{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:49:18Z","timestamp":1791521358537,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016925","name":"The Takeda Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H05182"],"award-info":[{"award-number":["JP22H05182"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPJS00420240022"],"award-info":[{"award-number":["JPJS00420240022"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H05188"],"award-info":[{"award-number":["JP22H05188"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ajpath.2026.08.003","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:05:41Z","timestamp":1788221141000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteasome Dysfunction in Basal Keratinocytes Drives Epidermal Disruption and Dermal Inflammation"],"prefix":"10.1016","author":[{"given":"Junko","family":"Morimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-1386","authenticated-orcid":false,"given":"Hisanori","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-2037","authenticated-orcid":false,"given":"Koji","family":"Yasutomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2026.08.003_bib1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: a model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrm2636","article-title":"Epidermal homeostasis: a balancing act of stem cells in the skin","volume":"10","author":"Blanpain","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nm.3643","article-title":"Emerging interactions between skin stem cells and their niches","volume":"20","author":"Hsu","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2026.08.003_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41556-018-0237-6","article-title":"Stem cell dynamics, migration and plasticity during wound healing","volume":"21","author":"Dekoninck","year":"2019","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nri2687","article-title":"Proteasomes in immune cells: more than peptide producers?","volume":"10","author":"Groettrup","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib6","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41590-018-0186-z","article-title":"The immunoproteasome and thymoproteasome: functions, evolution and human disease","volume":"19","author":"Murata","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib7","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.aax3769","article-title":"Cellular quality control by the ubiquitin-proteasome system and autophagy","volume":"366","author":"Pohl","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2026.08.003_bib8","doi-asserted-by":"crossref","first-page":"12365","DOI":"10.1074\/jbc.M114.558866","article-title":"Characterization of the testis-specific proteasome subunit alpha4s in mammals","volume":"289","author":"Uechi","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2026.08.003_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/oxfordjournals.jbchem.a124327","article-title":"Interferon-gamma induces different subunit organizations and functional diversity of proteasomes","volume":"115","author":"Aki","year":"1994","journal-title":"J Biochem"},{"key":"10.1016\/j.ajpath.2026.08.003_bib10","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.1141915","article-title":"Regulation of CD8+ T cell development by thymus-specific proteasomes","volume":"316","author":"Murata","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2026.08.003_bib11","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1038\/s41467-019-11346-y","article-title":"progression in spermatogenesis requires a type of testis-specific 20S core proteasome","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2026.08.003_bib12","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1172\/JCI58414","article-title":"A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans","volume":"121","author":"Kitamura","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2026.08.003_bib13","doi-asserted-by":"crossref","first-page":"14914","DOI":"10.1073\/pnas.1106015108","article-title":"Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome","volume":"108","author":"Arima","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2026.08.003_bib14","doi-asserted-by":"crossref","first-page":"6819","DOI":"10.1038\/s41467-021-27085-y","article-title":"Heterozygous missense variant of the proteasome subunit beta-type 9 causes neonatal-onset autoinflammation and immunodeficiency","volume":"12","author":"Kanazawa","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2026.08.003_bib15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.ajhg.2024.02.013","article-title":"Expanding the PRAAS spectrum: de novo mutations of immunoproteasome subunit beta-type 10 in six infants with SCID-Omenn syndrome","volume":"111","author":"van der Made","year":"2024","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajpath.2026.08.003_bib16","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jaci.2019.11.024","article-title":"PSMB10, the last immunoproteasome gene missing for PRAAS","volume":"145","author":"Sarrabay","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib17","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/art.42070","article-title":"Haploinsufficiency of PSMD12 causes proteasome dysfunction and subclinical autoinflammation","volume":"74","author":"Yan","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.905960","article-title":"Assessment of type I interferon signatures in undifferentiated inflammatory diseases: a Japanese multicenter experience","volume":"13","author":"Miyamoto","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib19","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.ajhg.2018.04.010","article-title":"Heterozygous truncating variants in POMP escape nonsense-mediated decay and cause a unique immune dysregulatory syndrome","volume":"102","author":"Poli","year":"2018","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajpath.2026.08.003_bib20","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ajhg.2010.02.018","article-title":"A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis","volume":"86","author":"Dahlqvist","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajpath.2026.08.003_bib21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2340\/0001555577225227","article-title":"Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK-syndrome): a rare, autosomal recessive disorder of keratohyaline formation?","volume":"77","author":"Vahlquist","year":"1997","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3389\/fimmu.2020.00641","article-title":"KLICK syndrome linked to a POMP mutation has features suggestive of an autoinflammatory keratinization disease","volume":"11","author":"Takeichi","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029471","article-title":"siRNA silencing of proteasome maturation protein (POMP) activates the unfolded protein response and constitutes a model for KLICK genodermatosis","volume":"7","author":"Dahlqvist","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2026.08.003_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.152681","article-title":"Blockade of the CXCR3\/CXCL10 axis ameliorates inflammation caused by immunoproteasome dysfunction","volume":"7","author":"Sasaki","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.ajpath.2026.08.003_bib25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/intimm\/dxaf021","article-title":"Proteasome dysfunction in T cells causes immunodeficiency via cell cycle disruption and apoptosis","volume":"37","author":"Shinebaatar","year":"2025","journal-title":"Int Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib51","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202350613","article-title":"Proteasome