{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:50:14Z","timestamp":1790117414557,"version":"4.0.1"},"reference-count":66,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2003JJ60438"],"award-info":[{"award-number":["2003JJ60438"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ajpath.2024.07.020","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T18:56:06Z","timestamp":1724093766000},"page":"2091-2105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["TRIM24 Up-Regulates ORM2 to Alleviate Abnormal Lipid Metabolism, Inflammation, and Oxidative Stress in Mice with Obstructive Sleep Apnea Syndrome and Metabolic Dysfunction\u2013Associated Steatotic Liver Disease"],"prefix":"10.1016","volume":"194","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingquan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2024.07.020_bib1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.ajpath.2024.07.020_bib2","article-title":"Obstructive sleep apnoea syndrome","volume":"1","author":"L\u00e9vy","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.ajpath.2024.07.020_bib3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1164\/ajrccm.165.5.2103001","article-title":"Obstructive sleep apnea is independently associated with insulin resistance","volume":"165","author":"Ip","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2024.07.020_bib4","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/j.chest.2020.05.600","article-title":"Sleep-disordered breathing and free fatty acid metabolism","volume":"158","author":"Stefanovski","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.ajpath.2024.07.020_bib5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1183\/09031936.00166808","article-title":"Sleep, sleep-disordered breathing and metabolic consequences","volume":"34","author":"L\u00e9vy","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2024.07.020_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-0032-1306426","article-title":"Obstructive sleep apnea-hypopnea syndrome and nonalcoholic fatty liver disease: emerging evidence and mechanisms","volume":"32","author":"Musso","year":"2012","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.ajpath.2024.07.020_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9649608","article-title":"Nocturnal hypoxia improves glucose disposal, decreases mitochondrial efficiency, and increases reactive oxygen species in the muscle and liver of C57BL\/6J mice independent of weight change","volume":"2018","author":"Ioja","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ajpath.2024.07.020_bib8","article-title":"Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD)","volume":"13","author":"Rong","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.ajpath.2024.07.020_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ajpath.2024.07.020_bib10","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/ijc.29519","article-title":"HIF-1 at the crossroads of hypoxia, inflammation, and cancer","volume":"138","author":"Balamurugan","year":"2016","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2024.07.020_bib11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/embo-reports\/kve130","article-title":"Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm","volume":"2","author":"Berra","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1016\/j.ajpath.2024.07.020_bib12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"Epstein","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2024.07.020_bib13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00109-016-1408-1","article-title":"Hypoxia-inducible factors as molecular targets for liver diseases","volume":"94","author":"Ju","year":"2016","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.ajpath.2024.07.020_bib14","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.5664\/jcsm.8682","article-title":"Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1[alpha] protein","volume":"16","author":"Gabryelska","year":"2020","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.ajpath.2024.07.020_bib15","first-page":"47","article-title":"Potential inflammatory markers in obstructive sleep apnea-hypopnea syndrome","volume":"17","author":"Lu","year":"2017","journal-title":"Bosn J Basic Med Sci"},{"key":"10.1016\/j.ajpath.2024.07.020_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41574-018-0096-z","article-title":"The role of hypoxia-inducible factors in metabolic diseases","volume":"15","author":"Gonzalez","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ajpath.2024.07.020_bib17","doi-asserted-by":"crossref","first-page":"7841","DOI":"10.3390\/ijms22157841","article-title":"Losartan prevents hepatic steatosis and macrophage polarization by inhibiting HIF-1[alpha] in a murine model of NAFLD","volume":"22","author":"Wang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2024.07.020_bib18","first-page":"3485","article-title":"Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression","volume":"125","author":"Mylonis","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2024.07.020_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cmet.2013.11.022","article-title":"Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth","volume":"19","author":"Sun","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2024.07.020_bib20","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2413","article-title":"TRIM family proteins and their emerging roles in innate immunity","volume":"8","author":"Ozato","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2024.07.020_bib21","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1002\/j.1460-2075.1996.tb01060.x","article-title":"A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors","volume":"15","author":"Le Douarin","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2024.07.020_bib22","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1128\/MCB.01705-12","article-title":"TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage","volume":"34","author":"Jain","year":"2014","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2024.07.020_bib23","doi-asserted-by":"crossref","first-page":"E568","DOI":"10.1073\/pnas.1522287113","article-title":"T-cell-intrinsic