{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:40:05Z","timestamp":1777549205907,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M762496"],"award-info":[{"award-number":["2024M762496"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20241270"],"award-info":[{"award-number":["GZC20241270"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503327"],"award-info":[{"award-number":["82503327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8250113914"],"award-info":[{"award-number":["8250113914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013064","name":"Key Research and Development Program of Jiangxi Province","doi-asserted-by":"publisher","award":["20243BBI91023"],"award-info":[{"award-number":["20243BBI91023"]}],"id":[{"id":"10.13039\/501100013064","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ajpath.2025.12.002","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:05:19Z","timestamp":1767139519000},"page":"836-849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optic Atrophy 1\u2013Mediated Mitochondrial Hyperfusion Orchestrates Yes-Associated Protein 1 Nuclear Translocation to Sustain Ameloblastoma Stemness"],"prefix":"10.1016","volume":"196","author":[{"given":"Jia-Jie","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Han","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-Xuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo-Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Zhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2025.12.002_bib1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/odi.12646","article-title":"Ameloblastoma: current etiopathological concepts and management","volume":"24","author":"Effiom","year":"2018","journal-title":"Oral Dis"},{"key":"10.1016\/j.ajpath.2025.12.002_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/odi.12702","article-title":"Ameloblastoma-clinical, radiological, and therapeutic findings","volume":"24","author":"Kreppel","year":"2018","journal-title":"Oral Dis"},{"key":"10.1016\/j.ajpath.2025.12.002_bib3","first-page":"168","article-title":"The World Health Organization classification of odontogenic lesions: a summary of the changes of the 2022 (5th) edition","volume":"38","author":"Soluk-Tekkesin","year":"2022","journal-title":"Turk Patoloji Derg"},{"key":"10.1016\/j.ajpath.2025.12.002_bib4","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.3390\/jcm13175339","article-title":"The effect of conservative vs. radical treatment of ameloblastoma on recurrence rate and quality of life: an umbrella review","volume":"13","author":"Gasparro","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.ajpath.2025.12.002_bib5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ijom.2015.12.016","article-title":"Recurrence rate following treatment for primary multicystic ameloblastoma: systematic review and meta-analysis","volume":"45","author":"Almeida Rde","year":"2016","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajpath.2025.12.002_bib6","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1186\/s12885-018-4802-y","article-title":"Clinical benefit and radiological response with BRAF inhibitor in a patient with recurrent ameloblastoma harboring V600E mutation","volume":"18","author":"Fernandes","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ajpath.2025.12.002_bib7","doi-asserted-by":"crossref","first-page":"217448","DOI":"10.1016\/j.canlet.2025.217448","article-title":"From pathogenesis to precision medicine: transformative advances in research and treatment of ameloblastoma","volume":"612","author":"Zhao","year":"2025","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajpath.2025.12.002_bib8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/oncolo\/oyae119","article-title":"Phase II study of vemurafenib in children and young adults with tumors harboring BRAF V600 mutations: NCI-COG pediatric MATCH trial (APEC1621) arm G","volume":"29","author":"Nelson","year":"2024","journal-title":"Oncologist"},{"key":"10.1016\/j.ajpath.2025.12.002_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/00220345241282256","article-title":"Trends in research of odontogenic keratocyst and ameloblastoma","volume":"104","author":"Liu","year":"2025","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajpath.2025.12.002_bib10","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41419-020-2560-7","article-title":"LGR5+ epithelial tumor stem-like cells generate a 3D-organoid model for ameloblastoma","volume":"11","author":"Chang","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajpath.2025.12.002_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41368-024-00281-4","article-title":"Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma","volume":"16","author":"Xiong","year":"2024","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.ajpath.2025.12.002_bib12","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.stem.2024.04.004","article-title":"Hallmarks of cancer stemness","volume":"31","author":"Loh","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2025.12.002_bib13","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.tcb.2023.03.009","article-title":"Mitochondria in cancer stem cells: Achilles heel or hard armor","volume":"33","author":"Zheng","year":"2023","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.ajpath.2025.12.002_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ajpath.2025.12.002_bib15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.mito.2021.06.004","article-title":"The differences in mitochondrial function, mitochondrial dynamics, and cell death between odontogenic cysts\/tumors and normal dental follicles","volume":"59","author":"Suppamaeteekulwat","year":"2021","journal-title":"Mitochondrion"},{"key":"10.1016\/j.ajpath.2025.12.002_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41580-024-00785-1","article-title":"Molecular mechanisms of mitochondrial dynamics","volume":"26","author":"T\u00e1bara","year":"2025","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2025.12.002_bib17","first-page":"32","article-title":"Mitochondrial quality control in human health and disease","volume":"11","author":"Liu","year":"2024","journal-title":"Mil Med Res"},{"key":"10.1016\/j.ajpath.2025.12.002_bib18","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1152\/physrev.00058.2021","article-title":"Mitochondria in health, disease, and aging","volume":"103","author":"Harrington","year":"2023","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ajpath.2025.12.002_bib19","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41580-025-00854-z","article-title":"Molecular machineries shaping the mitochondrial inner membrane","volume":"26","author":"Daumke","year":"2025","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2025.12.002_bib20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1177\/00220345231165209","article-title":"PD-1 carried on small extracellular vesicles leads to OSCC metastasis","volume":"102","author":"Zhang","year":"2023","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajpath.2025.12.002_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2023.100398","article-title":"Deep learning-based h-score quantification of immunohistochemistry-stained images","volume":"37","author":"Wen","year":"2024","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ajpath.2025.12.002_bib22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajpath.2025.12.002_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1161\/CIRCULATIONAHA.117.031258","article-title":"Epigenetic dysregulation of the dynamin-related protein 1 binding partners MiD49 and MiD51 increases mitotic mitochondrial fission and promotes pulmonary arterial hypertension: mechanistic and therapeutic