{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:15:35Z","timestamp":1774376135617,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872805"],"award-info":[{"award-number":["81872805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073771"],"award-info":[{"award-number":["82073771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104085"],"award-info":[{"award-number":["82104085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515110147"],"award-info":[{"award-number":["2020A1515110147"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011418"],"award-info":[{"award-number":["2021A1515011418"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515012025"],"award-info":[{"award-number":["2021A1515012025"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ajps.2022.10.001","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T02:59:47Z","timestamp":1667185187000},"page":"867-879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Liposome cocktail activator modulates hepatocytes and remodels the microenvironment to mitigate acute liver failure"],"prefix":"10.1016","volume":"17","author":[{"given":"Na","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runxiu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengming","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9062-8074","authenticated-orcid":false,"given":"Min","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"26","key":"10.1016\/j.ajps.2022.10.001_bib0001","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1056\/NEJMra1208937","article-title":"Acute liver failure","volume":"369","author":"Bernal","year":"2013","journal-title":"N Engl J Med"},{"issue":"10201","key":"10.1016\/j.ajps.2022.10.001_bib0002","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","article-title":"Acute liver failure","volume":"394","author":"Stravitz","year":"2019","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ajps.2022.10.001_bib0003","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00204-015-1456-2","article-title":"Drug-induced liver injury: an overview over the most critical compounds","volume":"89","author":"Bj\u00f6rnsson","year":"2015","journal-title":"Arch Toxicol"},{"issue":"5","key":"10.1016\/j.ajps.2022.10.001_bib0004","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1073\/pnas.81.5.1327","article-title":"N-acetyl-p-benzoquinone imine: a cytochrome p-450-mediated oxidation product of acetaminophen","volume":"81","author":"Dahlin","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.ajps.2022.10.001_bib0005","first-page":"331","article-title":"Immune mechanisms in acetaminophen-induced acute liver failure","volume":"3","author":"Krenkel","year":"2014","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"4","key":"10.1016\/j.ajps.2022.10.001_bib0006","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1172\/JCI59755","article-title":"The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation","volume":"122","author":"McGill","year":"2012","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.ajps.2022.10.001_bib0007","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1053\/j.gastro.2012.09.008","article-title":"Sterile inflammation in the liver","volume":"143","author":"Kubes","year":"2012","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.ajps.2022.10.001_bib0008","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1586\/17474124.2015.1060855","article-title":"Sterile inflammation in acute liver injury: myth or mystery?","volume":"9","author":"Woolbright","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.ajps.2022.10.001_bib0009","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ejim.2009.08.003","article-title":"Oxidative stress and thyroid hormones in patients with liver diseases","volume":"20","author":"Moustafa","year":"2009","journal-title":"Eur J Intern Med"},{"issue":"5","key":"10.1016\/j.ajps.2022.10.001_bib0010","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/CS20171313","article-title":"Liver inflammation and regeneration in drug-induced liver injury: sex matters!","volume":"132","author":"Sutti","year":"2018","journal-title":"Clin Sci"},{"issue":"1","key":"10.1016\/j.ajps.2022.10.001_bib0011","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jhep.2011.01.006","article-title":"Reactive oxygen species in the normal and acutely injured liver","volume":"55","author":"Jaeschke","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajps.2022.10.001_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120573","article-title":"A dopamine-precursor-based nanoprodrug for in-situ drug release and treatment of acute liver failure by inhibiting nlrp3 inflammasome and facilitating liver regeneration","volume":"268","author":"Zhan","year":"2021","journal-title":"Biomaterials"},{"issue":"25","key":"10.1016\/j.ajps.2022.10.001_bib0013","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","article-title":"Oxidative stress as a crucial factor in liver diseases","volume":"20","author":"Cicho\u017c-Lach","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajps.2022.10.001_bib0014","doi-asserted-by":"crossref","DOI":"10.1177\/2041731420986711","article-title":"Stem cell therapy and tissue engineering strategies using cell aggregates and decellularized scaffolds for the rescue of liver failure","volume":"12","author":"Zhang","year":"2021","journal-title":"J Tissue Eng"},{"issue":"7702","key":"10.1016\/j.ajps.2022.10.001_bib0015","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41586-018-0052-z","article-title":"Electrophilic properties of itaconate and derivatives regulate the i\u03bab\u03b6\u2013atf3 inflammatory axis","volume":"556","author":"Bambouskova","year":"2018","journal-title":"Nature"},{"issue":"7699","key":"10.1016\/j.ajps.2022.10.001_bib0016","doi-asserted-by":"crossref","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates nrf2 