{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:22:17Z","timestamp":1791858137745,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30-CA060553"],"award-info":[{"award-number":["P30-CA060553"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ajpath.2026.03.010","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:24:24Z","timestamp":1775150664000},"page":"2164-2177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Platelet Endothelial Cell Adhesion Molecule\u2013Dependent Leukocyte Transmigration Is an Essential Early Event in Endotoxin-Induced Uveitis"],"prefix":"10.1016","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-4738","authenticated-orcid":false,"given":"Vivienne Fang","family":"Shaver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7557-4162","authenticated-orcid":false,"given":"Maureen E.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-6107","authenticated-orcid":false,"given":"Meital A.","family":"Gewirtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7462-3898","authenticated-orcid":false,"given":"David P.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0884-1336","authenticated-orcid":false,"given":"Jeremy A.","family":"Lavine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-2757","authenticated-orcid":false,"given":"William A.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2026.03.010_bib1","article-title":"Incidence, prevalence, and risk factors of infectious uveitis and scleritis in the United States: a claims-based analysis","volume":"15","author":"Zhang","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2026.03.010_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/09273948.2016.1196713","article-title":"A focus on the epidemiology of uveitis","volume":"26","author":"Tsirouki","year":"2018","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.ajpath.2026.03.010_bib3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s40135-015-0076-6","article-title":"Infectious uveitis","volume":"3","author":"Lin","year":"2015","journal-title":"Curr Ophthalmol Rep"},{"key":"10.1016\/j.ajpath.2026.03.010_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2023.100453","article-title":"Aqueous macrophages contribute to conserved CCL2 and CXCL10 gradients in uveitis","volume":"4","author":"Lin","year":"2024","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.ajpath.2026.03.010_bib5","first-page":"1493","article-title":"MCP-1 expression in endotoxin-induced uveitis","volume":"43","author":"Tuaillon","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2026.03.010_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1165\/rcmb.2013-0142OC","article-title":"Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation","volume":"50","author":"Mercer","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2026.03.010_bib7","doi-asserted-by":"crossref","DOI":"10.1186\/cc7811","article-title":"CCR2 expression on neutrophils leads to detrimental tissue infiltration during sepsis","volume":"13","author":"Souto","year":"2009","journal-title":"Crit Care"},{"key":"10.1016\/j.ajpath.2026.03.010_bib8","doi-asserted-by":"crossref","first-page":"10883","DOI":"10.1074\/jbc.M309901200","article-title":"Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils","volume":"279","author":"Arndt","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2026.03.010_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-pathol-011110-130224","article-title":"Mechanisms of leukocyte transendothelial migration","volume":"6","author":"Muller","year":"2011","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.ajpath.2026.03.010_bib10","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/labinvest.3780446","article-title":"Leukocyte-endothelial cell interactions in the inflammatory response","volume":"82","author":"Muller","year":"2002","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2026.03.010_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00281-008-0106-7","article-title":"Mechanisms of leukocyte migration across the blood\u2013retina barrier","volume":"30","author":"Crane","year":"2008","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.ajpath.2026.03.010_bib12","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12974-021-02237-5","article-title":"Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury","volume":"18","author":"Abcouwer","year":"2021","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.ajpath.2026.03.010_bib27","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.ajpath.2022.07.008","article-title":"Platelet endothelial cell adhesion molecule (PECAM\/CD31) blockade modulates neutrophil recruitment patterns and reduces infarct size in experimental ischemic stroke","volume":"192","author":"Nadkarni","year":"2022","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2026.03.010_bib34","doi-asserted-by":"crossref","first-page":"G446","DOI":"10.1152\/ajpgi.00097.2007","article-title":"Pecam-1 (CD31) mediates transendothelial leukocyte migration in experimental colitis","volume":"293","author":"Rijcken","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.ajpath.2026.03.010_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.739","article-title":"Methods for imaging inflammation and transendothelial migration in vivo and ex vivo","volume":"3","author":"Fang","year":"2023","journal-title":"Curr Protoc"},{"key":"10.1016\/j.ajpath.2026.03.010_bib14","doi-asserted-by":"crossref","DOI":"10.3791\/61348","article-title":"Digestion of whole mouse eyes for multi-parameter flow cytometric analysis of mononuclear phagocytes","author":"Droho","year":"2020","journal-title":"J Vis