{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:17:45Z","timestamp":1790104665473,"version":"4.0.1"},"reference-count":177,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018559","name":"Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ajps.2024.100922","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T06:23:26Z","timestamp":1713939806000},"page":"100922","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glucocorticoids-based prodrug design: Current strategies and research progress"],"prefix":"10.1016","volume":"19","author":[{"given":"Hongbing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muse","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.ajps.2024.100922_bib0001","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ijpharm.2016.11.053","article-title":"Pharmaceutical technology can turn a traditional drug, dexamethasone into a first-line ocular medicine. A global perspective and future trends","volume":"516","author":"Rodr\u00edguez Villanueva","year":"2017","journal-title":"Int J Pharm"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0002","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/ceo.13702","article-title":"Local delivery of corticosteroids in clinical ophthalmology: a review","volume":"48","author":"Fung","year":"2020","journal-title":"Clin Experiment Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajps.2024.100922_bib0003","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1007\/s00134-020-06289-8","article-title":"Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS","volume":"46","author":"Meduri","year":"2020","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0004","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41584-020-0371-y","article-title":"Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases","volume":"16","author":"Hardy","year":"2020","journal-title":"Nat Rev Rheumatol"},{"issue":"8","key":"10.1016\/j.ajps.2024.100922_bib0005","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/s41565-020-0751-0","article-title":"Nanotechnology-based disinfectants and sensors for SARS-CoV-2","volume":"15","author":"Talebian","year":"2020","journal-title":"Nat Nanotechnol"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0006","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/s41467-021-21134-2","article-title":"Potential health and economic impacts of dexamethasone treatment for patients with COVID-19","volume":"12","author":"\u00c1guas","year":"2021","journal-title":"Nat Commun"},{"issue":"7813","key":"10.1016\/j.ajps.2024.100922_bib0007","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/d41586-020-01824-5","article-title":"Steroid is first drug shown to prevent deaths from COVID-19","volume":"582","author":"Ledford","year":"2020","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0008","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.1021\/acsnano.8b07865","article-title":"Dexamethasone increases cisplatin-loaded nanocarrier delivery and efficacy in metastatic breast cancer by normalizing the tumor microenvironment","volume":"13","author":"Martin","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.ajps.2024.100922_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2018.12.004","article-title":"Enhancing solid tumor therapy with sequential delivery of dexamethasone and docetaxel engineered in a single carrier to overcome stromal resistance to drug delivery","volume":"294","author":"Zhang","year":"2019","journal-title":"J Controll Release"},{"key":"10.1016\/j.ajps.2024.100922_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2018.04.010","article-title":"Efficacy of paclitaxel\/dexamethasone intra-tumoral delivery in treating orthotopic mouse breast cancer","volume":"279","author":"Popilski","year":"2018","journal-title":"J Controll Release"},{"key":"10.1016\/j.ajps.2024.100922_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119676","article-title":"Neutralizing tumor-promoting inflammation with polypeptide-dexamethasone conjugate for microenvironment modulation and colorectal cancer therapy","volume":"232","author":"Ma","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.ajps.2024.100922_bib0012","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejps.2016.08.029","article-title":"Evaluation of the antitumor effect of dexamethasone palmitate and doxorubicin co-loaded liposomes modified with a sialic acid-octadecylamine conjugate","volume":"93","author":"Sun","year":"2016","journal-title":"Eur J Pharmaceut Sci"},{"issue":"9","key":"10.1016\/j.ajps.2024.100922_bib0013","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1021\/acs.nanolett.0c02684","article-title":"Injectable anti-inflammatory nanofiber hydrogel to achieve systemic immunotherapy post local administration","volume":"20","author":"Chen","year":"2020","journal-title":"Nano Lett"},{"key":"10.1016\/j.ajps.2024.100922_bib0014","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jconrel.2023.02.042","article-title":"Postsurgical wound management and prevention of triple-negative breast cancer recurrence with a pryoptosis-inducing, photopolymerizable hydrogel","volume":"356","author":"Mi","year":"2023","journal-title":"J Controll Release"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0015","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1210\/endrev\/bnad016","article-title":"Treating the side effects of exogenous glucocorticoids: can we separate the good from the bad?","volume":"44","author":"Pofi","year":"2023","journal-title":"Endocr Rev"},{"issue":"4","key":"10.1016\/j.ajps.2024.100922_bib0016","doi-asserted-by":"crossref","DOI":"10.1530\/EJE-15-0464","article-title":"Cushing's syndrome: update on signs, symptoms and biochemical screening","volume":"173","author":"Nieman","year":"2015","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0017","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0163-7258(02)00297-8","article-title":"Mechanisms involved in the side effects of glucocorticoids","volume":"96","author":"Sch\u00e4cke","year":"2002","journal-title":"Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0018","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/ard.2005.038638","article-title":"Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data","volume":"65","author":"Da Silva","year":"2006","journal-title":"Ann Rheum Dis"},{"issue":"13","key":"10.1016\/j.ajps.2024.100922_bib0019","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.3390\/ijms20133122","article-title":"Proteomic analysis of morphologically changed tissues after prolonged dexamethasone treatment","volume":"20","author":"Malkawi","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0020","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1038\/s41467-021-23232-7","article-title":"Polymer-free corticosteroid dimer implants for controlled and sustained drug delivery","volume":"12","author":"Battiston","year":"2021","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.ajps.2024.100922_bib0021","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1001\/jamaophthalmol.2015.1823","article-title":"Incidence, risk Factors, and timing of elevated intraocular pressure after intravitreal triamcinolone acetonide injection for macular