{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:56:49Z","timestamp":1791644209774,"version":"4.3.4"},"reference-count":99,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005302","name":"University of Illinois at Urbana-Champaign","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ajpath.2020.09.013","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:58:52Z","timestamp":1602809932000},"page":"108-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pulmonary Mycosis Drives Forkhead Box Protein A2 Degradation and Mucus Hypersecretion through Activation of the Spleen Tyrosine Kinase\u2013Epidermal Growth Factor Receptor\u2013AKT\/Extracellular Signal-Regulated Kinase 1\/2 Signaling"],"prefix":"10.1016","volume":"191","author":[{"given":"Woosuk","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-9129","authenticated-orcid":false,"given":"Alina X.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1759-3896","authenticated-orcid":false,"given":"Aaron","family":"Sieve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8924-6960","authenticated-orcid":false,"given":"Shanny H.","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-2089","authenticated-orcid":false,"given":"Srinivasu","family":"Mudalagiriyappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-1628","authenticated-orcid":false,"given":"Miranda","family":"Vieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol W.","family":"Maddox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8022-1353","authenticated-orcid":false,"given":"Som G.","family":"Nanjappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-3950","authenticated-orcid":false,"given":"Gee W.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2020.09.013_bib1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1055\/s-0031-1295722","article-title":"Pulmonary blastomycosis","volume":"32","author":"Bariola","year":"2011","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ccm.2017.04.006","article-title":"Clinical manifestations and treatment of blastomycosis","volume":"38","author":"McBride","year":"2017","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1055\/s-0035-1562898","article-title":"New developments in blastomycosis","volume":"36","author":"Smith","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ccm.2017.04.004","article-title":"Clinical perspectives in the diagnosis and management of histoplasmosis","volume":"38","author":"Azar","year":"2017","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.idc.2015.10.009","article-title":"Histoplasmosis","volume":"30","author":"Wheat","year":"2016","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.ajpath.2020.09.013_bib6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/21505594.2019.1589363","article-title":"The mysterious desert dwellers: coccidioides immitis and Coccidioides posadasii, causative fungal agents of coccidioidomycosis","volume":"10","author":"Kollath","year":"2019","journal-title":"Virulence"},{"key":"10.1016\/j.ajpath.2020.09.013_bib7","first-page":"219","article-title":"Endemic blastomycosis in Mississippi: epidemiological and clinical studies","volume":"12","author":"Chapman","year":"1997","journal-title":"Semin Respir Infect"},{"key":"10.1016\/j.ajpath.2020.09.013_bib8","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/adpa.2002.34575","article-title":"Blastomycosis: the great pretender can also be an opportunist: initial clinical diagnosis and underlying diseases in 123 patients","volume":"6","author":"Lemos","year":"2002","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib9","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1399-3062.2007.00227.x","article-title":"Blastomycosis in solid organ transplant recipients","volume":"9","author":"Gauthier","year":"2007","journal-title":"Transpl Infect Dis"},{"key":"10.1016\/j.ajpath.2020.09.013_bib10","doi-asserted-by":"crossref","first-page":"847","DOI":"10.7326\/0003-4819-116-10-847","article-title":"Blastomycosis in patients with the acquired immunodeficiency syndrome","volume":"116","author":"Pappas","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1164\/rccm.2008-740ST","article-title":"An official American Thoracic Society statement: treatment of fungal infections in adult pulmonary and critical care patients","volume":"183","author":"Limper","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib12","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/alr.21549","article-title":"Effect of \u03b2-Glucan on MUC4 and MUC5B Expression in Human Airway Epithelial Cells: International Forum of Allergy & Rhinology","volume":"5","author":"Kim","year":"2015","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib13","doi-asserted-by":"crossref","first-page":"S198","DOI":"10.1513\/AnnalsATS.201803-154AW","article-title":"Fungi in mucoobstructive airway diseases","volume":"15","author":"Li","year":"2018","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.ajpath.2020.09.013_bib14","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1038\/s41598-019-39079-4","article-title":"Increase in secreted airway mucins and partial Muc5b STAT6\/FoxA2 regulation during Pneumocystis primary infection","volume":"9","author":"Rojas","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2020.09.013_bib15","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1056\/NEJMra0910061","article-title":"Airway mucus function and dysfuction","volume":"363","author":"John","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib16","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1056\/NEJMra1813799","article-title":"Muco-obstructive lung diseases","volume":"380","author":"Boucher","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/jcm6120112","article-title":"Airway mucus and asthma: the role of MUC5AC and MUC5B","volume":"6","author":"Bonser","year":"2017","journal-title":"J Clin Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nature12807","article-title":"Muc5b