{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:37:10Z","timestamp":1772120230628,"version":"3.50.1"},"reference-count":67,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005242","name":"Universite de Montreal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ajpath.2024.09.002","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T21:34:20Z","timestamp":1727300060000},"page":"2382-2397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endoplasmic Reticulum Stress Delays Choroid Development in the HCAR1 Knockout Mouse"],"prefix":"10.1016","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-3189","authenticated-orcid":false,"given":"Monir","family":"Modaresinejad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6022-6632","authenticated-orcid":false,"given":"Mohammad A.","family":"Mohammad Nezhady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3237-0420","authenticated-orcid":false,"given":"Tang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Bajon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houda","family":"Tahiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 C.","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-1102","authenticated-orcid":false,"given":"Pierre","family":"Lachapelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Chemtob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2024.09.002_bib1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.preteyeres.2009.12.002","article-title":"The multifunctional choroid","volume":"29","author":"Nickla","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajpath.2024.09.002_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgac166","article-title":"Vascular endothelial growth factor from retinal pigment epithelium is essential in choriocapillaris and axial length maintenance","volume":"1","author":"Zhang","year":"2022","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.ajpath.2024.09.002_bib3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/eye.2001.141","article-title":"The role of the retinal pigment epithelium: topographical variation and ageing changes","volume":"15","author":"Boulton","year":"2001","journal-title":"Eye"},{"key":"10.1016\/j.ajpath.2024.09.002_bib4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ajpath.2024.09.002_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/190724","article-title":"The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier\u2014implications for the pathogenesis of diabetic retinopathy","volume":"2010","author":"Sim\u00f3","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib6","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/eurheartj\/eht023","article-title":"The eye and the heart","volume":"34","author":"Flammer","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ajpath.2024.09.002_bib7","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708259","article-title":"Modulation of three key innate immune pathways for the most common retinal degenerative diseases","volume":"10","author":"Akhtar-Sch\u00e4fer","year":"2018","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.ajpath.2024.09.002_bib8","doi-asserted-by":"crossref","first-page":"8978","DOI":"10.1073\/pnas.0501971102","article-title":"Melanin photoprotection in the human retinal pigment epithelium and its correlation with light-induced cell apoptosis","volume":"102","author":"Seagle","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2024.09.002_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3390\/antiox9040347","article-title":"The relevance of oxidative stress in the pathogenesis and therapy of retinal dystrophies","volume":"9","author":"B Dom\u00e8nech","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.ajpath.2024.09.002_bib10","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2174\/156652410793937813","article-title":"The retinal pigment epithelium in health and disease","volume":"10","author":"Sparrrow J","year":"2010","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.ajpath.2024.09.002_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100969","article-title":"The retinal pigment epithelium: development, injury responses, and regenerative potential in mammalian and non-mammalian systems","volume":"85","author":"George","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajpath.2024.09.002_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1365-201X.1997.00030.x","article-title":"Glucose metabolism of the inner retina in pigs in darkness and light","volume":"160","author":"Wang","year":"1997","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.ajpath.2024.09.002_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.656000","article-title":"A metabolic landscape for maintaining retina integrity and function","volume":"14","author":"Viegas","year":"2021","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.ajpath.2024.09.002_bib14","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nm.1873","article-title":"The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis","volume":"14","author":"Sapieha","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2024.09.002_bib15","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/j.ajpath.2019.05.016","article-title":"M\u00fcller cell-localized G-protein-coupled receptor 81 (hydroxycarboxylic acid receptor 1) regulates inner retinal vasculature via norrin\/wnt pathways","volume":"189","author":"Madaan","year":"2019","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2010.02.012","article-title":"An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81","volume":"11","author":"Ahmed","year":"2010","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2024.09.002_bib17","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.bbrc.2008.10.088","article-title":"Role of GPR81 in lactate-mediated reduction of adipose lipolysis","volume":"377","author":"Cai","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2024.09.002_bib18","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1074\/jbc.M806409200","article-title":"Lactate inhibits lipolysis in fat cells through activation of an orphan g-protein-coupled receptor, GPR81","volume":"284","author":"Liu","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2024.09.002_bib19","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1053\/j.gastro.2014.03.014","article-title":"Lactate reduces liver and pancreatic injury in toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity","volume":"146","author":"Hoque","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2024.09.002_bib20","doi-asserted-by":"crossref","first-page":"60.e1","DOI":"10.1016\/j.ajog.2016.09.072","article-title":"Lactate produced during labor modulates uterine inflammation via GPR81 (HCA1)","volume":"216","author":"Madaan","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib21","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1177\/0271678X221077499","article-title":"Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult","volume":"42","author":"Chaudhari","year":"2022","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.ajpath.2024.09.002_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107451","article-title":"Lactate\/GPR81 signaling and proton motive force in cancer: role in angiogenesis, immune escape, nutrition, and Warburg phenomenon","volume":"206","author":"Brown","year":"2020","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.ajpath.2024.09.002_bib23","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.3390\/cells11203329","article-title":"Assessment of choroidal vasculature and innate immune cells in the eyes of albino and pigmented mice","volume":"11","author":"Zaitoun","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ajpath.2024.09.002_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108441","article-title":"Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion","volume":"204","author":"Miyagi","year":"2021","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2024.09.002_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ejphar.2005.01.015","article-title":"Inhibition of choroidal angiogenesis by calcium dobesilate in normal Wistar and diabetic GK rats","volume":"510","author":"Lameynardie","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib26","first-page":"2466","article-title":"Reattachment of retinas to cultured pigment epithelial monolayers from Xenopus laevis","volume":"35","author":"Defoe","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2024.09.002_bib27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.ajpath.2024.09.002_bib28","doi-asserted-by":"crossref","first-page":"981","DOI":"10.18632\/aging.100218","article-title":"CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits","volume":"2","author":"Picard","year":"2010","journal-title":"Aging"},{"key":"10.1016\/j.ajpath.2024.09.002_bib29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.18632\/aging.100563","article-title":"Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions","volume":"5","author":"Favret","year":"2013","journal-title":"Aging"},{"key":"10.1016\/j.ajpath.2024.09.002_bib30","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1167\/iovs.13-11896","article-title":"p75 Neurotrophin receptor participates in the choroidal antiangiogenic and apoptotic effects of t-lymphocyte\u2013derived microparticles","volume":"54","author":"Tahiri","year":"2013","journal-title":"Invest Opthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2024.09.002_bib31","doi-asserted-by":"crossref","first-page":"e488","DOI":"10.1038\/cddis.2013.12","article-title":"Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms","volume":"4","author":"Sahaboglu","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajpath.2024.09.002_bib32","doi-asserted-by":"crossref","first-page":"6238","DOI":"10.1167\/iovs.10-6742","article-title":"Choroidal involution is a key component of oxygen-induced retinopathy","volume":"52","author":"Shao","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2024.09.002_bib33","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.ajpath.2019.07.009","article-title":"The inability of the choroid to revascularize in oxygen-induced retinopathy results from increased p53\/miR-Let-7b activity","volume":"189","author":"Zhou","year":"2019","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib34","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1124\/jpet.112.192799","article-title":"3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes","volume":"341","author":"Liu","year":"2012","journal-title":"J Pharmacol Exp Therapeut"},{"key":"10.1016\/j.ajpath.2024.09.002_bib35","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1016\/j.ajpath.2016.08.004","article-title":"Choroidal involution is associated with a progressive degeneration of the outer retinal function in a model of retinopathy of prematurity: early role for IL-1[beta]","volume":"186","author":"Zhou","year":"2016","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49472-8","article-title":"Immunometabolic modulation of retinal inflammation by CD36 ligand","volume":"9","author":"Mellal","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2024.09.002_bib37","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1073\/pnas.1111561108","article-title":"Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin","volume":"109","author":"Liu","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2024.09.002_bib38","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","article-title":"On the dependency of cellular protein levels on mRNA abundance","volume":"165","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2024.09.002_bib39","first-page":"352","article-title":"Systems proteomics of liver mitochondria function","volume":"2016","author":"Williams","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2024.09.002_bib40","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1083\/jcb.201702058","article-title":"Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals","volume":"216","author":"Quir\u00f3s","year":"2017","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1117146","article-title":"Exogenous L-lactate administration in rat hippocampus increases expression of key regulators of mitochondrial biogenesis and antioxidant defense","volume":"16","author":"Akter","year":"2023","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.ajpath.2024.09.002_bib42","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1172\/JCI0216784","article-title":"Translational control in the endoplasmic reticulum stress response","volume":"110","author":"Ron","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2024.09.002_bib43","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.15252\/embr.201642195","article-title":"The integrated stress response","volume":"17","author":"Pakos-Zebrucka","year":"2016","journal-title":"EMBO Rep"},{"key":"10.1016\/j.ajpath.2024.09.002_bib44","doi-asserted-by":"crossref","first-page":"855","DOI":"10.15252\/msb.20156423","article-title":"Differential dynamics of the mammalian mRNA and protein expression response to misfolding stress","volume":"12","author":"Cheng","year":"2016","journal-title":"Mol Syst Biol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib45","doi-asserted-by":"crossref","first-page":"6708","DOI":"10.1016\/S0021-9258(17)39785-5","article-title":"The regulation of initiation of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2","volume":"259","author":"Matts","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2024.09.002_bib46","first-page":"1293","article-title":"Initiation