edema secondary to retinal vein occlusion SCORE study report 15","volume":"133","author":"Aref","year":"2015","journal-title":"JAMA Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0022","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2165\/00002512-199915060-00004","article-title":"Corticosteroids and glaucoma risk","volume":"15","author":"Tripathi","year":"1999","journal-title":"Drugs Aging"},{"issue":"22","key":"10.1016\/j.ajps.2024.100922_bib0023","doi-asserted-by":"crossref","first-page":"20304","DOI":"10.1021\/acsami.8b22693","article-title":"Role of liposome size, surface charge, and PEGylation on rheumatoid arthritis targeting therapy","volume":"11","author":"Ren","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.ajps.2024.100922_bib0024","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jconrel.2019.01.028","article-title":"Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma","volume":"296","author":"Deshantri","year":"2019","journal-title":"J Controll Release"},{"issue":"1\u20132","key":"10.1016\/j.ajps.2024.100922_bib0025","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijpharm.2018.02.001","article-title":"A novel dexamethasone-loaded liposome alleviates rheumatoid arthritis in rats","volume":"540","author":"Jia","year":"2018","journal-title":"Int J Pharm"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0026","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.apsb.2022.10.019","article-title":"Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis","volume":"13","author":"Zhao","year":"2023","journal-title":"Acta Pharm Sin B"},{"issue":"18","key":"10.1016\/j.ajps.2024.100922_bib0027","doi-asserted-by":"crossref","first-page":"21076","DOI":"10.1021\/acsami.1c04953","article-title":"Dual-stimuli responsive polymeric micelles for the effective treatment of rheumatoid arthritis","volume":"13","author":"He","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.ajps.2024.100922_bib0028","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jconrel.2016.03.035","article-title":"Targeted delivery of low-dose dexamethasone using PCL-PEG micelles for effective treatment of rheumatoid arthritis","volume":"230","author":"Wang","year":"2016","journal-title":"J Controll Release"},{"key":"10.1016\/j.ajps.2024.100922_bib0029","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biomaterials.2017.01.008","article-title":"Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy","volume":"122","author":"Wang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.ajps.2024.100922_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115356","article-title":"Functional chitosan oligosaccharide nanomicelles for topical ocular drug delivery of dexamethasone","volume":"227","author":"Xu","year":"2020","journal-title":"Carbohydr Polym"},{"issue":"9","key":"10.1016\/j.ajps.2024.100922_bib0031","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3390\/pharmaceutics13091357","article-title":"Atrial natriuretic peptide antibody-functionalised, PEGylated multiwalled carbon nanotubes for targeted ischemic stroke intervention","volume":"13","author":"Komane","year":"2021","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0032","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11696-021-01870-x","article-title":"Akbari Javar H. pH-Sensitive mesoporous bisphosphonate-based TiO2 nanoparticles utilized for controlled drug delivery of dexamethasone","volume":"76","author":"Motiei Pour","year":"2021","journal-title":"Chemical Papers"},{"key":"10.1016\/j.ajps.2024.100922_bib0033","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jconrel.2021.07.010","article-title":"Targeted-lung delivery of dexamethasone using gated mesoporous silica nanoparticles. A new therapeutic approach for acute lung injury treatment","volume":"337","author":"Garc\u00eda-Fern\u00e1ndez","year":"2021","journal-title":"J Controll Release"},{"key":"10.1016\/j.ajps.2024.100922_bib0034","article-title":"Recent trends in bioresponsive linker technologies of prodrug-based self-assembling nanomaterials","volume":"2021","author":"Nguyen","year":"2019","journal-title":"Biomaterials"},{"issue":"52","key":"10.1016\/j.ajps.2024.100922_bib0035","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202101460","article-title":"Small-molecule prodrug nanoassemblies: an emerging nanoplatform for anticancer drug delivery","volume":"17","author":"Li","year":"2021","journal-title":"Small"},{"issue":"12","key":"10.1016\/j.ajps.2024.100922_bib0036","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.addr.2012.03.006","article-title":"Development of macromolecular prodrug for rheumatoid arthritis","volume":"64","author":"Yuan","year":"2012","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.ajps.2024.100922_bib0037","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jconrel.2023.04.039","article-title":"Emerging nanoparticle platforms to improve the administration of glucocorticoids","volume":"358","author":"Tessier","year":"2023","journal-title":"J Controll Release"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0038","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201600124","article-title":"Reactive-oxygen-species-responsive drug delivery systems: promises and challenges","volume":"4","author":"Saravanakumar","year":"2017","journal-title":"Adv Sci"},{"key":"10.1016\/j.ajps.2024.100922_bib0039","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jconrel.2017.09.026","article-title":"Preclinical development of drug delivery systems for paclitaxel-based cancer chemotherapy","volume":"267","author":"Wang","year":"2017","journal-title":"J Controll Release"},{"issue":"17","key":"10.1016\/j.ajps.2024.100922_bib0040","doi-asserted-by":"crossref","first-page":"10027","DOI":"10.1039\/D0RA10674G","article-title":"Revisiting activity of some glucocorticoids as a potential inhibitor of SARS-CoV-2 main protease: theoretical study","volume":"11","author":"Elmaaty","year":"2021","journal-title":"RSC Adv"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0041","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.2042-7158.2011.01386.x","article-title":"Susceptibility of glucocorticoids to colonic metabolism and pharmacologic intervention in the metabolism: implication for therapeutic activity of colon-specific glucocorticoid 21-sulfate sodium at the target site","volume":"64","author":"Kong","year":"2012","journal-title":"J Pharmacy Pharmacol"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0042","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/10611860802546637","article-title":"Sulfate-conjugated methylprednisolone: evaluation as a colon-specific methylprednisolone prodrug and comparison with sulfate-conjugated prednisolone and dexamethasone","volume":"17","author":"Kong","year":"2009","journal-title":"J Drug Target"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0043","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/03639040500519441","article-title":"Synthesis and in vitro properties of dexamethasone 21-sulfate sodium as a colon-specific prodrug of dexamethasone","volume":"32","author":"Ho Kim","year":"2008","journal-title":"Drug Dev Ind