is required for airway defence","volume":"505","author":"Roy","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2020.09.013_bib19","doi-asserted-by":"crossref","first-page":"16528","DOI":"10.1073\/pnas.1206552109","article-title":"Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs","volume":"109","author":"Ehre","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2020.09.013_bib20","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1172\/JCI84910","article-title":"Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma","volume":"126","author":"Bonser","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2020.09.013_bib21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1165\/rcmb.2009-0151TR","article-title":"Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease","volume":"42","author":"Curran","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib22","doi-asserted-by":"crossref","first-page":"e24997","DOI":"10.4161\/tisb.24997","article-title":"Barrier function of airway tract epithelium","volume":"1","author":"Ganesan","year":"2013","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.ajpath.2020.09.013_bib23","first-page":"2914","article-title":"SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production","volume":"119","author":"Chen","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2020.09.013_bib24","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1172\/JCI29176","article-title":"SPDEF regulates goblet cell hyperplasia in the airway epithelium","volume":"117","author":"Park","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2020.09.013_bib25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1165\/rcmb.2006-0180OC","article-title":"IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production","volume":"36","author":"Zhen","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fimmu.2020.00515","article-title":"Inactivation of FOXA2 by respiratory bacterial pathogens and dysregulation of pulmonary mucus homeostasis","volume":"11","author":"Choi","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib27","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1242\/dev.00966","article-title":"Foxa2 regulates alveolarization and goblet cell hyperplasia","volume":"131","author":"Wan","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2020.09.013_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1465-9921-14-82","article-title":"Pyocyanin-induced mucin production is associated with redox modification of FOXA2","volume":"14","author":"Hao","year":"2013","journal-title":"Respir Res"},{"key":"10.1016\/j.ajpath.2020.09.013_bib29","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.2147\/COPD.S143279","article-title":"MAPK\/FoxA2-mediated cigarette smoke-induced squamous metaplasia of bronchial epithelial cells","volume":"12","author":"Du","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.ajpath.2020.09.013_bib30","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1128\/IAI.01989-14","article-title":"Mycoplasma pneumoniae modulates STAT3-STAT6\/EGFR-FOXA2 signaling to induce overexpression of airway mucins","volume":"82","author":"Hao","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2020.09.013_bib31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1462-5822.2011.01727.x","article-title":"Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2","volume":"14","author":"Hao","year":"2012","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib32","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/mi.2015.119","article-title":"Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewisx to increase binding to airway epithelial cells","volume":"9","author":"Jeffries","year":"2015","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib33","doi-asserted-by":"crossref","first-page":"e72528","DOI":"10.1371\/journal.pone.0072528","article-title":"Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT\/MEK-ERK MAP kinase signaling in pulmonary epithelial cells","volume":"8","author":"Xu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2020.09.013_bib34","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41385-020-0262-1","article-title":"Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPAR\u03b3-FOXA2-phosphatase signaling","volume":"13","author":"Choi","year":"2020","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib35","doi-asserted-by":"crossref","first-page":"e12957","DOI":"10.1111\/cmi.12957","article-title":"FOXA2 depletion leads to mucus hypersecretion in canine airways with respiratory diseases","volume":"21","author":"Choi","year":"2018","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib36","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jaci.2004.10.046","article-title":"TH1-mediated airway hyperresponsiveness independent of neutrophilic inflammation","volume":"115","author":"Cui","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib37","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.4049\/jimmunol.162.10.6178","article-title":"Th2-induced airway mucus production is dependent on IL-4R\u03b1, but not on eosinophils","volume":"162","author":"Cohn","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib38","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.4049\/jimmunol.162.10.6233","article-title":"IL-4 induces mucin gene expression and goblet cell metaplasia in\u00a0vitro and in\u00a0vivo","volume":"162","author":"Dabbagh","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib39","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1074\/jbc.M210429200","article-title":"Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine\/autocrine loop","volume":"278","author":"Chen","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2020.09.013_bib40","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1164\/rccm.200801-086OC","article-title":"IL-23 and Th17 cells enhance Th2-cell\u2013mediated eosinophilic airway inflammation in