Brito-Zer\u00f3n","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.ajpath.2020.09.002_bib7","doi-asserted-by":"crossref","first-page":"S142","DOI":"10.1097\/ICO.0000000000000586","article-title":"Tissue renin-angiotensin system in lacrimal gland fibrosis in a murine model of chronic graft-versus-host disease","volume":"34 Suppl 11","author":"Yaguchi","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.ajpath.2020.09.002_bib8","doi-asserted-by":"crossref","first-page":"4923426","DOI":"10.1155\/2017\/4923426","article-title":"A ligation of the lacrimal excretory duct in mouse induces lacrimal gland inflammation with proliferative cells","volume":"2017","author":"Liu","year":"2017","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.ajpath.2020.09.002_bib9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1542-0124(12)70177-5","article-title":"The aging lacrimal gland: changes in structure and function","volume":"6","author":"Rocha","year":"2008","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajpath.2020.09.002_bib10","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.exer.2007.01.015","article-title":"A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation","volume":"84","author":"Zoukhri","year":"2007","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2020.09.002_bib11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.exer.2009.03.020","article-title":"Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland","volume":"89","author":"Wu","year":"2009","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2020.09.002_bib12","doi-asserted-by":"crossref","first-page":"e451","DOI":"10.1038\/emm.2017.285","article-title":"Sleep deprivation disrupts the lacrimal system and induces dry eye disease","volume":"50","author":"Li","year":"2018","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.ajpath.2020.09.002_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1350-9462(02)00004-6","article-title":"Ocular lipid deposition and hyperlipoproteinaemia","volume":"21","author":"Crispin","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajpath.2020.09.002_bib14","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1001\/jama.1977.03270420050015","article-title":"Pseudo-Sjogren syndrome with hyperlipoproteinemia","volume":"237","author":"Goldman","year":"1977","journal-title":"JAMA"},{"key":"10.1016\/j.ajpath.2020.09.002_bib15","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1001\/archopht.118.9.1264","article-title":"Prevalence of and risk factors for dry eye syndrome","volume":"118","author":"Moss","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib16","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1755-3768.2010.01993.x","article-title":"Comorbidities of dry eye disease: a nationwide population-based study","volume":"90","author":"Wang","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib17","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jtos.2019.06.002","article-title":"Hyperlipidemia induces meibomian gland dysfunction","volume":"17","author":"Bu","year":"2019","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajpath.2020.09.002_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ajpath.2020.09.002_bib19","doi-asserted-by":"crossref","first-page":"9919","DOI":"10.1038\/s41598-018-28227-x","article-title":"Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sj\u00f6gren's syndrome animal models","volume":"8","author":"Hawley","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2020.09.002_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/02713680500428613","article-title":"Unique ultrastructure of exorbital lacrimal glands in male NOD and BALB\/c mice","volume":"31","author":"Ding","year":"2006","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.ajpath.2020.09.002_bib21","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0168-8278(99)80033-6","article-title":"Mitochondrial abnormalities in non-alcoholic steatohepatitis","volume":"31","author":"Caldwell","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1997.00001.x","article-title":"The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis","volume":"244","author":"McGarry","year":"1997","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.ajpath.2020.09.002_bib23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mce.2010.05.019","article-title":"Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements","volume":"325","author":"Song","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib24","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ajpath.2020.09.002_bib25","doi-asserted-by":"crossref","first-page":"5080843","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ajpath.2020.09.002_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ajpath.2020.09.002_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0891-5849(89)90010-5","article-title":"On the detection of lipid hydroperoxides in biological samples","volume":"7","author":"Pryor","year":"1989","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ajpath.2020.09.002_bib28","first-page":"821","article-title":"Morphological changes of myoepithelial cells of mouse lacrimal glands during postnatal development","volume":"10","author":"Wang","year":"1995","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0248-4900(96)84782-4","article-title":"Immunolocalization of myoepithelial cells in isolated acini of rat exorbital lacrimal gland: cellular distribution of muscarinic receptors","volume":"86","author":"Lemullois","year":"1996","journal-title":"Biol