Pharm"},{"issue":"4","key":"10.1016\/j.ajps.2024.100922_bib0044","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/BF02976952","article-title":"Synthesis and properties of prednisolone 21-sulfate sodium as a colon-specific prodrug of prednisolone","volume":"26","author":"Doh","year":"2003","journal-title":"Arch Pharm Res"},{"issue":"10","key":"10.1016\/j.ajps.2024.100922_bib0045","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.mad.2004.06.010","article-title":"Mechanisms of glucocorticoid receptor signaling during inflammation","volume":"125","author":"Smoak","year":"2004","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.ajps.2024.100922_bib0046","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jconrel.2014.05.039","article-title":"Liposomal corticosteroids for the treatment of inflammatory disorders and cancer","volume":"190","author":"Ozbakir","year":"2014","journal-title":"J Controll Release"},{"key":"10.1016\/j.ajps.2024.100922_bib0047","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jconrel.2020.05.028","article-title":"Structural optimization of HPMA copolymer-based dexamethasone prodrug for improved treatment of inflammatory arthritis","volume":"324","author":"Jia","year":"2020","journal-title":"J Controll Release"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0048","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jconrel.2013.02.001","article-title":"Targeted drug delivery to renal proximal tubule epithelial cells mediated by 2-glucosamine","volume":"167","author":"Lin","year":"2013","journal-title":"J Controll Release"},{"key":"10.1016\/j.ajps.2024.100922_bib0049","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jconrel.2019.04.027","article-title":"Nanomedicines for improved targetability to inflamed synovium for treatment of rheumatoid arthritis: multi-functionalization as an emerging strategy to optimize therapeutic efficacy","volume":"303","author":"Fang","year":"2019","journal-title":"J Controll Release"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0050","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.addr.2009.10.004","article-title":"HPMA copolymers: origins, early developments, present, and future","volume":"62","author":"Kope\u010dek","year":"2010","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0051","doi-asserted-by":"crossref","first-page":"R2","DOI":"10.1186\/ar2106","article-title":"Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis","volume":"9","author":"Wang","year":"2007","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"10.1016\/j.ajps.2024.100922_bib0052","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1007\/s11095-008-9683-3","article-title":"Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis","volume":"25","author":"Liu","year":"2008","journal-title":"Pharm Res"},{"issue":"5","key":"10.1016\/j.ajps.2024.100922_bib0053","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1186\/ar3130","article-title":"Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy","volume":"12","author":"Quan","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.ajps.2024.100922_bib0054","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1021\/mp100132h","article-title":"Pharmacokinetic and biodistribution studies of N-(2-Hydroxypropyl)methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model","volume":"7","author":"Quan","year":"2010","journal-title":"Mol Pharm"},{"key":"10.1016\/j.ajps.2024.100922_bib0055","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jconrel.2021.10.007","article-title":"Thermoresponsive polymeric dexamethasone prodrug for arthritis pain","volume":"339","author":"Zhao","year":"2021","journal-title":"J Controll Release"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0056","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s11095-015-1776-1","article-title":"The evaluation of the therapeutic efficacy and side effects of a macromolecular dexamethasone prodrug in the collagen-induced arthritis mouse model","volume":"33","author":"Quan","year":"2015","journal-title":"Pharm Res"},{"issue":"12","key":"10.1016\/j.ajps.2024.100922_bib0057","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1002\/art.34667","article-title":"Dexamethasone prodrug treatment prevents nephritis in lupus-prone (NZB x NZW)F1 mice without causing systemic side effects","volume":"64","author":"Yuan","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ajps.2024.100922_bib0058","article-title":"Head-to-head comparative pharmacokinetic and biodistribution (PK\/BD) study of two dexamethasone prodrug nanomedicines on lupus-prone NZB\/WF1 mice","volume":"29","author":"Wei","year":"2020","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ajps.2024.100922_bib0059","article-title":"Polymeric dexamethasone prodrugs attenuate lupus nephritis in MRL\/lpr mice with reduced glucocorticoid toxicity","volume":"44","author":"Zhao","year":"2022","journal-title":"Nanomedicine"},{"issue":"4","key":"10.1016\/j.ajps.2024.100922_bib0060","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1021\/mp2000555","article-title":"Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates","volume":"8","author":"Ren","year":"2011","journal-title":"Mol Pharm"},{"key":"10.1016\/j.ajps.2024.100922_bib0061","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2013.11.024","article-title":"Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects","volume":"175","author":"Ren","year":"2014","journal-title":"J Controll Release"},{"issue":"5","key":"10.1016\/j.ajps.2024.100922_bib0062","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1021\/acs.molpharmaceut.7b00045","article-title":"Pharmacokinetic and biodistribution studies of HPMA copolymer conjugates in an aseptic implant loosening mouse model","volume":"14","author":"Wei","year":"2017","journal-title":"Mol Pharm"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0063","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.clim.2015.03.027","article-title":"Macromolecular glucocorticoid prodrug improves the treatment of dextran sulfate sodium-induced mice ulcerative colitis","volume":"160","author":"Ren","year":"2015","journal-title":"Clin Immunol"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0064","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1177\/0883911511406326","article-title":"Synergistic effect of HPMA copolymer-bound doxorubicin and dexamethasone in vivo on mouse lymphomas","volume":"26","author":"Kostkov\u00e1","year":"2011","journal-title":"J Bioact Compat Polym"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0065","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1773-2247(08)50031-1","article-title":"Synthesis of a new mPEG-dexamethasone conjugate and preliminary bioavailability studies in rabbits","volume":"18","author":"Zacchigna","year":"2008","journal-title":"J Drug Deliv Sci Technol"},{"issue":"10","key":"10.1016\/j.ajps.2024.100922_bib0066","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1021\/bm100578c","article-title":"Syntheses of click PEG-dexamethasone conjugates for the treatment of rheumatoid arthritis","volume":"11","author":"Liu","year":"2010","journal-title":"Biomacromolecules"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0067","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1080\/10717544.2017.1410258","article-title":"Sialic