via alkylation of keap1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ajps.2022.10.001_bib0017","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/hep.31147","article-title":"Immune-responsive gene 1\/itaconate activates nuclear factor erythroid 2-related factor 2 in hepatocytes to protect against liver ischemia-reperfusion injury","volume":"72","author":"Yi","year":"2020","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.ajps.2022.10.001_bib0018","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1074\/jbc.C117.775270","article-title":"Dimethyl itaconate is not metabolized into itaconate intracellularly","volume":"292","author":"ElAzzouny","year":"2017","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.ajps.2022.10.001_bib0019","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/s41565-020-0752-z","article-title":"Dexamethasone nanomedicines for covid-19","volume":"15","author":"Lammers","year":"2020","journal-title":"Nat Nanotechnol"},{"issue":"1","key":"10.1016\/j.ajps.2022.10.001_bib0020","first-page":"25","article-title":"Applications of nanobiomaterials in the therapy and imaging of acute liver failure","volume":"13","author":"Jin","year":"2020","journal-title":"Nanomicro Lett"},{"issue":"4","key":"10.1016\/j.ajps.2022.10.001_bib0021","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1002\/hep.24507","article-title":"Genes inducing ips phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo","volume":"54","author":"Bhave","year":"2011","journal-title":"Hepatology"},{"issue":"1 Suppl","key":"10.1016\/j.ajps.2022.10.001_bib0022","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0168-8278(00)80412-2","article-title":"Liver regeneration","volume":"32","author":"Fausto","year":"2000","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.ajps.2022.10.001_bib0023","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/hep.28988","article-title":"Hepatostat: liver regeneration and normal liver tissue maintenance","volume":"65","author":"Michalopoulos","year":"2017","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.ajps.2022.10.001_bib0024","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/hep.28822","article-title":"Met and epidermal growth factor signaling: the pillars of liver regeneration?","volume":"64","author":"Albrecht","year":"2016","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.ajps.2022.10.001_bib0025","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1002\/hep.29340","article-title":"Pericentral hepatocytes produce insulin-like growth factor-2 to promote liver regeneration during selected injuries in mice","volume":"66","author":"Liu","year":"2017","journal-title":"Hepatology"},{"issue":"31","key":"10.1016\/j.ajps.2022.10.001_bib0026","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.3748\/wjg.v12.i31.4951","article-title":"Insights on augmenter of liver regeneration cloning and function","volume":"12","author":"Gatzidou","year":"2006","journal-title":"World J Gastroenterol"},{"issue":"12","key":"10.1016\/j.ajps.2022.10.001_bib0027","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajps.2022.10.001_bib0028","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijbiomac.2017.04.006","article-title":"Optimization of glycyrrhiza polysaccharide liposome by response surface methodology and its immune activities","volume":"102","author":"Wu","year":"2017","journal-title":"Int J Biol Macromol"},{"issue":"9","key":"10.1016\/j.ajps.2022.10.001_bib0029","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12092558","article-title":"Prolonging the half-life of histone deacetylase inhibitor belinostat via 50 nm scale liposomal subcutaneous delivery system for peripheral t-cell lymphoma","volume":"12","author":"Cheng","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.ajps.2022.10.001_bib0030","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0022-3565(25)21638-X","article-title":"Effect of liposome size and drug release properties on pharmacokinetics of encapsulated drug in rats","volume":"226","author":"Allen","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.ajps.2022.10.001_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2007.08.001","article-title":"Nanoparticles for drug delivery: the need for precision in reporting particle size parameters","volume":"69","author":"Gaumet","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"issue":"1","key":"10.1016\/j.ajps.2022.10.001_bib0032","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijpharm.2018.09.008","article-title":"Lipid-bilayer-coated nanogels allow for sustained release and enhanced internalization","volume":"551","author":"Qin","year":"2018","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.ajps.2022.10.001_bib0033","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ijpharm.2018.10.005","article-title":"Improved oral bioavailability of notoginsenoside r1 with sodium glycocholate-mediated liposomes: preparation by supercritical fluid technology and evaluation in vitro and in vivo","volume":"552","author":"Fan","year":"2018","journal-title":"Int J Pharm"},{"issue":"4","key":"10.1016\/j.ajps.2022.10.001_bib0034","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jhep.2014.05.033","article-title":"Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice","volume":"61","author":"Lin","year":"2014","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.ajps.2022.10.001_bib0035","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41419-019-1543-z","article-title":"Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide\/d-galactosamine-induced acute liver injury by licochalcone a","volume":"10","author":"Lv","year":"2019","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.ajps.2022.10.001_bib0036","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/cc7782","article-title":"Prolonged treatment with n-acetylcystine delays