{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:35:15Z","timestamp":1769524515606,"version":"3.49.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K11186"],"award-info":[{"award-number":["JP16K11186"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K16908"],"award-info":[{"award-number":["JP18K16908"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K09857"],"award-info":[{"award-number":["JP19K09857"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ajpath.2022.07.010","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T20:04:51Z","timestamp":1665086691000},"page":"1573-1591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Keratinocyte Growth Factor Stimulates Growth of p75+ Neural Crest Lineage Cells During Middle Ear Cholesteatoma Formation in Mice"],"prefix":"10.1016","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4168-6315","authenticated-orcid":false,"given":"Tomomi","family":"Yamamoto-Fukuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2232-2049","authenticated-orcid":false,"given":"Naotaro","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2022.07.010_bib1","doi-asserted-by":"crossref","first-page":"16063","DOI":"10.1038\/nrdp.2016.63","article-title":"Otitis media","volume":"2","author":"Schilder","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.ajpath.2022.07.010_bib2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s12105-018-0915-5","article-title":"Cholesteatoma pearls: practical points and update","volume":"12","author":"Castle","year":"2018","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib3","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/lary.24890","article-title":"Etiopathogenesis of acquired cholesteatoma: prominent theories and recent advances in biomolecular research","volume":"125","author":"Kuo","year":"2015","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ajpath.2022.07.010_bib4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10162-018-0662-z","article-title":"Keratinocyte growth factor (KGF) modulates epidermal progenitor cell kinetics through activation of p63 in middle ear cholesteatoma","volume":"19","author":"Yamamoto-Fukuda","year":"2018","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/cyto.a.22098","article-title":"Isolation and differentiation properties of neural crest stem cells","volume":"83","author":"Dupin","year":"2013","journal-title":"Cytometry A"},{"key":"10.1016\/j.ajpath.2022.07.010_bib6","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1126\/science.1232862","article-title":"Dual origin of the epithelium of the mammalian middle ear","volume":"339","author":"Thompson","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2022.07.010_bib7","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.bbrc.2009.01.031","article-title":"Development of mesenchymal stem cells partially originate from the neural crest","volume":"379","author":"Morikawa","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2022.07.010_bib9","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1126\/science.2475908","article-title":"Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth","volume":"245","author":"Finch","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2022.07.010_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1126\/science.1846048","article-title":"Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop","volume":"251","author":"Miki","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2022.07.010_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/01.LAB.0000050763.64145.CB","article-title":"Possible involvement of keratinocyte growth factor and its receptor in enhanced epithelial-cell proliferation and acquired recurrence of middle-ear cholesteatoma","volume":"83","author":"Yamamoto-Fukuda","year":"2003","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2022.07.010_bib11","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1007\/s00405-014-3237-6","article-title":"In\u00a0vivo over-expression of KGF mimic human middle ear cholesteatoma","volume":"272","author":"Yamamoto-Fukuda","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1267\/ahc.11052","article-title":"Temporal and spatial cellular distribution of neural crest derivatives and alpha cells during islet development","volume":"45","author":"Shimada","year":"2012","journal-title":"Acta Histochem Cytochem"},{"key":"10.1016\/j.ajpath.2022.07.010_bib13","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/hipo.20422","article-title":"Neuroanatomical and behavioral effects of a novel version of the cholinergic immunotoxin mu p75-saporin in mice","volume":"18","author":"Moreau","year":"2008","journal-title":"Hippocampus"},{"key":"10.1016\/j.ajpath.2022.07.010_bib14","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0960-9822(07)00562-3","article-title":"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase","volume":"8","author":"Danielian","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0014-5793(00)01338-7","article-title":"A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination","volume":"470","author":"Kawamoto","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ajpath.2022.07.010_bib16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1756-6606-4-34","article-title":"The dual origin of the peripheral olfactory system: placode and neural crest","volume":"4","author":"Katoh","year":"2011","journal-title":"Mol Brain"},{"key":"10.1016\/j.ajpath.2022.07.010_bib17","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/dvdy.22044","article-title":"Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells","volume":"239","author":"Hsu","year":"2010","journal-title":"Dev