{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:04:31Z","timestamp":1780495471654,"version":"3.54.1"},"reference-count":69,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["IC133077"],"award-info":[{"award-number":["IC133077"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ajpath.2025.04.018","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T09:29:32Z","timestamp":1748597372000},"page":"1376-1393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploratory Study of Prognostic Plasma Biomarkers in Patients with Pulmonary Arterial Hypertension"],"prefix":"10.1016","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4502-9383","authenticated-orcid":false,"given":"Yukimitsu","family":"Kuwabara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-3274","authenticated-orcid":false,"given":"Tetsuro","family":"Yokokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6625-9918","authenticated-orcid":false,"given":"Sarah-Eve","family":"Lemay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Sauvaget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Martineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8613-8455","authenticated-orcid":false,"given":"Sandra","family":"Breuils-Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Potus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7535-9972","authenticated-orcid":false,"given":"Steeve","family":"Provencher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Boucherat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2025.04.018_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/17476348.2024.2361037","article-title":"Extrapulmonary manifestations of pulmonary arterial hypertension","volume":"18","author":"Singh","year":"2024","journal-title":"Expert Rev Respir Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib2","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMra2000348","article-title":"Pulmonary arterial hypertension","volume":"385","author":"Hassoun","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib3","doi-asserted-by":"crossref","first-page":"L1131","DOI":"10.1152\/ajplung.00067.2020","article-title":"Perspective: pathobiological paradigms in pulmonary hypertension, time for reappraisal","volume":"318","author":"Tuder","year":"2020","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2025.04.018_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1164\/rccm.201606-1226PP","article-title":"Translational advances in the field of pulmonary hypertension: from cancer biology to new pulmonary arterial hypertension therapeutics: targeting cell growth and proliferation signaling hubs","volume":"195","author":"Pullamsetti","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib5","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1164\/rccm.201806-1160ST","article-title":"Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward: an official American Thoracic Society Research Statement","volume":"198","author":"Lahm","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib6","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01552-2021","article-title":"Mortality trends in pulmonary arterial hypertension in Canada: a temporal analysis of survival per ESC\/ERS guideline era","volume":"59","author":"Zelt","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2025.04.018_bib7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.chest.2019.02.004","article-title":"Predicting survival in patients with pulmonary arterial hypertension: the REVEAL risk score calculator 2.0 and comparison with ESC\/ERS-based risk assessment strategies","volume":"156","author":"Benza","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.ajpath.2025.04.018_bib8","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1183\/13993003.01032-2015","volume":"46","author":"Galie","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2025.04.018_bib9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S2213-2600(17)30161-3","article-title":"Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study","volume":"5","author":"Rhodes","year":"2017","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib10","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s44161-022-00113-w","article-title":"Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension","volume":"1","author":"Boucherat","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.ajpath.2025.04.018_bib11","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02428-2020","article-title":"Targeted proteomics of right heart adaptation to pulmonary arterial hypertension","volume":"57","author":"Amsallem","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2025.04.018_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7326\/0003-4819-145-4-200608150-00004","article-title":"Chronic Kidney Disease Epidemiology Collaboration: Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate","volume":"145","author":"Levey","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100168","article-title":"Proximity extension assay in combination with next-generation sequencing for high-throughput proteome-wide analysis","volume":"20","author":"Wik","year":"2021","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.ajpath.2025.04.018_bib14","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1164\/rccm.202305-0909OC","article-title":"Hypusine signaling promotes pulmonary vascular remodeling in pulmonary arterial hypertension","volume":"209","author":"Lemay","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib15","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1161\/CIRCULATIONAHA.124.070693","article-title":"Exploring integrin alpha5beta1 as a potential therapeutic target for pulmonary arterial hypertension: insights from comprehensive multicenter preclinical studies","volume":"151","author":"Lemay","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.ajpath.2025.04.018_bib16","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.ajpath.2025.04.018_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10654-011-9567-4","article-title":"PredictABEL: an R package for the assessment of risk prediction models","volume":"26","author":"Kundu","year":"2011","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ajpath.2025.04.018_bib18","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.032888","article-title":"Prognostic significance of proteomics-discovered circulating inflammatory biomarkers in patients with pulmonary arterial hypertension","volume":"13","author":"Yokokawa","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ajpath.2025.04.018_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.ede.0000147512.81966.ba","article-title":"Optimal cut-point and its corresponding Youden index to discriminate individuals using pooled blood samples","volume":"16","author":"Schisterman","year":"2005","journal-title":"Epidemiology"},{"key":"10.1016\/j.ajpath.2025.04.018_bib20","first-page":"2825","article-title":"Scikit-learn: machine learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J Mach Learn Res"},{"key":"10.1016\/j.ajpath.2025.04.018_bib21","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCRESAHA.121.319971","article-title":"The