{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:28:21Z","timestamp":1784762901398,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012131","name":"Department of Science and Technology of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1303200"],"award-info":[{"award-number":["2016YFC1303200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2505100"],"award-info":[{"award-number":["2022YFC2505100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019033","name":"Key Research and Development Program of Liaoning Province","doi-asserted-by":"publisher","award":["2020JH2\/10300063"],"award-info":[{"award-number":["2020JH2\/10300063"]}],"id":[{"id":"10.13039\/501100019033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ajpath.2023.10.007","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T22:02:53Z","timestamp":1698876173000},"page":"13-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Alternative Splicing Factor Heterogeneous Nuclear Ribonucleoprotein U as a Promising Biomarker for Gastric Cancer Risk and Prognosis with Tumor-Promoting Properties"],"prefix":"10.1016","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-160X","authenticated-orcid":false,"given":"Ying-ying","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-2379","authenticated-orcid":false,"given":"Meng-ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-jing","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-9036","authenticated-orcid":false,"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3637-0305","authenticated-orcid":false,"given":"Li-ping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2023.10.007_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2023.10.007_bib2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s12885-015-1328-4","article-title":"Determinants of gastric cancer screening attendance in Korea: a multi-level analysis","volume":"15","author":"Chang","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ajpath.2023.10.007_bib3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/gutjnl-2021-324060","article-title":"Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial","volume":"71","author":"Sundar","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2023.10.007_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s10120-018-0841-y","article-title":"Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations","volume":"22","author":"Yu","year":"2019","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.ajpath.2023.10.007_bib5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.7150\/ijbs.55120","article-title":"Crucial roles of different RNA-binding hnRNP proteins in stem cells","volume":"17","author":"Xie","year":"2021","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.ajpath.2023.10.007_bib6","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00439-016-1683-5","article-title":"The hnRNP family: insights into their role in health and disease","volume":"135","author":"Geuens","year":"2016","journal-title":"Hum Genet"},{"key":"10.1016\/j.ajpath.2023.10.007_bib7","first-page":"85","article-title":"The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression","volume":"1765","author":"Carpenter","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2023.10.007_bib8","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.18632\/aging.202411","article-title":"Identification of therapeutic targets and prognostic biomarkers from the hnRNP family in invasive breast carcinoma","volume":"13","author":"Zhou","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ajpath.2023.10.007_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/BJ20100396","article-title":"Functional diversity of the hnRNPs: past, present and perspectives","volume":"430","author":"Han","year":"2010","journal-title":"Biochem J"},{"key":"10.1016\/j.ajpath.2023.10.007_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.canlet.2017.03.013","article-title":"Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer","volume":"396","author":"K\u0119dzierska","year":"2017","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajpath.2023.10.007_bib11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1631\/jzus.B1900422","article-title":"Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis","volume":"21","author":"Zhu","year":"2020","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.ajpath.2023.10.007_bib12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.canlet.2014.06.019","article-title":"Emerging roles of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in cancer progression","volume":"352","author":"Barboro","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajpath.2023.10.007_bib13","doi-asserted-by":"crossref","first-page":"11111","DOI":"10.1111\/jcmm.15558","article-title":"Pan-cancer analysis of alternative splicing regulator heterogeneous nuclear ribonucleoproteins (hnRNPs) family and their prognostic potential","volume":"24","author":"Li","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ajpath.2023.10.007_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.gde.2021.10.008","article-title":"The role of SAF-A\/hnRNP U in regulating chromatin structure","volume":"72","author":"Marenda","year":"2022","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.ajpath.2023.10.007_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.semcdb.2018.07.006","article-title":"The role of nuclear matrix protein HNRNPU in maintaining the architecture of 3D genome","volume":"90","author":"Zhang","year":"2019","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.ajpath.2023.10.007_bib16","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/hep.30921","article-title":"hnRNPU\/TrkB defines a chromatin accessibility checkpoint for liver injury and nonalcoholic steatohepatitis pathogenesis","volume":"71","author":"Xiong","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2023.10.007_bib17","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/sj.onc.1209922","article-title":"hnRNP-U directly interacts with WT1 and modulates WT1 transcriptional activation","volume":"26","author":"Spraggon","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2023.10.007_bib18","doi-asserted-by":"crossref","first-page":"11469","DOI":"10.1080\/21655979.2022.2066754","article-title":"Heterogeneous nuclear ribonucleoprotein U-actin complex derived from extracellular vesicles facilitates proliferation and migration of human coronary artery endothelial cells by promoting RNA polymerase II transcription","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.ajpath.2023.10.007_bib19","doi-asserted-by":"crossref","first-page":"E3020","DOI":"10.1073\/pnas.1508461112","article-title":"hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function","volume":"112","author":"Ye","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2023.10.007_bib20","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1002\/cam4.2898","article-title":"LIMD1-AS1 suppressed non-small cell lung cancer progression through stabilizing LIMD1 mRNA via hnRNP U","volume":"9","author":"Pan","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.ajpath.2023.10.007_bib21","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1158\/0008-5472.CAN-19-0376","article-title":"DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing","volume":"79","author":"Xing","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2023.10.007_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13045-020-00857-7","article-title":"HNF4A-AS1\/hnRNPU\/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression","volume":"13","author":"Song","year":"2020","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.ajpath.2023.10.007_bib23","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1002\/jcb.29590","article-title":"Systematic