{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:30:58Z","timestamp":1793496658260,"version":"4.5.0"},"reference-count":118,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer&apos;s Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020360","name":"Infectious Diseases Society of America Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG061288"],"award-info":[{"award-number":["R01AG061288"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG089756"],"award-info":[{"award-number":["R01AG089756"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG085559"],"award-info":[{"award-number":["R21AG085559"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1NS122060"],"award-info":[{"award-number":["RF1NS122060"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56AG082361"],"award-info":[{"award-number":["R56AG082361"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1NS135617"],"award-info":[{"award-number":["RF1NS135617"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R61NS137365"],"award-info":[{"award-number":["R61NS137365"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS110687"],"award-info":[{"award-number":["R01NS110687"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG089640"],"award-info":[{"award-number":["R01AG089640"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ajpath.2024.11.006","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T18:57:00Z","timestamp":1734634620000},"page":"2118-2130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetically Engineered Mouse Models for Alzheimer Disease and Frontotemporal Dementia"],"prefix":"10.1016","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-9321","authenticated-orcid":false,"given":"Yuanpu","family":"Chiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangzhou","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-5570","authenticated-orcid":false,"given":"Zhen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2024.11.006_bib1","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/S0140-6736(05)67889-0","article-title":"Global prevalence of dementia: a Delphi consensus study","volume":"366","author":"Ferri","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2024.11.006_bib2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.ajpath.2024.11.006_bib4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/jnnp.66.2.137","article-title":"The cholinergic hypothesis of Alzheimer's disease: a review of progress","volume":"66","author":"Francis","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.ajpath.2024.11.006_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108352","article-title":"Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease","volume":"190","author":"Marucci","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ajpath.2024.11.006_bib6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.ajpath.2024.11.006_bib7","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ajpath.2024.11.006_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.00050.2017","article-title":"Blood-brain barrier: from physiology to disease and back","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ajpath.2024.11.006_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002270","article-title":"APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: a genetic screening study of familial and sporadic cases","volume":"14","author":"Lanoiselee","year":"2017","journal-title":"PLoS Med"},{"key":"10.1016\/j.ajpath.2024.11.006_bib10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrn2620","article-title":"Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy","volume":"10","author":"Bu","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-[beta] and Tau: the trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3233\/JAD-191227","article-title":"The amyloid, Tau, and neurodegeneration (A\/T\/N) classification applied to a clinical research cohort with long-term follow-up","volume":"74","author":"Grontvedt","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.ajpath.2024.11.006_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1192\/bjp.bp.115.167569","article-title":"Alzheimer's disease: the amyloid hypothesis on trial","volume":"208","author":"Harrison","year":"2016","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.ajpath.2024.11.006_bib14","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2024.11.006_bib15","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer's disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2024.11.006_bib16","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41467-024-44781-7","article-title":"Human whole-exome genotype data for Alzheimer's disease","volume":"15","author":"Leung","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2024.11.006_bib17","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/s41380-018-0112-7","article-title":"Whole exome sequencing study identifies novel rare and common Alzheimer\u2019s-associated variants involved in immune response and transcriptional regulation","volume":"25","author":"Bis","year":"2020","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.ajpath.2024.11.006_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2024.11.006_bib19","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1038\/s41593-023-01480-8","article-title":"The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation","volume":"26","author":"Nelson","year":"2023","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib20","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.ajpath.2024.11.006_bib21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer's disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.ajpath.2024.11.006_bib22","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ni.3102","article-title":"Innate immunity in Alzheimer's disease","volume":"16","author":"Heneka","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102068","article-title":"Alzheimer's disease as a viral disease: revisiting the infectious hypothesis","volume":"91","author":"Bruno","year":"2023","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.ajpath.2024.11.006_bib25","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","article-title":"Neurodegenerative tauopathies","volume":"24","author":"Lee","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1750-3639.2007.00052.x","article-title":"Hereditary frontotemporal dementia caused by Tau gene mutations","volume":"17","author":"van Swieten","year":"2007","journal-title":"Brain Pathol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib27","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s00415-019-09363-4","article-title":"An update on genetic frontotemporal dementia","volume":"266","author":"Greaves","year":"2019","journal-title":"J Neurol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib28","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1101\/gad.1583307","article-title":"The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer","volume":"21","author":"Hanahan","year":"2007","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2024.11.006_bib29","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/ng0904-921","article-title":"The knockout mouse project","volume":"36","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2024.11.006_bib30","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/373523a0","article-title":"Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein","volume":"373","author":"Games","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2024.11.006_bib31","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1172\/JCI6172","article-title":"Apo E structure