{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:33:27Z","timestamp":1788564807184,"version":"build-2803163510"},"reference-count":144,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA031901"],"award-info":[{"award-number":["AA031901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA030869"],"award-info":[{"award-number":["AA030869"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA009803"],"award-info":[{"award-number":["AA009803"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ajpath.2025.05.025","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T06:38:01Z","timestamp":1752734281000},"page":"92-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alcohol-Mediated Skeletal Muscle Adaptations and Their Impact on Comorbidities"],"prefix":"10.1016","volume":"196","author":[{"given":"Keishla M.","family":"Rodr\u00edguez-Graciani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-384X","authenticated-orcid":false,"given":"Paticia E.","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-3406","authenticated-orcid":false,"given":"Liz","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2025.05.025_bib1","first-page":"339","article-title":"Alcoholismus chronicus, or chronic alcohol disease","volume":"9","author":"Huss","year":"1852","journal-title":"Br Foreign Med Chir Rev"},{"key":"10.1016\/j.ajpath.2025.05.025_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJM182210010110402","article-title":"On a peculiar disease resulting from the use of ardent spirits","volume":"11","author":"Jackson","year":"1822","journal-title":"N Engl J Med Surg"},{"key":"10.1016\/j.ajpath.2025.05.025_bib4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.0954-6820.1955.tb03504.x","article-title":"Acute myoglobinuria; report of a case with fatal outcome","volume":"152","author":"Hed","year":"1955","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.ajpath.2025.05.025_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.0954-6820.1962.tb04224.x","article-title":"Acute muscular syndrome in chronic alcoholism","volume":"171","author":"Hed","year":"1962","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.ajpath.2025.05.025_bib6","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.0954-6820.1957.tb15508.x","article-title":"Myonecrosis and myoglobinuria in alcohol and barbiturate intoxication","volume":"158","author":"Fahlgren","year":"1957","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.ajpath.2025.05.025_bib7","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1111\/acer.13859","article-title":"Trends in adult alcohol use and binge drinking in the early 21st-century united states: a meta-analysis of 6 national survey series","volume":"42","author":"Grucza","year":"2018","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib8","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1001\/jamapsychiatry.2017.2161","article-title":"Prevalence of 12-month alcohol use, high-risk drinking, and DSM-IV alcohol use disorder in the United States, 2001-2002 to 2012-2013: results from the national epidemiologic survey on alcohol and related conditions","volume":"74","author":"Grant","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ajpath.2025.05.025_bib9","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.26346","article-title":"Trends in alcohol-related deaths by sex in the US, 1999-2020","volume":"6","author":"Karaye","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ajpath.2025.05.025_bib10","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1037\/abn0000304","article-title":"Interactive effects of ovarian steroid hormones on alcohol use and binge drinking across the menstrual cycle","volume":"126","author":"Martel","year":"2017","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib11","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/acer.13985","article-title":"Alcohol and women: a brief overview","volume":"43","author":"McCaul","year":"2019","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpnec.2020.100022","article-title":"The effects of menstrual cycle stage and hormonal contraception on alcohol consumption and craving: a pilot investigation","volume":"5","author":"Warren","year":"2021","journal-title":"Compr Psychoneuroendocrinol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib13","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cld.2012.08.002","article-title":"Alcohol metabolism","volume":"16","author":"Cederbaum","year":"2012","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.ajpath.2025.05.025_bib14","article-title":"Cellular bioenergetics: experimental evidence for alcohol-induced adaptations","volume":"3","author":"Simon","year":"2022","journal-title":"Function (Oxf)"},{"key":"10.1016\/j.ajpath.2025.05.025_bib15","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1111\/acer.13425","article-title":"Sarcopenia in alcoholic liver disease: clinical and molecular advances","volume":"41","author":"Dasarathy","year":"2017","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.35946\/arcr.v38.2.05","article-title":"Alcoholic myopathy: pathophysiologic mechanisms and clinical implications","volume":"38","author":"Simon","year":"2017","journal-title":"Alcohol Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1468-1331.2001.00303.x","article-title":"Alcoholic skeletal muscle myopathy: definitions, features, contribution of neuropathy, impact and