Cell"},{"key":"10.1016\/j.ajpath.2020.09.002_bib30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/ajcn.81.2.341","article-title":"Origins and evolution of the Western diet: health implications for the 21st century","volume":"81","author":"Cordain","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ajpath.2020.09.002_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00041433-200306000-00008","article-title":"Lipotoxicity: when tissues overeat","volume":"14","author":"Schaffer","year":"2003","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib32","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1681\/ASN.2016070731","article-title":"High-fat diet\u2013induced lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in the kidney","volume":"28","author":"Yamamoto","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.archoralbio.2016.10.033","article-title":"Altered autophagy and sympathetic innervation in salivary glands from high-fat diet mice","volume":"75","author":"de Carvalho","year":"2017","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib34","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.cellsig.2007.04.009","article-title":"Oxyl radicals, redox-sensitive signalling cascades and antioxidants","volume":"19","author":"Genestra","year":"2007","journal-title":"Cell Signal"},{"key":"10.1016\/j.ajpath.2020.09.002_bib35","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1158\/1940-6207.CAPR-18-0160","article-title":"Prevention of lipid peroxidation\u2013derived cyclic DNA adduct and mutation in high-fat diet\u2013induced hepatocarcinogenesis by Theaphenon E","volume":"11","author":"Coia","year":"2018","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.ajpath.2020.09.002_bib36","first-page":"355","article-title":"The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation","volume":"86","author":"Dandona","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2020.09.002_bib37","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/jn\/127.5.706","article-title":"A diet rich in fat and poor in dietary fiber increases the in\u00a0vitro formation of reactive oxygen species in human feces","volume":"127","author":"Erhardt","year":"1997","journal-title":"J Nutr"},{"key":"10.1016\/j.ajpath.2020.09.002_bib38","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1097\/HJH.0b013e32833ca68c","article-title":"Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice","volume":"28","author":"Kobayasi","year":"2010","journal-title":"J Hypertens"},{"key":"10.1016\/j.ajpath.2020.09.002_bib39","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00210-013-0871-2","article-title":"Cerebroprotective effect of resveratrol through antioxidant and anti-inflammatory effects in diabetic rats","volume":"386","author":"Prabhakar","year":"2013","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib40","doi-asserted-by":"crossref","first-page":"7432797","DOI":"10.1155\/2016\/7432797","article-title":"Oxidative stress and inflammation: what polyphenols can do for us?","volume":"2016","author":"Hussain","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ajpath.2020.09.002_bib41","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pharmthera.2017.08.011","article-title":"Oxidative stress and cellular pathways of asthma and inflammation: therapeutic strategies and pharmacological targets","volume":"181","author":"Mishra","year":"2018","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.ajpath.2020.09.002_bib42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-016-0666-8","article-title":"High-fat diet feeding differentially affects the development of inflammation in the central nervous system","volume":"13","author":"Guillemot-Legris","year":"2016","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.ajpath.2020.09.002_bib43","doi-asserted-by":"crossref","first-page":"4658583","DOI":"10.1155\/2018\/4658583","article-title":"High-fat diet and alcohol intake promotes inflammation and impairs skin wound healing in Wistar rats","volume":"2018","author":"Rosa","year":"2018","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.ajpath.2020.09.002_bib44","doi-asserted-by":"crossref","first-page":"e1800455","DOI":"10.1002\/mnfr.201800455","article-title":"High-fat diet, betaine, and polydextrose induce changes in adipose tissue inflammation and metabolism in C57BL\/6J mice","volume":"62","author":"Airaksinen","year":"2018","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.ajpath.2020.09.002_bib45","doi-asserted-by":"crossref","first-page":"e1800455","DOI":"10.1155\/2017\/9474896","article-title":"High fat diet\u00a0alters gut microbiota and the expression of paneth cell-antimicrobial peptides preceding changes of circulating inflammatory cytokines","volume":"2017","author":"Guo","year":"2017","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.ajpath.2020.09.002_bib46","doi-asserted-by":"crossref","first-page":"9015765","DOI":"10.1155\/2018\/9015765","article-title":"Protective effect of melatonin against oxidative stress-induced apoptosis and enhanced autophagy in human retinal pigment epithelium cells","volume":"2018","author":"Chang","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ajpath.2020.09.002_bib47","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s11064-016-2113-8","article-title":"Oxidative stress mediated hippocampal neuron apoptosis participated in carbon disulfide-induced rats cognitive