{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T06:53:14Z","timestamp":1758783194999,"version":"3.44.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ajps.2025.101061","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T19:17:39Z","timestamp":1745349459000},"page":"101061","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amphiphilic lipid-peptide engineered placenta-derived mesenchymal stem cells for liver fibrosis treatment"],"prefix":"10.1016","volume":"20","author":[{"given":"Hee Won","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-5029","authenticated-orcid":false,"given":"Dae Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungjun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeri","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok Kumar","family":"Jangid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaewon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyu Tae","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha Yeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4232-3441","authenticated-orcid":false,"given":"HyunJin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gi Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3678-2078","authenticated-orcid":false,"given":"Kyobum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajps.2025.101061_bib0001","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2016.97","article-title":"Liver regeneration\u2014Mechanisms and models to clinical application","volume":"13","author":"Forbes","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ajps.2025.101061_bib0002","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ajps.2025.101061_bib0003","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jconrel.2020.01.042","article-title":"Human adipose stem cell-derived extracellular nanovesicles for treatment of chornic liver fibrosis","volume":"320","author":"Han","year":"2020","journal-title":"J Controlled Release"},{"key":"10.1016\/j.ajps.2025.101061_bib0004","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajps.2025.101061_bib0005","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jhep.2023.04.036","article-title":"Changing epidemiology, global trends and implications for outcomes of NAFLD","volume":"3","author":"Wong","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajps.2025.101061_bib0006","doi-asserted-by":"crossref","first-page":"755","DOI":"10.4254\/wjh.v15.i6.755","article-title":"Treatment of liver fibrosis: past, current, and future","volume":"15","author":"Zhang","year":"2023","journal-title":"World J Hepatol"},{"key":"10.1016\/j.ajps.2025.101061_bib0007","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3748\/wjg.v21.i3.742","article-title":"Use of mesenchymal stem cells to treat liver fibrosis: current situation and future prospects","volume":"21","author":"Berardis","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.ajps.2025.101061_bib0008","article-title":"MSC-deried exosomes attenuate hepatic fibrosis in primary sclerosing cholangitis through inhibition of Th17 differentiation","volume":"19","author":"Chen","year":"2024","journal-title":"Asian J Pharm Sci"},{"key":"10.1016\/j.ajps.2025.101061_bib0009","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/SLA.0000000000001155","article-title":"Attenuation of postoperative acute liver failure by mesenchymal stem cell treatment due to metabolic implications","volume":"263","author":"Tautenhahn","year":"2016","journal-title":"Ann Surg"},{"key":"10.1016\/j.ajps.2025.101061_bib0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jhep.2020.09.014","article-title":"Cell therapy for advanced liver diseases: repair or rebuild","volume":"74","author":"Dwyer","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajps.2025.101061_bib0011","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jid.2019.07.721","article-title":"IL-1\u03b2\u2013primed mesenchymal stromal cells improve epidermal substitute engraftment and wound healing via matrix metalloproteinases and transforming growth factor-\u03b21","volume":"140","author":"Magne","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajps.2025.101061_bib0012","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jhep.2005.10.026","article-title":"Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats","volume":"44","author":"Oyagi","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajps.2025.101061_bib0013","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3390\/cells11020232","article-title":"Combination therapy of placenta-derived mesenchymal stem cells with WKYMVm