{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:09:46Z","timestamp":1778638186789,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination of Higher Education Personnel Improvement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2016\/19103-2"],"award-info":[{"award-number":["2016\/19103-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2022\/10740-0"],"award-info":[{"award-number":["2022\/10740-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/09624-9"],"award-info":[{"award-number":["2023\/09624-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ajpath.2024.09.009","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T01:40:04Z","timestamp":1730252404000},"page":"321-333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sphingosine Kinase 2 Controls the Aggressive Phenotype of Oral Squamous Cell Carcinoma by Regulating miR-205 and miR-296 through p53"],"prefix":"10.1016","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-035X","authenticated-orcid":false,"given":"Tha\u00eds Mor\u00e9","family":"Milan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-2746","authenticated-orcid":false,"given":"Lucas Oliveira","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-4754","authenticated-orcid":false,"given":"Andr\u00e9ia Machado","family":"Leopoldino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2024.09.009_bib1","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/S0140-6736(21)01550-6","article-title":"Head and neck cancer","volume":"398","author":"Mody","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2024.09.009_bib2","first-page":"1","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.ajpath.2024.09.009_bib3","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.3390\/cancers13215515","article-title":"New scenarios in pharmacological treatments of head and neck squamous cell carcinomas","volume":"13","author":"Porcheri","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ajpath.2024.09.009_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2021.685236","article-title":"Oral cancer stem cells: therapeutic implications and challenges","volume":"2","author":"Shahoumi","year":"2021","journal-title":"Front Oral Health"},{"key":"10.1016\/j.ajpath.2024.09.009_bib5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-023-01347-1","article-title":"Targeting p53 pathways: mechanisms, structures, and advances in therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.ajpath.2024.09.009_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41392-022-01297-0","article-title":"Targeted therapy for head and neck cancer: signaling pathways and clinical studies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ajpath.2024.09.009_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/CBM-203100","article-title":"Profile of sphingolipid-related genes and its association with prognosis highlights sphingolipid metabolism in oral cancer","volume":"32","author":"da Silva","year":"2021","journal-title":"Cancer Biomark"},{"key":"10.1016\/j.ajpath.2024.09.009_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbalip.2021.159057","article-title":"Sphingolipids signature in plasma and tissue as diagnostic and prognostic tools in oral squamous cell carcinoma, Biochimica Et Biophysica Acta","volume":"1867","author":"Faedo","year":"2022","journal-title":"Mol Cell Biol Lipids"},{"key":"10.1016\/j.ajpath.2024.09.009_bib9","doi-asserted-by":"crossref","first-page":"645","DOI":"10.21037\/atm-20-6742","article-title":"Inhibition of sphingosine kinase 2 down-regulates ERK\/c-Myc pathway and reduces cell proliferation in human epithelial ovarian cancer","volume":"9","author":"Dai","year":"2021","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.ajpath.2024.09.009_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.598218","article-title":"SphK2\/S1P promotes metastasis of triple-negative breast cancer through the PAK1\/LIMK1\/cofilin1 signaling pathway","volume":"8","author":"Shi","year":"2021","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.ajpath.2024.09.009_bib11","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1038\/s41388-020-1352-y","article-title":"SphK2 confers 5-fluorouracil resistance to colorectal cancer via upregulating H3K56ac-mediated DPD expression","volume":"39","author":"Zhang","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2024.09.009_bib12","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1158\/0008-5472.CAN-22-1638","article-title":"Sphingosine kinase 2 in stromal fibroblasts creates a hospitable tumor microenvironment in breast cancer","volume":"83","author":"Weigel","year":"2023","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2024.09.009_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119616","article-title":"Accumulation of sphingosine kinase 2 protein induces malignant transformation in oral keratinocytes associated with stemness, autophagy, senescence, and proliferation","volume":"1871","author":"Fugio","year":"2024","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.ajpath.2024.09.009_bib14","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2024.09.009_bib15","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/hed.26533","article-title":"microRNAs deregulation in head and neck squamous cell carcinoma","volume":"43","author":"Carron","year":"2021","journal-title":"Head Neck"},{"key":"10.1016\/j.ajpath.2024.09.009_bib16","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/s41587-023-01951-0","article-title":"Detection of transcriptome-wide microRNA-target interactions in single cells with agoTRIBE","volume":"42","author":"Sekar","year":"2024","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ajpath.2024.09.009_bib17","doi-asserted-by":"crossref","first-page":"14783","DOI":"10.1002\/jcp.28277","article-title":"The crucial role of ZEB2: from development to epithelial-to-mesenchymal transition and cancer complexity","volume":"234","author":"Fardi","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2024.09.009_bib18","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.3390\/cells11193131","article-title":"STAT3 and its targeting inhibitors in oral squamous cell carcinoma","volume":"11","author":"Jiang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ajpath.2024.09.009_bib19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3892\/ijo.2022.5395","article-title":"Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (review)","volume":"61","author":"Ma","year":"2022","journal-title":"Int J Oncol"},{"key":"10.1016\/j.ajpath.2024.09.009_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010503","article-title":"Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice","volume":"5","author":"Castilho","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2024.09.009_bib21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/ijc.2910610117","article-title":"Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies","volume":"61","author":"Cardinali","year":"1995","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2024.09.009_bib22","doi-asserted-by":"crossref","DOI":"10.3791\/52727","article-title":"Utilization of the soft agar colony formation assay to identify inhibitors of tumorigenicity in breast cancer cells","author":"Horibata","year":"2015","journal-title":"J Vis