determines VLDL clearance and atherosclerosis risk in mice","volume":"103","author":"Knouff","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2024.11.006_bib32","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single app knock-in mouse models of Alzheimer's disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib33","article-title":"Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD","volume":"6","author":"Oblak","year":"2020","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.1016\/j.ajpath.2024.11.006_bib34","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","article-title":"CRISPR-Cas9 knockin mice for genome editing and cancer modeling","volume":"159","author":"Platt","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2024.11.006_bib35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, A[beta] elevation, and amyloid plaques in transgenic mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2024.11.006_bib36","first-page":"307","article-title":"Microglial response to amyloid plaques in APPsw transgenic mice","volume":"152","author":"Frautschy","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib37","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0969-9961(03)00079-2","article-title":"Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype","volume":"13","author":"Lanz","year":"2003","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.ajpath.2024.11.006_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","article-title":"Co-expression of multiple transgenes in mouse CNS: a comparison of strategies","volume":"17","author":"Jankowsky","year":"2001","journal-title":"Biomol Eng"},{"key":"10.1016\/j.ajpath.2024.11.006_bib39","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13024-017-0231-7","article-title":"Practical considerations for choosing a mouse model of Alzheimer's disease","volume":"12","author":"Jankowsky","year":"2017","journal-title":"Mol Neurodegeneration"},{"key":"10.1016\/j.ajpath.2024.11.006_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008155","article-title":"Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation","volume":"15","author":"Onos","year":"2019","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ajpath.2024.11.006_bib41","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/sj.embor.7400784","article-title":"Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology","volume":"7","author":"Radde","year":"2006","journal-title":"EMBO Rep"},{"key":"10.1016\/j.ajpath.2024.11.006_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009764","article-title":"Synaptic plasticity in the hippocampus of a APP\/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice","volume":"5","author":"Gengler","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2024.11.006_bib43","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.713726","article-title":"Comprehensive evaluation of the 5XFAD mouse model for preclinical testing applications: a MODEL-AD study","volume":"13","author":"Oblak","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib45","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1161\/STROKEAHA.114.005179","article-title":"Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy","volume":"45","author":"Park","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.ajpath.2024.11.006_bib46","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.ajpath.2024.11.006_bib47","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.nbd.2009.09.004","article-title":"Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice","volume":"37","author":"Grueninger","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.ajpath.2024.11.006_bib48","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.neuron.2021.02.010","article-title":"Trem2 restrains the enhancement of tau accumulation and neurodegeneration by [beta]-amyloid pathology","volume":"109","author":"Lee","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.ajpath.2024.11.006_bib49","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.15252\/embj.201797397","article-title":"APP mouse models for Alzheimer's disease preclinical studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2024.11.006_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm6155","article-title":"An isogenic panel of app knock-in mouse models: profiling [beta]-secretase inhibition and endosomal abnormalities","volume":"8","author":"Watamura","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.ajpath.2024.11.006_bib51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13024-022-00547-7","article-title":"Novel app knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia","volume":"17","author":"Xia","year":"2022","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.ajpath.2024.11.006_bib52","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1073\/pnas.89.10.4471","article-title":"Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells","volume":"89","author":"Piedrahita","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2024.11.006_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc9375","article-title":"APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia","volume":"13","author":"Liu","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ajpath.2024.11.006_bib54","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2024.11.006_bib55","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2017.07.023","article-title":"TREM2 maintains microglial metabolic fitness in Alzheimer's disease","volume":"170","author":"Ulland","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2024.11.006_bib56","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.20142322","article-title":"TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models","volume":"212","author":"Jay","year":"2015","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2024.11.006_bib57","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1523\/JNEUROSCI.2110-16.2016","article-title":"Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease","volume":"37","author":"Jay","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib58","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1084\/jem.20171406","article-title":"Alzheimer's disease: a matter of blood-brain barrier dysfunction?","volume":"214","author":"Montagne","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2024.11.006_bib59","doi-asserted-by":"crossref","first-page":"13287","DOI":"10.1073\/pnas.94.24.13287","article-title":"Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology","volume":"94","author":"Sturchler-Pierrat","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2024.11.006_bib60","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/709145","article-title":"Immunocytochemical characterization of Alzheimer disease hallmarks in APP\/PS1 transgenic mice treated with a new anti-amyloid-[beta] vaccine","volume":"2013","author":"Carrera","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ajpath.2024.11.006_bib61","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/npp.2009.197","article-title":"Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease","volume":"35","author":"Kilgore","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ajpath.2024.11.006_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3988\/jcn.2011.7.1.1","article-title":"Cerebral amyloid angiopathy: a systematic review","volume":"7","author":"Biffi","year":"2011","journal-title":"J Clin Neurol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib63","doi-asserted-by":"crossref","first-page":"20296","DOI":"10.1074\/jbc.M312946200","article-title":"Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch\/Iowa