{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:54:15Z","timestamp":1785902055042,"version":"3.56.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Preventive Cardiology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ajpc.2025.101052","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T02:35:43Z","timestamp":1750905343000},"page":"101052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Association between baseline white blood cell count and future cardiovascular events in patients with stable coronary artery disease- Sub-analysis of the REAL-CAD trial-"],"prefix":"10.1016","volume":"23","author":[{"given":"Kozo","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Hibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Misumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Iwahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaomi","family":"Gohbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Hiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Iimuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Hokimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Daida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masunori","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryozo","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpc.2025.101052_bib0001","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.122.014497","article-title":"Culprit lesion morphology of rapidly progressive and extensive anterior-wall ST-segment elevation myocardial infarction","volume":"15","author":"Okada","year":"2022","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.ajpc.2025.101052_bib0002","doi-asserted-by":"crossref","DOI":"10.5551\/jat.64988","article-title":"Early, intensive and persistent lipid-lowering therapy for secondary prevention of acute coronary syndrome","author":"Okada","year":"2024","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.ajpc.2025.101052_bib0003","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.jacc.2019.08.012","article-title":"From subclinical atherosclerosis to plaque progression and acute coronary events: JACC State-of-the-art review","volume":"74","author":"Ahmadi","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajpc.2025.101052_bib0004","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1001\/jama.2016.13985","article-title":"Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis","volume":"316","author":"Silverman","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.ajpc.2025.101052_bib0005","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1161\/CIRCULATIONAHA.117.032615","article-title":"High-dose versus low-dose pitavastatin in Japanese patients with stable coronary artery disease (REAL-CAD): a randomized superiority trial","volume":"137","author":"Taguchi","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ajpc.2025.101052_bib0006","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/eurheartj\/ehu208","article-title":"Mendelian randomization studies in coronary artery disease","volume":"35","author":"Jansen","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ajpc.2025.101052_bib0007","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ajpc.2025.101052_bib0008","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0002-9149(03)00106-1","article-title":"Impact of high-sensitivity C-reactive protein on predicting long-term mortality of acute myocardial infarction","volume":"91","author":"Kinjo","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ajpc.2025.101052_bib0009","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa042378","article-title":"C-reactive protein levels and outcomes after statin therapy","volume":"352","author":"Ridker","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpc.2025.101052_bib0010","article-title":"Significance of persistent inflammation in patients with chronic coronary syndrome","volume":"3","author":"Iwata","year":"2024","journal-title":"JACC: Adv"},{"key":"10.1016\/j.ajpc.2025.101052_bib0011","first-page":"17","article-title":"Components of the complete blood count as risk predictors for coronary heart disease: in-depth review and update","volume":"40","author":"Madjid","year":"2013","journal-title":"Tex Heart Inst J"},{"key":"10.1016\/j.ajpc.2025.101052_bib0012","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0735-1097(02)02484-1","volume":"40","author":"Sabatine","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajpc.2025.101052_bib0013","article-title":"White blood cells and coronary heart disease: a mendelian randomization study","volume":"14","author":"Zhao","year":"2023","journal-title":"Front Genet"},{"key":"10.1016\/j.ajpc.2025.101052_bib0014","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1001\/archinte.165.5.500","article-title":"Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study","volume":"165","author":"Margolis","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ajpc.2025.101052_bib0015","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.jacc.2005.02.054","article-title":"Which white blood cell subtypes predict increased cardiovascular risk?","volume":"45","author":"Horne","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajpc.2025.101052_bib0016","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5551\/jat.9.219","article-title":"WBC count, atherosclerosis and coronary risk factors","volume":"9","author":"Hasegawa","year":"2002","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.ajpc.2025.101052_bib0017","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/aje\/kww226","article-title":"White blood cell count and total and cause-specific mortality in the Women's Health Initiative","volume":"186","author":"Kabat","year":"2017","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajpc.2025.101052_bib0018","article-title":"Total and differential WBC counts are related with coronary artery atherosclerosis and increase the risk for cardiovascular disease in Koreans","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpc.2025.101052_bib0019","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with Canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpc.2025.101052_bib0020","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa2021372","article-title":"Colchicine in patients with chronic coronary disease","volume":"383","author":"Nidorf","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpc.2025.101052_bib0021","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and safety of low-dose colchicine after myocardial infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpc.2025.101052_bib0022","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jacc.2004.07.056","article-title":"Leukocyte count and coronary heart disease: implications for risk assessment","volume":"44","author":"Madjid","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajpc.2025.101052_bib0023","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1161\/ATVBAHA.107.145987","article-title":"Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomography","volume":"27","author":"Raffel","year":"2007","journal-title":"Arter Thromb Vasc Biol"},{"key":"10.1016\/j.ajpc.2025.101052_bib0024","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jvs.2005.01.013","article-title":"Association of neutrophils and future cardiovascular events in patients with peripheral artery disease","volume":"41","author":"Haumer","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.ajpc.2025.101052_bib0025","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.ehj.2004.05.002","article-title":"Associations between differential leucocyte count and incident coronary heart disease: 1764 incident cases from seven prospective studies of 30,374 individuals","volume":"25","author":"Wheeler","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ajpc.2025.101052_bib0026","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.5551\/jat.5652","article-title":"Effects of statins on serum inflammatory markers: the U.S. National Health and Nutrition Examination Survey 1999-2004","volume":"17","author":"Yoon","year":"2010","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.ajpc.2025.101052_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237665","article-title":"Short-term effect of low-dose colchicine on inflammatory biomarkers, lipids, blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein","volume":"15","author":"Fiolet","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpc.2025.101052_bib0028","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/ehjqcco\/qcz055","article-title":"Residual inflammatory risk after contemporary lipid lowering therapy","volume":"6","author":"Riaz","year":"2020","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"10.1016\/j.ajpc.2025.101052_bib0029","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/bcp.12905","article-title":"Effect of monoclonal antibodies to PCSK9 on high-sensitivity C-reactive protein levels: a meta-analysis of 16 randomized controlled treatment arms","volume":"81","author":"Sahebkar","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.ajpc.2025.101052_bib0030","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-022348","article-title":"Impact of PCSK9 monoclonal antibodies on circulating hs-CRP levels: a systematic review and meta-analysis of randomised controlled trials","volume":"8","author":"Cao","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.ajpc.2025.101052_bib0031","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/cvr\/cvae034","article-title":"Effect of lipid-lowering therapies on C-reactive protein levels: a comprehensive meta-analysis of randomized controlled trials","volume":"120","author":"Xie","year":"2024","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ajpc.2025.101052_bib0032","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1253\/circj.CJ-19-1131","article-title":"JCS 2018 guideline on diagnosis of chronic coronary heart diseases","volume":"85","author":"Yamagishi","year":"2021","journal-title":"Circ J"},{"key":"10.1016\/j.ajpc.2025.101052_bib0033","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIR.0000000000001168","article-title":"2023 AHA\/ACC\/ACCP\/ASPC\/NLA\/PCNA guideline for the management of patients with chronic coronary disease: a report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"148","author":"Virani","year":"2023","journal-title":"Circulation"}],"container-title":["American Journal of Preventive Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666667725001278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666667725001278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:57:42Z","timestamp":1760648262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666667725001278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":33,"alternative-id":["S2666667725001278"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpc.2025.101052","relation":{},"ISSN":["2666-6677"],"issn-type":[{"value":"2666-6677","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between baseline white blood cell count and future cardiovascular events in patients with stable coronary artery disease- Sub-analysis of the REAL-CAD trial-","name":"articletitle","label":"Article Title"},{"value":"American Journal of Preventive Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpc.2025.101052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101052"}}