Tif1[alpha]\/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy","volume":"113","author":"Perez-Lloret","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2024.07.020_bib24","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20192083","article-title":"TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination","volume":"217","author":"Zhu","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2024.07.020_bib25","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ccell.2016.04.012","article-title":"TRIM24 is an oncogenic transcriptional activator in prostate cancer","volume":"29","author":"Groner","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ajpath.2024.07.020_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsab290","article-title":"Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype","volume":"45","author":"Zhen","year":"2022","journal-title":"Sleep"},{"key":"10.1016\/j.ajpath.2024.07.020_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jhep.2014.09.026","article-title":"TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice","volume":"62","author":"Jiang","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2024.07.020_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.phymed.2018.07.008","article-title":"Lycopus lucidus Turcz. ex Benth. attenuates free fatty acid-induced steatosis in HepG2 cells and non-alcoholic fatty liver disease in high-fat diet-induced obese mice","volume":"55","author":"Lee","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ajpath.2024.07.020_bib29","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1089\/jir.2014.0165","article-title":"Fatty acids induce a pro-inflammatory gene expression profile in huh-7 cells that attenuates the anti-HCV action of interferon","volume":"35","author":"Tse","year":"2015","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.ajpath.2024.07.020_bib30","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/cells12020276","article-title":"Macrophages: from simple phagocyte to an integrative regulatory cell for inflammation and tissue regeneration-a review of the literature","volume":"12","author":"Mamilos","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.ajpath.2024.07.020_bib31","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/s42255-022-00627-4","article-title":"Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis","volume":"4","author":"Zhou","year":"2022","journal-title":"Nat Metab"},{"key":"10.1016\/j.ajpath.2024.07.020_bib32","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nature09542","article-title":"TRIM24 links a non-canonical histone signature to breast cancer","volume":"468","author":"Tsai","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2024.07.020_bib33","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/hep.26699","article-title":"All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade","volume":"59","author":"Kim","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.07.020_bib34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/hep.20335","article-title":"Retinoic acid receptor alpha dominant negative form causes steatohepatitis and liver tumors in transgenic mice","volume":"40","author":"Yanagitani","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.07.020_bib35","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1164\/rccm.201806-1109TR","article-title":"Obstructive sleep apnea, hypoxia, and nonalcoholic fatty liver disease","volume":"199","author":"Mesarwi","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2024.07.020_bib36","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1183\/09031936.06.00084905","article-title":"Association between lipid peroxidation and inflammation in obstructive sleep apnoea","volume":"28","author":"Minoguchi","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2024.07.020_bib37","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.7150\/ijbs.71431","article-title":"Quantitative proteomics of HFD-induced fatty liver uncovers novel transcription factors of lipid metabolism","volume":"18","author":"Zhi","year":"2022","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.ajpath.2024.07.020_bib38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fneur.2012.00149","article-title":"Obstructive sleep apnea and non-alcoholic fatty liver disease: is the liver another target?","volume":"3","author":"Mirrakhimov","year":"2012","journal-title":"Front Neurol"},{"key":"10.1016\/j.ajpath.2024.07.020_bib39","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1164\/rccm.200804-608OC","article-title":"Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity","volume":"179","author":"Polotsky","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2024.07.020_bib40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jhep.2011.04.022","article-title":"Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese","volume":"56","author":"Aron-Wisnewsky","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2024.07.020_bib41","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \"hits\"?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2024.07.020_bib42","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/hep.23719","article-title":"Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites","volume":"52","author":"Neuschwander-Tetri","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.07.020_bib43","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.2337\/db10-0224","article-title":"Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL\/6 mice","volume":"59","author":"Duval","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.ajpath.2024.07.020_bib44","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1074\/jbc.M112.414771","article-title":"Chaperone-mediated autophagy targets hypoxia-inducible factor-1[alpha] (HIF-1[alpha]) for lysosomal degradation","volume":"288","author":"Hubbi","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2024.07.020_bib45","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12974-020-01905-2","article-title":"The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome","volume":"17","author":"Liu","year":"2020","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.ajpath.2024.07.020_bib46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1152\/japplphysiol.00177.2002","article-title":"Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1","volume":"94","author":"Ohga","year":"2003","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.ajpath.2024.07.020_bib47","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3390\/ijms20030459","article-title":"Obstructive