mutant form of amyloid beta-protein precursor","volume":"279","author":"Davis","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2024.11.006_bib64","doi-asserted-by":"crossref","first-page":"18007","DOI":"10.1523\/JNEUROSCI.3773-11.2011","article-title":"Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-[beta] amyloidosis","volume":"31","author":"Kim","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib65","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2024.11.006_bib66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-020-2247-3","article-title":"APOE4 leads to blood\u2013brain barrier dysfunction predicting cognitive decline","volume":"581","author":"Montagne","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2024.11.006_bib67","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature11087","article-title":"Apolipoprotein E controls cerebrovascular integrity via cyclophilin A","volume":"485","author":"Bell","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2024.11.006_bib68","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s43587-021-00073-z","article-title":"APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-[beta]","volume":"1","author":"Montagne","year":"2021","journal-title":"Nat Aging"},{"key":"10.1016\/j.ajpath.2024.11.006_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.838436","article-title":"The APOE[epsilon]3\/[epsilon]4 genotype drives distinct gene signatures in the cortex of young mice","volume":"14","author":"Foley","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib70","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13024-019-0337-1","article-title":"Lack of hepatic apoE does not influence early A[beta] deposition: observations from a new APOE knock-in model","volume":"14","author":"Huynh","year":"2019","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.ajpath.2024.11.006_bib71","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1326-9-11","article-title":"ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease","volume":"9","author":"Medway","year":"2014","journal-title":"Mol Neurodegeneration"},{"key":"10.1016\/j.ajpath.2024.11.006_bib72","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/s41591-019-0611-3","article-title":"Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report","volume":"25","author":"Arboleda-Velasquez","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2024.11.006_bib73","doi-asserted-by":"crossref","DOI":"10.1002\/alz.062610","article-title":"Trem2 R47H NSS; 5xFAD mice display age\/disease progression-dependent changes in plaques and plaque-associated microglia, and increased plasma neurofilament light chain","volume":"18","author":"Tran","year":"2022","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.ajpath.2024.11.006_bib74","doi-asserted-by":"crossref","first-page":"11524","DOI":"10.1073\/pnas.1710311114","article-title":"TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy","volume":"114","author":"Leyns","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2024.11.006_bib75","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/hmg\/ddx366","article-title":"Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal","volume":"27","author":"Kang","year":"2018","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajpath.2024.11.006_bib76","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12974-020-01915-0","article-title":"Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition","volume":"17","author":"Price","year":"2020","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.ajpath.2024.11.006_bib77","doi-asserted-by":"crossref","DOI":"10.1080\/19420862.2022.2107971","article-title":"Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice","volume":"14","author":"Zhao","year":"2022","journal-title":"MAbs"},{"key":"10.1016\/j.ajpath.2024.11.006_bib78","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.neuron.2020.09.029","article-title":"Emerging microglia biology defines novel therapeutic approaches for Alzheimer's disease","volume":"108","author":"Lewcock","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.ajpath.2024.11.006_bib79","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1038\/s41467-021-22624-z","article-title":"Generation of a humanized A[beta] expressing mouse demonstrating aspects of Alzheimer's disease-like pathology","volume":"12","author":"Baglietto-Vargas","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2024.11.006_bib80","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","article-title":"Frontotemporal dementia","volume":"386","author":"Bang","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2024.11.006_bib81","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/jnc.13588","article-title":"Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies","volume":"138","author":"Mackenzie","year":"2016","journal-title":"J Neurochem"},{"key":"10.1016\/j.ajpath.2024.11.006_bib82","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/ana.1083","article-title":"Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11-splice site in the tau gene","volume":"50","author":"Miyamoto","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib83","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41374-019-0197-x","article-title":"MAPT mutations, tauopathy, and mechanisms of neurodegeneration","volume":"99","author":"Strang","year":"2019","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2024.11.006_bib84","doi-asserted-by":"crossref","first-page":"10637","DOI":"10.1523\/JNEUROSCI.3279-05.2005","article-title":"Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)","volume":"25","author":"Ramsden","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib85","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1002\/alz.13784","article-title":"The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes","volume":"20","author":"Buchholz","year":"2024","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.ajpath.2024.11.006_bib86","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2353\/ajpath.2006.060002","article-title":"Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits","volume":"169","author":"Schindowski","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib87","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1523\/JNEUROSCI.6103-11.2013","article-title":"Dissociation of frontotemporal dementia\u2013related deficits and neuroinflammation in progranulin haploinsufficient mice","volume":"33","author":"Filiano","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib88","doi-asserted-by":"crossref","first-page":"E2849","DOI":"10.1073\/pnas.1722344115","article-title":"Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay","volume":"115","author":"Nguyen","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2024.11.006_bib89","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.neuron.2016.04.006","article-title":"Gain of toxicity from ALS\/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs","volume":"90","author":"Jiang","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.ajpath.2024.11.006_bib90","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.neuron.2016.04.005","article-title":"C9orf72 BAC mouse model with motor deficits and neurodegenerative features of ALS\/FTD","volume":"90","author":"Liu","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.ajpath.2024.11.006_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2007.05.010","article-title":"Knock-out and transgenic mouse models of