promotes hepatic function in a rat model with hepatic disease via vascular remodeling","volume":"11","author":"Jun","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ajps.2025.101061_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-01920-3","article-title":"Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application","volume":"11","author":"Lee","year":"2020","journal-title":"Stem cell res ther"},{"key":"10.1016\/j.ajps.2025.101061_bib0015","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/ten.teb.2023.0210","article-title":"Ex vivo peptide decoration strategies on stem cell surfaces for augmenting endothelium interaction","volume":"30","author":"Park","year":"2024","journal-title":"Tissue Eng Part B Rev"},{"key":"10.1016\/j.ajps.2025.101061_bib0016","first-page":"122","article-title":"Peptide therapeutics: current status and future directions","volume":"20","author":"Fosgerau","year":"2015","journal-title":"Drug Discov"},{"key":"10.1016\/j.ajps.2025.101061_bib0017","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.3389\/fimmu.2019.02095","article-title":"Formyl peptide receptor 2 activation ameliorates dermal fibrosis and inflammation in bleomycin-induced scleroderma","volume":"10","author":"Park","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajps.2025.101061_bib0018","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.3390\/ijms22042107","article-title":"Formyl peptide receptor 2 alleviates hepatic fibrosis in liver cirrhosis by vascular remodeling","volume":"22","author":"Jun","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajps.2025.101061_bib0019","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/00000658-200212000-00002","article-title":"Liver regeneration is an angiogenesis-associated phenomenon","volume":"236","author":"Drixler","year":"2002","journal-title":"Ann Surg"},{"key":"10.1016\/j.ajps.2025.101061_bib0020","doi-asserted-by":"crossref","first-page":"FDD75","DOI":"10.4155\/fdd-2022-0005","article-title":"Overcoming the shortcomings of peptide-based therapeutics","volume":"4","author":"Lamers","year":"2022","journal-title":"Future Drug Discov"},{"key":"10.1016\/j.ajps.2025.101061_bib0021","doi-asserted-by":"crossref","DOI":"10.1038\/srep36617","article-title":"PEPlife: a repository of the half-life of peptides","volume":"6","author":"Mathur","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajps.2025.101061_bib0022","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.actbio.2015.07.033","article-title":"Injectable PLGA microspheres encapsulating WKYMVM peptide for neovascularization","volume":"25","author":"Choi","year":"2015","journal-title":"Acta biomater"},{"key":"10.1016\/j.ajps.2025.101061_bib0023","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40580-023-00406-1","article-title":"Tailoring tumor-recognizable hyaluronic acid\u2013lipid conjugates to enhance anticancer efficacies of surface-engineered natural killer cells","volume":"10","author":"Lee","year":"2023","journal-title":"Nano Converg"},{"key":"10.1016\/j.ajps.2025.101061_bib0024","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1021\/acs.biomac.3c01373","article-title":"Optimized design of hyaluronic acid\u2013lipid conjugate biomaterial for augmenting CD44 recognition of surface-engineered NK cells","volume":"25","author":"Park","year":"2024","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ajps.2025.101061_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.145211","article-title":"Lipid anchor-mediated NK cell surface engineering for enhanced cancer immunotherapy","volume":"473","author":"Kim","year":"2023","journal-title":"Chem Eng J"},{"key":"10.1016\/j.ajps.2025.101061_bib0026","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1021\/am100134v","article-title":"Retention dynamics of amphiphilic polymers PEG-lipids and PVA-alkyl on the cell surface","volume":"2","author":"Inui","year":"2010","journal-title":"ACS Appl Mater Intercaes"},{"key":"10.1016\/j.ajps.2025.101061_bib0027","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11684-011-0114-1","article-title":"Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction mechanisms","volume":"5","author":"Li","year":"2011","journal-title":"Front Med"},{"key":"10.1016\/j.ajps.2025.101061_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.213059","article-title":"Lipid-mediated ex vivo cell surface engineering for augmented cellular functionalities","volume":"140","author":"Kim","year":"2022","journal-title":"Biomater Adv"},{"key":"10.1016\/j.ajps.2025.101061_bib0029","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40824-023-00404-8","article-title":"Polymeric