diagnosis","volume":"8","author":"Preedy","year":"2001","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib18","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00431-023-04820-9","article-title":"Elevated creatinine kinase levels amongst Dutch adolescents with acute alcohol intoxication","volume":"182","author":"Pigeaud","year":"2023","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.ajpath.2025.05.025_bib19","series-title":"Nutrition and skeletal muscle","first-page":"529","article-title":"Chapter 31 - alcoholic myopathy","author":"Gonz\u00e1lez-Reimers","year":"2019"},{"key":"10.1016\/j.ajpath.2025.05.025_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0376-8716(00)00219-2","article-title":"Alcoholic myopathy: biochemical mechanisms","volume":"63","author":"Preedy","year":"2001","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.ajpath.2025.05.025_bib21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/ajcn\/78.2.326","article-title":"Influence of nutritional status on alcoholic myopathy","volume":"78","author":"Nicolas","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ajpath.2025.05.025_bib22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/00952990.2022.2041025","article-title":"The functional and molecular effects of problematic alcohol consumption on skeletal muscle: a focus on athletic performance","volume":"48","author":"Caceres-Ayala","year":"2022","journal-title":"Am J Drug Alcohol Abuse"},{"key":"10.1016\/j.ajpath.2025.05.025_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252212280","article-title":"Alcohol alters skeletal muscle bioenergetic function: a scoping review","volume":"25","author":"DiLeo","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2025.05.025_bib24","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1111\/j.1530-0277.2007.00530.x","article-title":"Molecular and cellular events in alcohol-induced muscle disease","volume":"31","author":"Fernandez-Sola","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib25","doi-asserted-by":"crossref","first-page":"04","DOI":"10.35946\/arcr.v43.1.04","article-title":"Alcohol and skeletal muscle in health and disease","volume":"43","author":"Simon","year":"2023","journal-title":"Alcohol Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib26","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3390\/biom5042223","article-title":"Impact of alcohol on glycemic control and insulin action","volume":"5","author":"Steiner","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.ajpath.2025.05.025_bib27","doi-asserted-by":"crossref","first-page":"E699","DOI":"10.1152\/ajpendo.00006.2015","article-title":"Dysregulation of skeletal muscle protein metabolism by alcohol","volume":"308","author":"Steiner","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2025.05.025_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2019.110614","article-title":"Skeletal muscle mass index and phase angle are decreased in individuals with dependence on alcohol and other substances","volume":"71","author":"Coelho","year":"2020","journal-title":"Nutrition"},{"key":"10.1016\/j.ajpath.2025.05.025_bib29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4161\/auto.27918","article-title":"Alcohol-induced autophagy contributes to loss in skeletal muscle mass","volume":"10","author":"Thapaliya","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2025.05.025_bib30","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1186\/s12889-022-14275-6","article-title":"Alcohol consumption patterns and the risk of sarcopenia: a population-based cross-sectional study among Chinese women and men from Henan province","volume":"22","author":"Zhai","year":"2022","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ajpath.2025.05.025_bib31","doi-asserted-by":"crossref","first-page":"E967","DOI":"10.1152\/ajpendo.00513.2018","article-title":"Cellular and molecular signatures of alcohol-induced myopathy in women","volume":"316","author":"Shenkman","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2025.05.025_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/nu14051016","article-title":"High-fat diet augments the effect of alcohol on skeletal muscle mitochondrial dysfunction in mice","volume":"14","author":"Ismaeel","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ajpath.2025.05.025_bib33","first-page":"294","article-title":"The longitudinal association between alcohol consumption and muscle strength: a population-based prospective study","volume":"19","author":"Cui","year":"2019","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.ajpath.2025.05.025_bib34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0741-8329(90)90096-U","article-title":"A survey of muscle function in detoxified alcoholics","volume":"7","author":"Pendergast","year":"1990","journal-title":"Alcohol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.15288\/jsa.1999.60.413","article-title":"Muscle performance in detoxified alcoholics","volume":"60","author":"York","year":"1999","journal-title":"J Stud Alcohol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255946","article-title":"Effects of alcohol on skeletal muscle contractile performance in male and female mice","volume":"16","author":"Laudato","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2025.05.025_bib37","doi-asserted-by":"crossref","first-page":"R781","DOI":"10.1152\/ajpregu.00197.2021","article-title":"Skeletal muscle bioenergetic health and function in people living with HIV: association with glucose tolerance