acid-modified solid lipid nanoparticles as vascular endothelium-targeting carriers for ischemia-reperfusion-induced acute renal injury","volume":"24","author":"Hu","year":"2017","journal-title":"Drug Deliv"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0068","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3109\/1061186X.2010.504271","article-title":"Development of a novel polyethylene glycol-corticosteroid-conjugate with an acid-cleavable linker","volume":"19","author":"Funk","year":"2010","journal-title":"J Drug Target"},{"issue":"8","key":"10.1016\/j.ajps.2024.100922_bib0069","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.1021\/acsnano.8b01249","article-title":"Micelle-forming dexamethasone prodrug attenuates nephritis in lupus-prone mice without apparent glucocorticoid side effects","volume":"12","author":"Jia","year":"2018","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0070","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12274-018-2233-3","article-title":"Optimized in vivo performance of acid-liable micelles for the treatment of rheumatoid arthritis by one single injection","volume":"12","author":"Wang","year":"2018","journal-title":"Nano Res"},{"issue":"8","key":"10.1016\/j.ajps.2024.100922_bib0071","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.7150\/thno.19571","article-title":"E-selectin-targeted sialic acid-PEG-dexamethasone micelles for enhanced anti-inflammatory efficacy for acute kidney injury","volume":"7","author":"Hu","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.ajps.2024.100922_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101738","article-title":"Poly(ethylene glycol) alternatives in biomedical applications","volume":"48","author":"Yao","year":"2023","journal-title":"Nano Today"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0073","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1021\/acs.bioconjchem.3c00174","article-title":"PEGylated lipid nanoparticle formulations: immunological safety and efficiency perspective","volume":"34","author":"Tenchov","year":"2023","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.ajps.2024.100922_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115044","article-title":"The interplay between PEGylated nanoparticles and blood immune system","volume":"200","author":"Guo","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0075","doi-asserted-by":"crossref","DOI":"10.1080\/20022727.2018.1488497","article-title":"Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon","volume":"9","author":"Zakeri","year":"2018","journal-title":"Nano Rev Exp"},{"issue":"4","key":"10.1016\/j.ajps.2024.100922_bib0076","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/17425247.2019.1604681","article-title":"Recent advances in the development of polyethylenimine-based gene vectors for safe and efficient gene delivery","volume":"16","author":"Jiang","year":"2019","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.ajps.2024.100922_bib0077","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2147\/BCTT.S350403","article-title":"Polyethyleneimine (PEI) as a polymer-based co-delivery system for breast cancer therapy","volume":"14","author":"Fahira","year":"2022","journal-title":"Breast Cancer-Targets Therapy"},{"key":"10.1016\/j.ajps.2024.100922_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2021.100871","article-title":"Cancer nanomedicine based on polyethylenimine-mediated multifunctional nanosystems","volume":"124","author":"Li","year":"2022","journal-title":"Prog Mater Sci"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0079","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1021\/bc070012a","article-title":"Dexamethasone-conjugated low molecular weight polyethylenimine as a nucleus-targeting lipopolymer gene carrier","volume":"18","author":"Bae","year":"2007","journal-title":"Bioconjug Chem"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0080","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/jgm.1320","article-title":"Dexamethasone-conjugated polyethylenimine as an efficient gene carrier with an anti-apoptotic effect to cardiomyocytes","volume":"11","author":"Kim","year":"2009","journal-title":"J Gene Med"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0081","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1021\/mp4006003","article-title":"Delivery of hypoxia and glioma dual-specific suicide gene using dexamethasone conjugated polyethylenimine for glioblastoma-specific gene therapy","volume":"11","author":"Kim","year":"2014","journal-title":"Mol Pharm"},{"issue":"11","key":"10.1016\/j.ajps.2024.100922_bib0082","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1166\/jnn.2013.8084","article-title":"Synthesis of polyethylene glycol-oligo (glutamic acid) conjugated with polyethylenimine-dexamethasone for gene delivery applications","volume":"13","author":"Kim","year":"2013","journal-title":"J Nanosci Nanotechnol"},{"issue":"16","key":"10.1016\/j.ajps.2024.100922_bib0083","doi-asserted-by":"crossref","first-page":"14196","DOI":"10.1021\/am503483w","article-title":"Sandwich-type Au-PEI\/DNA\/PEI-Dexa nanocomplex for nucleus-targeted gene delivery in vitro and in vivo","volume":"6","author":"Chen","year":"2014","journal-title":"ACS Appl Mater Interfaces"},{"issue":"11","key":"10.1016\/j.ajps.2024.100922_bib0084","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/gt.2017.83","article-title":"A new combination therapy for asthma using dual-function dexamethasone-conjugated polyethylenimine and vitamin D binding protein siRNA","volume":"24","author":"Choi","year":"2017","journal-title":"Gene Ther"},{"key":"10.1016\/j.ajps.2024.100922_bib0085","article-title":"Therapeutic effect of pH-Responsive dexamethasone prodrug nanoparticles on acute lung injury","volume":"66","author":"Su","year":"2021","journal-title":"J Drug Deliv Sci Technol"},{"issue":"5","key":"10.1016\/j.ajps.2024.100922_bib0086","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3390\/polym12051114","article-title":"The use of Poly(-vinyl pyrrolidone) in the delivery of drugs: a review","volume":"12","author":"Franco","year":"2020","journal-title":"Polymers (Basel)"},{"issue":"5","key":"10.1016\/j.ajps.2024.100922_bib0087","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1021\/bm100095t","article-title":"Synthesis and characterization of glucocorticoid functionalized poly(N-vinyl pyrrolidone): a versatile prodrug for neural interface","volume":"11","author":"Cao","year":"2010","journal-title":"Biomacromolecules"},{"issue":"10","key":"10.1016\/j.ajps.2024.100922_bib0088","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1039\/D1NH00266J","article-title":"Encapsulation of polyprodrugs enables an efficient and controlled release of dexamethasone","volume":"6","author":"Li","year":"2021","journal-title":"Nanoscale Horiz"},{"key":"10.1016\/j.ajps.2024.100922_bib0089","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijpharm.2006.05.002","article-title":"Dexamethasone conjugated poly(amidoamine) dendrimer as a gene carrier for efficient nuclear translocation","volume":"320","author":"Choi","year":"2006","journal-title":"Int J