biomaterial-inspired cell surface modulation for the development of novel anticancer therapeutics","volume":"27","author":"Jangid","year":"2023","journal-title":"Biomater Res"},{"key":"10.1016\/j.ajps.2025.101061_bib0030","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1021\/acs.biomac.3c00916","article-title":"Ex vivo surface decoration of phenylboronic acid onto natural killer cells for sialic acid-mediated versatile cancer cell targeting","volume":"25","author":"Jangid","year":"2023","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ajps.2025.101061_bib0031","article-title":"Surface engineering of natural killer cells with CD44-targeting ligands for augmented cancer immunotherapy","volume":"20","author":"Kim","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.ajps.2025.101061_bib0032","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00441-009-0780-3","article-title":"Hyaluronan substratum induces multidrug resistance in human mesenchymal stem cells via CD44 signaling","volume":"336","author":"Liu","year":"2009","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajps.2025.101061_bib0033","first-page":"276","article-title":"Enhanced angiogenic potential of adipose-derived stem cell sheets by integration with cell spheroids of the same source","volume":"13","author":"Yu","year":"2022","journal-title":"Stem Cell ResTher"},{"key":"10.1016\/j.ajps.2025.101061_bib0034","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.21037\/jgo-20-394","article-title":"Morphine promotes angiogenesis by activating PI3K\/akt\/HIF-1\u03b1 pathway and upregulating VEGF in hepatocellular carcinoma","volume":"12","author":"Wang","year":"2021","journal-title":"J Gastrointest Oncol"},{"key":"10.1016\/j.ajps.2025.101061_bib0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.actbio.2019.03.052","article-title":"Coacervate-mediated exogenous growth factor delivery for scarless skin regeneration","volume":"90","author":"Park","year":"2019","journal-title":"Acta biomater"},{"key":"10.1016\/j.ajps.2025.101061_bib0036","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/146532400539305","article-title":"The nonhematopoietic mesenchymal stem cell committee workshop. Nonhematopoietic mesenchymal stem cells: what are they?","volume":"2","author":"Horwitz","year":"2000","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ajps.2025.101061_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-020-00433-z","article-title":"Perspective of placenta derived mesenchymal stem cells in acute liver failure","volume":"10","author":"Saleh","year":"2020","journal-title":"Cell & biosci"},{"key":"10.1016\/j.ajps.2025.101061_bib0038","doi-asserted-by":"crossref","first-page":"e5846","DOI":"10.1371\/journal.pone.0005846","article-title":"Aging and replicative senescence have related effects on human stem and progenitor cells","volume":"4","author":"Wagner","year":"2009","journal-title":"PLoS one"},{"key":"10.1016\/j.ajps.2025.101061_bib0039","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00441-011-1249-8","article-title":"Human chorionic-plate-derived mesenchymal stem cells and Wharton\u2019s jelly-derived mesenchymal stem cells: a comparative analysis of their potential as placenta-derived stem cells","volume":"346","author":"Kim","year":"2011","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajps.2025.101061_bib0040","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00441-007-0504-5","article-title":"Human-placenta-derived mesenchymal stem cells inhibit proliferation and function of allogeneic immune cells","volume":"330","author":"Li","year":"2007","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajps.2025.101061_bib0041","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s13287-021-02358-x","article-title":"Human placental mesenchymal stem cells ameliorate liver fibrosis in mice by upregulation of Caveolin1 in hepatic stellate cells","volume":"12","author":"Yao","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.ajps.2025.101061_bib0042","doi-asserted-by":"crossref","first-page":"79","DOI":"10.15283\/ijsc.2015.8.1.79","article-title":"Epigenetic alterations of IL-6\/STAT3 signaling by placental stem cells promote hepatic regeneration in a rat model with CCl4-induced liver injury","volume":"8","author":"Jung","year":"2015","journal-title":"Int J Stem Cell"},{"key":"10.1016\/j.ajps.2025.101061_bib0043","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/stem.1396","article-title":"Human placenta-derived mesenchymal stem cells promote hepatic