Dyn"},{"key":"10.1016\/j.ajpath.2022.07.010_bib18","doi-asserted-by":"crossref","first-page":"7607","DOI":"10.1073\/pnas.1101347108","article-title":"Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation","volume":"108","author":"Katayama","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2022.07.010_bib19","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2022.07.010_bib20","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.jtcvs.2008.11.037","article-title":"Keratinocyte growth factor accelerates compensatory growth in the remaining lung after trilobectomy in rats","volume":"137","author":"Matsumoto","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ajpath.2022.07.010_bib21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1023\/A:1004171517639","article-title":"Effects of various decalcification protocols on detection of DNA strand breaks by terminal dUTP nick end labelling","volume":"32","author":"Yamamoto-Fukuda","year":"2000","journal-title":"Histochem J"},{"key":"10.1016\/j.ajpath.2022.07.010_bib22","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.ajpath.2020.04.007","article-title":"L1CAM-ILK-YAP mechanotransduction drives proliferative activity of epithelial cells in middle ear cholesteatoma","volume":"190","author":"Yamamoto-Fukuda","year":"2020","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib23","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3109\/00016489.2014.907501","article-title":"KGFR as a possible therapeutic target in middle ear cholesteatoma","volume":"134","author":"Yamamoto-Fukuda","year":"2014","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mce.2019.01.002","article-title":"The Gata2 repression during 3T3-L1 preadipocyte differentiation is dependent on a rapid decrease in histone acetylation in response to glucocorticoid receptor activation","volume":"483","author":"Ishijima","year":"2019","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib25","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1158\/0008-5472.CAN-07-5424","article-title":"TGFBR1\u22176A enhances the migration and invasion of MCF-7 breast cancer cells through RhoA activation","volume":"68","author":"Rosman","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2022.07.010_bib26","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chembiol.2010.03.006","article-title":"Virtual ligand screening of the p300\/CBP histone acetyl transferase: identification of a selective small molecule inhibitor","volume":"17","author":"Bowers","year":"2010","journal-title":"Chem Biol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10162-021-00801-7","article-title":"Super-enhancer acquisition drives FOXC2 expression in middle ear cholesteatoma","volume":"22","author":"Yamamoto-Fukuda","year":"2021","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib28","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1242\/jcs.055061","article-title":"Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor","volume":"122","author":"Vilar","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2022.07.010_bib29","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1080\/00016489.2017.1351040","article-title":"Evaluation of YAP signaling in a rat tympanic membrane under a continuous negative pressure load and in human middle ear cholesteatoma","volume":"137","author":"Akiyama","year":"2017","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ydbio.2013.04.026","article-title":"The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling","volume":"379","author":"Lewis","year":"2013","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib31","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.stem.2008.03.005","article-title":"Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad","volume":"2","author":"Nagoshi","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2022.07.010_bib32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.stem.2020.10.006","article-title":"A hierarchy of proliferative and migratory keratinocytes maintains the tympanic membrane","volume":"28","author":"Frumm","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2022.07.010_bib33","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1073\/pnas.86.5.1563","article-title":"Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice","volume":"86","author":"Vassar","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2022.07.010_bib34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1432-0436.1986.tb00400.x","article-title":"Cytokeratin expression in squamous metaplasia of the human uterine cervix","volume":"31","author":"Gigi-Leitner","year":"1986","journal-title":"Differentiation"},{"key":"10.1016\/j.ajpath.2022.07.010_bib35","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0012-1606(89)90134-6","article-title":"The appearance of acetylated \u03b1-tubulin during early development and cellular differentiation in Xenopus","volume":"136","author":"Chu","year":"1989","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib36","doi-asserted-by":"crossref","first-page":"854024","DOI":"10.1155\/2015\/854024","article-title":"Updates and knowledge gaps in cholesteatoma research","volume":"2015","author":"Kuo","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ajpath.2022.07.010_bib37","first-page":"786","article-title":"Pathogenesis of attic cholesteatoma: clinical and immunohistochemical support for combination of retraction theory and proliferation theory","volume":"21","author":"Sudhoff","year":"2000","journal-title":"Am