and alcohol use","volume":"321","author":"Levitt","year":"2021","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s42003-018-0157-9","article-title":"Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors","volume":"1","author":"Noori","year":"2018","journal-title":"Commun Biol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib39","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/jn\/133.4.1154","article-title":"Alcohol affects the skeletal muscle proteins, titin and nebulin in male and female rats","volume":"133","author":"Hunter","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.ajpath.2025.05.025_bib40","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1111\/acer.14179","article-title":"Chronic alcohol consumption, but not acute intoxication, decreases in vitro skeletal muscle contractile function","volume":"43","author":"Crowell","year":"2019","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib41","doi-asserted-by":"crossref","first-page":"10011","DOI":"10.3389\/adar.2021.10011","article-title":"Alcohol use disorders and their harmful effects on the contractility of skeletal, cardiac and smooth muscles","volume":"1","author":"Alleyne","year":"2021","journal-title":"Adv Drug Alcohol Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2739\/kurumemedj.36.155","article-title":"Ethanol induced EMG changes and muscle force in a patient with polyneuropathy","volume":"36","author":"Farkkila","year":"1989","journal-title":"Kurume Med J"},{"key":"10.1016\/j.ajpath.2025.05.025_bib43","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1139\/h11-137","article-title":"The effects of acute alcohol consumption and eccentric muscle damage on neuromuscular function","volume":"37","author":"Barnes","year":"2012","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.ajpath.2025.05.025_bib44","first-page":"251","article-title":"Association between the amount of alcohol intake and masseter muscle activity levels recorded during sleep in healthy young women","volume":"20","author":"Hojo","year":"2007","journal-title":"Int J Prosthodont"},{"key":"10.1016\/j.ajpath.2025.05.025_bib45","first-page":"219","article-title":"Muscle tension and experienced control: effects of alcohol intake vs biofeedback on alcoholics and non-alcoholics","volume":"7","author":"Engstrom","year":"1979","journal-title":"Curr Alcohol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib46","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3109\/00952999809016912","article-title":"Isometric muscle strength in alcoholic and nonalcoholic liver-transplantation candidates","volume":"24","author":"Panzak","year":"1998","journal-title":"Am J Drug Alcohol Abuse"},{"key":"10.1016\/j.ajpath.2025.05.025_bib47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jsams.2008.12.627","article-title":"Acute alcohol consumption aggravates the decline in muscle performance following strenuous eccentric exercise","volume":"13","author":"Barnes","year":"2010","journal-title":"J Sci Med Sport"},{"key":"10.1016\/j.ajpath.2025.05.025_bib48","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1123\/ijsnem.2016-0171","article-title":"Effect of alcohol consumption on recovery from eccentric exercise induced muscle damage in females","volume":"27","author":"McLeay","year":"2017","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"10.1016\/j.ajpath.2025.05.025_bib49","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00421-010-1655-8","article-title":"A low dose of alcohol does not impact skeletal muscle performance after exercise-induced muscle damage","volume":"111","author":"Barnes","year":"2011","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib50","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.3390\/diagnostics14171891","article-title":"Ultrasound assessment of sarcopenia in alcoholic liver disease","volume":"14","author":"Enciu","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.ajpath.2025.05.025_bib51","first-page":"1730","article-title":"Alcoholic myopathy: evaluation with magnetic resonance imaging--a case study","volume":"21","author":"Kishi","year":"1997","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib52","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1097\/01.ALC.0000148104.24425.AE","article-title":"MRI and muscle signal intensities in alcoholics compared with control subjects","volume":"28","author":"Bigliocchi","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib53","doi-asserted-by":"crossref","first-page":"360A","DOI":"10.1111\/j.1530-0277.1996.tb01808.x","article-title":"Effect of chronic alcohol intake on energy metabolism in human muscle","volume":"20","author":"Yazaki","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib54","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0149-936X(88)90075-6","article-title":"Computed tomography in acute alcoholic myopathy","volume":"12","author":"Grau","year":"1988","journal-title":"J Comput Tomogr"},{"key":"10.1016\/j.ajpath.2025.05.025_bib55","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0026-0495(93)90214-9","article-title":"Distribution of adipose tissue and muscle mass in alcoholic men","volume":"42","author":"Kvist","year":"1993","journal-title":"Metabolism"},{"key":"10.1016\/j.ajpath.2025.05.025_bib56","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1007\/s00535-024-02137-4","article-title":"Alcohol-associated liver disease increases the risk of muscle loss and mortality in patients