regeneration in CCl4-injured rat liver model via increased autophagic mechanism","volume":"31","author":"Jung","year":"2013","journal-title":"Stem cells"},{"key":"10.1016\/j.ajps.2025.101061_bib0044","doi-asserted-by":"crossref","first-page":"61","DOI":"10.18632\/aging.202348","article-title":"Human placenta-derived mesenchymal stem cells trigger repair system in TAA-injured rat model via antioxidant effect","volume":"13","author":"Na","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ajps.2025.101061_bib0045","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.3390\/cells12232708","article-title":"Increased hepatocyte growth factor secretion by placenta-derived mesenchymal stem cells improves ovarian function in an ovariectomized rat model via vascular remodeling by wnt signaling activation","volume":"12","author":"Park","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.ajps.2025.101061_bib0046","doi-asserted-by":"crossref","first-page":"12967","DOI":"10.1021\/acsami.6b16434","article-title":"Temporary single-cell coating for bioprocessing with a cationic polymer","volume":"9","author":"Ribeiro","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.ajps.2025.101061_bib0047","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.biomaterials.2007.11.048","article-title":"Behavior of synthetic polymers immobilized on a cell membrane","volume":"29","author":"Teramura","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.ajps.2025.101061_bib0048","article-title":"Amphiphilic lipid conjugate-mediated surface engineering of placenta-derived mesenchymal stem cells for alleviating liver damage and fibrosis","author":"Kim","year":"2024","journal-title":"Chem Eng J"},{"key":"10.1016\/j.ajps.2025.101061_bib0049","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1038\/s41598-019-43321-4","article-title":"WKYMVm hexapeptide, a strong formyl peptide receptor 2 agonist, attenuates hyperoxia-induced lung injuries in newborn mice","volume":"9","author":"Kim","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajps.2025.101061_bib0050","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41598-017-00314-5","article-title":"Formyl peptide receptors promotes neural differentiation in mouse neural stem cells by ROS generation and regulation of PI3K-AKT signaling","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajps.2025.101061_bib0051","doi-asserted-by":"crossref","first-page":"335","DOI":"10.12998\/wjcc.v6.i10.335","article-title":"Research progress on signaling pathways in cirrhotic portal hypertension","volume":"6","author":"Xu","year":"2018","journal-title":"World J Clin Cases"},{"key":"10.1016\/j.ajps.2025.101061_bib0052","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/stem.1578","article-title":"WKYMVm-induced activation of formyl peptide receptor 2 stimulates ischemic neovasculogenesis by promoting homing of endothelial colony-forming cells","volume":"32","author":"Heo","year":"2014","journal-title":"Stem cells"},{"key":"10.1016\/j.ajps.2025.101061_bib0053","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.febslet.2013.03.036","article-title":"WKYMVm-induced cross-talk between FPR2 and HGF receptor in human prostate epithelial cell line PNT1A","volume":"587","author":"Cattaneo","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ajps.2025.101061_bib0054","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s12276-023-00941-1","article-title":"Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver","volume":"55","author":"Lee","year":"2023","journal-title":"Exp Mol Med"},{"issue":"8","key":"10.1016\/j.ajps.2025.101061_bib0055","article-title":"Protective role of morin, a flavonoid, against high glucose induced oxidative stress mediated apoptosis in primary rat hepatocytes","volume":"7","author":"Kappor","year":"2012","journal-title":"PLOs One"},{"key":"10.1016\/j.ajps.2025.101061_bib0056","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nature Rev Immunol"},{"key":"10.1016\/j.ajps.2025.101061_bib0057","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduction Targeted Ther"},{"key":"10.1016\/j.ajps.2025.101061_bib0058","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1440-1746.2010.06549.x","article-title":"Hepatocyte growth factor twenty years on: much more than a growth factor","volume":"26","author":"Nakamura","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ajps.2025.101061_bib0059","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1053\/j.gastro.2014.01.061","article-title":"Vascular endothelial growth factor promotes fibrosis resolution and repair in