{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:41:23Z","timestamp":1780393283694,"version":"3.54.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100021806","name":"Hsinchu Science Park","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["VTA113-A-4-2"],"award-info":[{"award-number":["VTA113-A-4-2"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113EA-005"],"award-info":[{"award-number":["V113EA-005"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113D701-001-MY2-1"],"award-info":[{"award-number":["V113D701-001-MY2-1"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113EA-019"],"award-info":[{"award-number":["V113EA-019"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113C-024"],"award-info":[{"award-number":["V113C-024"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 111-2314-B-001-009"],"award-info":[{"award-number":["MOST 111-2314-B-001-009"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-A049-043-MY3"],"award-info":[{"award-number":["NSTC 112-2314-B-A049-043-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2314-B-001-009"],"award-info":[{"award-number":["111-2314-B-001-009"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ajpath.2024.10.006","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T05:22:02Z","timestamp":1730092922000},"page":"188-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Peroxisome Proliferator-Activated Receptor \u03b1\/\u03b3 and Cannabinoid Receptor 2 Agonist Attenuated Nonalcoholic Steatohepatitis Exosome-Related Abnormalities in Mice"],"prefix":"10.1016","volume":"195","author":[{"given":"Chia-Chang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hsiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Yun","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Cheng","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Wen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Wei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-0397","authenticated-orcid":false,"given":"Ying-Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Chieh","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chih","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2024.10.006_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1053\/j.gastro.2015.05.044","article-title":"Association of adipose tissue inflammation with histologic severity of nonalcoholic fatty liver disease","volume":"149","author":"Plessis","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2024.10.006_bib2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jcmgh.2015.01.001","article-title":"Hepatic injury in nonalcoholic steatohepatitis contributes to altered intestinal permeability","volume":"1","author":"Luther","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.47162\/RJME.62.2.17","article-title":"Systemic and adipose tissue inflammation in NASH: correlations with histopathological aspects","volume":"62","author":"Micu","year":"2021","journal-title":"Rom J Morphol Embryol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib4","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S2468-1253(20)30216-8","article-title":"Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial","volume":"5","author":"Kessoku","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1440-1746.2011.06939.x","article-title":"Peroxisome proliferator-activated receptor-[alpha] agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis","volume":"27","author":"Larter","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib6","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1111\/liv.15005","article-title":"PPAR-gamma-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH","volume":"41","author":"Gastaldelli","year":"2021","journal-title":"Liver Int"},{"key":"10.1016\/j.ajpath.2024.10.006_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2022.111839","article-title":"Peroxisome proliferator-activated receptors-alpha and gamma synergism modulate the gut-adipose tissue axis and mitigate obesity","volume":"562","author":"Miranda","year":"2023","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib8","doi-asserted-by":"crossref","first-page":"16638","DOI":"10.1074\/jbc.275.22.16638","article-title":"Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity","volume":"275","author":"Guerre-Millo","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2024.10.006_bib9","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1073\/pnas.0306743102","article-title":"Deletion of PPAR[gamma] in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance","volume":"102","author":"Jones","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2024.10.006_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.plefa.2005.04.008","article-title":"The effect of PPARgamma ligands on the adipose tissue in insulin resistance","volume":"73","author":"Hammarstedt","year":"2005","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.ajpath.2024.10.006_bib11","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1210\/jc.2015-4381","article-title":"Cannabinoid receptor 2 as antiobesity target: inflammation, fat storage, and browning modulation","volume":"101","author":"Rossi","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2024.10.006_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140592","article-title":"Anti-obesity effect of the CB2 receptor agonist JWH-015 in diet-induced obese mice","volume":"10","author":"Verty","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2024.10.006_bib13","doi-asserted-by":"crossref","first-page":"32869","DOI":"10.1074\/jbc.M110.135509","article-title":"Adipose tissue-specific inhibition of hypoxia-inducible factor 1[alpha] induces obesity and glucose intolerance by impeding energy expenditure in mice","volume":"285","author":"Zhang","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2024.10.006_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.molimm.2016.03.008","article-title":"STEAP4 and HIF-1[alpha] gene expressions in visceral and subcutaneous adipose tissue of the morbidly obese