{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:11:24Z","timestamp":1781842284386,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR205968"],"award-info":[{"award-number":["NIHR205968"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014461","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014461","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/P028608\/1"],"award-info":[{"award-number":["EP\/P028608\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ajpath.2024.10.023","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T16:10:11Z","timestamp":1735229411000},"page":"663-670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Computational Pathology Detection of Hypoxia-Induced Morphologic Changes in Breast Cancer"],"prefix":"10.1016","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-3676","authenticated-orcid":false,"given":"Petru","family":"Manescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Geradts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delmiro","family":"Fernandez-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2024.10.023_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41389-017-0011-9","article-title":"The hypoxic tumour microenvironment","volume":"7","author":"Petrova","year":"2018","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ajpath.2024.10.023_bib2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/s41416-021-01630-4","article-title":"Breast cancer hypoxia in relation to prognosis and benefit from radiotherapy after breast-conserving surgery in a large, randomised trial with long-term follow-up","volume":"126","author":"Tutzauer","year":"2022","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2024.10.023_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12038-019-9977-0","article-title":"Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer","volume":"45","author":"Pant","year":"2020","journal-title":"J Biosci"},{"key":"10.1016\/j.ajpath.2024.10.023_bib4","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41588-018-0318-2","article-title":"Molecular landmarks of tumor hypoxia across cancer types","volume":"51","author":"Bhandari","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2024.10.023_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10555-007-9055-1","article-title":"Hypoxia in cancer: significance and impact on clinical outcome","volume":"26","author":"Vaupel","year":"2007","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.ajpath.2024.10.023_bib6","first-page":"1222","article-title":"Integration of immune and hypoxia gene signatures improves the prediction of radiosensitivity in breast cancer","volume":"12","author":"Yan","year":"2022","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.ajpath.2024.10.023_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"10.1016\/j.ajpath.2024.10.023_bib8","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.3892\/ol.2020.11733","article-title":"Development and validation of a hypoxia-related prognostic signature for breast cancer","volume":"20","author":"Wang","year":"2020","journal-title":"Oncol Lett"},{"key":"10.1016\/j.ajpath.2024.10.023_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41523-023-00518-1","article-title":"Biological insights and novel biomarker discovery through deep learning approaches in breast cancer histopathology","volume":"9","author":"Mandair","year":"2023","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.ajpath.2024.10.023_bib10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s42256-021-00303-4","article-title":"Morphological and molecular breast cancer profiling through explainable machine learning","volume":"3","author":"Binder","year":"2021","journal-title":"Nat Mach Intell"},{"key":"10.1016\/j.ajpath.2024.10.023_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature11412","article-title":"Comprehensive molecular portraits of human breast tumours","volume":"490","author":"Koboldt","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2024.10.023_bib12","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/sj.bjc.6605450","article-title":"Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene","volume":"102","author":"Buffa","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2024.10.023_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","article-title":"Threshold selection method from gray-level histograms","volume":"9","author":"Otsu","year":"1979","journal-title":"IEEE Trans Syst Man Cybern"},{"key":"10.1016\/j.ajpath.2024.10.023_bib14","series-title":"3rd International Conference on Learning Representations ICLR 2015\u2014Conf. Track Proc","first-page":"1","article-title":"Very deep convolutional networks for large-scale image recognition","author":"Simonyan","year":"2015"},{"key":"10.1016\/j.ajpath.2024.10.023_bib15","series-title":"2009 IEEE Conference on Computer Vision and Pattern Recognition (CVPR)","first-page":"248","article-title":"ImageNet: a large-scale hierarchical image database","author":"Deng","year":"2010"},{"key":"10.1016\/j.ajpath.2024.10.023_bib16","first-page":"3376","article-title":"Attention-based deep multiple instance learning","volume":"Vol. 5","author":"Ilse","year":"2018"},{"key":"10.1016\/j.ajpath.2024.10.023_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7717\/peerj-cs.536","article-title":"Gray level co-occurrence matrix (GLCM) texture based crop classification using low altitude remote sensing platforms","volume":"7","author":"Iqbal","year":"2021","journal-title":"PeerJ Comput Sci"},{"key":"10.1016\/j.ajpath.2024.10.023_bib18","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1109\/TMI.2021.3085712","article-title":"MoNuSAC2020: a multi-organ nuclei segmentation and classification challenge","volume":"40","author":"Verma","year":"2021","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.ajpath.2024.10.023_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-022-01645-2","article-title":"The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies","volume":"21","author":"Bai","year":"2022","journal-title":"Mol Cancer"},{"key":"10.1016\/j.ajpath.2024.10.023_bib20","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1172\/JCI84427","article-title":"The impact of hypoxia on tumor-associated macrophages","volume":"126","author":"Henze","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2024.10.023_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101460","article-title":"Integrative analysis of hypoxia-associated signature in pan-cancer","volume":"23","author":"Zhang","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.ajpath.2024.10.023_bib22","first-page":"1","article-title":"Construction of a hypoxia-derived gene model to predict the prognosis and therapeutic response of head and neck squamous cell carcinoma","volume":"12","author":"Wang","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2024.10.023_bib23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s42255-019-0045-8","article-title":"Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy","volume":"1","author":"Ye","year":"2019","journal-title":"Nat Metab"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024004693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024004693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:31:17Z","timestamp":1750811477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944024004693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0002944024004693"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.10.023","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational Pathology Detection of Hypoxia-Induced Morphologic Changes in Breast Cancer","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}