latest in animal models of pulmonary hypertension and right ventricular failure","volume":"130","author":"Boucherat","year":"2022","journal-title":"Circ Res"},{"key":"10.1016\/j.ajpath.2025.04.018_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1152\/physrev.00045.2017","article-title":"The TNF family of ligands and receptors: communication modules in the immune system and beyond","volume":"99","author":"Dostert","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ajpath.2025.04.018_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw3172","article-title":"Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats","volume":"12","author":"Wang","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib24","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41586-023-06047-y","article-title":"EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia","volume":"617","author":"Bilgic","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2025.04.018_bib25","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1128\/MCB.24.4.1608-1613.2004","article-title":"Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency","volume":"24","author":"Newton","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2025.04.018_bib26","article-title":"Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2025.04.018_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00109-017-1619-0","article-title":"FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension","volume":"96","author":"Bourgeois","year":"2018","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.ajpath.2025.04.018_bib28","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI23203","article-title":"Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension","volume":"115","author":"McMurtry","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2025.04.018_bib29","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1183\/13993003.01448-2015","article-title":"Role of interleukin-1 receptor 1\/MyD88 signalling in the development and progression of pulmonary hypertension","volume":"48","author":"Parpaleix","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2025.04.018_bib51","doi-asserted-by":"crossref","DOI":"10.1177\/2045894020931317","article-title":"Plasma adrenomedullin peptides and precursor levels in pulmonary arterial hypertension disease severity and risk stratification","volume":"10","author":"Bouzina","year":"2020","journal-title":"Pulm Circ"},{"key":"10.1016\/j.ajpath.2025.04.018_bib52","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1093\/rheumatology\/keac055","article-title":"The prognostic value of sST2 in connective tissue disease patients with pulmonary hypertension","volume":"61","author":"Ye","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ajpath.2025.04.018_bib53","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/clc.22262","article-title":"Plasma soluble ST2 levels correlate with disease severity and predict clinical worsening in patients with pulmonary arterial hypertension","volume":"37","author":"Zheng","year":"2014","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.ajpath.2025.04.018_bib54","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.ijcard.2012.12.031","article-title":"Serum soluble ST2 and interleukin-33 levels in patients with pulmonary arterial hypertension","volume":"168","author":"Carlomagno","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ajpath.2025.04.018_bib55","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.124.012067","article-title":"Proteomic signatures of right ventricular outcomes in pulmonary arterial hypertension","volume":"17","author":"Pi","year":"2024","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ajpath.2025.04.018_bib56","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1378\/chest.10-0302","article-title":"Increased expression of growth differentiation factor-15 in systemic sclerosis-associated pulmonary arterial hypertension","volume":"139","author":"Meadows","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.ajpath.2025.04.018_bib57","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1164\/rccm.200802-235OC","article-title":"Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension","volume":"178","author":"Nickel","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib58","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12195","article-title":"The diagnostic and prognostic value of growth differentiation factor-15 in systemic lupus erythematosus-associated pulmonary arterial hypertension","volume":"13","author":"Qian","year":"2023","journal-title":"Pulm Circ"},{"key":"10.1016\/j.ajpath.2025.04.018_bib59","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1164\/rccm.202109-2106OC","article-title":"Mining the plasma proteome for insights into the molecular pathology of pulmonary arterial hypertension","volume":"205","author":"Harbaum","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib60","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/ard-2022-223237","article-title":"Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis","volume":"82","author":"Sanges","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ajpath.2025.04.018_bib61","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13075-018-1679-8","article-title":"Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis","volume":"20","author":"Rice","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ajpath.2025.04.018_bib62","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1161\/CIRCULATIONAHA.122.061501","article-title":"Serum and pulmonary expression profiles of the activin signaling system in pulmonary arterial hypertension","volume":"147","author":"Guignabert","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.ajpath.2025.04.018_bib63","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01483-2024","article-title":"Effect of sotatercept on circulating proteomics in pulmonary arterial hypertension","volume":"64","author":"Savale","year":"2024","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2025.04.018_bib64","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s40291-016-0214-3","article-title":"Utility of hepatocyte growth factor as a biomarker for early diagnosis of pulmonary artery hypertension","volume":"20","author":"Liang","year":"2016","journal-title":"Mol Diagn Ther"},{"key":"10.1016\/j.ajpath.2025.04.018_bib65","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/ard.61.3.261","article-title":"Correlation between plasma concentrations of calcitonin gene related peptide and pulmonary pressure in patients with systemic sclerosis","volume":"61","author":"Bartosik","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ajpath.2025.04.018_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910574","article-title":"miR-29a-3p\/THBS2 axis regulates PAH-induced cardiac fibrosis","volume":"22","author":"Hsu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2025.04.018_bib67","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00528-2022","article-title":"Clinical phenotyping of plasma thrombospondin-2 reveals relationship to