liver recovery from acetaminophen hepatotoxicity","volume":"13","author":"Yang","year":"2009","journal-title":"Critical Care"},{"issue":"4","key":"10.1016\/j.ajps.2022.10.001_bib0037","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jhep.2016.11.017","article-title":"Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure","volume":"66","author":"Woolbright","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajps.2022.10.001_bib0038","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.brainres.2010.11.010","article-title":"Expression of keap1\u2013nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion","volume":"1370","author":"Tanaka","year":"2011","journal-title":"Brain Res"},{"issue":"4","key":"10.1016\/j.ajps.2022.10.001_bib0039","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI25790","article-title":"Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis","volume":"116","author":"Thimmulappa","year":"2006","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.ajps.2022.10.001_bib0040","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.freeradbiomed.2011.04.026","article-title":"Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury","volume":"51","author":"Wei","year":"2011","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10.1016\/j.ajps.2022.10.001_bib0041","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.taap.2010.03.016","article-title":"Enhanced expression of nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet","volume":"245","author":"Zhang","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"issue":"58","key":"10.1016\/j.ajps.2022.10.001_bib0042","doi-asserted-by":"crossref","first-page":"9275","DOI":"10.1038\/sj.onc.1207024","article-title":"Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels","volume":"22","author":"Morito","year":"2003","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.ajps.2022.10.001_bib0043","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/toxsci\/59.1.169","article-title":"High sensitivity of nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of are-regulated drug metabolizing enzymes and antioxidant genes","volume":"59","author":"Enomoto","year":"2001","journal-title":"Toxicol Sci"},{"issue":"4","key":"10.1016\/j.ajps.2022.10.001_bib0044","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2015.03.039","article-title":"Mechanisms of liver fibrosis resolution","volume":"63","author":"Tacke","year":"2015","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.ajps.2022.10.001_bib0045","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1002\/hep.24815","article-title":"The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis","volume":"55","author":"Liu","year":"2012","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.ajps.2022.10.001_bib0046","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J Hepatol"},{"issue":"11","key":"10.1016\/j.ajps.2022.10.001_bib0047","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nri3088","article-title":"Transcriptional regulation of macrophage polarization: enabling diversity with identity","volume":"11","author":"Lawrence","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"10.1016\/j.ajps.2022.10.001_bib0048","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nrgastro.2015.95","article-title":"Alternatively activated macrophages mediate fibrosis","volume":"12","author":"Weber","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ajps.2022.10.001_bib0049","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1038\/ncomms5696","article-title":"Tsc1 controls macrophage polarization to prevent inflammatory disease","volume":"5","author":"Zhu","year":"2014","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.ajps.2022.10.001_bib0050","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1139\/y82-058","article-title":"Acetaminophen toxicity in fed and fasted mice","volume":"60","author":"Walker","year":"1982","journal-title":"Can J Physiol Pharmacol"},{"issue":"6","key":"10.1016\/j.ajps.2022.10.001_bib0051","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3858\/emm.2008.40.6.686","article-title":"Ginsenoside rb1 attenuates intestinal ischemia-reperfusion- induced liver injury by inhibiting nf-kappab activation","volume":"40","author":"Wang","year":"2008","journal-title":"Exp Mol Med"},{"issue":"5","key":"10.1016\/j.ajps.2022.10.001_bib0052","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0025-7125(05)70472-7","article-title":"Evaluation of abnormal liver function tests","volume":"80","author":"Moseley","year":"1996","journal-title":"Med Clin North Am"},{"issue":"23","key":"10.1016\/j.ajps.2022.10.001_bib0053","doi-asserted-by":"crossref","first-page":"6936","DOI":"10.7150\/thno.37380","article-title":"Lipopolysaccharide-anchored macrophages hijack tumor microtube networks for selective drug transport and augmentation of antitumor effects in orthotopic lung cancer","volume":"9","author":"Guo","year":"2019","journal-title":"Theranostics"}],"container-title":["Asian Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1818087622000976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1818087622000976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:47:56Z","timestamp":1761724076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1818087622000976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S1818087622000976"],"URL":"https:\/\/doi.org\/10.1016\/j.ajps.2022.10.001","relation":{},"ISSN":["1818-0876"],"issn-type":[{"value":"1818-0876","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liposome cocktail activator modulates hepatocytes and remodels the microenvironment to mitigate acute liver failure","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajps.2022.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Shenyang Pharmaceutical University. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}