Pharm"},{"key":"10.1016\/j.ajps.2024.100922_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/6582825","article-title":"Nuclear-targeting delivery of CRISPRa system for upregulation of \u03b2-defensin against virus infection by dexamethasone and phenylalanine dual-modified dendrimer","volume":"2020","author":"Zuo","year":"2020","journal-title":"Adv Polymer Technol"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0091","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/13880209.2018.1517183","article-title":"Synthesis, characterization and evaluation of transfection efficiency of dexamethasone conjugated poly(propyleneimine) nanocarriers for gene delivery","volume":"56","author":"Malaekeh-Nikouei","year":"2018","journal-title":"Pharm Biol"},{"issue":"1\u20132","key":"10.1016\/j.ajps.2024.100922_bib0092","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijpharm.2013.03.056","article-title":"Comparative anti-inflammatory activity of poly(amidoamine) (PAMAM) dendrimer\u2013dexamethasone conjugates with dexamethasone-liposomes","volume":"449","author":"Choksi","year":"2013","journal-title":"Int J Pharm"},{"key":"10.1016\/j.ajps.2024.100922_bib0093","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.biomaterials.2017.02.016","article-title":"Subconjunctival injectable dendrimer-dexamethasone gel for the treatment of corneal inflammation","volume":"125","author":"Soiberman","year":"2017","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.ajps.2024.100922_bib0094","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jtos.2018.05.004","article-title":"Subconjunctival dendrimer-drug therapy for the treatment of dry eye in a rabbit model of induced autoimmune dacryoadenitis","volume":"16","author":"Lin","year":"2018","journal-title":"Ocular Surface"},{"key":"10.1016\/j.ajps.2024.100922_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111837","article-title":"PAMAM dendrimer as a talented multifunctional biomimetic nanocarrier for cancer diagnosis and therapy","volume":"204","author":"Surekha","year":"2021","journal-title":"Colloids Surfaces B: Biointerfaces"},{"key":"10.1016\/j.ajps.2024.100922_bib0096","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120485","article-title":"Dendrimers based cancer nanotheranostics: an overview","volume":"600","author":"Saluja","year":"2021","journal-title":"Int J Pharm"},{"issue":"8","key":"10.1016\/j.ajps.2024.100922_bib0097","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1517\/17425255.2015.1052404","article-title":"Preclinical studies of dendrimer prodrugs","volume":"11","author":"Kojima","year":"2015","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.ajps.2024.100922_bib0098","doi-asserted-by":"crossref","first-page":"e1409","DOI":"10.1002\/wnan.1409","article-title":"Dendrimer-based nanocarriers: a versatile platform for drug delivery","volume":"9","author":"Hsu","year":"2016","journal-title":"WIREs Nanomedi Nanobiotechnol"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0099","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/jcp.20152","article-title":"Steroids dilate nuclear pores imaged with atomic force microscopy","volume":"202","author":"Shahin","year":"2005","journal-title":"J Cell Physiol"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0100","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1021\/bc070012a","article-title":"Dexamethasone-conjugated low molecular weight polyethylenimine as a nucleus-targeting lipopolymer gene carrier","volume":"18","author":"Mi Bae","year":"2007","journal-title":"Bioconjug Chem"},{"issue":"S2","key":"10.1016\/j.ajps.2024.100922_bib0101","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1002\/ajh.26750","article-title":"Antibody drug conjugates for the treatment of multiple myeloma","volume":"98","author":"Leong","year":"2023","journal-title":"Am J Hematol"},{"key":"10.1016\/j.ajps.2024.100922_bib0102","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108235","article-title":"Antibody drug conjugates: the dos and don'ts in clinical development","volume":"240","author":"Tolcher","year":"2022","journal-title":"Pharmacol Ther"},{"issue":"12","key":"10.1016\/j.ajps.2024.100922_bib0103","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/s43018-022-00495-7","article-title":"Recent progress in antibody\u2013drug conjugate therapy for cancer","volume":"3","author":"Hurvitz","year":"2022","journal-title":"Nat Cancer"},{"key":"10.1016\/j.ajps.2024.100922_bib0104","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jconrel.2021.12.013","article-title":"Benefits and challenges of antibody drug conjugates as novel form of chemotherapy","volume":"341","author":"Fatima","year":"2022","journal-title":"J Controll Release"},{"issue":"16","key":"10.1016\/j.ajps.2024.100922_bib0105","doi-asserted-by":"crossref","first-page":"11958","DOI":"10.1021\/acs.jmedchem.1c00541","article-title":"Development of novel glucocorticoids for use in antibody-drug conjugates for the treatment of inflammatory diseases","volume":"64","author":"Han","year":"2021","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0106","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41392-022-00947-7","article-title":"Antibody drug conjugate: the \u201cbiological missile\u201d for targeted cancer therapy","volume":"7","author":"Fu","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"8","key":"10.1016\/j.ajps.2024.100922_bib0107","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/mt.2012.103","article-title":"Targeting the hemoglobin scavenger receptor CD163 in macrophages highly increases the anti-inflammatory potency of dexamethasone","volume":"20","author":"Graversen","year":"2012","journal-title":"Molecular Therapy"},{"key":"10.1016\/j.ajps.2024.100922_bib0108","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.omtm.2016.11.004","article-title":"Antibody-directed glucocorticoid targeting to CD163 in M2-type macrophages attenuates fructose-induced liver inflammatory changes","volume":"4","author":"Svendsen","year":"2017","journal-title":"Molecular Therapy-Methods Clin Develop"},{"issue":"4","key":"10.1016\/j.ajps.2024.100922_bib0109","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1021\/jacs.5b12547","article-title":"Discovery of pyrophosphate diesters as tunable, soluble, and bioorthogonal linkers for site-specific antibody-drug conjugates","volume":"138","author":"Kern","year":"2016","journal-title":"J Am Chem Soc"},{"issue":"9","key":"10.1016\/j.ajps.2024.100922_bib0110","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1021\/acs.bioconjchem.6b00337","article-title":"Novel phosphate modified cathepsin B linkers: improving aqueous solubility and enhancing payload scope of ADCs","volume":"27","author":"Kern","year":"2016","journal-title":"Bioconjug Chem"},{"issue":"7","key":"10.1016\/j.ajps.2024.100922_bib0111","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1021\/acs.bioconjchem.8b00312","article-title":"Development of anti-CD74 antibody-drug conjugates to target glucocorticoids to immune cells","volume":"29","author":"Brandish","year":"2018","journal-title":"Bioconjug Chem"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0112","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1021\/acs.jmedchem.1c02099","article-title":"Design