{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:38:47Z","timestamp":1791819527071,"version":"4.3.4"},"reference-count":74,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21OD031970"],"award-info":[{"award-number":["R21OD031970"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ajpath.2022.07.006","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T18:22:28Z","timestamp":1659896548000},"page":"1546-1558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impaired Mitochondria Promote Aging-Associated Sebaceous Gland Dysfunction and Pathology"],"prefix":"10.1016","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4366-968X","authenticated-orcid":false,"given":"Noha S.","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy B.","family":"Foote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-8616","authenticated-orcid":false,"given":"Keshav K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2022.07.006_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.biocel.2009.11.017","article-title":"Sebocytes, multifaceted epithelial cells: lipid production and holocrine secretion","volume":"42","author":"Schneider","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1152\/physrev.1989.69.2.383","article-title":"Control and function of sebaceous glands","volume":"69","author":"Thody","year":"1989","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ajpath.2022.07.006_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1194\/jlr.R700015-JLR200","article-title":"Thematic review series: skin lipids: sebaceous gland lipids: friend or foe?","volume":"49","author":"Smith","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2022.07.006_bib4","doi-asserted-by":"crossref","first-page":"S417","DOI":"10.1194\/jlr.R800039-JLR200","article-title":"The outer frontier: the importance of lipid metabolism in the skin","volume":"50","author":"Feingold","year":"2009","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2022.07.006_bib5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1194\/jlr.R700016-JLR200","article-title":"Thematic Review Series: skin lipids: antimicrobial lipids at the skin surface","volume":"49","author":"Drake","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2022.07.006_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1523-1747.2004.t01-2-.x","article-title":"Regulation of human sebaceous glands","volume":"123","author":"Thiboutot","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib7","first-page":"363","article-title":"The anatomy of the visual system","volume":"2","author":"Duke-Elder","year":"1961","journal-title":"A Syst Ophthalmol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/bjo.61.4.302-a","article-title":"Wolff's anatomy of the eye and orbit","volume":"61","author":"Wybar","year":"1977","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib9","first-page":"845","article-title":"Pathology of the clitoral and prepucial glands in aging F344 rats","volume":"30","author":"Reznik","year":"1980","journal-title":"Lab Anim Sci"},{"key":"10.1016\/j.ajpath.2022.07.006_bib10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1515\/BC.2007.046","article-title":"Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-\/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation","volume":"388","author":"Binczek","year":"2007","journal-title":"Biol Chem"},{"issue":"Suppl","key":"10.1016\/j.ajpath.2022.07.006_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-0625.2004.00255.x","article-title":"Androgen action on human skin - from basic research to clinical significance","volume":"13","author":"Zouboulis","year":"2004","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/1523-1747.ep12676783","article-title":"Endocrinologic control of the development and activity of the human sebaceous gland","volume":"62","author":"Pochi","year":"1974","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00516546","article-title":"Hormonal control of hamster ear sebaceous gland lipogenesis","volume":"275","author":"Hall","year":"1983","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.ajpath.2022.07.006_bib14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1600-0625.2009.00890.x","article-title":"New developments in our understanding of acne pathogenesis and treatment","volume":"18","author":"Kurokawa","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.exger.2008.07.005","article-title":"Interplay of IGF-I and 17\u03b2-estradiol at age-specific levels in human sebocytes and fibroblasts in\u00a0vitro","volume":"43","author":"Makrantonaki","year":"2008","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00109-005-0715-8","article-title":"Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands","volume":"84","author":"Alestas","year":"2006","journal-title":"J Mol Med"},{"key":"10.1016\/j.ajpath.2022.07.006_bib17","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1523-1747.2003.12411.x","article-title":"Expression of peroxisome proliferator-activated receptor and CCAAT\/enhancer binding protein transcription factors in cultured human sebocytes","volume":"121","author":"Chen","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib18","first-page":"269","article-title":"Peroxisome proliferator-activated receptors and skin development","volume":"54","author":"Rosenfield","year":"2000","journal-title":"Horm Res"},{"key":"10.1016\/j.ajpath.2022.07.006_bib19","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1046\/j.1365-2230.2001.00894.x","article-title":"Chronological ageing and photoageing of the human sebaceous gland","volume":"26","author":"Zouboulis","year":"2001","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib20","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41419-020-2649-z","article-title":"Mitochondria in skin health, aging, and disease","volume":"11","author":"Sreedhar","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajpath.2022.07.006_bib21","doi-asserted-by":"crossref","first-page":"33S","DOI":"10.1097\/PRS.0000000000007619","article-title":"Mitochondrial secrets of youthfulness","volume":"147","author":"Singh","year":"2021","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.ajpath.2022.07.006_bib22","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/exd.14184","article-title":"Sebaceous gland: milestones of 30-year modelling research dedicated to the \u201cbrain of the skin.