{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:13:58Z","timestamp":1788988438557,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK054927"],"award-info":[{"award-number":["DK054927"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK120491"],"award-info":[{"award-number":["DK120491"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.ajpath.2021.10.005","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:07:28Z","timestamp":1635379648000},"page":"43-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Exosome Biogenesis and Lysosome Function Determine Podocyte Exosome Release and Glomerular Inflammatory Response during Hyperhomocysteinemia"],"prefix":"10.1016","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-8434","authenticated-orcid":false,"given":"Dandan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3836-3272","authenticated-orcid":false,"given":"Guangbi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owais M.","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin-Lan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2021.10.005_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib3","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1172\/JCI81132","article-title":"Extracellular vesicles and infectious diseases: new complexity to an old story","volume":"126","author":"Schorey","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2021.10.005_bib4","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/j.1460-2075.1990.tb08268.x","article-title":"A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence","volume":"9","author":"Rubartelli","year":"1990","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2021.10.005_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.arr.2016.05.001","article-title":"Impact of lysosome status on extracellular vesicle content and release","volume":"32","author":"Eitan","year":"2016","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.ajpath.2021.10.005_bib6","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/ki.2011.292","article-title":"Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases","volume":"80","author":"van Balkom","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2021.10.005_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1681\/ASN.2015010074","article-title":"Extracellular vesicles in renal diseases: more than novel biomarkers?","volume":"27","author":"Erdbr\u00fcgger","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1681\/ASN.2004070564","article-title":"Apical cell membranes are shed into urine from injured podocytes: a novel phenomenon of podocyte injury","volume":"16","author":"Hara","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00467-011-2035-2","article-title":"Urinary exosomal WT1 in childhood nephrotic syndrome","volume":"27","author":"Lee","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00125-016-4190-2","article-title":"Assessment of urinary microparticles in normotensive patients with type 1 diabetes","volume":"60","author":"Lytvyn","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.ajpath.2021.10.005_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00467-017-3816-z","article-title":"Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases","volume":"34","author":"St\u00e5hl","year":"2019","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00467-002-0865-7","article-title":"Surface markers of platelet function in idiopathic nephrotic syndrome in children","volume":"17","author":"Tkaczyk","year":"2002","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib13","doi-asserted-by":"crossref","first-page":"166146","DOI":"10.1016\/j.bbadis.2021.166146","article-title":"Contribution of podocyte inflammatory exosome release to glomerular inflammation and sclerosis during hyperhomocysteinemia","volume":"1867","author":"Huang","year":"2021","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.ajpath.2021.10.005_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00018-017-2595-9","article-title":"Current knowledge on exosome biogenesis and release","volume":"75","author":"Hessvik","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ajpath.2021.10.005_bib15","doi-asserted-by":"crossref","first-page":"17442","DOI":"10.1074\/jbc.M110.107821","article-title":"Secretory mechanisms and intercellular transfer of microRNAs in living cells","volume":"285","author":"Kosaka","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2021.10.005_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.yjmcc.2014.05.001","article-title":"Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells","volume":"74","author":"Wang","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib17","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.jaci.2012.12.1565","article-title":"Proinflammatory role of epithelial cell-derived exosomes in allergic airway inflammation","volume":"131","author":"Kulshreshtha","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib18","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/ni.2647","article-title":"Exosomes mediate the cell-to-cell transmission of IFN-alpha-induced antiviral activity","volume":"14","author":"Li","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib19","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.bbamcr.2019.02.007","article-title":"Lysosomal regulation of extracellular vesicle excretion during d-ribose-induced NLRP3 inflammasome activation in podocytes","volume":"1866","author":"Hong","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.ajpath.2021.10.005_bib20","doi-asserted-by":"crossref","first-page":"C481","DOI":"10.1152\/ajpcell.00150.2019","article-title":"Control of lysosomal TRPML1 channel activity and exosome release by acid ceramidase in mouse podocytes","volume":"317","author":"Li","year":"2019","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib21","doi-asserted-by":"crossref","first-page":"158856","DOI":"10.1016\/j.bbalip.2020.158856","article-title":"Abnormal podocyte TRPML1 channel activity and exosome release in mice with podocyte-specific Asah1 gene