{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:52:31Z","timestamp":1787169151876,"version":"build-2736575974"},"reference-count":60,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA051008"],"award-info":[{"award-number":["P30 CA051008"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","award":["101113193"],"award-info":[{"award-number":["101113193"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD025153"],"award-info":[{"award-number":["S10 OD025153"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ajpath.2025.01.012","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T02:49:25Z","timestamp":1739414965000},"page":"875-890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Multimodal Diagnostic Imaging of Metabolic Dysfunction\u2013Associated Steatotic Liver Disease"],"prefix":"10.1016","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7689-353X","authenticated-orcid":false,"given":"Alissa","family":"Keegan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5597-2112","authenticated-orcid":false,"given":"Gayathri","family":"Malamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichien","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Korolowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-5268","authenticated-orcid":false,"given":"Blythe D.","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Ecelbarger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Moya","family":"Rubiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Avantaggiati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6403-2261","authenticated-orcid":false,"given":"Moshe","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Rich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Alfano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-950X","authenticated-orcid":false,"given":"Avi","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Fricke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-2373","authenticated-orcid":false,"given":"Chris","family":"Albanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jithin","family":"Jose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-1096","authenticated-orcid":false,"given":"Olga","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2025.01.012_bib1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.tem.2024.02.007","article-title":"Current status and future trends of the global burden of MASLD","volume":"35","author":"Miao","year":"2024","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2025.01.012_bib2","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1053\/j.gastro.2020.01.051","article-title":"Therapeutic landscape for NAFLD in 2020","volume":"158","author":"Neuschwander-Tetri","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2025.01.012_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi0759","article-title":"Found in translation-fibrosis in metabolic dysfunction-associated steatohepatitis (MASH)","volume":"15","author":"Wang","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ajpath.2025.01.012_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2024.01.038","article-title":"New horizons in the diagnosis and management of patients with MASLD","volume":"122","author":"van Erpecum","year":"2024","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ajpath.2025.01.012_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejim.2024.01.013","article-title":"Non-invasive testing and risk-stratification in patients with MASLD","volume":"122","author":"Zoncape","year":"2024","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ajpath.2025.01.012_bib6","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1158\/1078-0432.CCR-16-1780","article-title":"Sequencing of sipuleucel-t and androgen deprivation therapy in men with hormone-sensitive biochemically recurrent prostate cancer: a phase II randomized trial","volume":"23","author":"Antonarakis","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2025.01.012_bib7","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.3390\/ijms23105675","article-title":"Empagliflozin treatment attenuates hepatic steatosis by promoting white adipose expansion in obese TallyHo mice","volume":"23","author":"Kurtz","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2025.01.012_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.898799","article-title":"Oral N-acetylcysteine decreases IFN-gamma production and ameliorates ischemia-reperfusion injury in steatotic livers","volume":"13","author":"Liggett","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2025.01.012_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1147111","article-title":"Updates on quantitative MRI of diffuse liver disease: a narrative review","volume":"2022","author":"Zerunian","year":"2022","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.ajpath.2025.01.012_bib10","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1053\/j.gastro.2018.12.036","article-title":"Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease","volume":"156","author":"Castera","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2025.01.012_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2024.111749","article-title":"Non-invasive imaging biomarkers in chronic liver disease","volume":"181","author":"Maino","year":"2024","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.ajpath.2025.01.012_bib12","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1007\/s00261-024-04406-5","article-title":"It's time for a unified North American guideline on the use of ultrasound and MRI in patients with MASLD","volume":"49","author":"Wilson","year":"2024","journal-title":"Abdom Radiol (NY)"},{"issue":"Suppl 1","key":"10.1016\/j.ajpath.2025.01.012_bib13","first-page":"S23","article-title":"Diagnosis and non-invasive assessment of MASLD in type 2 diabetes and obesity","volume":"59","author":"Chan","year":"2024","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.ajpath.2025.01.012_bib14","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1109\/TBME.2013.2283507","article-title":"Small-animal whole-body photoacoustic tomography: a review","volume":"61","author":"Xia","year":"2014","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.ajpath.2025.01.012_bib15","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.28.12.121205","article-title":"Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine","volume":"28","author":"Riksen","year":"2023","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.ajpath.2025.01.012_bib16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cbpa.2018.03.016","article-title":"Recent progress in photoacoustic molecular