implications","volume":"138","author":"Chen","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ajpath.2025.12.002_bib24","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1158\/0008-5472.CAN-21-3910","article-title":"Mitochondrial micropeptide STMP1 enhances mitochondrial fission to promote tumor metastasis","volume":"82","author":"Xie","year":"2022","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2025.12.002_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajpath.2025.12.002_bib26","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajpath.2025.12.002_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btac757","article-title":"GSEApy: a comprehensive package for performing gene set enrichment analysis in Python","volume":"39","author":"Fang","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajpath.2025.12.002_bib28","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1177\/00220345251340892","article-title":"Single-cell insights into unicystic and solid ameloblastoma heterogeneity","volume":"104","author":"Feng","year":"2025","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajpath.2025.12.002_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41368-025-00364-w","article-title":"Programmed death-ligand 1 regulates ameloblastoma growth and recurrence","volume":"17","author":"Zhang","year":"2025","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.ajpath.2025.12.002_bib30","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1038\/s41418-021-00747-6","article-title":"Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism","volume":"28","author":"Corrado","year":"2021","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.ajpath.2025.12.002_bib31","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41586-023-06441-6","article-title":"Structural mechanism of mitochondrial membrane remodelling by human OPA1","volume":"620","author":"von der Malsburg","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2025.12.002_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41392-020-0170-6","article-title":"p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer","volume":"5","author":"Wen","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ajpath.2025.12.002_bib33","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41573-025-01234-0","article-title":"Targeting the Hippo pathway in cancer","volume":"24","author":"Harvey","year":"2025","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.ajpath.2025.12.002_bib34","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41580-023-00644-5","article-title":"Control of stem cell renewal and fate by YAP and TAZ","volume":"24","author":"Driskill","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2025.12.002_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/jop.13611","article-title":"Radiologic specific growth rate of ameloblastomas: a clinicopathological correlation","volume":"54","author":"Smit","year":"2025","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.ajpath.2025.12.002_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adx4562","article-title":"Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors","volume":"11","author":"Pellattiero","year":"2025","journal-title":"Sci Adv"},{"key":"10.1016\/j.ajpath.2025.12.002_bib37","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.oraloncology.2017.07.021","article-title":"Oncogenic signalling pathways in benign odontogenic cysts and tumours","volume":"72","author":"Diniz","year":"2017","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ajpath.2025.12.002_bib38","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41556-018-0124-1","article-title":"The multifaceted contributions of mitochondria to cellular metabolism","volume":"20","author":"Spinelli","year":"2018","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2025.12.002_bib39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12943-025-02265-2","article-title":"Cancer stem cells and niches: challenges in immunotherapy resistance","volume":"24","author":"Pan","year":"2025","journal-title":"Mol Cancer"},{"key":"10.1016\/j.ajpath.2025.12.002_bib40","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12943-018-0882-1","article-title":"The role of YAP\/TAZ activity in cancer metabolic reprogramming","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol Cancer"},{"key":"10.1016\/j.ajpath.2025.12.002_bib41","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41467-024-55660-6","article-title":"YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution","volume":"16","author":"Faraji","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2025.12.002_bib42","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1177\/00220345251336164","article-title":"Epithelial YAP1 regulates ameloblast differentiation through SHH\/FGF signaling","volume":"104","author":"Zheng","year":"2025","journal-title":"J Dental Res"},{"key":"10.1016\/j.ajpath.2025.12.002_bib43","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1007\/s00784-018-2693-6","article-title":"Yes-associated protein (YAP) molecule expression in odontogenic epithelium of ameloblastoma","volume":"23","author":"Anand","year":"2018","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.ajpath.2025.12.002_bib44","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1111\/odi.14882","article-title":"Does YAP influence cell proliferation and apoptosis in benign epithelial odontogenic lesions?","volume":"30","author":"Gon\u00e7alo","year":"2024","journal-title":"Oral Dis"},{"key":"10.1016\/j.ajpath.2025.12.002_bib45","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12105-024-01686-7","article-title":"Factors associated with recurrence of ameloblastoma: a scoping review","volume":"18","author":"Inthong","year":"2024","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.ajpath.2025.12.002_bib46","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/MOO.0000000000000238","article-title":"Ameloblastomas of the mandible and maxilla","volume":"24","author":"Parmar","year":"2016","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ajpath.2025.12.002_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jdsr.2020.12.003","article-title":"Molecular biological findings of ameloblastoma","volume":"57","author":"Fuchigami","year":"2021","journal-title":"Jpn Dent Sci Rev"},{"key":"10.1016\/j.ajpath.2025.12.002_bib48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12032-023-01993-z","article-title":"BRAF inhibitors in BRAF V600E-mutated ameloblastoma: systematic review of rare cases in the literature","volume":"40","author":"Ebeling","year":"2023","journal-title":"Med Oncol"},{"key":"10.1016\/j.ajpath.2025.12.002_bib49","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jcms.2023.10.003","article-title":"Current concepts in targeted therapies for benign tumors of the jaw - a review of the literature","volume":"51","author":"Graillon","year":"2023","journal-title":"J Craniomaxillofac Surg"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944025004626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944025004626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:47:44Z","timestamp":1777398464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944025004626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0002944025004626"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2025.12.002","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optic Atrophy 1\u2013Mediated Mitochondrial Hyperfusion Orchestrates Yes-Associated Protein 1 Nuclear Translocation to Sustain Ameloblastoma Stemness","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2025.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Investigative Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}