analysis of survival-associated alternative splicing signatures in clear cell renal cell carcinoma","volume":"121","author":"Chen","year":"2020","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.ajpath.2023.10.007_bib24","first-page":"A68","article-title":"The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge","volume":"19","author":"Tomczak","year":"2015","journal-title":"Contemp Oncol (Pozn)"},{"key":"10.1016\/j.ajpath.2023.10.007_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5134050","article-title":"Identification of upregulated HNRNPs associated with poor prognosis in pancreatic cancer","volume":"2019","author":"Qiao","year":"2019","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ajpath.2023.10.007_bib26","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.3390\/cancers12123499","article-title":"In silico and in\u00a0vitro analysis of lncRNA XIST reveals a panel of possible lung cancer regulators and a five-gene diagnostic signature","volume":"12","author":"Katopodis","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.ajpath.2023.10.007_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/1873-3468.13943","article-title":"The splicing regulatory factor hnRNPU is a novel transcriptional target of c-Myc in hepatocellular carcinoma","volume":"595","author":"Zhang","year":"2021","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ajpath.2023.10.007_bib28","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.12659\/MSM.906313","article-title":"Possible molecular markers for the diagnosis of pancreatic ductal adenocarcinoma","volume":"24","author":"Shen","year":"2018","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.ajpath.2023.10.007_bib29","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/j.gastro.2008.01.071","article-title":"Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands","volume":"134","author":"de Vries","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2023.10.007_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215764","article-title":"Helicobacter pylori infection induces stem cell-like properties in Correa cascade of gastric cancer","volume":"542","author":"He","year":"2022","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajpath.2023.10.007_bib31","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jfma.2022.11.008","article-title":"Evolution of the Correa's cascade steps: a long-term endoscopic surveillance among non-ulcer dyspepsia and gastric ulcer after H. pylori eradication","volume":"122","author":"Cheng","year":"2023","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.ajpath.2023.10.007_bib32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/gutjnl-2019-319631","article-title":"Early gastric cancer detection in high-risk patients: a multicentre randomised controlled trial on the effect of second-generation narrow band imaging","volume":"70","author":"Yoshida","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2023.10.007_bib33","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.21129","article-title":"Assessment of the diagnostic efficiency of a liquid biopsy assay for early detection of gastric cancer","volume":"4","author":"Izumi","year":"2021","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ajpath.2023.10.007_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112898","article-title":"HNRNPU promotes the progression of hepatocellular carcinoma by enhancing CDK2 transcription","volume":"409","author":"Liang","year":"2021","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2023.10.007_bib35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12672-022-00568-0","article-title":"High expression of RUVBL1 and HNRNPU is associated with poor overall survival in stage I and II non-small cell lung cancer patients","volume":"13","author":"Dur\u015blewicz","year":"2022","journal-title":"Discov Oncol"},{"key":"10.1016\/j.ajpath.2023.10.007_bib36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/cge.14200","article-title":"Nomograms for prognostic risk assessment in glioblastoma multiforme: applications and limitations","volume":"102","author":"Zheng","year":"2022","journal-title":"Clin Genet"},{"key":"10.1016\/j.ajpath.2023.10.007_bib37","doi-asserted-by":"crossref","first-page":"11919","DOI":"10.18632\/aging.202896","article-title":"Bioinformatic analyses and experimental validation of the role of m6A RNA methylation regulators in progression and prognosis of adrenocortical\u00a0carcinoma","volume":"13","author":"Xu","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ajpath.2023.10.007_bib38","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.258991","article-title":"SAF-A promotes origin licensing and replication fork progression to ensure robust DNA replication","volume":"135","author":"Connolly","year":"2022","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2023.10.007_bib39","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/s41419-022-05376-6","article-title":"HNRNPU promotes the progression of triple-negative breast cancer via RNA transcription and alternative splicing mechanisms","volume":"13","author":"Han","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajpath.2023.10.007_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105270","article-title":"A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing","volume":"25","author":"Isaac","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.ajpath.2023.10.007_bib41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.molcel.2012.01.009","article-title":"Nuclear matrix factor hnRNP U\/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation","volume":"45","author":"Xiao","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/j.ajpath.2023.10.007_bib42","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41419-018-0539-4","article-title":"Modulation of alternative splicing induced by paclitaxel in human lung cancer","volume":"9","author":"Zhu","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajpath.2023.10.007_bib43","first-page":"1591","article-title":"Isoforms S and L of MRPL33 from alternative splicing have isoform-specific roles in the chemoresponse to epirubicin in gastric cancer cells via the PI3K\/AKT signaling pathway","volume":"54","author":"Li","year":"2019","journal-title":"Int J Oncol"},{"key":"10.1016\/j.ajpath.2023.10.007_bib44","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.3390\/ijms23084107","article-title":"A monoclonal anti-HMGB1 antibody attenuates neurodegeneration in an experimental animal model of glaucoma","volume":"23","author":"Tonner","year":"2022","journal-title":"Int J Mol Sci"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944023004145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944023004145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:43:38Z","timestamp":1757695418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944023004145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0002944023004145"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2023.10.007","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alternative Splicing Factor Heterogeneous Nuclear Ribonucleoprotein U as a Promising Biomarker for Gastric Cancer Risk and Prognosis with Tumor-Promoting Properties","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2023.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}