dysfunction","volume":"42","author":"Wang","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1016\/j.ajpath.2020.09.002_bib48","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.ajpath.2012.01.019","article-title":"Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice","volume":"180","author":"Kojima","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib49","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bcp.2017.04.014","article-title":"Apigenin, a modulator of PPAR\u03b3, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation","volume":"136","author":"Feng","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib50","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1089\/ars.2016.6776","article-title":"Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis","volume":"26","author":"Spahis","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ajpath.2020.09.002_bib51","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajpath.2020.09.002_bib52","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1136\/bjo.68.9.674","article-title":"Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease","volume":"68","author":"Damato","year":"1984","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib53","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1167\/iovs.15-17003","article-title":"Role of matrix metalloproteinases 2 and 9 in lacrimal gland disease in animal models of Sj\u00f6gren's syndrome","volume":"56","author":"Aluri","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2020.09.002_bib54","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s40610-015-0020-4","article-title":"Myoepithelial cells: their origin and function in lacrimal gland morphogenesis, homeostasis, and repair","volume":"1","author":"Makarenkova","year":"2015","journal-title":"Curr Mol Biol Rep"},{"key":"10.1016\/j.ajpath.2020.09.002_bib55","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1530\/REP-19-0259","article-title":"A switch from high-fat to normal diet does not restore sperm quality but prevents metabolic syndrome","volume":"158","author":"Cris\u00f3stomo","year":"2019","journal-title":"Reproduction"},{"key":"10.1016\/j.ajpath.2020.09.002_bib56","doi-asserted-by":"crossref","first-page":"27541","DOI":"10.1038\/srep27541","article-title":"Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis","volume":"6","author":"Kowalski","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2020.09.002_bib57","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fnbeh.2016.00225","article-title":"Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations","volume":"10","author":"Boitard","year":"2016","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.ajpath.2020.09.002_bib58","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biochi.2016.12.019","article-title":"The role and regulation of the peroxisome proliferator activated receptor alpha in human liver","volume":"136","author":"Kersten","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.ajpath.2020.09.002_bib59","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3390\/ijms21010207","article-title":"High fat diet suppresses peroxisome proliferator-activated receptors and reduces dopaminergic neurons in the substantia nigra","volume":"21","author":"Kao","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2020.09.002_bib60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.lfs.2018.03.053","article-title":"High-fat diet affects gut nutrients transporters in hypo and hyperthyroid mice by PPAR-a independent mechanism","volume":"202","author":"Losacco","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.ajpath.2020.09.002_bib61","first-page":"400","article-title":"Fibrates increase human REV-ERB\u03b1 expression in liver via a novel peroxisome proliferator-activated receptor response element","volume":"13","author":"Gervois","year":"1999","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib62","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/jcp.25804","article-title":"The role of various peroxisome proliferator-activated receptors and their ligands in clinical practice","volume":"233","author":"Derosa","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2020.09.002_bib63","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1073\/pnas.89.10.4653","article-title":"Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor","volume":"89","author":"G\u00f6ttlicher","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2020.09.002_bib64","doi-asserted-by":"crossref","first-page":"5494","DOI":"10.1167\/iovs.18-24504","article-title":"Sleep\u00a0deprivation induces dry eye through inhibition of PPAR\u03b1 expression in corneal epithelium","volume":"59","author":"Tang","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2020.09.002_bib65","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/108076803322660495","article-title":"Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells","volume":"19","author":"Beauregard","year":"2003","journal-title":"J Ocul Pharmacol Ther"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944020304132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944020304132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:37:22Z","timestamp":1757695042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944020304132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":65,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0002944020304132"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2020.09.002","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-Fat Diet\u2013Induced Functional and Pathologic Changes in Lacrimal Gland","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2020.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}