composition in immune cells implies special immune-cell-specific immunoproteasome function","volume":"54","author":"Inholz","year":"2024","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/exd.15052","article-title":"Elastin and collagen fibres in cutaneous wound healing","volume":"33","author":"Gardeazabal","year":"2024","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib27","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.4049\/jimmunol.0901829","article-title":"IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis","volume":"184","author":"He","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib28","article-title":"Interleukin-17A drives IL-19 and IL-24 expression in skin stromal cells regulating keratinocyte proliferation","volume":"12","author":"Xu","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1365-2133.2012.10961.x","article-title":"Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)-19, IL-20 and IL-24","volume":"167","author":"Wang","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib30","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2013.10.009","article-title":"Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice","volume":"39","author":"Kumari","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.ajpath.2026.08.003_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-42595-z","article-title":"Inhibition of IL-17 ameliorates keratinocyte-borne cytokine responses in an in vitro model for house-dust-mite triggered atopic dermatitis","volume":"13","author":"Haertle","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2026.08.003_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jid.2016.09.008","article-title":"Lupus skin is primed for IL-6 inflammatory responses through a keratinocyte-mediated autocrine type I interferon loop","volume":"137","author":"Stannard","year":"2017","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib33","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.coph.2012.02.009","article-title":"IL-36 in psoriasis","volume":"12","author":"Towne","year":"2012","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib34","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1016\/j.bbamcr.2013.07.024","article-title":"When ER stress reaches a dead end","volume":"1833","author":"Urra","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2026.08.003_bib35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/ijd.12695","article-title":"Proteasome-associated autoinflammatory syndromes: advances in pathogeneses, clinical presentations, diagnosis, and management","volume":"54","author":"McDermott","year":"2015","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib36","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.alit.2019.12.003","article-title":"IL-24: a new player in the pathogenesis of pro-inflammatory and allergic skin diseases","volume":"69","author":"Mitamura","year":"2020","journal-title":"Allergol Int"},{"key":"10.1016\/j.ajpath.2026.08.003_bib37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41586-026-10167-6","article-title":"A metabolic alarmin from keratinocytes potentiates systemic humoral immunity","volume":"652","author":"Ji","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2026.08.003_bib38","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ajpath.2025.11.005","article-title":"Neurogenic inflammation and immune dysregulation in psoriasis: mechanistic pathways and emerging interventions","volume":"196","author":"Singh","year":"2026","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib39","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.jaci.2022.03.010","article-title":"Neuroimmune communication regulating pruritus in atopic dermatitis","volume":"149","author":"Steinhoff","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib40","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.3390\/ijms24055001","article-title":"Molecular mechanisms of neurogenic inflammation of the skin","volume":"24","author":"Marek-Jozefowicz","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajpath.2026.08.003_bib41","doi-asserted-by":"crossref","first-page":"C1757","DOI":"10.1152\/ajpcell.00147.2022","article-title":"Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides","volume":"323","author":"Slominski","year":"2022","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.det.2016.07.005","article-title":"Dermatologic manifestations of monogenic autoinflammatory diseases","volume":"35","author":"Shwin","year":"2017","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.ajpath.2026.08.003_bib43","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3390\/biom11081213","article-title":"Cell adhesion molecules in normal skin and melanoma","volume":"11","author":"D'Arcy","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.ajpath.2026.08.003_bib44","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000053720","article-title":"Role of apoptosis in atopic dermatitis","volume":"124","author":"Trautmann","year":"2001","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib45","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1046\/j.0022-202x.2001.01474.x","article-title":"The differential fate of cadherins during T-cell-induced keratinocyte apoptosis leads to spongiosis in eczematous dermatitis","volume":"117","author":"Trautmann","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib46","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/jid.2008.394","article-title":"Increased hyaluronan production and decreased E-cadherin expression by cytokine-stimulated keratinocytes lead to spongiosis formation","volume":"129","author":"Ohtani","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2026.08.003_bib47","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1038\/s41467-023-39020-4","article-title":"Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis","volume":"14","author":"Ma","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2026.08.003_bib48","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cytogfr.2018.01.003","article-title":"Dermal fibroblasts-a heterogeneous population with regulatory function in wound healing","volume":"39","author":"Stunova","year":"2018","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.ajpath.2026.08.003_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117210","article-title":"Status and role of the ubiquitin-proteasome system in renal fibrosis","volume":"178","author":"Chen","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.ajpath.2026.08.003_bib50","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.3390\/ijms27052318","article-title":"The ubiquitin-specific protease family: master regulators of renal fibrosis pathogenesis and therapeutic targets","volume":"27","author":"Wang","year":"2026","journal-title":"Int J Mol Sci"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944026002397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944026002397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:01:43Z","timestamp":1791518503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944026002397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":51,"alternative-id":["S0002944026002397"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2026.08.003","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteasome Dysfunction in Basal Keratinocytes Drives Epidermal Disruption and Dermal Inflammation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2026.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Investigative Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}