{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:26:25Z","timestamp":1793409985395,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01 HL107380"],"award-info":[{"award-number":["R01 HL107380"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["F31 HL158002"],"award-info":[{"award-number":["F31 HL158002"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ajpath.2023.11.017","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T16:26:02Z","timestamp":1703780762000},"page":"384-401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mammalian Target of Rapamycin Complex 1 Activation in Macrophages Contributes to Persistent Lung Inflammation following Respiratory Tract Viral Infection"],"prefix":"10.1016","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0110-6793","authenticated-orcid":false,"given":"Brydie R.","family":"Huckestein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5813-5616","authenticated-orcid":false,"given":"Kelly","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Westcott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan K.","family":"Alder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Antos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay K.","family":"Kolls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-7711","authenticated-orcid":false,"given":"John F.","family":"Alcorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2023.11.017_bib2","first-page":"730","article-title":"Alveolitis induced by influenza virus","volume":"128","author":"Jakab","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.ajpath.2023.11.017_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13","volume":"171","author":"Sigurs","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2023.11.017_bib4","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jaci.2011.06.037","article-title":"Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma","volume":"128","author":"Guilbert","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib5","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/infdis\/jix167","article-title":"Human metapneumovirus infection in chronic obstructive pulmonary disease: impact of\u00a0glucocorticosteroids and interferon","volume":"215","author":"Kan","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2023.11.017_bib6","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.ajpath.2016.12.012","article-title":"Epigenetic and transcriptomic regulation of lung repair during recovery from influenza infection","volume":"187","author":"Pociask","year":"2017","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature14112","article-title":"Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury","volume":"517","author":"Vaughan","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2023.11.017_bib8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ajpath.2019.11.003","article-title":"Distinct chronic post-viral lung diseases upon infection with influenza or parainfluenza viruses differentially impact superinfection outcome","volume":"190","author":"Garcia","year":"2020","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib9","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.4049\/jimmunol.1800671","article-title":"Influenza A virus infection causes chronic lung disease linked to sites of active viral RNA remnants","volume":"201","author":"Keeler","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.trsl.2020.01.005","article-title":"Next-generation direct-acting influenza therapeutics","volume":"220","author":"Toots","year":"2020","journal-title":"Transl Res"},{"key":"10.1016\/j.ajpath.2023.11.017_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3904\/kjim.2014.29.1.132","article-title":"Transgovernmental Enterprise for Pandemic Influenza in Korea: Severe influenza treatment guideline","volume":"29","author":"Choi","year":"2014","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.ajpath.2023.11.017_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3390\/v15020318","article-title":"Therapeutic targeting of inflammation and virus simultaneously ameliorates influenza pneumonia and protects from morbidity and mortality","volume":"15","author":"Pandey","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.ajpath.2023.11.017_bib13","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1186\/s12913-023-10091-9","article-title":"Swept under the carpet: a qualitative study of patient perspectives on long COVID, treatments, services, and mental health","volume":"23","author":"Hawke","year":"2023","journal-title":"BMC Health Serv Res"},{"key":"10.1016\/j.ajpath.2023.11.017_bib14","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12866-020-01890-9","article-title":"Redox control in the pathophysiology of influenza virus infection","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1089\/ars.2019.7727","article-title":"Mitochondrial reactive oxygen species contribute to pathological inflammation during influenza A virus infection in mice","volume":"32","author":"To","year":"2020","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ajpath.2023.11.017_bib16","doi-asserted-by":"crossref","first-page":"27643","DOI":"10.1074\/jbc.M603536200","article-title":"The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity","volume":"281","author":"Schieke","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2023.11.017_bib17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nri3901","article-title":"Regulation of innate immune cell function by mTOR","volume":"15","author":"Weichhart","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib18","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri3198","article-title":"Regulation and function of mTOR signalling in T cell fate decisions","volume":"12","author":"Chi","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006635","article-title":"Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication","volume":"13","author":"Kuss-Duerkop","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2023.11.017_bib20","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1139\/bcb-2016-0048","article-title":"Rapamycin alleviates oxidative stress-induced damage in rat erythrocytes","volume":"94","author":"Singh","year":"2016","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007428","article-title":"Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration","volume":"14","author":"Jia","year":"2018","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2023.11.017_bib22","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.celrep.2017.04.039","article-title":"Targeting metabolic reprogramming by influenza infection for therapeutic intervention","volume":"19","author":"Smallwood","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2023.11.017_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3851\/IMP2080","article-title":"Inhibition of influenza A virus replication by antagonism of a PI3K-AKT-mTOR pathway member identified by gene-trap insertional mutagenesis","volume":"22","author":"Murray","year":"2012","journal-title":"Antivir Chem Chemother"},{"key":"10.1016\/j.ajpath.2023.11.017_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4049\/immunohorizons.1700030","article-title":"STAT1 is required for suppression of type 17 immunity during influenza and bacterial superinfection","volume":"1","author":"Lee","year":"2017","journal-title":"Immunohorizons"},{"key":"10.1016\/j.ajpath.2023.11.017_bib25","doi-asserted-by":"crossref","first-page":"760","DOI":"10.4049\/jimmunol.2200261","article-title":"Heterotypic influenza infections mitigate susceptibility to secondary bacterial infection","volume":"209","author":"Cipolla","year":"2022","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/infdis\/jix571","article-title":"Severe influenza is characterized by prolonged immune activation: results from the SHIVERS cohort study","volume":"217","author":"Wong","year":"2018","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2023.11.017_bib27","doi-asserted-by":"crossref","first-page":"11208","DOI":"10.1128\/JVI.00654-11","article-title":"Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice","volume":"85","author":"Marcelin","year":"2011","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2023.11.017_bib29","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.vaccine.2022.12.041","article-title":"Factors associated with humoral immune response in older adults who received egg-free influenza vaccine","volume":"41","author":"Williams","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.ajpath.2023.11.017_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: from growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib31","doi-asserted-by":"crossref","first-page":"268ra179","DOI":"10.1126\/scitranslmed.3009892","article-title":"mTOR inhibition improves immune function in the