with cirrhosis","volume":"59","author":"Hanai","year":"2024","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib57","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/hepr.14186","article-title":"Prognostic significance of skeletal muscle mass in patients with alcohol-related cirrhosis","volume":"55","author":"Shibamoto","year":"2025","journal-title":"Hepatol Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib58","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1186\/s13054-020-03282-x","article-title":"Medical Research Council-sumscore: a tool for evaluating muscle weakness in patients with post-intensive care syndrome","volume":"24","author":"Turan","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.ajpath.2025.05.025_bib59","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1111\/jgs.16082","article-title":"Alcohol consumption and functional limitations in older men: does muscle strength mediate them?","volume":"67","author":"Wang","year":"2019","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.ajpath.2025.05.025_bib60","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00223-023-01081-4","article-title":"Alcohol consumption and measures of sarcopenic muscle risk: cross-sectional and prospective associations within the UK Biobank Study","volume":"113","author":"Skinner","year":"2023","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ajpath.2025.05.025_bib61","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1111\/acer.15149","article-title":"Longitudinal assessment of strength and body composition in a mouse model of chronic alcohol-related myopathy","volume":"47","author":"Ganjayi","year":"2023","journal-title":"Alcohol Clin Exp Res (Hoboken)"},{"key":"10.1016\/j.ajpath.2025.05.025_bib62","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1111\/acer.14907","article-title":"Neuromuscular mechanisms of weakness in a mouse model of chronic alcoholic myopathy","volume":"46","author":"Moser","year":"2022","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib63","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1152\/japplphysiol.00599.2023","article-title":"Effects of chronic alcohol intoxication on aerobic exercise-induced adaptations in female mice","volume":"136","author":"Tice","year":"2024","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.ajpath.2025.05.025_bib64","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1097\/01.alc.0000174768.78427.f6","article-title":"Ethanol feeding impairs insulin-stimulated glucose uptake in isolated rat skeletal muscle: role of Gs alpha and cAMP","volume":"29","author":"Wan","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib65","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3390\/nu4081058","article-title":"Impaired insulin\/IGF signaling in experimental alcohol-related myopathy","volume":"4","author":"Nguyen","year":"2012","journal-title":"Nutrients"},{"key":"10.1016\/j.ajpath.2025.05.025_bib66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1475-2891-9-14","article-title":"Effects of body weight and alcohol consumption on insulin sensitivity","volume":"9","author":"Paulson","year":"2010","journal-title":"Nutr J"},{"key":"10.1016\/j.ajpath.2025.05.025_bib67","series-title":"Handbook of substance misuse and addictions","first-page":"943","article-title":"Chronic alcohol and skeletal muscle","author":"Bourgeois","year":"2022"},{"key":"10.1016\/j.ajpath.2025.05.025_bib68","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-nutr-071816-064642","article-title":"Mechanisms underlying muscle protein imbalance induced by alcohol","volume":"38","author":"Kimball","year":"2018","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.ajpath.2025.05.025_bib69","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb1101-1014","article-title":"Akt\/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo","volume":"3","author":"Bodine","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib70","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11010-018-3488-4","article-title":"Ethanol acutely antagonizes the refeeding-induced increase in mTOR-dependent protein synthesis and decrease in autophagy in skeletal muscle","volume":"456","author":"Steiner","year":"2019","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ajpath.2025.05.025_bib71","doi-asserted-by":"crossref","first-page":"C1557","DOI":"10.1152\/ajpcell.00407.2011","article-title":"Rag GTPases and AMPK\/TSC2\/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine","volume":"302","author":"Hong-Brown","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib72","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/biom14050527","article-title":"The influence of stress and binge-patterned alcohol drinking on mouse skeletal muscle protein synthesis and degradation pathways","volume":"14","author":"Reed","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.ajpath.2025.05.025_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2023.111914","article-title":"Mealtime alcohol consumption suppresses skeletal muscle mTORC1 signaling in female mice","volume":"566-567","author":"Bridges","year":"2023","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib74","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13929","article-title":"Lack of sexual dimorphism on the inhibitory effect of alcohol on muscle protein synthesis in rats under basal conditions and after anabolic stimulation","volume":"6","author":"Lang","year":"2018","journal-title":"Physiol