\u201d","volume":"29","author":"Zouboulis","year":"2020","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-94-007-2869-1_14","article-title":"Mitochondria and aging","volume":"942","author":"Lee","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib24","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41419-018-0765-9","article-title":"Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function","volume":"9","author":"Singh","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajpath.2022.07.006_bib25","first-page":"432","article-title":"Supersaturated solutions of fat stains in dilute isopropanol for demonstration of acute fatty degeneration not shown by Herxheimer's technique","volume":"36","author":"Lillie","year":"1943","journal-title":"Arch Pathol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-1-4939-6670-7_10","article-title":"Sudan Black B, the specific histochemical stain for lipofuscin: a novel method to detect senescent cells","volume":"1534","author":"Evangelou","year":"2017","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib27","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging: an evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ajpath.2022.07.006_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01960","article-title":"Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes?","volume":"8","author":"Fulop","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib29","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.2174\/138161206777947470","article-title":"Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology","volume":"12","author":"Salvioli","year":"2006","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.ajpath.2022.07.006_bib30","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.micinf.2006.04.001","article-title":"Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines\/chemokines in human sebocytes","volume":"8","author":"Nagy","year":"2006","journal-title":"Microbes Infect"},{"key":"10.1016\/j.ajpath.2022.07.006_bib31","first-page":"65","article-title":"Mitochondrial dysfunction enhances lipolysis and intracellular lipid accumulation in 3T3-L1 adipocytes","volume":"4","author":"Abu Bakar","year":"2015","journal-title":"Int J Pharma Med Biol Sci"},{"key":"10.1016\/j.ajpath.2022.07.006_bib32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.18632\/aging.100527","article-title":"Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence: a method applicable in cryo-preserved and archival tissues","volume":"5","author":"Georgakopoulou","year":"2013","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ajpath.2022.07.006_bib33","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/emboj\/20.6.1215","article-title":"Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin","volume":"20","author":"Ghazizadeh","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2022.07.006_bib34","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cell.2006.06.048","article-title":"Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland","volume":"126","author":"Horsley","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2022.07.006_bib35","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.stem.2009.04.014","article-title":"Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis","volume":"4","author":"Jensen","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2022.07.006_bib36","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1126\/science.1087573","article-title":"Notch-mediated restoration of regenerative potential to aged muscle","volume":"302","author":"Conboy","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2022.07.006_bib37","doi-asserted-by":"crossref","first-page":"9194","DOI":"10.1073\/pnas.0503280102","article-title":"Cell intrinsic alterations underlie hematopoietic stem cell aging","volume":"102","author":"Rossi","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2022.07.006_bib38","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature05091","article-title":"Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing","volume":"443","author":"Molofsky","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2022.07.006_bib39","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1158\/0008-5472.CAN-05-4006","article-title":"Oncogene-induced senescence: putting the brakes on tumor development","volume":"66","author":"Braig","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2022.07.006_bib40","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jdermsci.2016.10.005","article-title":"Sox9 facilitates proliferation, differentiation and lipogenesis in primary cultured human sebocytes","volume":"85","author":"Shi","year":"2017","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.ajpath.2022.07.006_bib42","doi-asserted-by":"crossref","first-page":"e37137","DOI":"10.1371\/journal.pone.0037137","article-title":"LGR6 is a high affinity receptor of R-Spondins and potentially functions as a tumor suppressor","volume":"7","author":"Gong","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2022.07.006_bib43","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.stem.2013.07.010","article-title":"The epidermis comprises autonomous compartments maintained by distinct stem cell populations","volume":"13","author":"Page","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2022.07.006_bib44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/exd.12340","article-title":"Epidermal expression of Lgr6 is dependent on nerve endings and Schwann cells","volume":"23","author":"Liao","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib45","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.celrep.2015.12.041","article-title":"Compartmentalized epidermal activation of \u03b2-catenin differentially affects lineage reprogramming and underlies tumor heterogeneity","volume":"14","author":"Kretzschmar","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2022.07.006_bib46","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1126\/science.1184733","article-title":"Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin","volume":"327","author":"Snippert","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2022.07.006_bib47","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/pcmr.12921","article-title":"Mitochondrial DNA-depleter mouse as a model to study human pigmentary skin disorders","volume":"34","author":"Villavicencio","year":"2021","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.ajpath.2022.07.006_bib48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/geronj\/2.1.85","article-title":"Winter ailments of the old","volume":"2","author":"Angelides","year":"1947","journal-title":"J Gerontol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib49","first-page":"63","article-title":"Areolar sebaceous hyperplasia: a case report","volume":"58","author":"Belinch\u00f3n","year":"1996","journal-title":"Cutis"},{"key":"10.1016\/j.ajpath.2022.07.006_bib50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0190-9622(97)70345-1","article-title":"Familial presenile sebaceous gland hyperplasia","volume":"36","author":"Boonchai","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib51","first-page":"53","article-title":"Erythrosis interfollicularis colli and cutis rhomboidalis nuchae: two sides of a coin","volume":"28","author":"Wollina","year":"2019","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"10.1016\/j.ajpath.2022.07.006_bib52","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4161\/derm.1.2.8486","article-title":"Differentiation of the sebaceous