Exp"},{"key":"10.1016\/j.ajpath.2024.09.009_bib23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajpath.2024.09.009_bib24","first-page":"229","article-title":"Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas","volume":"95","author":"Anneroth","year":"1987","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.ajpath.2024.09.009_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.104799","article-title":"Staging and grading of oral squamous cell carcinoma: an update","volume":"107","author":"Almangush","year":"2020","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ajpath.2024.09.009_bib47","doi-asserted-by":"crossref","first-page":"119","DOI":"10.21037\/acs.2017.03.14","article-title":"8th edition of AJCC\/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice","volume":"6","author":"Rice","year":"2017","journal-title":"Ann Cardiothorac Surg"},{"key":"10.1016\/j.ajpath.2024.09.009_bib26","doi-asserted-by":"crossref","first-page":"577","DOI":"10.7314\/APJCP.2014.15.2.577","article-title":"Insights into the diverse roles of miR-205 in human cancers","volume":"15","author":"Orang","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.ajpath.2024.09.009_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12929-019-0511-3","article-title":"Low let-7d and high miR-205 expression levels positively influence HNSCC patient outcome","volume":"26","author":"Kolenda","year":"2019","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.ajpath.2024.09.009_bib28","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.prp.2018.09.026","article-title":"The promising role of miR-296 in human cancer","volume":"214","author":"Zhu","year":"2018","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.ajpath.2024.09.009_bib29","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1016\/j.molcel.2022.09.002","article-title":"Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB","volume":"82","author":"Jouravleva","year":"2022","journal-title":"Mol Cell"},{"key":"10.1016\/j.ajpath.2024.09.009_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.ajpath.2024.09.009_bib31","doi-asserted-by":"crossref","first-page":"8127","DOI":"10.3390\/molecules27238127","article-title":"Mebendazole impedes the proliferation and migration of pancreatic cancer cells through SK1 inhibition dependent pathway","volume":"27","author":"Limbu","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ajpath.2024.09.009_bib32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1124\/jpet.109.163444","article-title":"Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2","volume":"333","author":"French","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ajpath.2024.09.009_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.707424","article-title":"HOTTIP-miR-205-ZEB2 axis confers cisplatin resistance to ovarian cancer cells","volume":"9","author":"Dong","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.ajpath.2024.09.009_bib34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-94-007-4572-8_15","article-title":"PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA","volume":"62","author":"Dieckman","year":"2012","journal-title":"Subcell Biochem"},{"key":"10.1016\/j.ajpath.2024.09.009_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6683391","article-title":"MMP-9 knockdown inhibits oral squamous cell carcinoma lymph node metastasis in the nude mouse tongue-xenografted model through the RhoC\/Src pathway","volume":"2021","author":"Yin","year":"2021","journal-title":"Anal Cell Pathol"},{"key":"10.1016\/j.ajpath.2024.09.009_bib36","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1158\/1538-7445.AM2023-428","article-title":"Abstract 428: the role of sphingosine kinase 2 in overcoming EGFR-tyrosine kinase inhibitor resistance, EMT and NSCLC tumor progression","volume":"83","author":"Nasifuzzaman","year":"2023","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2024.09.009_bib37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12672-021-00430-9","article-title":"Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer","volume":"12","author":"Xu","year":"2021","journal-title":"Discov Oncol"},{"key":"10.1016\/j.ajpath.2024.09.009_bib38","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41419-019-1671-5","article-title":"Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2\/AKT\/[beta]-catenin pathway in glioma","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajpath.2024.09.009_bib39","first-page":"397","article-title":"miR-137 is a diagnostic tumor-suppressive miRNA that targets SPHK2 to promote M1-type tumor-associated macrophage polarization","volume":"26","author":"Liu","year":"2023","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.ajpath.2024.09.009_bib40","article-title":"Ubiquitination destabilizes protein sphingosine kinase 2 to regulate glioma malignancy","volume":"15","author":"Wang","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.ajpath.2024.09.009_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/cells11101631","article-title":"The complex interaction between P53 and miRNAs joins new awareness in physiological stress responses","volume":"11","author":"Capaccia","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ajpath.2024.09.009_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105179","article-title":"The P53\/microRNA network: a potential tumor suppressor with a role in anticancer therapy","volume":"160","author":"Sargolzaei","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.ajpath.2024.09.009_bib43","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3390\/cancers14010238","article-title":"The functional role of extracellular matrix proteins in cancer","volume":"14","author":"Popova","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.ajpath.2024.09.009_bib44","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1097\/SLA.0b013e3181dd4ea9","article-title":"The prognostic and chemotherapeutic value of miR-296 in esophageal squamous cell carcinoma","volume":"251","author":"Hong","year":"2010","journal-title":"Ann Surg"},{"key":"10.1016\/j.ajpath.2024.09.009_bib45","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/onc.2012.637","article-title":"MicroRNA-296-5p increases proliferation in gastric cancer through repression of caudal-related homeobox 1","volume":"33","author":"Li","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2024.09.009_bib46","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1159\/000368792","article-title":"miRNA-205 is a candidate tumor suppressor that targets ZEB2 in renal cell carcinoma","volume":"37","author":"Chen","year":"2014","journal-title":"Oncol Res Treat"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294402400395X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294402400395X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:20:28Z","timestamp":1778635228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000294402400395X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S000294402400395X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.09.009","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sphingosine Kinase 2 Controls the Aggressive Phenotype of Oral Squamous Cell Carcinoma by Regulating miR-205 and miR-296 through p53","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}