{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:47:59Z","timestamp":1790376479366,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K07677"],"award-info":[{"award-number":["23K07677"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006323","name":"National Institute for Physiological Sciences","doi-asserted-by":"publisher","award":["22-NIPS107"],"award-info":[{"award-number":["22-NIPS107"]}],"id":[{"id":"10.13039\/501100006323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004017","name":"Japanese Association of Dialysis Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004017","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.ajpath.2024.01.008","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T12:03:25Z","timestamp":1706875405000},"page":"673-683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bicellular Localization of Tricellular Junctional Protein Angulin-3\/ILDR2 Allows Detection of Podocyte Injury"],"prefix":"10.1016","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3300-0597","authenticated-orcid":false,"given":"Atsuko Y.","family":"Higashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira C.","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-1477","authenticated-orcid":false,"given":"Tomohito","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Furuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Furuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichiro J.","family":"Kazama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2024.01.008_bib1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1242\/jcs.072058","article-title":"LSR defines cell corners for tricellular tight junction formation in epithelial cells","volume":"124","author":"Masuda","year":"2011","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2024.01.008_bib2","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1242\/jcs.138271","article-title":"Analysis of the \u201cangulin\u201d proteins LSR, ILDR1 and ILDR2 \u2013 tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis","volume":"126","author":"Higashi","year":"2013","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2024.01.008_bib3","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202005062","article-title":"Angulin-1 seals tricellular contacts independently of tricellulin and claudins","volume":"220","author":"Sugawara","year":"2021","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2024.01.008_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024640","article-title":"Defining the molecular character of the developing and adult kidney podocyte","volume":"6","author":"Brunskill","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2024.01.008_bib5","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.kint.2017.04.022","article-title":"Genome-wide identification of genes essential for podocyte cytoskeletons based on single-cell RNA sequencing","volume":"92","author":"Lu","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2024.01.008_bib6","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/ki.2012.487","article-title":"Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks","volume":"83","author":"Boerries","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2024.01.008_bib7","doi-asserted-by":"crossref","first-page":"15874","DOI":"10.1073\/pnas.2005477117","article-title":"Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury","volume":"117","author":"Kirita","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2024.01.008_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1195037","article-title":"Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot process","volume":"11","author":"Gerlach","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.ajpath.2024.01.008_bib9","first-page":"90","article-title":"Differentiation of epithelial foot processes and filtration slits: sequential appearance of occluding junctions, epithelial polyanion, and slit membranes in developing glomeruli","volume":"39","author":"Reeves","year":"1978","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2024.01.008_bib10","first-page":"132","article-title":"Morphological process of podocyte development revealed by block-face scanning electron microscopy","volume":"130","author":"Ichimura","year":"2017","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2024.01.008_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00441-017-2590-3","article-title":"New structural insights into podocyte biology","volume":"369","author":"Grahammer","year":"2017","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajpath.2024.01.008_bib12","doi-asserted-by":"crossref","first-page":"F1082","DOI":"10.1152\/ajprenal.00338.2015","article-title":"Advanced electron microscopic techniques provide a deeper insight into the peculiar features of podocytes","volume":"309","author":"Burghardt","year":"2015","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.ajpath.2024.01.008_bib13","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.114.5.699","article-title":"Glomerular permeability, II: ferritin transfer across the glomerular capillary wall in nephrotic rats","volume":"114","author":"Farquhar","year":"1961","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2024.01.008_bib14","first-page":"397","article-title":"A freeze-fracture study of the junctions between glomerular epithelial cells in aminonucleoside nephrosis","volume":"32","author":"Ryan","year":"1975","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2024.01.008_bib15","first-page":"209","article-title":"Intercellular junctions in podocytes of the nephrotic glomerulus as seen with freeze-fracture","volume":"33","author":"Pricam","year":"1975","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2024.01.008_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1247\/csf.20.151","article-title":"A novel method of preparing rat-monoclonal antibody-producing hybridomas by using rat medial iliac lymph node cells","volume":"20","author":"Kishiro","year":"1995","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.ajpath.2024.01.008_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-91464-0","article-title":"CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma","volume":"11","author":"Watanabe","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2024.01.008_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","article-title":"Efficient selection for high-expression transfectants with a novel eukaryotic vector","volume":"108","author":"Niwa","year":"1991","journal-title":"Gene"},{"key":"10.1016\/j.ajpath.2024.01.008_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01004-z","article-title":"Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland","volume":"11","author":"Higashi","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2024.01.008_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1109\/34.659930","article-title":"An unbiased detector of curvilinear structures","volume":"20","author":"Steger","year":"1998","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"10.1016\/j.ajpath.2024.01.008_bib21","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajpath.2024.01.008_bib22","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1083\/jcb.200510043","article-title":"Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells","volume":"171","author":"Ikenouchi","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2024.01.008_bib23","first-page":"43","article-title":"Alterations of the glomerular epithelium in acute aminonucleoside nephrosis: evidence for formation of occluding junctions and epithelial cell detachment","volume":"34","author":"Caulfield","year":"1976","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2024.01.008_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120674","article-title":"Deficiency of angulin-2\/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice","volume":"10","author":"Higashi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2024.01.008_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67319-5","article-title":"Angulin-2\/ILDR1, a tricellular tight junction protein, does not affect water transport in the mouse large intestine","volume":"10","author":"Hempstock","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2024.01.008_bib26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s10157-020-01985-7","article-title":"Adult-onset minimal change disease: the significance of histological chronic changes for clinical presentation and outcome","volume":"25","author":"Stefan","year":"2021","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.ajpath.2024.01.008_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12882-018-0999-x","article-title":"Adult minimal-change disease: observational data from a UK centre on patient characteristics, therapies, and outcomes","volume":"19","author":"Fenton","year":"2018","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.ajpath.2024.01.008_bib28","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.kint.2017.09.019","article-title":"Confocal super-resolution imaging of the glomerular filtration barrier enabled by tissue expansion","volume":"93","author":"Unnersj\u00f6-Jess","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2024.01.008_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11553-x","article-title":"Structured illumination microscopy and automatized image processing as a rapid diagnostic tool for podocyte effacement","volume":"7","author":"Siegerist","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2024.01.008_bib30","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.ekir.2021.04.021","article-title":"Quantitative analyses of foot processes, mitochondria, and basement membranes by structured illumination","volume":"6","author":"Matsumoto","year":"2021","journal-title":"Kidney Int Rep"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024000385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024000385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:10:00Z","timestamp":1762081800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944024000385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0002944024000385"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.01.008","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bicellular Localization of Tricellular Junctional Protein Angulin-3\/ILDR2 Allows Detection of Podocyte Injury","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}