Rep"},{"key":"10.1016\/j.ajpath.2025.05.025_bib75","doi-asserted-by":"crossref","first-page":"R1777","DOI":"10.1152\/ajpregu.00056.2008","article-title":"Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscle","volume":"294","author":"Vary","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib76","doi-asserted-by":"crossref","first-page":"R887","DOI":"10.1152\/ajpregu.00083.2013","article-title":"Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius","volume":"304","author":"Korzick","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib77","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1093\/infdis\/jir508","article-title":"Disrupted anabolic and catabolic processes may contribute to alcohol-accentuated SAIDS-associated wasting","volume":"204","author":"LeCapitaine","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2025.05.025_bib78","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbagen.2009.05.007","article-title":"Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy","volume":"1800","author":"Marzetti","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2025.05.025_bib79","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1126\/science.175.4019.327","article-title":"Ethanol produces muscle damage in human volunteers","volume":"175","author":"Song","year":"1972","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2025.05.025_bib80","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.freeradbiomed.2019.09.031","article-title":"Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy","volume":"145","author":"Kumar","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ajpath.2025.05.025_bib81","doi-asserted-by":"crossref","first-page":"91","DOI":"10.33594\/000000327","article-title":"Multiomics-identified intervention to restore ethanol-induced dysregulated proteostasis and secondary sarcopenia in alcoholic liver disease","volume":"55","author":"Singh","year":"2021","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.ajpath.2025.05.025_bib82","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1111\/acer.14453","article-title":"Ethanol-impaired myogenic differentiation is associated with decreased myoblast glycolytic function","volume":"44","author":"Levitt","year":"2020","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib83","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1083\/jcb.201312066","article-title":"Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling","volume":"205","author":"Eisner","year":"2014","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib84","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1096\/fj.201903166R","article-title":"Alcohol induces mitochondrial fragmentation and stress responses to maintain normal muscle function in Caenorhabditis elegans","volume":"34","author":"Oh","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2025.05.025_bib85","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/ana.410310509","article-title":"Oxidative metabolism in muscle mitochondria from patients with chronic alcoholism","volume":"31","author":"Cardellach","year":"1992","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib86","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0024-3205(82)90637-3","article-title":"The interaction of endurance running and ethanol on skeletal muscle mitochondria","volume":"30","author":"Farrar","year":"1982","journal-title":"Life Sci"},{"key":"10.1016\/j.ajpath.2025.05.025_bib87","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1097\/01.ALC.0000145787.66405.59","article-title":"Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism","volume":"28","author":"Lang","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib88","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3389\/fphys.2020.00749","article-title":"PPARdelta attenuates alcohol-mediated insulin resistance by enhancing fatty acid-induced mitochondrial uncoupling and antioxidant defense in skeletal muscle","volume":"11","author":"Koh","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149968","article-title":"Binge alcohol induces NRF2-related antioxidant response in the skeletal muscle of female mice","volume":"714","author":"Tice","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2025.05.025_bib90","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/acer.12771","article-title":"Alcohol differentially alters extracellular matrix and adhesion molecule expression in skeletal muscle and heart","volume":"39","author":"Steiner","year":"2015","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib91","first-page":"60","article-title":"Effects of increased matrix metalloproteinase-9 expression on skeletal muscle fibrosis in prolonged alcoholic myopathies of rats","volume":"5","author":"Wang","year":"2012","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.ajpath.2025.05.025_bib92","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jcb.24945","article-title":"Adamts1 mediates ethanol-induced alterations in collagen and elastin via a FoxO1-sestrin3-AMPK signaling cascade in myocytes","volume":"116","author":"Hong-Brown","year":"2015","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.ajpath.2025.05.025_bib93","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2050-490X-1-2","article-title":"Chronic alcohol ingestion delays skeletal muscle regeneration following injury","volume":"1","author":"Dekeyser","year":"2013","journal-title":"Regen