{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:26:38Z","timestamp":1782743198331,"version":"3.54.5"},"reference-count":26,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100950"],"award-info":[{"award-number":["82100950"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["23ZR1452600"],"award-info":[{"award-number":["23ZR1452600"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ajpath.2024.08.008","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T16:57:51Z","timestamp":1725123471000},"page":"2341-2355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spatial Transcriptomics Reveals the Transcriptomic Signatures in a Mouse Model of Pediatric Metabolic Dysfunction\u2013Associated Steatohepatitis"],"prefix":"10.1016","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-3614","authenticated-orcid":false,"given":"Lu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Yang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Chang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Gao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2024.08.008_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.08.008_bib2","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.08.008_bib3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/cld.1027","article-title":"Epidemiology of pediatric nonalcoholic fatty liver disease","volume":"17","author":"Yu","year":"2021","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.ajpath.2024.08.008_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140908","article-title":"The prevalence of non-alcoholic fatty liver disease in children and adolescents: a systematic review and meta-analysis","volume":"10","author":"Anderson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2024.08.008_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41575-019-0169-z","article-title":"NAFLD in children: new genes, new diagnostic modalities and new drugs","volume":"16","author":"Nobili","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2024.08.008_bib6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/hep.20842","article-title":"Histopathology of pediatric nonalcoholic fatty liver disease","volume":"42","author":"Schwimmer","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.08.008_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119403","article-title":"A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): chronic intermittent hypoxia exacerbates Western diet-induced NASH","volume":"276","author":"Zhou","year":"2021","journal-title":"Life Sci"},{"key":"10.1016\/j.ajpath.2024.08.008_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158817","article-title":"An animal model for the juvenile non-alcoholic fatty liver disease and non-alcoholic steatohepatitis","volume":"11","author":"Marin","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2024.08.008_bib9","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2023-330577","article-title":"Spatial transcriptomics reveals a low extent of transcriptionally active hepatitis B virus integration in patients with HBsAg loss","author":"Yu","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2024.08.008_bib10","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1002\/hep4.2001","article-title":"Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis","volume":"6","author":"Chung","year":"2022","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.ajpath.2024.08.008_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg3750","article-title":"Comprehensive analysis of spatial architecture in primary liver cancer","volume":"7","author":"Wu","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.ajpath.2024.08.008_bib12","doi-asserted-by":"crossref","first-page":"E261","DOI":"10.1152\/ajpendo.00676.2007","article-title":"Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice","volume":"294","author":"Lee","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2024.08.008_bib13","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3390\/metabo13101043","article-title":"Lactobacillus johnsonii attenuates liver steatosis and bile acid dysregulation in parenteral nutrition-fed rats","volume":"13","author":"Xu","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.ajpath.2024.08.008_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/biom6010005","article-title":"Moderate (2%, v\/v) ethanol feeding alters hepatic wound healing after acute carbon tetrachloride exposure in mice","volume":"6","author":"Deshpande","year":"2016","journal-title":"Biomolecules"},{"key":"10.1016\/j.ajpath.2024.08.008_bib15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.ajpath.2024.08.008_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jhep.2016.05.005","article-title":"A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer","volume":"65","author":"Asgharpour","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2024.08.008_bib17","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000200","article-title":"Experimental models of fatty liver diseases: status and appraisal","volume":"7","author":"Wang","year":"2023","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.ajpath.2024.08.008_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/0023677215571192","article-title":"The carbon tetrachloride model in mice","volume":"49","author":"Scholten","year":"2015","journal-title":"Lab Anim"},{"key":"10.1016\/j.ajpath.2024.08.008_bib19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jhep.2018.03.011","article-title":"A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer","volume":"69","author":"Tsuchida","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2024.08.008_bib20","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/hep.26230","article-title":"Hedgehog pathway and pediatric nonalcoholic fatty liver disease","volume":"57","author":"Swiderska-Syn","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.08.008_bib21","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/MCG.0b013e31821377e4","article-title":"Hepatic lipid peroxidation and cytochrome P-450 2E1 in pediatric nonalcoholic fatty liver disease and its subtypes","volume":"45","author":"Bell","year":"2011","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.ajpath.2024.08.008_bib22","article-title":"Increased hepatic cytochrome P450 2E1 (CYP2E1) activity in children with biopsy-proven nonalcoholic steatohepatitis (NASH): 1125","volume":"56","author":"Bozic","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.08.008_bib23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jhep.2012.08.018","article-title":"CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease","volume":"58","author":"Leung","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2024.08.008_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232416063","article-title":"Amelioration of hepatic steatosis by the androgen receptor inhibitor EPI-001 in mice and human hepatic cells is associated with the inhibition of CYP2E1","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2024.08.008_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1293\/tox.26.175","article-title":"Thioacetamide-induced hepatocellular necrosis is attenuated in diet-induced obese mice","volume":"26","author":"Shirai","year":"2013","journal-title":"J Toxicol Pathol"},{"key":"10.1016\/j.ajpath.2024.08.008_bib26","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/hep4.1940","article-title":"Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease","volume":"6","author":"Yao","year":"2022","journal-title":"Hepatol Commun"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024003274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024003274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T01:04:56Z","timestamp":1764551096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944024003274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0002944024003274"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.08.008","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial Transcriptomics Reveals the Transcriptomic Signatures in a Mouse Model of Pediatric Metabolic Dysfunction\u2013Associated Steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}