mice","volume":"178","author":"Wakashin","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib41","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1164\/rccm.200904-0573OC","article-title":"Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness","volume":"180","author":"Wilson","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib42","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.4049\/jimmunol.0803022","article-title":"IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells","volume":"183","author":"Bautista","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib43","doi-asserted-by":"crossref","first-page":"L320","DOI":"10.1152\/ajplung.00440.2002","article-title":"Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1\u03b2 in human bronchial epithelia","volume":"286","author":"Gray","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cyto.2011.07.430","article-title":"The role of cytokines and chemokines in Histoplasma capsulatum infection","volume":"58","author":"Kroetz","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.ajpath.2020.09.013_bib45","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.4049\/jimmunol.168.11.5746","article-title":"BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-\u03b1 production through TGF-\u03b2-dependent and-independent mechanisms","volume":"168","author":"Finkel-Jimenez","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib46","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1172\/JCI11037","article-title":"Mutation of the WI-1 gene yields an attenuated Blastomyces dermatitidis strain that induces host resistance","volume":"106","author":"W\u00fcthrich","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2020.09.013_bib47","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.4049\/jimmunol.175.8.5288","article-title":"IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts","volume":"175","author":"W\u00fcthrich","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib48","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/oxfordjournals.aje.a121184","article-title":"Prevalence and incidence studies of human and canine blastomycosis II: yearly incidence studies in three selected states, 1960\u20131967","volume":"92","author":"Furcolow","year":"1970","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib49","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2460\/javma.1998.213.05.658","article-title":"Blastomycosis in dogs: 115 cases (1980-1995)","volume":"213","author":"Arceneaux","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.ajpath.2020.09.013_bib50","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.2353\/ajpath.2009.090166","article-title":"Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis","volume":"175","author":"Caldwell","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib51","doi-asserted-by":"crossref","first-page":"6088","DOI":"10.1021\/ac025890a","article-title":"Small-scale analysis of O-linked oligosaccharides from glycoproteins and mucins separated by gel electrophoresis","volume":"74","author":"Schulz","year":"2002","journal-title":"Anal Chem"},{"key":"10.1016\/j.ajpath.2020.09.013_bib52","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-065X.2009.00793.x","article-title":"\u03b2-Glucan recognition by the innate immune system","volume":"230","author":"Goodridge","year":"2009","journal-title":"Immunol Rev"},{"key":"10.1016\/j.ajpath.2020.09.013_bib53","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1128\/jb.106.3.946-948.1971","article-title":"Cell wall composition of the yeastlike and mycelial forms of Blastomyces dermatitidis","volume":"106","author":"Kanetsuna","year":"1971","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib54","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1128\/JCM.01737-13","article-title":"Point-counterpoint: \u03b2-d-glucan testing is important for diagnosis of invasive fungal infections","volume":"51","author":"Theel","year":"2013","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib55","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fmicb.2020.00147","article-title":"Radioimmunotherapy of blastomycosis in a mouse model with a (1\u2192 3)-\u03b2-glucans targeting antibody","volume":"11","author":"Helal","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib56","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3109\/08830185.2013.777065","article-title":"C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways","volume":"32","author":"Plato","year":"2013","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib57","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1074\/jbc.272.1.217","article-title":"Epidermal growth factor (EGF)-induced generation of hydrogen peroxide role in EGF receptor-mediated tyrosine phosphorylation","volume":"272","author":"Bae","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2020.09.013_bib58","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13046-018-0728-0","article-title":"The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance","volume":"37","author":"Weng","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2020.09.013_bib59","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.9025.1","article-title":"EGF receptor ligands: recent advances","volume":"5","author":"Singh","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.ajpath.2020.09.013_bib60","doi-asserted-by":"crossref","first-page":"834","DOI":"10.4049\/jimmunol.0901490","article-title":"The overexpression of heparin-binding epidermal growth factor is responsible for Th17-induced airway remodeling in an experimental asthma model","volume":"185","author":"Wang","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib61","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.chom.2016.02.001","article-title":"Fungal mimicry of a mammalian aminopeptidase disables innate immunity and promotes