J Otol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib38","doi-asserted-by":"crossref","first-page":"e160","DOI":"10.1097\/MAO.0000000000002060","article-title":"Cellular dynamics in early healing of mouse tympanic membranes","volume":"40","author":"Chari","year":"2019","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000320612","article-title":"Localization of progenitor\/stem cells in the human tympanic membrane","volume":"16","author":"Knutsson","year":"2011","journal-title":"Audiol Neurootol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.exer.2009.03.009","article-title":"Identification of neural crest-derived stem cell-like cells from the corneal limbus of juvenile mice","volume":"89","author":"Brandl","year":"2009","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2022.07.010_bib41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1634\/stemcells.2007-0281","article-title":"A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin","volume":"26","author":"Hunt","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.ajpath.2022.07.010_bib42","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.bbrc.2007.04.031","article-title":"Isolation of multipotent stem cells from adult rat periodontal ligament by neurosphere-forming culture system","volume":"357","author":"Techawattanawisal","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2022.07.010_bib43","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/ncb0901-778","article-title":"Isolation of multipotent adult stem cells from the dermis of mammalian skin","volume":"3","author":"Toma","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib44","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000151447","article-title":"Isolation of distinct progenitor stem cell populations from dental pulp","volume":"189","author":"Waddington","year":"2009","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.ajpath.2022.07.010_bib45","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1089\/scd.2006.0068","article-title":"Highly efficient neural differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery","volume":"16","author":"Widera","year":"2007","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.ajpath.2022.07.010_bib46","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1002\/stem.104","article-title":"Adult palatum as a novel source of neural crest-related stem cells","volume":"27","author":"Widera","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.ajpath.2022.07.010_bib47","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1073\/pnas.0400629101","article-title":"Self-renewal capacity is a widespread property of various types of neural crest precursor cells","volume":"101","author":"Trentin","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2022.07.010_bib48","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0012-1606(80)90501-1","article-title":"Clonal analysis of quail neural crest cells: they are pluripotent and differentiate in\u00a0vitro in the absence of noncrest cells","volume":"80","author":"Sieber-Blum","year":"1980","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib49","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0092-8674(92)90393-Q","article-title":"Isolation of a stem cell for neurons and glia from the mammalian neural crest","volume":"71","author":"Stemple","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2022.07.010_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-02088-w","article-title":"Structural absorption by barbule microstructures of super black bird of paradise feathers","volume":"9","author":"McCoy","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2022.07.010_bib51","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41583-021-00503-2","article-title":"Riding the crest to get a head: neural crest evolution in vertebrates","volume":"22","author":"Martik","year":"2021","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ajpath.2022.07.010_bib52","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1601-0825.2005.01176.x","article-title":"FGF signalling in craniofacial development and developmental disorders","volume":"12","author":"Nie","year":"2006","journal-title":"Oral Dis"},{"key":"10.1016\/j.ajpath.2022.07.010_bib53","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.4049\/jimmunol.167.4.1954","article-title":"Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb","volume":"167","author":"Revest","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib54","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1182\/blood-2002-04-1036","article-title":"Regulation of thymic epithelium by keratinocyte growth factor","volume":"100","author":"Erickson","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2022.07.010_bib55","doi-asserted-by":"crossref","first-page":"109699","DOI":"10.1016\/j.ijporl.2019.109699","article-title":"Keratinocyte growth factor (KGF) induces stem\/progenitor cell growth in middle ear mucosa","volume":"128","author":"Yamamoto-Fukuda","year":"2020","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib56","doi-asserted-by":"crossref","first-page":"dev154393","DOI":"10.1242\/dev.154393","article-title":"Mapping the distribution of stem\/progenitor cells across the mouse middle ear during homeostasis and inflammation","volume":"145","author":"Tucker","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2022.07.010_bib57","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1242\/dev.034629","article-title":"Multiple roles for Sox2 in the developing and adult mouse