Med Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib94","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3390\/biom10030441","article-title":"Chronic alcohol dysregulates skeletal muscle myogenic gene expression after hind limb immobilization in female rats","volume":"10","author":"Levitt","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.ajpath.2025.05.025_bib95","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/acer.14221","article-title":"Chronic alcohol consumption enhances skeletal muscle wasting in mice bearing cachectic cancers: the role of TNFalpha\/Myostatin Axis","volume":"44","author":"Li","year":"2020","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib96","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/j.2040-4603.2015.tb00646.x","article-title":"Satellite cells and skeletal muscle regeneration","volume":"5","author":"Dumont","year":"2015","journal-title":"Compr Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib97","doi-asserted-by":"crossref","first-page":"R837","DOI":"10.1152\/ajpregu.00502.2013","article-title":"Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques","volume":"306","author":"Simon","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib98","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/07487304221141464","article-title":"Chronic alcohol consumption disrupts the skeletal muscle circadian clock in female mice","volume":"38","author":"Tice","year":"2023","journal-title":"J Biol Rhythms"},{"key":"10.1016\/j.ajpath.2025.05.025_bib99","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bbrc.2016.09.117","article-title":"Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle","volume":"479","author":"Khayrullin","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2025.05.025_bib100","doi-asserted-by":"crossref","first-page":"E606","DOI":"10.1152\/ajpendo.00187.2021","article-title":"Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids","volume":"321","author":"Tice","year":"2021","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2025.05.025_bib101","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.alcohol.2022.05.005","article-title":"Alcohol use in older adult US population: trends, causes and consequences","volume":"107","author":"Keyes","year":"2023","journal-title":"Alcohol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib102","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.exger.2012.03.019","article-title":"Alcohol use disorders in the elderly: a brief overview from epidemiology to treatment options","volume":"47","author":"Caputo","year":"2012","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib103","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jcsm.12411","article-title":"Sarcopenia and its association with falls and fractures in older adults: a systematic review and meta-analysis","volume":"10","author":"Yeung","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ajpath.2025.05.025_bib104","article-title":"Frailty syndrome in women with osteoporosis, should physicians consider screening? A cross-sectional study","volume":"19","author":"Rahimipour Anaraki","year":"2023","journal-title":"Bone Rep"},{"key":"10.1016\/j.ajpath.2025.05.025_bib105","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1038\/s41598-019-38893-0","article-title":"Skeletal muscle mass as a mortality predictor among nonagenarians and centenarians: a prospective cohort study","volume":"9","author":"Wang","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2025.05.025_bib106","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejim.2015.04.013","article-title":"Muscular strength as a strong predictor of mortality: a narrative review","volume":"26","author":"Volaklis","year":"2015","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ajpath.2025.05.025_bib107","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1249\/MSS.0000000000001448","article-title":"Associations of muscle mass and strength with all-cause mortality among US older adults","volume":"50","author":"Li","year":"2018","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.ajpath.2025.05.025_bib108","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2012-001722","article-title":"Emergency department visits for fall-related fractures among older adults in the USA: a retrospective cross-sectional analysis of the National Electronic Injury Surveillance System All Injury Program, 2001-2008","volume":"3","author":"Orces","year":"2013","journal-title":"BMJ Open"},{"key":"10.1016\/j.ajpath.2025.05.025_bib109","first-page":"255","article-title":"Increase in fall-related hospitalizations in the United States, 2001-2008","volume":"71","author":"Hartholt","year":"2011","journal-title":"J Trauma"},{"key":"10.1016\/j.ajpath.2025.05.025_bib110","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12877-017-0507-3","article-title":"High prevalence of sarcopenia among binge drinking elderly women: a nationwide population-based study","volume":"17","author":"Yoo","year":"2017","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.ajpath.2025.05.025_bib111","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/GME.0000000000000879","article-title":"Associations between high-risk alcohol consumption and sarcopenia among postmenopausal women","volume":"24","author":"Kwon","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.ajpath.2025.05.025_bib112","doi-asserted-by":"crossref","first-page":"G241","DOI":"10.1152\/ajpgi.00373.2020","article-title":"Sarcopenia