elderly","volume":"6","author":"Mannick","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ajpath.2023.11.017_bib32","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.matbio.2018.06.006","article-title":"Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis","volume":"80","author":"Bell","year":"2019","journal-title":"Matrix Biol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib33","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0140-6736(02)11772-7","article-title":"Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?","volume":"360","author":"Cheung","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2023.11.017_bib34","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1126\/science.1132998","article-title":"RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates","volume":"314","author":"Pichlmair","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2023.11.017_bib35","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1073\/pnas.0400937101","article-title":"Recognition of single-stranded RNA viruses by toll-like receptor 7","volume":"101","author":"Lund","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2023.11.017_bib36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ni.1859","article-title":"The AIM2 inflammasome is critical for innate immunity to Francisella tularensis","volume":"11","author":"Fernandes-Alnemri","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.stem.2014.07.012","article-title":"Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function","volume":"15","author":"Hogan","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2023.11.017_bib38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3389\/fcimb.2020.00287","article-title":"Regulations of glycolytic activities on macrophages functions in tumor and infectious inflammation","volume":"10","author":"Yu","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-immunol-020711-075024","article-title":"Regulation of immune responses by mTOR","volume":"30","author":"Powell","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib40","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.2005","article-title":"The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2","volume":"12","author":"Delgoffe","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib41","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nature12297","article-title":"mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function","volume":"499","author":"Zeng","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2023.11.017_bib42","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08155","article-title":"mTOR regulates memory CD8 T-cell differentiation","volume":"460","author":"Araki","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2023.11.017_bib43","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.4049\/jimmunol.1400074","article-title":"Cutting edge: generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR","volume":"193","author":"Sowell","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib44","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.4049\/jimmunol.1201767","article-title":"B cell-specific deficiencies in mTOR limit humoral immune responses","volume":"191","author":"Zhang","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib45","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12931-017-0618-6","article-title":"Sirolimus alters lung pathology and viral load following influenza A virus infection","volume":"18","author":"Alsuwaidi","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.ajpath.2023.11.017_bib46","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fimmu.2018.00270","article-title":"Metabolic modulation in macrophage effector function","volume":"9","author":"Diskin","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib47","doi-asserted-by":"crossref","first-page":"913","DOI":"10.4049\/jimmunol.2100230","article-title":"mTORC1 signaling regulates proinflammatory macrophage function and metabolism","volume":"207","author":"Collins","year":"2021","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib48","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1038\/ncomms3834","article-title":"The TSC-mTOR pathway regulates macrophage polarization","volume":"4","author":"Byles","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2023.11.017_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2795090","article-title":"The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases","volume":"2016","author":"Tan","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ajpath.2023.11.017_bib50","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.3389\/fimmu.2018.03155","article-title":"mTOR-dependent oxidative stress regulates oxLDL-induced trained innate immunity in human monocytes","volume":"9","author":"Sohrabi","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib51","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1084\/jem.20080201","article-title":"Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand","volume":"205","author":"Herold","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2023.11.017_bib52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12929-014-0099-6","article-title":"The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection","volume":"21","author":"Lin","year":"2014","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.ajpath.2023.11.017_bib53","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.4049\/jimmunol.180.4.2562","article-title":"CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality","volume":"180","author":"Lin","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib54","doi-asserted-by":"crossref","first-page":"508","DOI":"10.4049\/jimmunol.1001002","article-title":"CCR2-antagonist prophylaxis reduces pulmonary immune pathology and markedly improves survival during influenza infection","volume":"186","author":"Lin","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110456","article-title":"Interferon-gamma promotes monocyte-mediated lung injury during influenza infection","volume":"38","author":"Schmit","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2023.11.017_bib56","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.4049\/jimmunol.1200604","article-title":"Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury","volume":"190","author":"Osterholzer","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib57","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1084\/jem.20162152","article-title":"Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span","volume":"214","author":"Misharin","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2023.11.017_bib58","doi-asserted-by":"crossref","first-page":"6243","DOI":"10.1016\/j.cell.2021.11.033","article-title":"SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis","volume":"184","author":"Wendisch","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2023.11.017_bib59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.it.2006.11.002","article-title":"IL-12p40: an inherently agonistic cytokine","volume":"28","author":"Cooper","year":"2007","journal-title":"Trends Immunol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib60","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1084\/jem.193.3.339","article-title":"Interleukin 12 p40 production by barrier epithelial cells during airway inflammation","volume":"193","author":"Walter","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2023.11.017_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007001","article-title":"Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer","volume":"14","author":"Gounder","year":"2018","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2023.11.017_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.676183","article-title":"Rapamycin improves the response of effector and memory CD8(+) T cells induced by immunization with ASP2 of Trypanosoma cruzi","volume":"11","author":"Moraschi","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.ajpath.2023.11.017_bib63","doi-asserted-by":"crossref","first-page":"757","DOI":"10.4049\/jimmunol.1400188","article-title":"Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections","volume":"193","author":"Goldberg","year":"2014","journal-title":"J Immunol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944023004856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944023004856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T01:42:23Z","timestamp":1740793343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944023004856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0002944023004856"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2023.11.017","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mammalian Target of Rapamycin Complex 1 Activation in Macrophages Contributes to Persistent Lung Inflammation following Respiratory Tract Viral Infection","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2023.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}