trachea","volume":"136","author":"Que","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2022.07.010_bib58","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.1016\/j.ydbio.2018.06.012","article-title":"Early specification and development of rabbit neural crest cells","volume":"444","author":"Betters","year":"2018","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib59","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1634\/stemcells.2006-0494","article-title":"Identification of human oral keratinocyte stem\/progenitor cells by neurotrophin receptor p75 and the role of neurotrophin\/p75 signaling","volume":"25","author":"Nakamura","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.ajpath.2022.07.010_bib60","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13046-014-0062-0","article-title":"Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention","volume":"33","author":"Kaufhold","year":"2014","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2022.07.010_bib61","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1242\/dev.01907","article-title":"The Snail genes as inducers of cell movement and survival: implications in development and cancer","volume":"132","author":"Barrallo-Gimeno","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2022.07.010_bib62","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3892\/ol.2016.4642","article-title":"Snail levels control the migration mechanism of mesenchymal tumor cells","volume":"12","author":"Belgiovine","year":"2016","journal-title":"Oncol Lett"},{"key":"10.1016\/j.ajpath.2022.07.010_bib63","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ijc.2910440719","article-title":"Reversible transition towards a fibroblastic phenotype in a rat carcinoma cell line","volume":"4","author":"Boyer","year":"1989","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2022.07.010_bib64","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1091\/mbc.1.13.975","article-title":"Alternative patterns of mitogenesis and cell scattering induced by acidic FGF as a function of cell density in a rat bladder carcinoma cell line","volume":"4","author":"Valles","year":"1990","journal-title":"Cell Regul"},{"key":"10.1016\/j.ajpath.2022.07.010_bib65","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1073\/pnas.87.3.1124","article-title":"Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line","volume":"87","author":"Valles","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2022.07.010_bib66","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1091\/mbc.1.13.1003","article-title":"Expression of TGF\u03b1 induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line","volume":"1","author":"Gavrilovic","year":"1990","journal-title":"Cell Regul"},{"key":"10.1016\/j.ajpath.2022.07.010_bib67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/bs.ctdb.2014.11.003","article-title":"Extended multipotency of neural crest cells and neural crest-derived cells","volume":"111","author":"Motohashi","year":"2015","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib68","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2022.07.010_bib69","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1165\/rcmb.2006-0384OC","article-title":"Keratinocyte growth factor improves repair in the injured tracheal epithelium","volume":"37","author":"Gomperts","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib70","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/dbio.1999.9464","article-title":"A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis","volume":"216","author":"Botchkareva","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2022.07.010_bib71","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nature11538","article-title":"Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation","volume":"490","author":"Landsberg","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2022.07.010_bib72","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/scd.2008.0362","article-title":"Isolation and characterization of neural crest stem cells derived from in\u00a0vitro-differentiated human embryonic stem cells","volume":"18","author":"Jiang","year":"2009","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.ajpath.2022.07.010_bib73","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.reth.2020.06.001","article-title":"Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood","volume":"15","author":"Al-Bakri","year":"2020","journal-title":"Regen Ther"},{"key":"10.1016\/j.ajpath.2022.07.010_bib74","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12015-017-9797-2","article-title":"Identification of a novel high yielding source of multipotent adult human neural crest-derived stem cells","volume":"14","author":"Sch\u00fcrmann","year":"2018","journal-title":"Stem Cell Rev Rep"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944022002413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944022002413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:41:08Z","timestamp":1757695268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944022002413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":74,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0002944022002413"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2022.07.010","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Keratinocyte Growth Factor Stimulates Growth of p75+ Neural Crest Lineage Cells During Middle Ear Cholesteatoma Formation in Mice","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2022.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}