Exp"},{"key":"10.1016\/j.ajpath.2026.03.010_bib15","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1167\/iovs.14-13883","article-title":"Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice","volume":"55","author":"Qiu","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2026.03.010_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3390\/vetsci10030207","article-title":"Effects of oral 5-aminolevulinic acid on lipopolysaccharide-induced ocular inflammation in rats","volume":"10","author":"Otaka","year":"2023","journal-title":"Vet Sci"},{"key":"10.1016\/j.ajpath.2026.03.010_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/s12974-018-1373-4","article-title":"Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation","volume":"15","author":"Kokona","year":"2018","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.ajpath.2026.03.010_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1006897","article-title":"More than meets the eye: the role of microglia in healthy and diseased retina","volume":"13","author":"Murenu","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2026.03.010_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nmeth.3322","article-title":"Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes","volume":"12","author":"Hasenberg","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajpath.2026.03.010_bib20","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.ajpath.2025.09.012","article-title":"Prostaglandin E2 signaling triggers CD31-independent transendothelial migration in vitro and in vivo","volume":"196","author":"Hayashi","year":"2026","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2026.03.010_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-3-7091-0693-8_29","article-title":"Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhage","volume":"111","author":"Sansing","year":"2011","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.ajpath.2026.03.010_bib22","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1182\/blood-2008-02-139634","article-title":"Neutrophil secretion products pave the way for inflammatory monocytes","volume":"112","author":"Soehnlein","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2026.03.010_bib23","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3390\/ijms21020651","article-title":"Potent and broad but not unselective cleavage of cytokines and chemokines by human neutrophil elastase and proteinase 3","volume":"21","author":"Fu","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2026.03.010_bib24","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1084\/jem.179.3.1059","article-title":"Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo","volume":"179","author":"Bogen S, Pak S, Garifallou M, Deng X, Muller WA","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2026.03.010_bib25","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.yexmp.2009.09.013","article-title":"Blocking platelet\/endothelial cell adhesion molecule 1 (PECAM) inhibits disease progression and prevents joint erosion in established collagen antibody induced arthritis","volume":"88","author":"Dasgupta","year":"2010","journal-title":"Exp Mol Pathol"},{"issue":"Suppl 1","key":"10.1016\/j.ajpath.2026.03.010_bib26","article-title":"Inhibition of PECAM-1 significantly delays leukocyte extravasation into the subcortex post-stroke","volume":"36","author":"Arias","year":"2022","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2026.03.010_bib28","doi-asserted-by":"crossref","first-page":"L112","DOI":"10.1152\/ajplung.00069.2025","article-title":"PMN recruitment in inflammatory lung injury models follows classical transendothelial migration paradigms requiring PECAM-1 and CD99","volume":"329","author":"Haynes","year":"2025","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2026.03.010_bib29","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.4049\/jimmunol.178.2.1136","article-title":"CD99 is a key mediator of the transendothelial migration of neutrophils1","volume":"178","author":"Lou","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2026.03.010_bib30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ni749","article-title":"CD99 plays a major role in the migration of monocytes through endothelial junctions","volume":"3","author":"Schenkel","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2026.03.010_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jim.2019.112677","article-title":"Comparative analysis of inflammatory response in the BALB\/c and C57BL\/6 mouse strains in an endotoxin-induced uveitis model","volume":"476","author":"Maga\u00f1a-Guerrero","year":"2020","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.ajpath.2026.03.010_bib32","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.3390\/ijms17111825","article-title":"MMP-3 deficiency alleviates endotoxin-induced acute inflammation in the posterior eye segment","volume":"17","author":"Van Hove","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2026.03.010_bib33","first-page":"473","article-title":"Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model","volume":"9","author":"Chu","year":"2016","journal-title":"Dis Model Mech"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944026000933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944026000933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:40:59Z","timestamp":1789990859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944026000933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0002944026000933"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2026.03.010","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet Endothelial Cell Adhesion Molecule\u2013Dependent Leukocyte Transmigration Is an Essential Early Event in Endotoxin-Induced Uveitis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2026.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Investigative Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}