gland","volume":"1","author":"Niemann","year":"2009","journal-title":"Dermatoendocrinol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib53","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/1523-1747.ep12277224","article-title":"Age-related changes in sebaceous wax ester secretion rates in men and women","volume":"85","author":"Jacobsen","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib54","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.exer.2009.08.013","article-title":"Age-related changes in the meibomian gland","volume":"89","author":"Nien","year":"2009","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2022.07.006_bib55","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1167\/iovs.10-6997f","article-title":"The international workshop on meibomian gland dysfunction: report of the diagnosis subcommittee","volume":"52","author":"Tomlinson","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2022.07.006_bib56","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.ophtha.2017.05.031","article-title":"Meibomian gland disease: the role of gland dysfunction in dry eye disease","volume":"124","author":"Chhadva","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajpath.2022.07.006_bib57","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1096\/fj.07-104877","article-title":"Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling","volume":"22","author":"Dobrosi","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2022.07.006_bib58","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1038\/jid.2012.94","article-title":"Protein kinase C isoforms have differential roles in the regulation of human sebocyte biology","volume":"132","author":"G\u00e9czy","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib59","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/bjd.13229","article-title":"Leptin promotes a proinflammatory lipid profile and induces inflammatory pathways in human SZ95 sebocytes","volume":"171","author":"T\u00f6r\u0151csik","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib60","doi-asserted-by":"crossref","first-page":"e99328","DOI":"10.1371\/journal.pone.0099328","article-title":"Oxidative stress induced age dependent meibomian gland dysfunction in Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice","volume":"9","author":"Ibrahim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2022.07.006_bib61","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archopht.124.9.1286","article-title":"Influence of aging on the polar and neutral lipid profiles in human meibomian gland secretions","volume":"124","author":"Sullivan","year":"2006","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib62","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/sj.jid.5700336","article-title":"Peroxisome proliferator-activated receptors increase human sebum production","volume":"126","author":"Trivedi","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib63","doi-asserted-by":"crossref","first-page":"16710","DOI":"10.1074\/jbc.273.27.16710","article-title":"Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor \u03b1 and \u03b3 activators in a tissue- and inducer-specific manner","volume":"273","author":"Motojima","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2022.07.006_bib64","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1600-0625.2009.00929.x","article-title":"Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis","volume":"19","author":"Zouboulis","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib65","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1046\/j.1523-1747.1999.00487.x","article-title":"Rat preputial sebocyte differentiation involves peroxisome proliferator-activated receptors","volume":"112","author":"Rosenfield","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib66","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00403-009-1019-6","article-title":"Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes","volume":"302","author":"Lee","year":"2010","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.ajpath.2022.07.006_bib67","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5114\/ada.2017.67070","article-title":"Melanin and lipofuscin as hallmarks of skin aging","volume":"34","author":"Skoczy\u0144ska","year":"2017","journal-title":"Postepy Dermatol Alergol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib68","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1523-1747.2002.01708.x","article-title":"Photoaging is associated with protein oxidation in human skin in\u00a0vivo","volume":"118","author":"Sander","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib69","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/j.1365-2133.2007.08108.x","article-title":"Photoageing: mechanism, prevention and therapy","volume":"157","author":"Yaar","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib70","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.bbabio.2015.05.014","article-title":"Stem cells, mitochondria and aging","volume":"1847","author":"Ahlqvist","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2022.07.006_bib71","doi-asserted-by":"crossref","first-page":"138","DOI":"10.5021\/ad.2011.23.2.138","article-title":"Sox9 increases the proliferation and colony-forming activity of outer root sheath cells cultured in\u00a0vitro","volume":"23","author":"Shi","year":"2011","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib72","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.7150\/ijms.8383","article-title":"Activated hair follicle stem cells and Wnt\/\u03b2-catenin signaling involve in pathnogenesis of sebaceous neoplasms","volume":"11","author":"Qiu","year":"2014","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.ajpath.2022.07.006_bib73","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ydbio.2015.05.002","article-title":"A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5","volume":"404","author":"Norum","year":"2015","journal-title":"Dev Biol Dev Biol"},{"key":"10.1016\/j.ajpath.2022.07.006_bib74","doi-asserted-by":"crossref","first-page":"11873","DOI":"10.1073\/pnas.1834202100","article-title":"Indian hedgehog and \u03b2-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis","volume":"100","author":"Niemann","year":"2003","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944022002140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944022002140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:08:58Z","timestamp":1762081738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944022002140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":74,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0002944022002140"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2022.07.006","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired Mitochondria Promote Aging-Associated Sebaceous Gland Dysfunction and Pathology","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2022.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}