and development of glucocorticoid receptor modulators as immunology antibody-drug conjugate payloads","volume":"65","author":"Hobson","year":"2022","journal-title":"J Med Chem"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0113","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1021\/acs.jmedchem.2c00339","article-title":"Antibody-drug conjugates for immunology","volume":"65","author":"Dragovich","year":"2022","journal-title":"J Med Chem"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0114","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/art.42415","volume":"75","author":"Buttgereit","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.ajps.2024.100922_bib0115","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2017.02.006","article-title":"Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides","volume":"250","author":"Dissanayake","year":"2017","journal-title":"J Controll Release"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0116","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1039\/D0CS00556H","article-title":"Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs)","volume":"50","author":"Cooper","year":"2021","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.ajps.2024.100922_bib0117","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.addr.2016.06.015","article-title":"Peptide-drug conjugates as effective prodrug strategies for targeted delivery","volume":"110","author":"Wang","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"issue":"10","key":"10.1016\/j.ajps.2024.100922_bib0118","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.tips.2021.07.001","article-title":"Peptide\u2013drug conjugate-based novel molecular drug delivery system in cancer","volume":"42","author":"Zhu","year":"2021","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0119","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/02652048.2010.520093","article-title":"Development and characterization of nanoparticulate formulation of a water soluble prodrug of dexamethasone by HIP complexation","volume":"28","author":"Gaudana","year":"2010","journal-title":"J Microencapsul"},{"issue":"10","key":"10.1016\/j.ajps.2024.100922_bib0120","doi-asserted-by":"crossref","first-page":"9966","DOI":"10.1021\/acsnano.8b04143","article-title":"Tandem enzymatic self-assembly and slow release of dexamethasone enhances its antihepatic fibrosis effect","volume":"12","author":"Tang","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.ajps.2024.100922_bib0121","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.129623","article-title":"Dexamethasone-peptide prodrug supramolecular hydrogel effectively alleviates experimental autoimmune uveitis (EAU)","volume":"421","author":"Zhang","year":"2021","journal-title":"Chem Eng J"},{"key":"10.1016\/j.ajps.2024.100922_bib0122","first-page":"591","article-title":"High drug payload nanoparticles formed from dexamethasone-peptide conjugates for the treatment of endotoxin-induced uveitis in rabbit","volume":"14","author":"Yu","year":"2019","journal-title":"J Microencapsul"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0123","doi-asserted-by":"crossref","first-page":"9546","DOI":"10.1021\/acsnano.2c02804","article-title":"Energy landscapes of supramolecular peptide-drug conjugates directed by linker selection and drug topology","volume":"16","author":"Sis","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.ajps.2024.100922_bib0124","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jconrel.2018.12.025","article-title":"Cartilage-targeting dexamethasone prodrugs increase the efficacy of dexamethasone","volume":"295","author":"Formica","year":"2019","journal-title":"J Controll Release"},{"key":"10.1016\/j.ajps.2024.100922_bib0125","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jconrel.2020.09.005","article-title":"Release of functional dexamethasone by intracellular enzymes: a modular peptide-based strategy for ocular drug delivery","volume":"327","author":"Bhattacharya","year":"2020","journal-title":"J Controll Release"},{"issue":"4","key":"10.1016\/j.ajps.2024.100922_bib0126","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF02353640","article-title":"In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery","volume":"23","author":"Leopold","year":"1995","journal-title":"J Pharmacokinetics Biopharmaceut"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0127","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1021\/acsnano.2c11058","article-title":"Minimalist nanocomplex with dual regulation of endothelial function and inflammation for targeted therapy of inflammatory vascular diseases","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ajps.2024.100922_bib0128","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jconrel.2022.12.058","article-title":"Nanostructured multifunctional stimuli-responsive glycopolypeptide-based copolymers for biomedical applications","volume":"354","author":"Sedighi","year":"2023","journal-title":"J Controll Release"},{"issue":"10","key":"10.1016\/j.ajps.2024.100922_bib0129","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1016\/j.apsb.2022.05.020","article-title":"Carbohydrate-based drugs launched during 2000-2021","volume":"12","author":"Cao","year":"2022","journal-title":"Acta Pharm Sin B"},{"issue":"18","key":"10.1016\/j.ajps.2024.100922_bib0130","doi-asserted-by":"crossref","first-page":"10950","DOI":"10.1021\/acs.chemrev.0c01338","article-title":"Carbohydrate-based macromolecular biomaterials","volume":"121","author":"Su","year":"2021","journal-title":"Chem Rev"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0131","first-page":"G210","article-title":"A novel colon-specific steroid prodrug enhances sodium chloride absorption in rat colitis","volume":"269","author":"Fedorak","year":"1995","journal-title":"Am J Physiol"},{"issue":"11","key":"10.1016\/j.ajps.2024.100922_bib0132","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1023\/A:1018956232628","article-title":"In vitro evaluation of dexamethasone-\u03b2-D-Glucuronide for colon-specific drug delivery","volume":"10","author":"Haeberlin","year":"1993","journal-title":"Pharm Res"},{"issue":"4","key":"10.1016\/j.ajps.2024.100922_bib0133","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1023\/A:1015838825437","article-title":"Colon-specific delivery of dexamethasone from a glucoside prodrug in the guinea pig","volume":"8","year":"1991","journal-title":"Pharm Res"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0134","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1021\/jm00369a005","article-title":"A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteria","volume":"27","author":"Friend","year":"2002","journal-title":"J Med Chem"},{"issue":"10","key":"10.1016\/j.ajps.2024.100922_bib0135","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1136\/gut.35.10.1439","article-title":"A budesonide prodrug accelerates treatment of colitis in rats","volume":"35","author":"Cui","year":"1994","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0136","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/bdd.2510150207","article-title":"Glucocorticoid-dextran conjugates as potential prodrugs for colon-specific