tauopathies","volume":"30","author":"Denk","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.ajpath.2024.11.006_bib92","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/ana.23722","article-title":"Mouse models of frontotemporal dementia","volume":"72","author":"Roberson","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib93","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2024.11.006_bib94","first-page":"4639","article-title":"Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia","volume":"24","author":"Yin","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2024.11.006_bib95","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fncel.2017.00196","article-title":"Mouse models of C9orf72 hexanucleotide repeat expansion in amyotrophic lateral sclerosis\/frontotemporal dementia","volume":"11","author":"Batra","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib96","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1080\/09168451.2020.1714420","article-title":"Single-nucleus RNA sequencing reveals transcriptional changes of hippocampal neurons in APP23 mouse model of Alzheimer's disease","volume":"84","author":"Zhong","year":"2020","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.ajpath.2024.11.006_bib97","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer's disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2024.11.006_bib98","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.celrep.2017.09.039","article-title":"Temporal tracking of microglia activation in neurodegeneration at single-cell resolution","volume":"21","author":"Mathys","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2024.11.006_bib99","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.immuni.2018.01.011","article-title":"High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease","volume":"48","author":"Mrdjen","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.ajpath.2024.11.006_bib100","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.celrep.2019.03.099","article-title":"The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to A[beta] plaques","volume":"27","author":"Sala Frigerio","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2024.11.006_bib101","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41591-019-0695-9","article-title":"Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer's disease","volume":"26","author":"Zhou","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2024.11.006_bib102","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017742118","article-title":"Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease","volume":"118","author":"Ellwanger","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2024.11.006_bib103","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.neuron.2021.01.027","article-title":"White matter aging drives microglial diversity","volume":"109","author":"Safaiyan","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.ajpath.2024.11.006_bib104","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.674189","article-title":"GPCRomics of homeostatic and disease-associated human microglia","volume":"12","author":"Hsiao","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib105","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/s41590-018-0212-1","article-title":"The identity and function of microglia in neurodegeneration","volume":"19","author":"Song","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib106","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13024-018-0296-y","article-title":"Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model","volume":"13","author":"Wang","year":"2018","journal-title":"Mol Neurodegeneration"},{"key":"10.1016\/j.ajpath.2024.11.006_bib107","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41593-020-0624-8","article-title":"Disease-associated astrocytes in Alzheimer's disease and aging","volume":"23","author":"Habib","year":"2020","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib108","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41467-023-36519-8","article-title":"Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice","volume":"14","author":"Park","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2024.11.006_bib109","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cell.2020.06.038","article-title":"Spatial transcriptomics and in situ sequencing to study Alzheimer's disease","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2024.11.006_bib110","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.2174\/138161212799315885","article-title":"Nonhuman primate models of Alzheimer-like cerebral proteopathy","volume":"18","author":"Heuer","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.ajpath.2024.11.006_bib111","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.bbadis.2013.03.016","article-title":"A canine model of human aging and Alzheimer's disease","volume":"1832","author":"Head","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2024.11.006_bib112","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0167-4781(96)00232-1","article-title":"Amyloid precursor protein in guinea pigs--complete cDNA sequence and alternative splicing","volume":"1351","author":"Beck","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2024.11.006_bib113","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/gerona\/glac073","article-title":"Nontransgenic guinea pig strains exhibit hallmarks of human brain aging and Alzheimer's disease","volume":"77","author":"Wahl","year":"2022","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.ajpath.2024.11.006_bib114","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41580-020-0259-3","article-title":"Human organoids: model systems for human biology and medicine","volume":"21","author":"Kim","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2024.11.006_bib115","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.neuron.2018.05.008","article-title":"APOE4 causes widespread molecular and cellular alterations associated with Alzheimer's disease phenotypes in human iPSC-derived brain cell types","volume":"98","author":"Lin","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.ajpath.2024.11.006_bib116","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41591-020-0886-4","article-title":"Reconstruction of the human blood\u2013brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes","volume":"26","author":"Blanchard","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2024.11.006_bib117","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neuron.2017.03.042","article-title":"iPSC-derived human microglia-like cells to study neurological diseases","volume":"94","author":"Abud","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.ajpath.2024.11.006_bib118","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41586-022-05277-w","article-title":"Maturation and circuit integration of transplanted human cortical organoids","volume":"610","author":"Revah","year":"2022","journal-title":"Nature"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024004474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944024004474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:23:30Z","timestamp":1793496210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944024004474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":118,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0002944024004474"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.11.006","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetically Engineered Mouse Models for Alzheimer Disease and Frontotemporal Dementia","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2024.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}