in chronic liver disease: mechanisms and countermeasures","volume":"320","author":"Allen","year":"2021","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib113","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1016\/j.clnu.2020.03.032","article-title":"Skeletal muscle loss phenotype in cirrhosis: A nationwide analysis of hospitalized patients","volume":"39","author":"Vural","year":"2020","journal-title":"Clin Nutr"},{"key":"10.1016\/j.ajpath.2025.05.025_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109498","article-title":"L-Isoleucine reverses hyperammonemia-induced myotube mitochondrial dysfunction and post-mitotic senescence","volume":"123","author":"Kumar","year":"2024","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.ajpath.2025.05.025_bib115","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13852","article-title":"Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin-mediated deacetylation","volume":"22","author":"Mishra","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.ajpath.2025.05.025_bib116","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s40520-021-01902-2","article-title":"Excessive alcohol intake and liver fibrosis are associated with skeletal muscle mass reduction in elderly men: the Wakayama study","volume":"34","author":"Onishi","year":"2022","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib117","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1016\/j.clnesp.2016.04.002","article-title":"Macronutrient and alcohol intake is associated with intermuscular adipose tissue in a randomly selected group of younger and older men and women","volume":"13","author":"Sj\u00f6holm","year":"2016","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.ajpath.2025.05.025_bib118","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1530-0277.2007.00549.x","article-title":"Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wasting","volume":"32","author":"Molina","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib119","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1186\/s12864-015-2329-z","article-title":"Chronic binge alcohol administration dysregulates global regulatory gene networks associated with skeletal muscle wasting in simian immunodeficiency virus-infected macaques","volume":"16","author":"Simon","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ajpath.2025.05.025_bib120","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1111\/acer.12545","article-title":"Chronic binge alcohol administration accentuates expression of pro-fibrotic and inflammatory genes in the skeletal muscle of simian immunodeficiency virus-infected macaques","volume":"38","author":"Dodd","year":"2014","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib121","first-page":"298","article-title":"Chronic binge alcohol-induced dysregulation of mitochondrial-related genes in skeletal muscle of simian immunodeficiency virus-infected rhesus macaques at end-stage disease","volume":"52","author":"Duplanty","year":"2017","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib122","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13625","article-title":"Myoblast mitochondrial respiration is decreased in chronic binge alcohol administered simian immunodeficiency virus-infected antiretroviral-treated rhesus macaques","volume":"6","author":"Duplanty","year":"2018","journal-title":"Physiol Rep"},{"key":"10.1016\/j.ajpath.2025.05.025_bib123","doi-asserted-by":"crossref","first-page":"R240","DOI":"10.1152\/ajpregu.00146.2017","article-title":"Decreased myoblast differentiation in chronic binge alcohol-administered simian immunodeficiency virus-infected male macaques: role of decreased miR-206","volume":"313","author":"Simon","year":"2017","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib124","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1152\/physiolgenomics.00043.2019","article-title":"Epigenomic mechanisms of alcohol-induced impaired differentiation of skeletal muscle stem cells; role of Class IIA histone deacetylases","volume":"51","author":"Adler","year":"2019","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.ajpath.2025.05.025_bib125","doi-asserted-by":"crossref","first-page":"C1626","DOI":"10.1152\/ajpcell.00290.2024","article-title":"Extracellular vesicle miR-206 improves chronic binge alcohol-mediated decreased myoblast differentiation in SIV-infected female macaques","volume":"327","author":"Bourgeois","year":"2024","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib126","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1111\/acer.14941","article-title":"Alcohol use, physical activity, and muscle strength moderate the relationship between body composition and frailty risk among people living with HIV","volume":"46","author":"Levitt","year":"2022","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib127","doi-asserted-by":"crossref","first-page":"100411","DOI":"10.18632\/oncotarget.22243","article-title":"Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ajpath.2025.05.025_bib128","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002761","article-title":"Cost-effectiveness of financial incentives for improving diet and health through Medicare and Medicaid: a microsimulation study","volume":"16","author":"Lee","year":"2019","journal-title":"PLoS Med"},{"key":"10.1016\/j.ajpath.2025.05.025_bib129","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002981","article-title":"Cardiometabolic