factor protein modifications and inhibition of protein synthesis","volume":"7","author":"Duncan","year":"1987","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib47","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1046\/j.1432-1033.2002.02974.x","article-title":"Phosphorylation of initiation factor-2[alpha] is required for activation of internal translation initiation during cell differentiation","volume":"269","author":"Gerlitz","year":"2002","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.ajpath.2024.09.002_bib48","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/j.bbamcr.2013.05.002","article-title":"Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response","volume":"1833","author":"Chan","year":"2013","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.ajpath.2024.09.002_bib49","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/1566524016666160523143937","article-title":"The role of the PERK\/eIF2[alpha]\/ATF4\/CHOP signaling pathway in tumor progression during endoplasmic reticulum stress","volume":"16","author":"Rozpedek","year":"2016","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.ajpath.2024.09.002_bib50","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ccell.2017.12.003","article-title":"Oncogenic KRAS regulates amino acid homeostasis and asparagine biosynthesis via ATF4 and alters sensitivity to l-asparaginase","volume":"33","author":"Gwinn","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ajpath.2024.09.002_bib51","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05033","article-title":"The small molecule ISRIB reverses the effects of eIF2[alpha] phosphorylation on translation and stress granule assembly","volume":"4","author":"Sidrauski","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.ajpath.2024.09.002_bib52","doi-asserted-by":"crossref","first-page":"e1672","DOI":"10.1038\/cddis.2015.49","article-title":"Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity","volume":"6","author":"Halliday","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajpath.2024.09.002_bib53","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/eye.2016.216","article-title":"Structural and molecular changes in the aging choroid: implications for age-related macular degeneration","volume":"31","author":"Chirco","year":"2017","journal-title":"Eye"},{"key":"10.1016\/j.ajpath.2024.09.002_bib54","article-title":"Choroidal changes in diabetic patients with different stages of diabetic retinopathy","volume":"12","author":"Hamadneh","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.ajpath.2024.09.002_bib55","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0002-9440(10)65138-3","article-title":"Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris","volume":"155","author":"Blaauwgeers","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib56","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1167\/iovs.05-1229","article-title":"VEGF expression and receptor activation in the choroid during development and in the adult","volume":"47","author":"Saint-Geniez","year":"2006","journal-title":"Invest Opthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2024.09.002_bib57","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1146\/annurev-vision-100419-115156","article-title":"Retina metabolism and metabolism in the pigmented epithelium: a busy intersection","volume":"7","author":"Hurley","year":"2021","journal-title":"Annu Rev Vis Sci"},{"key":"10.1016\/j.ajpath.2024.09.002_bib58","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.3390\/cells10071640","article-title":"Participation of L-lactate and its receptor hcar1\/gpr81 in neurovisual development","volume":"10","author":"Laroche","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ajpath.2024.09.002_bib59","doi-asserted-by":"crossref","first-page":"C1502","DOI":"10.1152\/ajpcell.00346.2023","article-title":"Versatile lactate signaling via HCAR1: a multifaceted GPCR involved in many biological processes","volume":"325","author":"Mohammad Nezhady","year":"2023","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib60","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.2353\/ajpath.2010.100526","article-title":"Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy","volume":"177","author":"Stahl","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib61","doi-asserted-by":"crossref","first-page":"16349","DOI":"10.1074\/jbc.274.23.16349","article-title":"Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner","volume":"274","author":"Fujio","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2024.09.002_bib62","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.bbrc.2011.06.078","article-title":"Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin","volume":"410","author":"Tian","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2024.09.002_bib63","doi-asserted-by":"crossref","first-page":"R611","DOI":"10.1016\/j.cub.2022.04.083","article-title":"Ribosome biogenesis and the cellular energy economy","volume":"32","author":"Shore","year":"2022","journal-title":"Curr Biol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib64","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1215\/S1152851705000232","article-title":"The role of pericytes in blood-vessel formation and maintenance","volume":"7","author":"Bergers","year":"2005","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042488","article-title":"Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation","volume":"7","author":"Edqvist","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2024.09.002_bib66","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1161\/ATVBAHA.119.313179","article-title":"SCF (stem cell factor) and cKIT modulate pathological ocular neovascularization","volume":"39","author":"Kim","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2024.09.002_bib67","article-title":"KIT ligand protects against both light-induced and genetic photoreceptor degeneration","volume":"9","author":"Li","year":"2020","journal-title":"Elife"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024003547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024003547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T11:54:11Z","timestamp":1732276451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944024003547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":67,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0002944024003547"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.09.002","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.01.12.575419","asserted-by":"object"}]},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endoplasmic Reticulum Stress Delays Choroid Development in the HCAR1 Knockout Mouse","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}