{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:33:39Z","timestamp":1775198019538,"version":"3.50.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,20]],"date-time":"2027-01-20T00:00:00Z","timestamp":1800403200000},"content-version":"am","delay-in-days":353,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R35 HL155652"],"award-info":[{"award-number":["R35 HL155652"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ajpath.2025.09.012","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:14:04Z","timestamp":1760742844000},"page":"618-632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prostaglandin E2 Signaling Triggers CD31-Independent Transendothelial Migration in Vitro and in Vivo"],"prefix":"10.1016","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6968-1463","authenticated-orcid":false,"given":"Vanessa","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-827X","authenticated-orcid":false,"given":"Michael A.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-2757","authenticated-orcid":false,"given":"William A.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2025.09.012_bib1","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1084\/jem.20040965","article-title":"Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration","volume":"200","author":"Shaw","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib2","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1083\/jcb.200112126","article-title":"Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes","volume":"157","author":"Barreiro","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib3","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.4049\/jimmunol.157.9.3995","article-title":"L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity","volume":"157","author":"Tu","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1084\/jem.178.2.449","article-title":"PECAM-1 is required for transendothelial migration of leukocytes","volume":"178","author":"Muller","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib5","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature01300","article-title":"Targeted recycling of PECAM from endothelial cell surface-connected compartments during diapedesis","volume":"421","author":"Mamdouh","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2025.09.012_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ni749","article-title":"CD99 plays a major role in the migration of monocytes through endothelial junctions","volume":"3","author":"Schenkel","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/15419060701755966","article-title":"The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response","volume":"14","author":"Schenkel","year":"2007","journal-title":"Cell Commun Adhes"},{"key":"10.1016\/j.ajpath.2025.09.012_bib8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.yexmp.2015.08.011","article-title":"CD99-like 2 (CD99L2)-deficient mice are defective in the acute inflammatory response","volume":"99","author":"Rutledge","year":"2015","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib9","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1182\/blood-2009-12-256388","article-title":"CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis","volume":"116","author":"Bixel","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2025.09.012_bib10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-pathol-011110-130224","article-title":"Mechanisms of leukocyte transendothelial migration","volume":"6","author":"Muller","year":"2011","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib11","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1161\/ATVBAHA.107.145821","article-title":"Endothelial signaling by Ig-like cell adhesion molecules","volume":"27","author":"van Buul","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/cvr\/cvq003","article-title":"The regulation of leucocyte transendothelial migration by endothelial signalling events","volume":"86","author":"Fernandez-Borja","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ajpath.2025.09.012_bib13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nrm2889","article-title":"Breaching multiple barriers: leukocyte motility through venular walls and the interstitium","volume":"11","author":"Nourshargh","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1084\/jem.179.3.1059","article-title":"Monoclonal antibody to murine PECAM-1 [CD31] blocks acute inflammation in vivo","volume":"179","author":"Bogen","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib15","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1084\/jem.185.7.1349","article-title":"Soluble domain 1 of platelet-endothelial cell adhesion molecule (PECAM) is sufficient to block transendothelial migration in vitro and in vivo","volume":"185","author":"Liao","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib16","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.4049\/jimmunol.173.10.6403","article-title":"Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains","volume":"173","author":"Schenkel","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib17","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.4049\/jimmunol.162.5.3022","article-title":"Genetic evidence for functional redundancy of platelet\/endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions","volume":"162","author":"Duncan","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib18","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1182\/blood.V97.6.1854","article-title":"Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane","volume":"97","author":"Thompson","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2025.09.012_bib19","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1084\/jem.20020324","article-title":"PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane","volume":"196","author":"Dangerfield","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1172\/JCI0213595","article-title":"Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice","volume":"109","author":"Graesser","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2025.09.012_bib21","doi-asserted-by":"crossref","first-page":"6455","DOI":"10.4049\/jimmunol.168.12.6455","article-title":"Absence