{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:04:31Z","timestamp":1789607071296,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX23_3408"],"award-info":[{"award-number":["KYCX23_3408"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81761128018"],"award-info":[{"award-number":["81761128018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572871"],"award-info":[{"award-number":["81572871"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ajpath.2026.04.013","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:45:52Z","timestamp":1778546752000},"page":"1755-1776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Nucleoporin NUP188 Enhances Liver Cancer Stemness via POU Class 5 Homeobox 1 Import and SRY-Box Transcription Factor 2 Stabilization"],"prefix":"10.1016","volume":"196","author":[{"given":"Jieying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyao","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-8052","authenticated-orcid":false,"given":"Juling","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2026.04.013_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ajpath.2026.04.013_bib2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/ijc.33313","article-title":"Is it possible to halve the incidence of liver cancer in China by 2050?","volume":"148","author":"Shi","year":"2021","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2026.04.013_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cld.2015.01.001","article-title":"Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability","volume":"19","author":"McGlynn","year":"2015","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.ajpath.2026.04.013_bib4","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1172\/JCI66024","article-title":"Cancer stem cells in the development of liver cancer","volume":"HCC123","author":"Yamashita","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2026.04.013_bib5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2011.06.005","article-title":"CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation","volume":"9","author":"Lee","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2026.04.013_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2021.101664","article-title":"The clinical, prognostic and therapeutic significance of liver cancer stem cells and their markers","volume":"45","author":"Zarebska","year":"2021","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fphys.2020.00239","article-title":"Role of nucleoporins and transport receptors in cell differentiation","volume":"11","author":"Khan","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib8","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000562","article-title":"The nuclear pore complex and nuclear transport","volume":"2","author":"Wente","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuint.2017.01.020","article-title":"Importins in the maintenance and lineage commitment of ES cells","volume":"105","author":"Yasuhara","year":"2017","journal-title":"Neurochem Int"},{"key":"10.1016\/j.ajpath.2026.04.013_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ceb.2014.01.007","article-title":"Nuclear trafficking in health and disease","volume":"28","author":"Mor","year":"2014","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmed.2013.10.003","article-title":"Gating pluripotency via nuclear pores","volume":"20","author":"Yang","year":"2014","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.ajpath.2026.04.013_bib12","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.molcel.2012.08.030","article-title":"Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells","volume":"48","author":"Lin","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/j.ajpath.2026.04.013_bib13","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/stem.168","article-title":"Acetylation of sox2 induces its nuclear export in embryonic stem cells","volume":"27","author":"Baltus","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.ajpath.2026.04.013_bib14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ncb1521","article-title":"Triggering neural differentiation of ES cells by subtype switching of importin-alpha","volume":"9","author":"Yasuhara","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib15","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.devcel.2011.11.021","article-title":"A change in nuclear pore complex composition regulates cell differentiation","volume":"22","author":"D'Angelo","year":"2012","journal-title":"Dev Cell"},{"key":"10.1016\/j.ajpath.2026.04.013_bib16","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1101\/gad.310359.117","article-title":"Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis","volume":"31","author":"Sump","year":"2017","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2026.04.013_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.15252\/embr.201744523","article-title":"ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation","volume":"19","author":"Hazawa","year":"2018","journal-title":"EMBO Rep"},{"key":"10.1016\/j.ajpath.2026.04.013_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12967-015-0609-7","article-title":"Integrated analysis of miRNA, gene, and pathway regulatory networks in hepatic cancer stem cells","volume":"13","author":"Ding","year":"2015","journal-title":"J Transl Med"},{"key":"10.1016\/j.ajpath.2026.04.013_bib19","doi-asserted-by":"crossref","first-page":"102144","DOI":"10.1016\/j.labinv.2024.102144","article-title":"Lymphocyte function in tertiary lymphoid structures predicts hepatocellular carcinoma outcome","volume":"104","author":"Li","year":"2024","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2026.04.013_bib20","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000701","article-title":"Lysosome-related genes and RNF19B as prognostic markers for survival and immunotherapy efficacy in hepatocellular carcinoma","volume":"15","author":"Li","year":"2024","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib21","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1158\/1078-0432.CCR-04-0713","article-title":"X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization","volume":"10","author":"Camp","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2026.04.013_bib22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jim.2009.06.008","article-title":"ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays","volume":"347","author":"Hu","year":"2009","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.ajpath.2026.04.013_bib23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41586-019-1373-2","article-title":"A human liver cell atlas reveals heterogeneity and epithelial progenitors","volume":"572","author":"Aizarani","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2026.04.013_bib24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.semcancer.2019.08.007","article-title":"SOX2 in development and cancer