{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:05:28Z","timestamp":1789607128833,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009156","name":"Nantong Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["JC2024005"],"award-info":[{"award-number":["JC2024005"]}],"id":[{"id":"10.13039\/501100009156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ajpath.2026.04.012","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:10:07Z","timestamp":1778548207000},"page":"1735-1754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteolipid Protein 1 Homeostatically Regulates Schwann and Endothelial Cell Function and Communication in Peripheral Nerve Repair"],"prefix":"10.1016","volume":"196","author":[{"given":"Panjian","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyue","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2026.04.012_bib1","doi-asserted-by":"crossref","first-page":"8652","DOI":"10.3390\/ijms21228652","article-title":"Peripheral nerve regeneration and muscle reinnervation","volume":"21","author":"Gordon","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2026.04.012_bib2","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1007\/s00018-020-03516-9","article-title":"Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury","volume":"77","author":"Nocera","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ajpath.2026.04.012_bib3","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041360","article-title":"Schwann cell development and myelination","volume":"16","author":"Salzer","year":"2024","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib4","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1017\/S0317167100053798","article-title":"Canadian Association of Neuroscience review: axonal regeneration in the peripheral and central nervous systems - current issues and advances","volume":"31","author":"Fenrich","year":"2004","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.ajpath.2026.04.012_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1248922","article-title":"Neuron-Schwann cell interactions in peripheral nervous system homeostasis, disease, and preclinical treatment","volume":"17","author":"Oliveira","year":"2023","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.ajpath.2026.04.012_bib6","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00401-015-1482-4","article-title":"Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury","volume":"130","author":"Chen","year":"2015","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.1129560","article-title":"Editorial: the function of Schwann cells in peripheral nervous system","volume":"16","author":"He","year":"2023","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.ajpath.2026.04.012_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/glia.23892","article-title":"Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge","volume":"69","author":"Min","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.ajpath.2026.04.012_bib9","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.7150\/thno.40919","article-title":"Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ajpath.2026.04.012_bib10","first-page":"E8072","article-title":"Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury","volume":"114","author":"Lutz","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2026.04.012_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10571-023-01442-5","article-title":"Roles of macrophages and their interactions with Schwann cells after peripheral nerve injury","volume":"44","author":"Wu","year":"2023","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib12","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.222059","article-title":"Tau modulates Schwann cell proliferation, migration and differentiation following peripheral nerve injury","volume":"132","author":"Yi","year":"2019","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2026.04.012_bib13","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1113\/JP270874","article-title":"The repair Schwann cell and its function in regenerating nerves","volume":"594","author":"Jessen","year":"2016","journal-title":"J Physiol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib14","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrg1158","article-title":"Blood vessels and nerves: common signals, pathways and diseases","volume":"4","author":"Carmeliet","year":"2003","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ajpath.2026.04.012_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature12681","article-title":"Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis","volume":"505","author":"Ding","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2026.04.012_bib16","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1016\/j.cell.2024.04.010","article-title":"Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact","volume":"187","author":"Toma","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2026.04.012_bib17","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/ar.23919","article-title":"Vascularization strategies for peripheral nerve tissue engineering","volume":"301","author":"Muangsanit","year":"2018","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.ajpath.2026.04.012_bib18","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cell.2015.07.021","article-title":"Macrophage-induced blood vessels guide Schwann cell-mediated regeneration of peripheral nerves","volume":"162","author":"Cattin","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2026.04.012_bib19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fncel.2017.00323","article-title":"Overlapping mechanisms of peripheral nerve regeneration and angiogenesis following sciatic nerve transection","volume":"11","author":"Wang","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.ajpath.2026.04.012_bib20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.conb.2017.09.003","article-title":"Schwann cells as drivers of tissue repair and regeneration","volume":"47","author":"Carr","year":"2017","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.mcn.2004.06.001","article-title":"Retrograde propagation of GDNF-mediated signals in sympathetic neurons","volume":"27","author":"Coulpier","year":"2004","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.ajpath.2026.04.012_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-60761-938-3_6","article-title":"The blood-nerve barrier: structure