pathogenicity","volume":"19","author":"Sterkel","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ajpath.2020.09.013_bib62","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/infdis\/jit283","article-title":"Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection","volume":"208","author":"W\u00fcthrich","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2020.09.013_bib63","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/cimm.1993.1153","article-title":"IL-4, IgE, and interferon-\u03b3 production in pulmonary blastomycosis: comparison in mice untreated, immunized, or treated with an antifungal (SCH 39304)","volume":"149","author":"Brummer","year":"1993","journal-title":"Cell Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib64","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/mi.2014.75","article-title":"Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33","volume":"8","author":"Verma","year":"2015","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib65","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01224-19","article-title":"Investigation of genetic susceptibility to blastomycosis reveals interleukin-6 as a potential susceptibility locus","volume":"10","author":"Merkhofer","year":"2019","journal-title":"MBio"},{"key":"10.1016\/j.ajpath.2020.09.013_bib66","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature10957","article-title":"Pathogen-induced human TH 17 cells produce IFN-\u03b3 or IL-10 and are regulated by IL-1\u03b2","volume":"484","author":"Zielinski","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2020.09.013_bib67","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1128\/CMR.00056-09","article-title":"Clinical and laboratory update on blastomycosis","volume":"23","author":"Saccente","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ajpath.2020.09.013_bib68","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2460\/javma.239.3.335","article-title":"Temporal and spatial distribution of blastomycosis cases among humans and dogs in Illinois (2001\u20132007)","volume":"239","author":"Herrmann","year":"2011","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.ajpath.2020.09.013_bib69","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1164\/rccm.2204023","article-title":"Mice are a good model of human airway disease","volume":"166","author":"Gelfand","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib70","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1164\/rccm.2204001","article-title":"Mice are not a good model of human airway disease","volume":"166","author":"Persson","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib71","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1183\/09031936.00046308","article-title":"Animal models of ventilator-associated pneumonia","volume":"33","author":"Luna","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2020.09.013_bib72","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4168\/aair.2016.8.4.282","article-title":"Allergic bronchopulmonary aspergillosis: a perplexing clinical entity","volume":"8","author":"Shah","year":"2016","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.ajpath.2020.09.013_bib73","doi-asserted-by":"crossref","first-page":"999","DOI":"10.4049\/jimmunol.1002257","article-title":"Induction of mucin and MUC5AC expression by the protease activity of Aspergillus fumigatus in airway epithelial cells","volume":"187","author":"Oguma","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib74","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.4049\/jimmunol.166.8.5219","article-title":"Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma","volume":"166","author":"Blease","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib75","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1182\/blood-2006-05-024406","article-title":"The \u03b2-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria","volume":"108","author":"Yadav","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2020.09.013_bib76","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1084\/jem.20021787","article-title":"Collaborative induction of inflammatory responses by dectin-1 and toll-like receptor 2","volume":"197","author":"Gantner","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2020.09.013_bib77","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1007\/s10096-012-1624-8","article-title":"Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells","volume":"31","author":"Sun","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ajpath.2020.09.013_bib78","doi-asserted-by":"crossref","first-page":"e12741","DOI":"10.1111\/cmi.12741","article-title":"Blastomyces dermatitidis serine protease dipeptidyl peptidase IVA (DppIVA) cleaves ELR+ CXC chemokines altering their effects on neutrophils","volume":"19","author":"Lorenzini","year":"2017","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib79","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0192-0561(89)90106-9","article-title":"Enhanced killing of Blastomyces dermatitidis by gamma interferon-activated murine peripheral blood polymorphonuclear neutrophils","volume":"11","author":"Morrison","year":"1989","journal-title":"Int J Immunopharmacol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib80","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1165\/rcmb.2004-0195OC","article-title":"Interferon-\u03b3 inhibits STAT6 signal transduction and gene expression in human airway epithelial cells","volume":"31","author":"Heller","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib81","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.4049\/jimmunol.1000223","article-title":"Foxa2 programs Th2 cell-mediated innate immunity in the developing lung","volume":"184","author":"Chen","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib82","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1165\/rcmb.2009-0313OC","article-title":"NF-\u03baB mediates IL-1\u03b2\u2013and IL-17A\u2013induced