biology","volume":"67","author":"Novak","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib25","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S1097-2765(02)00727-X","article-title":"Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta","volume":"10","author":"Cingolani","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.ajpath.2026.04.013_bib26","doi-asserted-by":"crossref","first-page":"37013","DOI":"10.1074\/jbc.M405117200","article-title":"Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation","volume":"279","author":"Pan","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2026.04.013_bib27","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1021\/cb2000296","article-title":"Importazole, a small molecule inhibitor of the transport receptor importin-beta","volume":"6","author":"Soderholm","year":"2011","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1158\/2159-8290.CD-18-0706","article-title":"PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer","volume":"9","author":"Rebecca","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.ajpath.2026.04.013_bib29","doi-asserted-by":"crossref","first-page":"16157","DOI":"10.1073\/pnas.0908201106","article-title":"C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration","volume":"106","author":"Teesalu","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2026.04.013_bib30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41575-021-00508-3","article-title":"Cancer stem cells in hepatocellular carcinoma - from origin to clinical implications","volume":"19","author":"Lee","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrm.2016.147","article-title":"The nuclear pore complex: understanding its function through structural insight","volume":"18","author":"Beck","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib32","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/19491034.2017.1395542","article-title":"Nuclear pore complexes as hubs for gene regulation","volume":"9","author":"D'Angelo","year":"2018","journal-title":"Nucleus"},{"key":"10.1016\/j.ajpath.2026.04.013_bib33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.yexcr.2003.09.014","article-title":"Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans","volume":"292","author":"Olsson","year":"2004","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2026.04.013_bib34","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.devcel.2017.05.007","article-title":"Nuclear pores regulate muscle development and maintenance by assembling a localized Mef2C complex","volume":"41","author":"Raices","year":"2017","journal-title":"Dev Cell"},{"key":"10.1016\/j.ajpath.2026.04.013_bib35","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.cell.2018.07.015","article-title":"Nuclear pores promote lethal prostate cancer by increasing POM121-driven E2F1, MYC, and AR nuclear import","volume":"174","author":"Rodriguez-Bravo","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2026.04.013_bib36","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1083\/jcb.200912045","article-title":"The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex","volume":"189","author":"Theerthagiri","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib37","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.7150\/thno.21717","article-title":"XIAP limits autophagic degradation of Sox2 and is a therapeutic target in nasopharyngeal carcinoma stem cells","volume":"8","author":"Ji","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.ajpath.2026.04.013_bib38","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1101\/gad.260919.115","article-title":"The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing","volume":"29","author":"Jacinto","year":"2015","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2026.04.013_bib39","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.neuron.2019.02.018","article-title":"Nucleoporin Seh1 interacts with Olig2\/Brd7 to promote oligodendrocyte differentiation and myelination","volume":"102","author":"Liu","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.ajpath.2026.04.013_bib40","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/hep.28123","article-title":"Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009","volume":"62","author":"Younossi","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2026.04.013_bib41","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/jgh.12116","article-title":"Non-alcoholic fatty liver disease contributes to hepatocarcinogenesis in non-cirrhotic liver: a clinical and pathological study","volume":"28","author":"Alexander","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib42","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/hep.28368","article-title":"Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: a multicenter prospective study","volume":"63","author":"Piscaglia","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2026.04.013_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114114","article-title":"The role of RNA binding proteins in hepatocellular carcinoma","volume":"182","author":"Zhang","year":"2022","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.ajpath.2026.04.013_bib44","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.7150\/jca.96800","article-title":"TARDBP is a candidate diagnostic biomarker promoting tumor progression via impacting tumor immunity and tumor microenvironment","volume":"15","author":"Luo","year":"2024","journal-title":"J Cancer"},{"key":"10.1016\/j.ajpath.2026.04.013_bib45","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201900358","article-title":"Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis","volume":"2","author":"Roczniak-Ferguson","year":"2019","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.ajpath.2026.04.013_bib46","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201906031","article-title":"Differential turnover of Nup188 controls its levels at centrosomes and role in centriole duplication","volume":"219","author":"Vishnoi","year":"2020","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2026.04.013_bib47","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.3390\/cancers12113253","article-title":"Deubiquitinating enzyme-mediated signaling networks in cancer stem cells","volume":"12","author":"Kaushal","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ajpath.2026.04.013_bib48","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1136\/gutjnl-2019-319616","article-title":"USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1alpha\/USP22 positive feedback loop upon TP53 inactivation","volume":"69","author":"Ling","year":"2020","journal-title":"Gut"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944026001355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944026001355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:25:46Z","timestamp":1789604746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944026001355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0002944026001355"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2026.04.013","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Nucleoporin NUP188 Enhances Liver Cancer Stemness via POU Class 5 Homeobox 1 Import and SRY-Box Transcription Factor 2 Stabilization","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2026.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}