deletion","volume":"1866","author":"Li","year":"2021","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.ajpath.2021.10.005_bib22","doi-asserted-by":"crossref","first-page":"102013","DOI":"10.1016\/j.redox.2021.102013","article-title":"Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes","volume":"43","author":"Li","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib23","doi-asserted-by":"crossref","first-page":"e21732","DOI":"10.1096\/fj.202100385R","article-title":"Regulatory role of mammalian target of rapamycin signaling in exosome secretion and osteogenic changes in smooth muscle cells lacking acid ceramidase gene","volume":"35","author":"Bhat","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2021.10.005_bib24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","article-title":"NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder","volume":"36","author":"Alcocer-G\u00f3mez","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.ajpath.2021.10.005_bib25","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/ijnp\/pyx065","article-title":"NLRP3 inflammasome contributes to lipopolysaccharide-induced depressive-like behaviors via indoleamine 2,3-dioxygenase induction","volume":"20","author":"Jeon","year":"2017","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib26","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1194\/jlr.M072587","article-title":"NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury","volume":"58","author":"Li","year":"2017","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2021.10.005_bib27","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00109-014-1246-y","article-title":"Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis","volume":"93","author":"Peng","year":"2015","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.ajpath.2021.10.005_bib28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/jcmm.14761","article-title":"Medial calcification in the arterial wall of smooth muscle cell-specific Smpd1 transgenic mice: a ceramide-mediated vasculopathy","volume":"24","author":"Bhat","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ajpath.2021.10.005_bib29","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.bbadis.2015.08.010","article-title":"Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction","volume":"1852","author":"Essandoh","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2021.10.005_bib30","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1002\/jnr.22438","article-title":"Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice","volume":"88","author":"Tabatadze","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.ajpath.2021.10.005_bib31","doi-asserted-by":"crossref","first-page":"E1495","DOI":"10.1073\/pnas.1717065115","article-title":"Effects of rapamycin on growth hormone receptor knockout mice","volume":"115","author":"Fang","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2021.10.005_bib32","doi-asserted-by":"crossref","first-page":"ra75","DOI":"10.1126\/scisignal.2000559","article-title":"mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells","volume":"2","author":"Chen","year":"2009","journal-title":"Sci Signal"},{"key":"10.1016\/j.ajpath.2021.10.005_bib33","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.ajpath.2020.02.008","article-title":"Podocytopathy and nephrotic syndrome in mice with podocyte-specific deletion of the Asah1 gene: role of ceramide accumulation in glomeruli","volume":"190","author":"Li","year":"2020","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.freeradbiomed.2013.10.009","article-title":"Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia","volume":"67","author":"Abais","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ajpath.2021.10.005_bib35","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1159\/000373989","article-title":"Enhanced epithelial-to-mesenchymal transition associated with lysosome dysfunction in podocytes: role of p62\/Sequestosome 1 as a signaling hub","volume":"35","author":"Li","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.ajpath.2021.10.005_bib36","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1159\/000363046","article-title":"Inhibition of hyperhomocysteinemia-induced inflammasome activation and glomerular sclerosis by NLRP3 gene deletion","volume":"34","author":"Xia","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.ajpath.2021.10.005_bib37","doi-asserted-by":"crossref","first-page":"27159","DOI":"10.1074\/jbc.M114.567537","article-title":"Nod-like receptor protein 3 (NLRP3) inflammasome activation and podocyte injury via thioredoxin-interacting protein (TXNIP) during hyperhomocysteinemia","volume":"289","author":"Abais","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2021.10.005_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1124\/jpet.116.233239","article-title":"Protective action of anandamide and its COX-2 metabolite against l-homocysteine-induced NLRP3 inflammasome activation and injury in podocytes","volume":"358","author":"Li","year":"2016","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ajpath.2021.10.005_bib39","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nri2936","article-title":"Emerging inflammasome effector mechanisms","volume":"11","author":"Lamkanfi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.ajpath.2021.10.005_bib42","doi-asserted-by":"crossref","first-page":"21119","DOI":"10.1074\/jbc.C200179200","article-title":"The PYRIN-CARD protein ASC is an activating adaptor for caspase-1","volume":"277","author":"Srinivasula","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2021.10.005_bib43","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.ajpath.2011.07.019","article-title":"Acid sphingomyelinase gene deficiency ameliorates the hyperhomocysteinemia-induced glomerular injury in mice","volume":"179","author":"Boini","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib44","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1084\/jem.183.3.1161","article-title":"B lymphocytes secrete antigen-presenting vesicles","volume":"183","author":"Raposo","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2021.10.005_bib45","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1073\/pnas.1131852100","article-title":"Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: distinct roles for CD54 and B7 