and functional significance","volume":"686","author":"Weerasuriya","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.21037\/atm-22-81","article-title":"Endothelial cells promote the proliferation and migration of Schwann cells","volume":"10","author":"Meng","year":"2022","journal-title":"Ann Transl Med"},{"issue":"Pt 4","key":"10.1016\/j.ajpath.2026.04.012_bib24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1469-7580.2000.19740591.x","article-title":"VEGF enhances intraneural angiogenesis and improves nerve regeneration after axotomy","volume":"197","author":"Hobson","year":"2000","journal-title":"J Anat"},{"key":"10.1016\/j.ajpath.2026.04.012_bib25","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/ar.23842","article-title":"Evaluation of vascular endothelial growth factor (VEGF) and its family member expression after peripheral nerve regeneration and denervation","volume":"301","author":"Muratori","year":"2018","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.ajpath.2026.04.012_bib26","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.4103\/1673-5374.276327","article-title":"The role of vascularization in nerve regeneration of nerve graft","volume":"15","author":"Saffari","year":"2020","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.ajpath.2026.04.012_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12272-020-01287-2","article-title":"Pathological angiogenesis and inflammation in tissues","volume":"44","author":"Jeong","year":"2021","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.ajpath.2026.04.012_bib28","doi-asserted-by":"crossref","first-page":"11169","DOI":"10.3390\/ijms222011169","article-title":"Extracellular environment-controlled angiogenesis, and potential application for peripheral nerve regeneration","volume":"22","author":"Saio","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2026.04.012_bib29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.conb.2016.04.005","article-title":"The multicellular complexity of peripheral nerve regeneration","volume":"39","author":"Cattin","year":"2016","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib30","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ncb3134","article-title":"Force transmission during adhesion-independent migration","volume":"17","author":"Bergert","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib31","doi-asserted-by":"crossref","first-page":"114514","DOI":"10.1016\/j.celrep.2024.114514","article-title":"Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration","volume":"43","author":"Fu","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2026.04.012_bib32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3390\/biom14040459","article-title":"Applications of exosomal miRNAs from mesenchymal stem cells as skin boosters","volume":"14","author":"Zheng","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.ajpath.2026.04.012_bib33","article-title":"The regulatory functionality of exosomes derived from hUMSCs in 3D culture for Alzheimer's disease therapy","volume":"16","author":"Yang","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.ajpath.2026.04.012_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159158","article-title":"Extracellular vesicles from vascular endothelial cells promote survival, proliferation and motility of oligodendrocyte precursor cells","volume":"11","author":"Kurachi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2026.04.012_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113968","article-title":"Extracellular vesicles and their role in peripheral nerve regeneration","volume":"350","author":"Hercher","year":"2022","journal-title":"Exp Neurol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib36","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.molmed.2024.03.005","article-title":"Pelizaeus-Merzbacher disease: on the cusp of myelin medicine","volume":"30","author":"Elitt","year":"2024","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.ajpath.2026.04.012_bib37","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/ana.10466","article-title":"Schwann cell expression of PLP1 but not DM20 is necessary to prevent neuropathy","volume":"53","author":"Shy","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10456-022-09858-1","article-title":"Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression","volume":"26","author":"Rocha","year":"2023","journal-title":"Angiogenesis"},{"key":"10.1016\/j.ajpath.2026.04.012_bib39","doi-asserted-by":"crossref","first-page":"e12935","DOI":"10.1111\/bpa.12935","article-title":"Mediators of cerebral hypoperfusion and blood-brain barrier leakiness in Alzheimer's disease, vascular dementia and mixed dementia","volume":"31","author":"Tayler","year":"2021","journal-title":"Brain Pathol"},{"key":"10.1016\/j.ajpath.2026.04.012_bib40","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.cell.2007.06.054","article-title":"Autocrine VEGF signaling is required for vascular homeostasis","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2026.04.012_bib41","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"Cursiefen","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2026.04.012_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay6391","article-title":"Macrophages of diverse phenotypes drive vascularization of engineered tissues","volume":"6","author":"Graney","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.ajpath.2026.04.012_bib43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.31083\/j.jin2103091","article-title":"Evaluation methods of a rat sciatic nerve crush injury model","volume":"21","author":"An","year":"2022","journal-title":"J Integr Neurosci"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944026001343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944026001343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:24:56Z","timestamp":1789604696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944026001343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0002944026001343"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2026.04.012","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteolipid Protein 1 Homeostatically Regulates Schwann and Endothelial Cell Function and Communication in Peripheral Nerve Repair","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2026.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Investigative Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}