of platelet endothelial cell adhesion molecule-1 (CD31) leads to increased severity of local and systemic IgE-mediated anaphylaxis and modulation of mast cell activation","volume":"168","author":"Wong","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib22","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0002-9440(10)63890-4","article-title":"Lack of platelet endothelial cell adhesion molecule-1 attenuates foreign body inflammation because of decreased angiogenesis","volume":"162","author":"Solowiej","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib23","doi-asserted-by":"crossref","first-page":"H621","DOI":"10.1152\/ajpheart.00289.2016","article-title":"4D intravital microscopy uncovers critical strain differences for the roles of PECAM and CD99 in leukocyte diapedesis","volume":"311","author":"Sullivan","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004316","article-title":"PECAM-independent thioglycollate peritonitis is associated with a locus on murine chromosome 2","volume":"4","author":"Seidman","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2025.09.012_bib25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41392-020-00443-w","article-title":"Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ajpath.2025.09.012_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.plefa.2013.04.004","article-title":"The role of prostaglandin E2 in human vascular inflammation","volume":"89","author":"Gomez","year":"2013","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.ajpath.2025.09.012_bib27","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tips.2012.02.004","article-title":"Prostaglandins and chronic inflammation","volume":"33","author":"Aoki","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.ajpath.2025.09.012_bib28","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib29","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1074\/jbc.R600038200","article-title":"Prostaglandin E receptors","volume":"282","author":"Sugimoto","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2025.09.012_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0031-6997(25)06784-5","article-title":"International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes","volume":"46","author":"Coleman","year":"1994","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.ajpath.2025.09.012_bib31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/365166a0","article-title":"Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity","volume":"365","author":"Namba","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2025.09.012_bib32","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1432-1033.1993.tb18248.x","article-title":"Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase","volume":"217","author":"Irie","year":"1993","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.ajpath.2025.09.012_bib33","doi-asserted-by":"crossref","first-page":"14496","DOI":"10.1021\/bi00252a016","article-title":"Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals","volume":"33","author":"An","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.ajpath.2025.09.012_bib34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1006\/bbrc.1997.6655","article-title":"Two isoforms of prostaglandin EP3 receptor exhibiting constitutive activity and agonist-dependent activity in rho-mediated stress fiber formation","volume":"234","author":"Hasegawa","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2025.09.012_bib35","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1016\/S0021-9258(18)53832-1","article-title":"Two isoforms of the EP3 receptor with different carboxyl-terminal domains: identical ligand binding properties and different coupling properties with Gi proteins","volume":"268","author":"Sugimoto","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2025.09.012_bib36","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1084\/jem.20150353","article-title":"TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response","volume":"212","author":"Weber","year":"2015","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1084\/jem.170.2.399","article-title":"A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions","volume":"170","author":"Muller","year":"1989","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib38","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.176.3.819","article-title":"Monocyte-selective transendothelial migration: dissection of the binding and transmigration phases by an in vitro assay","volume":"176","author":"Muller","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib39","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1073\/pnas.80.18.5699","article-title":"Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies","volume":"80","author":"Wright","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2025.09.012_bib40","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1084\/jem.171.5.1753","article-title":"The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies","volume":"171","author":"Metlay","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib41","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.ajpath.2016.01.010","article-title":"Targeted recycling of the lateral border recycling compartment precedes adherens junction dissociation during transendothelial migration","volume":"186","author":"Gonzalez","year":"2016","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib42","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0092-8674(93)90398-A","article-title":"Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development","volume":"72","author":"Ehlich","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2025.09.012_bib43","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.immuni.2023.08.001","article-title":"Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis","volume":"56","author":"Fu","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.ajpath.2025.09.012_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.739","article-title":"Methods for imaging inflammation and transendothelial migration in vivo and ex vivo","volume":"3","author":"Fang","year":"2023","journal-title":"Curr