molecules","volume":"100","author":"Hwang","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2021.10.005_bib46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0165-2478(03)00128-7","article-title":"MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells","volume":"89","author":"Utsugi-Kobukai","year":"2003","journal-title":"Immunol Lett"},{"key":"10.1016\/j.ajpath.2021.10.005_bib47","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/eji.200535615","article-title":"Direct exosome stimulation of peripheral human T cells detected by ELISPOT","volume":"36","author":"Admyre","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib48","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00011-020-01318-0","article-title":"Tumor-derived exosomes in the regulation of macrophage polarization","volume":"69","author":"Baig","year":"2020","journal-title":"Inflamm Res"},{"key":"10.1016\/j.ajpath.2021.10.005_bib49","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1471-2407-13-421","article-title":"Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization","volume":"13","author":"Jang","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ajpath.2021.10.005_bib50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13046-018-0815-2","article-title":"M1-like tumor-associated macrophages activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma","volume":"37","author":"Xiao","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2021.10.005_bib51","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1288\/00005537-196605000-00006","article-title":"Regional chemotherapy of cancer of the head and neck","volume":"76","author":"Krementz","year":"1966","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ajpath.2021.10.005_bib52","doi-asserted-by":"crossref","first-page":"67387","DOI":"10.18632\/oncotarget.11794","article-title":"Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ajpath.2021.10.005_bib53","doi-asserted-by":"crossref","first-page":"7398","DOI":"10.18632\/oncotarget.23238","article-title":"Breast cancer cell-derived exosomes and macrophage polarization are associated with lymph node metastasis","volume":"9","author":"Piao","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.ajpath.2021.10.005_bib54","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.3390\/ijms21051559","article-title":"Podocyte lysosome dysfunction in chronic glomerular diseases","volume":"21","author":"Li","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2021.10.005_bib55","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1007\/s00125-012-2661-7","article-title":"Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin","volume":"55","author":"Hara","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.ajpath.2021.10.005_bib56","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.nbd.2011.01.029","article-title":"Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission","volume":"42","author":"Alvarez-Erviti","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.ajpath.2021.10.005_bib57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/1873-3468.12024","article-title":"Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression","volume":"590","author":"Cui","year":"2016","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ajpath.2021.10.005_bib58","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1006\/geno.1998.5334","article-title":"Cloning and characterization of the full-length cDNA and genomic sequences encoding murine acid ceramidase","volume":"50","author":"Li","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/j.ajpath.2021.10.005_bib59","first-page":"63","article-title":"Cyclic ADP-ribose and NAADP in vascular regulation and diseases","volume":"2","author":"Li","year":"2013","journal-title":"Messenger (Los Angel)"},{"key":"10.1016\/j.ajpath.2021.10.005_bib60","doi-asserted-by":"crossref","first-page":"e63506","DOI":"10.1371\/journal.pone.0063506","article-title":"Dysregulated autophagy contributes to\u00a0podocyte damage in Fabry\u2019s disease","volume":"8","author":"Liebau","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2021.10.005_bib61","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2147\/DMSO.S61438","article-title":"Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus","volume":"7","author":"Lorber","year":"2014","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.ajpath.2021.10.005_bib62","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2009.2461","article-title":"Activation of membrane NADPH oxidase associated with lysosome-targeted acid sphingomyelinase in coronary endothelial cells","volume":"12","author":"Bao","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ajpath.2021.10.005_bib63","doi-asserted-by":"crossref","first-page":"H992","DOI":"10.1152\/ajpheart.00958.2009","article-title":"Triggering role of acid sphingomyelinase in endothelial lysosome-membrane fusion and dysfunction in coronary arteries","volume":"298","author":"Bao","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ajpath.2021.10.005_bib64","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.bbalip.2010.09.001","article-title":"Visfatin-induced lipid raft redox signaling platforms and dysfunction in glomerular endothelial cells","volume":"1801","author":"Boini","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2021.10.005_bib65","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s12035-020-02243-3","article-title":"Exosome release is modulated by the mitochondrial-lysosomal crosstalk in Parkinson\u2019s disease stress conditions","volume":"58","author":"Currim","year":"2021","journal-title":"Mol Neurobiol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944021004430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944021004430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:40:08Z","timestamp":1757695208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944021004430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0002944021004430"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2021.10.005","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosome Biogenesis and Lysosome Function Determine Podocyte Exosome Release and Glomerular Inflammatory Response during Hyperhomocysteinemia","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2021.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}