disease costs associated with suboptimal diet in the United States: a cost analysis based on a microsimulation model","volume":"16","author":"Jardim","year":"2019","journal-title":"PLoS Med"},{"key":"10.1016\/j.ajpath.2025.05.025_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167584","article-title":"Chronic alcohol consumption exacerbates ischemia-associated skeletal muscle mitochondrial dysfunction in a murine model of peripheral artery disease","volume":"1871","author":"Fletcher","year":"2025","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.ajpath.2025.05.025_bib131","article-title":"Relationships between alcohol use, musculoskeletal pain, and work-related burnout","volume":"58","author":"Chen","year":"2022","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.ajpath.2025.05.025_bib132","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/s0304-3959(02)00372-x","article-title":"Musculoskeletal pain in the Netherlands: prevalences, consequences and risk groups, the DMC(3)-study","volume":"102","author":"Picavet","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.ajpath.2025.05.025_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.136119","article-title":"Alcohol amplifies cingulate cortex signaling and facilitates immobilization-induced hyperalgesia in female rats","volume":"761","author":"Cucinello-Ragland","year":"2021","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.ajpath.2025.05.025_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2020.108475","article-title":"Sex moderates the effects of experimentally induced musculoskeletal pain on alcohol demand in healthy drinkers","volume":"219","author":"Stennett","year":"2021","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.ajpath.2025.05.025_bib135","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.nmd.2021.07.005","article-title":"Exploring the influence of smoking and alcohol consumption on clinical severity in patients with facioscapulohumeral muscular dystrophy","volume":"31","author":"Vincenten","year":"2021","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.ajpath.2025.05.025_bib136","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1186\/s12889-023-16773-7","article-title":"Lifestyle risk factors of self-reported fibromyalgia in the Norwegian Women and Cancer (NOWAC) study","volume":"23","author":"Benebo","year":"2023","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ajpath.2025.05.025_bib137","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1002\/ejp.2012","article-title":"Lifestyle behaviour in adolescence and musculoskeletal pain 11 years later: the Trondelag Health Study","volume":"26","author":"Smedbraten","year":"2022","journal-title":"Eur J Pain"},{"key":"10.1016\/j.ajpath.2025.05.025_bib138","doi-asserted-by":"crossref","DOI":"10.1177\/17448069221075345","article-title":"Probiotics attenuate alcohol-induced muscle mechanical hyperalgesia: preliminary observations","volume":"18","author":"Green","year":"2022","journal-title":"Mol Pain"},{"key":"10.1016\/j.ajpath.2025.05.025_bib139","first-page":"2023","article-title":"Natural history of alcoholic myopathy: a 5-year study","volume":"22","author":"Estruch","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajpath.2025.05.025_bib140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/qjmed\/93.1.35","article-title":"Low-dose ethanol consumption allows strength recovery in chronic alcoholic myopathy","volume":"93","author":"Fernandez-Sola","year":"2000","journal-title":"QJM"},{"key":"10.1016\/j.ajpath.2025.05.025_bib141","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/mus.20168","article-title":"Effects of alcohol on skeletal and cardiac muscle","volume":"30","author":"Urbano-Marquez","year":"2004","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ajpath.2025.05.025_bib142","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/9780470511848.ch12","article-title":"Alcoholic myopathy and acetaldehyde","volume":"285","author":"Preedy","year":"2007","journal-title":"Novartis Found Symp"},{"key":"10.1016\/j.ajpath.2025.05.025_bib143","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/jcsm.12685","article-title":"Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia-reperfusion damage","volume":"12","author":"Alves","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ajpath.2025.05.025_bib144","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD(+) metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2025.05.025_bib145","article-title":"Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state","volume":"14","author":"Gao","year":"2024","journal-title":"Sci Rep"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944025002433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944025002433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:54:29Z","timestamp":1773039269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944025002433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":144,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0002944025002433"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2025.05.025","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alcohol-Mediated Skeletal Muscle Adaptations and Their Impact on Comorbidities","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2025.05.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Investigative Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}