sleep apnea and inflammation: proof of concept based on two illustrative cytokines","volume":"20","author":"Kheirandish-Gozal","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2024.07.020_bib48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11325-018-1678-7","article-title":"Non-alcoholic fatty liver disease is an independent risk factor for inflammation in obstructive sleep apnea syndrome in obese Asian Indians","volume":"23","author":"Bhatt","year":"2019","journal-title":"Sleep Breath"},{"key":"10.1016\/j.ajpath.2024.07.020_bib49","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/cbin.11592","article-title":"E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3\/caspase-1\/IL-1[beta]-mediated pyroptosis in endometriosis","volume":"45","author":"Hang","year":"2021","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.ajpath.2024.07.020_bib50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1053\/smrv.2002.0261","article-title":"Obstructive sleep apnoea syndrome--an oxidative stress disorder","volume":"7","author":"Lavie","year":"2003","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.ajpath.2024.07.020_bib51","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1164\/rccm.200504-560OC","article-title":"Oxidative stress and left ventricular function with chronic intermittent hypoxia in rats","volume":"172","author":"Chen","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2024.07.020_bib52","doi-asserted-by":"crossref","first-page":"G871","DOI":"10.1152\/ajpgi.00145.2007","article-title":"Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver","volume":"293","author":"Savransky","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.ajpath.2024.07.020_bib53","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1080\/17461391.2019.1571114","article-title":"Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): roles of oxidative stress and inflammation","volume":"19","author":"Farzanegi","year":"2019","journal-title":"Eur J Sport Sci"},{"key":"10.1016\/j.ajpath.2024.07.020_bib54","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1038\/s41467-022-31735-0","article-title":"TRIM24 is an insulin-responsive regulator of P-bodies","volume":"13","author":"Wei","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2024.07.020_bib55","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/TP.0000000000002480","article-title":"Nonalcoholic fatty liver disease: basic pathogenetic mechanisms in the progression from NAFLD to NASH","volume":"103","author":"Pierantonelli","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.ajpath.2024.07.020_bib56","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/j.ymthe.2022.02.021","article-title":"Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma","volume":"30","author":"Yang","year":"2022","journal-title":"Mol Ther"},{"key":"10.1016\/j.ajpath.2024.07.020_bib57","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.lfs.2018.10.053","article-title":"ApoA-1 accelerates regeneration of small-for-size fatty liver graft after transplantation","volume":"215","author":"Li","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.ajpath.2024.07.020_bib58","article-title":"Hepatic MDM2 causes metabolic associated fatty liver disease by blocking triglyceride-VLDL secretion via ApoB degradation","volume":"9","author":"Lin","year":"2022","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.ajpath.2024.07.020_bib59","article-title":"Orm2 deficiency aggravates high-fat diet-induced obesity through gut microbial dysbiosis and intestinal inflammation","volume":"68","author":"Li","year":"2024","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.ajpath.2024.07.020_bib60","doi-asserted-by":"crossref","first-page":"20533","DOI":"10.1002\/jcp.28653","article-title":"Role of acute-phase protein ORM in a mice model of ischemic stroke","volume":"234","author":"Wan","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2024.07.020_bib61","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41580-018-0010-5","article-title":"Born to run: control of transcription elongation by RNA polymerase II","volume":"19","author":"Chen","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2024.07.020_bib62","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1053\/jhep.2003.50273","article-title":"HNF4: a central regulator of hepatocyte differentiation and function","volume":"37","author":"Watt","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.07.020_bib63","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jcmgh.2021.06.007","article-title":"6-Gingerol ameliorates hepatic steatosis via HNF4[alpha]\/miR-467b-3p\/GPAT1 cascade","volume":"12","author":"Ahn","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2024.07.020_bib64","first-page":"152","article-title":"Effect of hypoxia on UDP-glucuronosyl transferase mRNA expression in human hepatocarcinoma functional liver celL4 cell line","volume":"71","author":"Kato","year":"2016","journal-title":"Pharmazie"},{"key":"10.1016\/j.ajpath.2024.07.020_bib65","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1038\/ncomms8466","article-title":"A metabolic stress-inducible miR-34a-HNF4[alpha] pathway regulates lipid and lipoprotein metabolism","volume":"6","author":"Xu","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2024.07.020_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/mtm.2014.39","article-title":"AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease","volume":"1","author":"Vil\u00e0","year":"2014","journal-title":"Mol Ther Methods Clin Dev"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024002967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024002967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T20:23:41Z","timestamp":1762028621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944024002967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":66,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0002944024002967"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.07.020","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRIM24 Up-Regulates ORM2 to Alleviate Abnormal Lipid Metabolism, Inflammation, and Oxidative Stress in Mice with Obstructive Sleep Apnea Syndrome and Metabolic Dysfunction\u2013Associated Steatotic Liver Disease","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}