imaging","volume":"45","author":"Yao","year":"2018","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.ajpath.2025.01.012_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5080267","article-title":"State-of-the-art preclinical photoacoustic imaging in oncology: recent advances in cancer theranostics","volume":"2019","author":"Gargiulo","year":"2019","journal-title":"Contrast Media Mol Imaging"},{"key":"10.1016\/j.ajpath.2025.01.012_bib18","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41598-018-37310-2","article-title":"Spectral photoacoustic imaging to estimate in\u00a0vivo placental oxygenation during preeclampsia","volume":"9","author":"Lawrence","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2025.01.012_bib19","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.7150\/thno.41211","article-title":"In\u00a0vivo assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging","volume":"10","author":"Xie","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ajpath.2025.01.012_bib20","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41377-020-00399-0","article-title":"Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles","volume":"9","author":"Dai","year":"2020","journal-title":"Light Sci Appl"},{"key":"10.1016\/j.ajpath.2025.01.012_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1148\/radiol.2021204134","article-title":"Quantitative functional evaluation of liver fibrosis in mice with dynamic contrast-enhanced photoacoustic imaging","volume":"300","author":"Lv","year":"2021","journal-title":"Radiology"},{"key":"10.1016\/j.ajpath.2025.01.012_bib22","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3390\/diagnostics10090705","article-title":"Photoacoustic imaging for assessing tissue oxygenation changes in rat hepatic fibrosis","volume":"10","author":"Karmacharya","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.ajpath.2025.01.012_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12072-020-10121-2","article-title":"How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?","volume":"15","author":"Geng","year":"2021","journal-title":"Hepatol Int"},{"key":"10.1016\/j.ajpath.2025.01.012_bib24","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1038\/s41467-019-11984-2","article-title":"Early detection and staging of chronic liver diseases with a protein MRI contrast agent","volume":"10","author":"Salarian","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2025.01.012_bib25","first-page":"77","article-title":"Distribution of collagen types I, III, and V in fibrotic and neoplastic human liver","volume":"34","author":"Yamamoto","year":"1984","journal-title":"Acta Pathol Jpn"},{"key":"10.1016\/j.ajpath.2025.01.012_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2023.100562","article-title":"Diagnosis of liver fibrosis and liver function reserve through non-invasive multispectral photoacoustic imaging","volume":"33","author":"Qiu","year":"2023","journal-title":"Photoacoustics"},{"key":"10.1016\/j.ajpath.2025.01.012_bib27","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.7150\/thno.78548","article-title":"Multimodal assessment of non-alcoholic fatty liver disease with transmission-reflection optoacoustic ultrasound","volume":"13","author":"Lafci","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.ajpath.2025.01.012_bib28","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1364\/BOE.7.005081","article-title":"Preclinical detection of liver fibrosis using dual-modality photoacoustic\/ultrasound system","volume":"7","author":"van den Berg","year":"2016","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ajpath.2025.01.012_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2023.100454","article-title":"Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis","volume":"29","author":"Fasoula","year":"2023","journal-title":"Photoacoustics"},{"key":"10.1016\/j.ajpath.2025.01.012_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/frsip.2022.984901","article-title":"Recent advances in photoacoustic blind source spectral unmixing approaches and the enhanced detection of endogenous tissue chromophores","volume":"2","author":"Grasso","year":"2022","journal-title":"Front Signal Process"},{"key":"10.1016\/j.ajpath.2025.01.012_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2022.100367","article-title":"Superpixel spectral unmixing framework for the volumetric assessment of tissue chromophores: a photoacoustic data-driven approach","volume":"26","author":"Grasso","year":"2022","journal-title":"Photoacoustics"},{"key":"10.1016\/j.ajpath.2025.01.012_bib32","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3390\/nu9101072","article-title":"Animal models of nonalcoholic fatty liver disease-a starter's guide","volume":"9","author":"Van Herck","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.ajpath.2025.01.012_bib33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-1-62703-068-7_6","article-title":"The TALLYHO mouse as a model of human type 2 diabetes","volume":"933","author":"Kim","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ajpath.2025.01.012_bib34","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.bbadis.2018.04.024","article-title":"Animal models of NAFLD from the pathologist's point of view","volume":"1865","author":"Denk","year":"2019","journal-title":"Biochim Biophys Acta, Mol Basis Dis"},{"key":"10.1016\/j.ajpath.2025.01.012_bib35","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/jgh.14122","article-title":"Mouse models of non-alcoholic steatohepatitis: a reflection on recent literature","volume":"33","author":"Haczeyni","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2025.01.012_bib36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1364\/OL.20.000237","article-title":"Proposed method for molecular optical imaging","volume":"20","author":"Betzig","year":"1995","journal-title":"Opt Lett"},{"key":"10.1016\/j.ajpath.2025.01.012_bib37","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1109\/TBME.1979.326455","article-title":"Theoretical analysis of diffuse reflectance from a two-layer tissue model","volume":"26","author":"Takatani","year":"1979","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.ajpath.2025.01.012_bib38","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/clinchem\/37.9.1633","article-title":"Absorption-spectra of human fetal and adult oxyhemoglobin, de-oxyhemoglobin, carboxyhemoglobin, and methemoglobin","volume":"37","author":"Zijlstra","year":"1991","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajpath.2025.01.012_bib39","doi-asserted-by":"crossref","DOI":"10.1117\/1.2085149","article-title":"Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy","volume":"10","author":"van