MUC5B expression in airway epithelial cells","volume":"45","author":"Fujisawa","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib83","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.bbrc.2007.03.141","article-title":"Enhanced IL-1\u03b2-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-\u03baB signaling","volume":"357","author":"Muselet-Charlier","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2020.09.013_bib84","doi-asserted-by":"crossref","first-page":"386S","DOI":"10.1378\/chest.117.5_suppl_2.386S","article-title":"Role of neutrophil elastase in hypersecretion during COPD exacerbations, and proposed therapies","volume":"117","author":"Nadel","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.ajpath.2020.09.013_bib85","first-page":"188","article-title":"The endemic mimic: blastomycosis an illness often misdiagnosed","volume":"125","author":"Bradsher","year":"2014","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"10.1016\/j.ajpath.2020.09.013_bib86","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.3201\/eid2509.190587","article-title":"Blastomycosis misdiagnosed as tuberculosis, India","volume":"25","author":"Kumar","year":"2019","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.ajpath.2020.09.013_bib87","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1086\/383317","article-title":"Granulomatous infectious diseases associated with tumor necrosis factor antagonists","volume":"38","author":"Wallis","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajpath.2020.09.013_bib88","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/13693786.2012.685960","article-title":"Blastomycosis in India: report of an imported case and current status","volume":"51","author":"Randhawa","year":"2013","journal-title":"Med Mycol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib89","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1128\/IAI.69.3.1847-1855.2001","article-title":"Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology","volume":"69","author":"Mohan","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2020.09.013_bib90","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1128\/iai.28.2.398-403.1980","article-title":"Cell-mediated immunoprotection in blastomycosis","volume":"28","author":"Cozad","year":"1980","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2020.09.013_bib91","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1128\/iai.37.2.670-678.1982","article-title":"Protection against pulmonary blastomycosis: correlation with cellular and humoral immunity in mice after subcutaneous nonlethal infection","volume":"37","author":"Morozumi","year":"1982","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2020.09.013_bib92","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3389\/fped.2019.00350","article-title":"Immune response to Mycobacterium tuberculosis: a narrative review","volume":"7","author":"de Martino","year":"2019","journal-title":"Front Pediatr"},{"key":"10.1016\/j.ajpath.2020.09.013_bib93","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.4049\/jimmunol.140.8.2786","article-title":"In\u00a0vivo and in\u00a0vitro activation of pulmonary macrophages by IFN-gamma for enhanced killing of Paracoccidioides brasiliensis or Blastomyces dermatitidis","volume":"140","author":"Brummer","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib94","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/mi.2014.136","article-title":"Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge","volume":"8","author":"Monin","year":"2015","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib95","doi-asserted-by":"crossref","first-page":"e0122560","DOI":"10.1371\/journal.pone.0122560","article-title":"Protection against Mycobacterium tuberculosis infection offered by a new multistage subunit vaccine correlates with increased number of IFN-\u03b3+ IL-2+ CD4+ and IFN-\u03b3+ CD8+ T cells","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2020.09.013_bib96","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/path.4399","article-title":"The IL-13\/IL-4R \u03b1 axis is involved in tuberculosis-associated pathology","volume":"234","author":"Heitmann","year":"2014","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2020.09.013_bib97","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1182\/blood-2009-08-236711","article-title":"Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion","volume":"115","author":"Varin","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2020.09.013_bib98","doi-asserted-by":"crossref","first-page":"23243","DOI":"10.1074\/jbc.M300096200","article-title":"Interleukin-1\u03b2 and tumor necrosis factor-\u03b1 induce MUC5AC overexpression through a mechanism involving ERK\/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells","volume":"278","author":"Song","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2020.09.013_bib99","doi-asserted-by":"crossref","first-page":"17255","DOI":"10.1074\/jbc.M211835200","volume":"278","author":"Takenobu","year":"2003","journal-title":"J Biol Chem"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944020304600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944020304600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:37:24Z","timestamp":1757695044000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944020304600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":99,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0002944020304600"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2020.09.013","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulmonary Mycosis Drives Forkhead Box Protein A2 Degradation and Mucus Hypersecretion through Activation of the Spleen Tyrosine Kinase\u2013Epidermal Growth Factor Receptor\u2013AKT\/Extracellular Signal-Regulated Kinase 1\/2 Signaling","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2020.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}