patients","volume":"73","author":"Ozmen","year":"2016","journal-title":"Mol Immunol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib15","doi-asserted-by":"crossref","first-page":"E1118","DOI":"10.1152\/ajpendo.00435.2007","article-title":"Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob\/ob and dietary obese mice","volume":"293","author":"Ye","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2024.10.006_bib16","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2014.05.012","article-title":"Increased adipocyte O2 consumption triggers HIF-1alpha, causing inflammation and insulin resistance in obesity","volume":"157","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2024.10.006_bib17","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1128\/MCB.00192-09","article-title":"Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue","volume":"29","author":"Halberg","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1534-5807(02)00131-4","article-title":"Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1\/Stra13: a mechanism for regulation of adipogenesis by hypoxia","volume":"2","author":"Yun","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.ajpath.2024.10.006_bib19","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.4049\/jimmunol.166.12.7543","article-title":"Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor [alpha] expression during hypoxia","volume":"166","author":"Narravula","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib20","first-page":"1307","article-title":"Effect of pioglitazone on expression of hypoxia-inducible factor 1[alpha] and vascular endothelial growth factor in ischemic hindlimb of diabetic rats","volume":"18","author":"Zhang","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.ajpath.2024.10.006_bib21","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/tox.23369","article-title":"Fenofibrate inhibits hypoxia-inducible factor-1 alpha and carbonic anhydrase expression through activation of AMP-activated protein kinase\/HO-1\/Sirt1 pathway in glioblastoma cells","volume":"36","author":"Lin","year":"2021","journal-title":"Environ Toxicol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib22","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/j.euroneuro.2016.10.003","article-title":"CB2 cannabinoid receptors modulate HIF-1alpha and TIM-3 expression in a hypoxia-ischemia mouse model","volume":"26","author":"Kossatz","year":"2016","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib23","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/s41401-022-01037-8","article-title":"CB2R agonist GW405833 alleviates acute liver failure in mice via inhibiting HIF-1[alpha]-mediated reprogramming of glycometabolism and macrophage proliferation","volume":"44","author":"Cai","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.ajpath.2024.10.006_bib24","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2337\/db08-1098","article-title":"Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response","volume":"58","author":"Pasarica","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.ajpath.2024.10.006_bib25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/CIRCULATIONAHA.110.970145","article-title":"Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity","volume":"123","author":"Gealekman","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ajpath.2024.10.006_bib26","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1111\/bph.12608","article-title":"The dual PPAR[alpha]\/[gamma] agonist aleglitazar increases the number and function of endothelial progenitor cells: implications for vascular function and atherogenesis","volume":"171","author":"Werner","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2045259","article-title":"PPAR[alpha] targeting GDF11 inhibits vascular endothelial cell senescence in an atherosclerosis model","volume":"2021","author":"Dou","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ajpath.2024.10.006_bib28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1515\/nipt-2023-0016","article-title":"Activation of CB2R by synthetic CB2R agonist, PM289, improves brain endothelial barrier properties, decreases inflammatory response and enhances endothelial repair","volume":"2","author":"Bullock","year":"2023","journal-title":"NeuroImmune Pharm Ther"},{"key":"10.1016\/j.ajpath.2024.10.006_bib29","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1038\/oby.2011.251","article-title":"Intestinal permeability is associated with visceral adiposity in healthy women","volume":"19","author":"Gummesson","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.ajpath.2024.10.006_bib30","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1096\/fj.13-234203","article-title":"Visceral adipose tissue and leptin increase colonic epithelial tight junction permeability via a RhoA-ROCK-dependent pathway","volume":"28","author":"Le Drean","year":"2014","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2024.10.006_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92966-7","article-title":"Fenofibrate promotes PPAR[alpha]-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus","volume":"11","author":"Crakes","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2024.10.006_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.toxlet.2022.12.015","article-title":"PPAR[gamma] activation inhibits endocytosis of claudin-4 and protects against deoxynivalenol-induced intestinal barrier dysfunction in IPEC-J2 cells and weaned piglets","volume":"375","author":"Li","year":"2023","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.ajpath.2024.10.006_bib33","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.jhep.2014.05.049","article-title":"Long-term cannabinoid type 2 receptor agonist therapy decreases bacterial translocation in rats with cirrhosis and ascites","volume":"61","author":"Yang","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib34","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.ajpath.2010.11.052","article-title":"beta-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARgamma pathway","volume":"178","author":"Allisson","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib35","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/bph.12907","article-title":"Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent","volume":"172","author":"Borrelli","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1162992","article-title":"Adipose tissue-derived exosomes contribute to obesity-associated liver diseases in long-term high-fat diet-fed mice, but not in short-term","volume":"10","author":"Son","year":"2023","journal-title":"Front Nutr"},{"key":"10.1016\/j.ajpath.2024.10.006_bib37","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.2337\/db09-0216","article-title":"Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance","volume":"58","author":"Deng","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.ajpath.2024.10.006_bib38","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1021\/acsnano.0c01860","article-title":"Visceral adipose tissue derived exosomes exacerbate colitis severity via pro-inflammatory MiRNAs in high fat diet fed mice","volume":"14","author":"Wei","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.ajpath.2024.10.006_bib39","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/oby.20679","article-title":"Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages","volume":"22","author":"Kranendonk","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.ajpath.2024.10.006_bib40","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.cell.2018.09.005","article-title":"An endothelial-to-adipocyte extracellular vesicle axis governed by metabolic state","volume":"175","author":"Crewe","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2024.10.006_bib41","doi-asserted-by":"crossref","DOI":"10.1155\/2007\/52546","article-title":"Stimulatory effects of peroxisome proliferator-activated receptor-gamma on fcgamma receptor-mediated phagocytosis by alveolar macrophages","volume":"2007","author":"Aronoff","year":"2007","journal-title":"PPAR Res"},{"key":"10.1016\/j.ajpath.2024.10.006_bib42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1172\/JCI88883","article-title":"The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis","volume":"127","author":"Crewe","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2024.10.006_bib43","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.10.006_bib44","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jnutbio.2007.02.010","article-title":"Loss of PPAR[gamma] in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue","volume":"19","author":"Guri","year":"2008","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.ajpath.2024.10.006_bib45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1742-2094-2-29","article-title":"Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation","volume":"2","author":"Ehrhart","year":"2005","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.ajpath.2024.10.006_bib46","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41598-017-00342-1","article-title":"Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor","volume":"7","author":"Guida","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2024.10.006_bib47","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbi.2015.06.002","article-title":"Endocannabinoids drive the acquisition of an alternative phenotype in microglia","volume":"49","author":"Mecha","year":"2015","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.ajpath.2024.10.006_bib48","doi-asserted-by":"crossref","first-page":"35161","DOI":"10.1074\/jbc.M112.367367","article-title":"Activation of peroxisome proliferator-activated receptor [alpha] (PPAR[alpha]) suppresses hypoxia-inducible factor-1[alpha] (HIF-1[alpha]) signaling in cancer cells","volume":"287","author":"Zhou","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2024.10.006_bib49","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/hep.30215","article-title":"Macrophage-specific hypoxia-inducible factor-1alpha contributes to impaired autophagic flux in nonalcoholic steatohepatitis","volume":"69","author":"Wang","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2024.10.006_bib50","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1002\/j.2040-4603.2023.tb00254.x","article-title":"Extracellular matrix (ECM) and fibrosis in adipose tissue: overview and perspectives","volume":"13","author":"Sun","year":"2023","journal-title":"Compr Physiol"},{"key":"10.1016\/j.ajpath.2024.10.006_bib51","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.trsl.2021.01.006","article-title":"Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities","volume":"239","author":"Camino","year":"2021","journal-title":"Transl Res"},{"key":"10.1016\/j.ajpath.2024.10.006_bib52","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1007\/s00125-012-2658-2","article-title":"Effect of rosiglitazone on capillary density and angiogenesis in adipose tissue of normoglycaemic humans in a randomised controlled trial","volume":"55","author":"Gealekman","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.ajpath.2024.10.006_bib53","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1096\/fj.12-221812","article-title":"Vascular endothelial growth factor is important for brown adipose tissue development and maintenance","volume":"27","author":"Bagchi","year":"2013","journal-title":"FASEB J"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024003985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024003985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:14:16Z","timestamp":1777392856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944024003985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0002944024003985"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.10.006","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peroxisome Proliferator-Activated Receptor \u03b1\/\u03b3 and Cannabinoid Receptor 2 Agonist Attenuated Nonalcoholic Steatohepatitis Exosome-Related Abnormalities in Mice","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}