right ventricular structure and function in pulmonary hypertension","volume":"9","author":"Dittrich","year":"2023","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.ajpath.2025.04.018_bib36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12872-020-01461-w","article-title":"Serum human epididymis protein 4 level as a predictor of clinical worsening in idiopathic pulmonary arterial hypertension: a pilot study","volume":"20","author":"Jin","year":"2020","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.ajpath.2025.04.018_bib68","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1007\/s00392-023-02162-y","article-title":"Fibroblast growth factor 23 as a biomarker of right ventricular dysfunction in pulmonary hypertension","volume":"112","author":"Widmann","year":"2023","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.ajpath.2025.04.018_bib69","doi-asserted-by":"crossref","DOI":"10.1177\/2045894019895446","article-title":"Higher plasma fibroblast growth factor 23 levels are associated with a higher risk profile in pulmonary arterial hypertension","volume":"9","author":"Bouzina","year":"2019","journal-title":"Pulm Circ"},{"key":"10.1016\/j.ajpath.2025.04.018_bib30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2025.04.018_bib31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ahj.2022.05.006","article-title":"Prognostic value of brain natriuretic peptides in patients with pulmonary arterial hypertension: a systematic review and meta-analysis","volume":"250","author":"Hendriks","year":"2022","journal-title":"Am Heart J"},{"key":"10.1016\/j.ajpath.2025.04.018_bib32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1164\/rccm.201903-0656CI","article-title":"Beyond the lungs: systemic manifestations of pulmonary arterial hypertension","volume":"201","author":"Nickel","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib33","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr424","article-title":"Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood","volume":"39","author":"Lundberg","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2025.04.018_bib34","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1538\/expanim.24-0020","article-title":"EDA2R knockdown alleviates myocardial ischemia\/reperfusion injury through inhibiting the activation of the NF-kappaB signaling pathway","volume":"73","author":"Guan","year":"2024","journal-title":"Exp Anim"},{"key":"10.1016\/j.ajpath.2025.04.018_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.15586\/aei.v50i5.670","article-title":"Knockdown of EDA2R alleviates hyperoxia-induced lung epithelial cell injury by inhibiting NF-kappaB pathway","volume":"50","author":"Jia","year":"2022","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.ajpath.2025.04.018_bib37","doi-asserted-by":"crossref","first-page":"67748","DOI":"10.18632\/oncotarget.11682","article-title":"Elevated serum concentrations of HE4 as a novel biomarker of disease severity and renal fibrosis in kidney disease","volume":"7","author":"Wan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ajpath.2025.04.018_bib38","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.021069","article-title":"HE4 predicts progressive fibrosis and cardiovascular events in patients with dilated cardiomyopathy","volume":"10","author":"Yamamoto","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ajpath.2025.04.018_bib39","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3892\/or.2012.2114","article-title":"WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes","volume":"29","author":"Chen","year":"2013","journal-title":"Oncol Rep"},{"key":"10.1016\/j.ajpath.2025.04.018_bib40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3892\/or.2015.4339","article-title":"Recombinant HE4 protein promotes proliferation of pancreatic and endometrial cancer cell lines","volume":"35","author":"Lu","year":"2016","journal-title":"Oncol Rep"},{"key":"10.1016\/j.ajpath.2025.04.018_bib41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12931-022-02040-7","article-title":"Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease","volume":"23","author":"Zhan","year":"2022","journal-title":"Respir Res"},{"key":"10.1016\/j.ajpath.2025.04.018_bib42","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nm.2989","article-title":"Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib43","first-page":"H681","article-title":"CGRP and somatostatin modulate chronic hypoxic pulmonary hypertension","volume":"263","author":"Tjen","year":"1992","journal-title":"Am J Phys"},{"key":"10.1016\/j.ajpath.2025.04.018_bib44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0014-2999(98)00475-0","article-title":"Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline","volume":"355","author":"Yoshihara","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ajpath.2025.04.018_bib45","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.148135","article-title":"SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization","volume":"6","author":"Suwa","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.ajpath.2025.04.018_bib46","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1038\/s41467-018-06860-4","article-title":"Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance","volume":"9","author":"Chen","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2025.04.018_bib47","article-title":"Copper transport protein antioxidant-1 promotes inflammatory neovascularization via chaperone and transcription factor function","volume":"5","author":"Chen","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2025.04.018_bib48","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1165\/rcmb.2011-0296OC","article-title":"Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans","volume":"46","author":"Bogaard","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2025.04.018_bib49","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1164\/rccm.202310-1887OC","article-title":"Biological age, chronological age, and survival in pulmonary fibrosis: a causal mediation analysis","volume":"210","author":"Pugashetti","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2025.04.018_bib50","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1165\/rcmb.2023-0335LE","article-title":"Time is running out in pulmonary arterial hypertension: the epigenetic clock is clicking","volume":"70","author":"El Kabbout","year":"2024","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944025001816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944025001816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T10:44:04Z","timestamp":1753353844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944025001816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":69,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0002944025001816"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2025.04.018","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploratory Study of Prognostic Plasma Biomarkers in Patients with Pulmonary Arterial Hypertension","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2025.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}