Veen","year":"2005","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.ajpath.2025.01.012_bib40","article-title":"Diffuse optical spectroscopy of breast tissue extended to 1100 nm","volume":"14","author":"Taroni","year":"2009","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.ajpath.2025.01.012_bib41","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1364\/AO.52.002494","article-title":"Recipes to make organic phantoms for diffusive optical spectroscopy","volume":"52","author":"Quarto","year":"2013","journal-title":"Appl Opt"},{"key":"10.1016\/j.ajpath.2025.01.012_bib42","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.22.1.015006","article-title":"Diffuse optical characterization of collagen absorption from 500 to 1700 nm","volume":"22","author":"Sekar","year":"2017","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.ajpath.2025.01.012_bib43","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1038\/s41591-019-0669-y","article-title":"Detection of collagens by multispectral optoacoustic tomography as an imaging biomarker for Duchenne muscular dystrophy","volume":"25","author":"Regensburger","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2025.01.012_bib44","first-page":"427","article-title":"The susceptibility of hepatic collagen to homologous collagenase in human and experimental cirrhosis of the liver","volume":"100","author":"Perez-Tamayo","year":"1980","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2025.01.012_bib45","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.3390\/biom10111585","article-title":"Digital image analysis of picrosirius red staining: a robust method for multi-organ fibrosis quantification and characterization","volume":"10","author":"Courtoy","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.ajpath.2025.01.012_bib46","article-title":"Fibrosis quantification using multiphoton excitation imaging of picrosirius red stained cardiac tissue","author":"Jones","year":"2023","journal-title":"Res Sq"},{"key":"10.1016\/j.ajpath.2025.01.012_bib47","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.3390\/molecules26113316","article-title":"Collagen characterization in a model of nonalcoholic steatohepatitis with fibrosis; a call for development of targeted therapeutics","volume":"26","author":"Pellicano","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ajpath.2025.01.012_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173914","article-title":"A morphological method for ammonia detection in liver","volume":"12","author":"Gutierrez-de-Juan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2025.01.012_bib49","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1007\/s00261-022-03647-6","article-title":"Assessment of hepatic fibrosis and inflammation with look-locker T1 mapping and magnetic resonance elastography with histopathology as reference standard","volume":"47","author":"von Ulmenstein","year":"2022","journal-title":"Abdom Radiol (NY)"},{"key":"10.1016\/j.ajpath.2025.01.012_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/srep15408","article-title":"Liver fibrosis and Gd-EOB-DTPA-enhanced MRI: a histopathologic correlation","volume":"5","author":"Verloh","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2025.01.012_bib51","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1148\/radiol.2018180051","article-title":"Quantification of liver fibrosis at T1 and T2 mapping with extracellular volume fraction MRI: preclinical results","volume":"288","author":"Luetkens","year":"2018","journal-title":"Radiology"},{"key":"10.1016\/j.ajpath.2025.01.012_bib52","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3892\/etm.2021.9656","article-title":"Quantitative T2 mapping of rats with chronic hepatitis","volume":"21","author":"Wang","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.ajpath.2025.01.012_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102530","article-title":"The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice","volume":"298","author":"Wang","year":"2022","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2025.01.012_bib54","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/jmri.27601","article-title":"MRI measures of murine liver fibrosis","volume":"54","author":"Lindquist","year":"2021","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.ajpath.2025.01.012_bib55","article-title":"Association between hemoglobin and non-alcoholic fatty liver disease (NAFLD) in United States adults: results from NHANES 2017-2020","volume":"44","author":"Yao","year":"2024","journal-title":"Prev Med Rep"},{"key":"10.1016\/j.ajpath.2025.01.012_bib56","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jhep.2010.07.004","article-title":"Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: new targets for the treatment of portal hypertension?","volume":"53","author":"Thabut","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2025.01.012_bib57","doi-asserted-by":"crossref","first-page":"688","DOI":"10.7150\/thno.14555","article-title":"A phosphorus phthalocyanine formulation with intense absorbance at 1000 nm for deep optical imaging","volume":"6","author":"Zhou","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.ajpath.2025.01.012_bib58","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.20.3.036002","article-title":"Transurethral light delivery for prostate photoacoustic imaging","volume":"20","author":"Lediju Bell","year":"2015","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.ajpath.2025.01.012_bib59","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1364\/BOE.463057","article-title":"Ultrathin, high-speed, all-optical photoacoustic endomicroscopy probe for guiding minimally invasive surgery","volume":"13","author":"Zhao","year":"2022","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ajpath.2025.01.012_bib60","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/nm.2823","article-title":"Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in\u00a0vivo","volume":"18","author":"Yang","year":"2012","journal-title":"Nat Med"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944025000483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944025000483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:33:48Z","timestamp":1777628028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944025000483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0002944025000483"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2025.01.012","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multimodal Diagnostic Imaging of Metabolic Dysfunction\u2013Associated Steatotic Liver Disease","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2025.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}