Protoc"},{"key":"10.1016\/j.ajpath.2025.09.012_bib45","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1182\/blood-2002-01-0027","article-title":"Platelet endothelial cell adhesion molecule-1 (PECAM-1\/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease","volume":"100","author":"Wilkinson","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2025.09.012_bib46","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0002-9440(10)64519-1","article-title":"PECAM-1 (CD31) expression modulates bleeding time in vivo","volume":"157","author":"Mahooti","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1182\/blood-2003-01-0003","article-title":"PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis","volume":"102","author":"Gao","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2025.09.012_bib48","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1182\/blood.V97.6.1727","article-title":"Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen","volume":"97","author":"Patil","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2025.09.012_bib49","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0006-291X(03)00313-9","article-title":"PECAM-1 promotes beta-catenin accumulation and stimulates endothelial cell proliferation","volume":"303","author":"Biswas","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2025.09.012_bib50","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0076-6879(08)02009-0","article-title":"Assays of transendothelial migration in vitro","volume":"443","author":"Muller","year":"2008","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib51","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1521-6934(03)00043-9","article-title":"Pharmacokinetics of prostaglandins","volume":"17","author":"Bygdeman","year":"2003","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/147274","article-title":"Randomized comparison of isosorbide mononitrate and PGE2 gel for cervical ripening at term including high risk pregnancy","volume":"2014","author":"Agarwal","year":"2014","journal-title":"Int J Reprod Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib53","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1210\/endo.137.6.8641211","article-title":"Prostaglandin E2 activates phospholipase C and elevates intracellular calcium in cultured myometrial cells: involvement of EP1 and EP3 receptor subtypes","volume":"137","author":"Asb\u00f3th","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2025.09.012_bib54","doi-asserted-by":"crossref","first-page":"14509","DOI":"10.1016\/S0021-9258(17)36652-8","article-title":"cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets","volume":"269","author":"Butt","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2025.09.012_bib55","doi-asserted-by":"crossref","first-page":"14320","DOI":"10.1073\/pnas.0507072102","article-title":"Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration","volume":"102","author":"Howe","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2025.09.012_bib56","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/312315a0","article-title":"Inositol trisphosphate, a novel second messenger in cellular signal transduction","volume":"312","author":"Berridge","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2025.09.012_bib57","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/16711","article-title":"Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol","volume":"397","author":"Hofmann","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2025.09.012_bib58","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1083\/jcb.120.6.1371","article-title":"Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells","volume":"120","author":"Huang","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1054\/ceca.2001.0210","article-title":"Endothelial intracellular Ca2+ release following monocyte adhesion is required for the transendothelial migration of monocytes","volume":"30","author":"Kielbassa-Schnepp","year":"2001","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ajpath.2025.09.012_bib60","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1083\/jcb.200404129","article-title":"A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them","volume":"167","author":"Carman","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib61","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1084\/jem.20190008","article-title":"Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis","volume":"216","author":"Sullivan","year":"2019","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2025.09.012_bib62","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41583-022-00624-2","article-title":"CaMKII: a central molecular organizer of synaptic plasticity, learning and memory","volume":"23","author":"Yasuda","year":"2022","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ajpath.2025.09.012_bib63","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1002\/eji.200838605","article-title":"Endothelial Src kinase regulates membrane recycling from the lateral border recycling compartment during leukocyte transendothelial migration","volume":"38","author":"Dasgupta","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2025.09.012_bib64","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.4049\/jimmunol.0803192","article-title":"A novel and critical role for tyrosine 663 in PECAM trafficking and transendothelial migration","volume":"182","author":"Dasgupta","year":"2009","journal-title":"J Immunol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944025003761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944025003761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T01:10:03Z","timestamp":1775178603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944025003761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0002944025003761"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2025.09.012","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prostaglandin E2 Signaling Triggers CD31-Independent Transendothelial Migration in Vitro and in Vivo","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2025.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Investigative Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}