delivery: steady-state pharmacokinetics in the rat","volume":"15","author":"Mcleod","year":"2010","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/j.ajps.2024.100922_bib0137","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121900","article-title":"Inflammation-targeted sialic acid-dexamethasone conjugates for reducing the side effects of glucocorticoids","volume":"622","author":"Liu","year":"2022","journal-title":"Int J Pharm"},{"issue":"1\u20132","key":"10.1016\/j.ajps.2024.100922_bib0138","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijpharm.2008.08.034","article-title":"Synthesis and evaluation of dextran-budesonide conjugates as colon specific prodrugs for treatment of ulcerative colitis","volume":"365","author":"Varshosaz","year":"2009","journal-title":"Int J Pharm"},{"key":"10.1016\/j.ajps.2024.100922_bib0139","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jcis.2013.11.061","article-title":"A macromolecular prodrug strategy for combinatorial drug delivery","volume":"417","author":"Li","year":"2014","journal-title":"J Colloid Interface Sci"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0168-3659(01)00532-6","article-title":"Colon-specific delivery of prednisolone-appended \u03b1-cyclodextrin conjugate: alleviation of systemic side effect after oral administration","volume":"79","author":"Yano","year":"2002","journal-title":"J Controll Release"},{"key":"10.1016\/j.ajps.2024.100922_bib0141","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106263","article-title":"Biomimetic micelles to accurately regulate the inflammatory microenvironment for glomerulonephritis treatment","volume":"181","author":"Zhang","year":"2022","journal-title":"Pharmacol Res"},{"issue":"5","key":"10.1016\/j.ajps.2024.100922_bib0142","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3748\/wjg.v8.i5.913","article-title":"Synthesis of an enzyme-dependent prodrug and evaluation of its potential for colon targeting","volume":"8","author":"Pang","year":"2002","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0143","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0016-5085(94)90599-1","article-title":"A glucocorticoid prodrug facilitates normal mucosal function in rat colitis without adrenal suppression","volume":"106","author":"McLeod","year":"1994","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.ajps.2024.100922_bib0144","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.apsb.2018.04.003","article-title":"Drug metabolism in drug discovery and development","volume":"8","author":"Zhang","year":"2018","journal-title":"Acta Pharm Sin B"},{"issue":"7","key":"10.1016\/j.ajps.2024.100922_bib0145","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1002\/cjoc.200990237","article-title":"A novel liposomal dexamethasone palmitate formulation and anti-inflammatory effects on mice","volume":"27","author":"Li","year":"2009","journal-title":"Chin J Chem"},{"issue":"5","key":"10.1016\/j.ajps.2024.100922_bib0146","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1007\/s13346-021-01112-3","article-title":"Improving dexamethasone drug loading and efficacy in treating arthritis through a lipophilic prodrug entrapped into PLGA-PEG nanoparticles","volume":"12","author":"Sim\u00f3n-V\u00e1zquez","year":"2022","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.ajps.2024.100922_bib0147","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jconrel.2019.01.015","article-title":"Dexamethasone palmitate nanoparticles: an efficient treatment for rheumatoid arthritis","volume":"296","author":"Lorscheider","year":"2019","journal-title":"J Controll Release"},{"issue":"2\u20133","key":"10.1016\/j.ajps.2024.100922_bib0148","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0169-409X(95)00122-N","article-title":"Limethason as a lipid microsphere preparation: an overview","volume":"20","author":"Yokoyama","year":"1996","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0149","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1089\/jop.2012.0044","article-title":"A preliminary evaluation of dexamethasone palmitate emulsion: a novel intravitreal sustained delivery of corticosteroid for treatment of macular edema","volume":"29","author":"Daull","year":"2013","journal-title":"J Ocular Pharmacol Therapeut"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0150","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1136\/ard.41.3.263","article-title":"Tissue distribution and anti-inflammatory activity of corticosteroids incorporated in lipid emulsion","volume":"41","author":"Mizushima","year":"1982","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.ajps.2024.100922_bib0151","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1124\/mol.108.050153","article-title":"Enhanced anti-inflammation of inhaled dexamethasone palmitate using mannosylated liposomes in an endotoxin-induced lung inflammation model","volume":"74","author":"Wijagkanalan","year":"2008","journal-title":"Mol Pharmacol"},{"issue":"7","key":"10.1016\/j.ajps.2024.100922_bib0152","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11095-019-2609-4","article-title":"Neutrophil-mediated delivery of dexamethasone palmitate-loaded liposomes decorated with a sialic acid conjugate for rheumatoid arthritis treatment","volume":"36","author":"Hu","year":"2019","journal-title":"Pharm Res"},{"key":"10.1016\/j.ajps.2024.100922_bib0153","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120381","article-title":"Combining dexamethasone and TNF-\u03b1 siRNA within the same nanoparticles to enhance anti-inflammatory effect","volume":"598","author":"G\u00fcrcan","year":"2021","journal-title":"Int J Pharm"},{"issue":"7","key":"10.1016\/j.ajps.2024.100922_bib0154","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1021\/acs.molpharmaceut.9b00237","article-title":"Nanoscale lipophilic prodrugs of dexamethasone with enhanced pharmacokinetics","volume":"16","author":"Lorscheider","year":"2019","journal-title":"Mol Pharm"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0155","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1021\/nn102357y","article-title":"Uniformity of drug payload and its effect on stability of solid lipid nanoparticles containing an ester prodrug","volume":"5","author":"Kim","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.ajps.2024.100922_bib0156","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejpb.2021.12.001","article-title":"Mannosylation of budesonide palmitate nanoprodrugs for improved macrophage targeting","volume":"170","author":"Pinheiro do Nascimento","year":"2022","journal-title":"Eur J Pharmaceut Biopharmaceut"},{"key":"10.1016\/j.ajps.2024.100922_bib0157","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejps.2017.09.013","article-title":"Dexamethasone palmitate large porous particles: a controlled release formulation for lung delivery of corticosteroids","volume":"113","author":"N'Guessan","year":"2018","journal-title":"Eur J Pharmaceut Sci"},{"issue":"18","key":"10.1016\/j.ajps.2024.100922_bib0158","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1002\/smll.201200437","article-title":"High payload dual therapeutic-imaging nanocarriers for triggered tumor delivery","volume":"8","author":"Kim","year":"2012","journal-title":"Small"},{"key":"10.1016\/j.ajps.2024.100922_bib0159","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120509","article-title":"Tiny dexamethasone palmitate nanoparticles for intravitreal injection: optimization and in vivo evaluation","volume":"600","author":"Canioni","year":"2021","journal-title":"Int J Pharm"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0160","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/10611860310001595247","article-title":"Cellular uptake of a dexamethasone palmitate-low density lipoprotein complex by macrophages and foam cells","volume":"11","author":"Tauchi","year":"2003","journal-title":"J Drug Target"},{"key":"10.1016\/j.ajps.2024.100922_bib0161","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.134880","article-title":"Excipient-free prodrug-based three-in-one nanoparticles co-deliver diversified agents to amplify tumor therapy","volume":"435","author":"Zhang","year":"2022","journal-title":"Chem Eng J"},{"key":"10.1016\/j.ajps.2024.100922_bib0162","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jconrel.2018.07.026","article-title":"Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids","volume":"286","author":"Chen","year":"2018","journal-title":"J Controll Release"},{"issue":"4","key":"10.1016\/j.ajps.2024.100922_bib0163","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1021\/acs.nanolett.9b05340","article-title":"Modular acid-activatable acetone-based ketal-linked nanomedicine by dexamethasone prodrugs for enhanced anti-rheumatoid arthritis with low side effects","volume":"20","author":"Xu","year":"2020","journal-title":"Nano Lett"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0164","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3109\/17453677008991521","article-title":"Synovial pH in rheumatoid knee joints:II. the effect of local corticosteroid treatment","volume":"41","author":"Goldie","year":"2009","journal-title":"Acta Orthop Scand"},{"issue":"11","key":"10.1016\/j.ajps.2024.100922_bib0165","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202207490","article-title":"Nanomedicines reprogram synovial macrophages by scavenging nitric oxide and silencing CA9 in progressive osteoarthritis","volume":"10","author":"Yan","year":"2023","journal-title":"Adv Sci"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0166","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ajps.2020.07.002","article-title":"Intra-Articular injection of acid-sensitive stearoxyl-ketal-dexamethasone microcrystals for long-acting arthritis therapy","volume":"16","author":"Xu","year":"2021","journal-title":"Asian J Pharm Sci"},{"issue":"5","key":"10.1016\/j.ajps.2024.100922_bib0167","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1007\/s10620-012-2495-7","article-title":"Glycyrrhizin enhances therapeutic activity of a colon-specific methylprednisolone prodrug against experimental colitis","volume":"58","author":"Lee","year":"2013","journal-title":"Dig Dis Sci"},{"issue":"5","key":"10.1016\/j.ajps.2024.100922_bib0168","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1021\/mp100412z","article-title":"Synthesis, transport and mechanism of a type I prodrug: l-carnitine ester of prednisolone","volume":"8","author":"Mo","year":"2011","journal-title":"Mol Pharm"},{"issue":"1\u20132","key":"10.1016\/j.ajps.2024.100922_bib0169","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijpharm.2014.08.049","article-title":"l-Carnitine ester of prednisolone: pharmacokinetic and pharmacodynamic evaluation of a type I prodrug","volume":"475","author":"Mo","year":"2014","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.ajps.2024.100922_bib0170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/art.23230","article-title":"Amphipathic weak acid glucocorticoid prodrugs remote-loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: a novel approach to treating autoimmune arthritis","volume":"58","author":"Avnir","year":"2007","journal-title":"Arthritis Rheumatism"},{"key":"10.1016\/j.ajps.2024.100922_bib0171","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.colsurfb.2018.01.051","article-title":"Supramolecular nanofibers of dexamethasone derivatives to form hydrogel for topical ocular drug delivery","volume":"164","author":"Zhang","year":"2018","journal-title":"Colloids Surfaces B-Biointerfaces"},{"key":"10.1016\/j.ajps.2024.100922_bib0172","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jcis.2018.05.059","article-title":"Cation instructed steroidal prodrug supramolecular hydrogel","volume":"528","author":"Zhou","year":"2018","journal-title":"J Colloid Interface Sci"},{"issue":"2","key":"10.1016\/j.ajps.2024.100922_bib0173","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s44222-022-00004-6","article-title":"Biomaterials tools to modulate the tumour microenvironment in immunotherapy","volume":"1","author":"Chao","year":"2023","journal-title":"Nature Rev Bioeng"},{"issue":"6","key":"10.1016\/j.ajps.2024.100922_bib0174","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.bmcl.2013.01.060","article-title":"A nitrophenyl-based prodrug type for colorectal targeting of prednisolone, budesonide and celecoxib","volume":"23","author":"Marquez Ruiz","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"issue":"10","key":"10.1016\/j.ajps.2024.100922_bib0175","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1021\/jm8016317","article-title":"Design, synthesis, and pharmacological effects of a cyclization-activated steroid prodrug for colon targeting in inflammatory bowel disease","volume":"52","author":"Ruiz","year":"2009","journal-title":"J Med Chem"},{"issue":"8","key":"10.1016\/j.ajps.2024.100922_bib0176","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1021\/acs.bioconjchem.1c00200","article-title":"Dexamethasone and fumaric acid ester conjugate synergistically inhibits inflammation and NF-\u03baB in macrophages","volume":"32","author":"Genito","year":"2021","journal-title":"Bioconjug Chem"},{"issue":"3","key":"10.1016\/j.ajps.2024.100922_bib0177","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202102848","article-title":"Multiplexing nanodrug ameliorates liver fibrosis via ROS elimination and inflammation suppression","volume":"18","author":"Xu","year":"2021","journal-title":"Small"}],"container-title":["Asian Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1818087624000394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1818087624000394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T19:09:36Z","timestamp":1720206576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1818087624000394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":177,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S1818087624000394"],"URL":"https:\/\/doi.org\/10.1016\/j.ajps.2024.100922","relation":{},"ISSN":["1818-0876"],"issn-type":[{"value":"1818-0876","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucocorticoids-based prodrug design: Current strategies and research progress","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajps.2024.100922","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Shenyang Pharmaceutical University. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100922"}}