mice","volume":"146","author":"Yang","year":"2014","journal-title":"Gastroenterol"},{"key":"10.1016\/j.ajps.2025.101061_bib0060","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.672658","article-title":"Interleukin-10 attenuates liver fibrosis exacerbated by thermoneutrality","volume":"8","author":"Nga","year":"2021","journal-title":"Front Med"},{"key":"10.1016\/j.ajps.2025.101061_bib0061","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41575-023-00807-x","article-title":"Hepatic inflammatory responses in liver fibrosis","volume":"20","author":"Hammerich","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.ajps.2025.101061_bib0062","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41467-022-35637-z","article-title":"Ligand-tethered lipid nanoparticels for targeted RNA delivery to treat liver fibrosis","volume":"14","author":"Han","year":"2023","journal-title":"Nat commun"},{"key":"10.1016\/j.ajps.2025.101061_bib0063","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","article-title":"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-\u03b2 as major players and therapeutic targets","volume":"10","author":"Gressner","year":"2006","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ajps.2025.101061_bib0064","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/j.ajpath.2019.07.019","article-title":"Smooth muscle \u03b1-actin deficiency leads to decreased liver fibrosis via impaired cytoskeletal signaling in hepatic stellate cells","volume":"189","author":"Rockey","year":"2019","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajps.2025.101061_bib0065","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.ajps.2025.101061_bib0066","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1073\/pnas.92.7.2572","article-title":"Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions","volume":"92","author":"Sanderson","year":"1995","journal-title":"Proc Natol Acad Sci"},{"key":"10.1016\/j.ajps.2025.101061_bib0067","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s40139-015-0089-8","article-title":"TGF-\u03b2 in hepatic stellate cell activation and liver fibrogenesis: updated","volume":"3","author":"Dewidar","year":"2015","journal-title":"Curr Pathobiol Rep"},{"key":"10.1016\/j.ajps.2025.101061_bib0068","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/j.2040-4603.2013.tb00529.x","article-title":"Hepatic stellate cells and liver fibrosis","volume":"3","author":"Puche","year":"2013","journal-title":"Compr physiol"},{"key":"10.1016\/j.ajps.2025.101061_bib0069","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.3748\/wjg.v13.i19.2707","article-title":"Generation of human\/rat xenograft animal model for the study of human donor stem cell behaviors in vivo","volume":"13","author":"Sun","year":"2007","journal-title":"World J Gastroenterol:WJG"},{"key":"10.1016\/j.ajps.2025.101061_bib0070","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.3748\/wjg.15.3611","article-title":"Phenotypic changes of human cells in human-rat liver during partial hepatectomy-induced regeneration","volume":"15","author":"Sun","year":"2009","journal-title":"World J Gastroenterol:WJG"},{"key":"10.1016\/j.ajps.2025.101061_bib0071","first-page":"352","article-title":"Measurement and clinical usefulness of bilirubin in liver disease","volume":"2","author":"Guerra Ruiz","year":"2021","journal-title":"Adv Lab Med"},{"key":"10.1016\/j.ajps.2025.101061_bib0072","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3109\/10715762.2015.1133906","article-title":"Longitudinal study of circulating oxidized LDL and HDL and fatty liver: the cardiovascular risk in Young Finns Study","volume":"50","author":"Kaikkonen","year":"2016","journal-title":"Free Radical Res"},{"key":"10.1016\/j.ajps.2025.101061_bib0073","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-020-01274-y","article-title":"Long term N-acetylcysteine administration rescues liver steatosis via endoplasmic reticulum stress with unfolded protein response in mice","volume":"19","author":"Tsai","year":"2020","journal-title":"Lipids Health Dis"},{"issue":"2","key":"10.1016\/j.ajps.2025.101061_bib0074","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/dvdy.20020","article-title":"VEGF coordinates interaction of pericytes and endothelial cells during vasculogenesis and experimental angiogenesis","volume":"229","author":"Hagedorn","year":"2004","journal-title":"Dev dyn"},{"key":"10.1016\/j.ajps.2025.101061_bib0075","article-title":"Smart microneedle arrays integrating cell-free therapy and nanocatalysis to treat liver fibrosis","volume":"2024","author":"Xu","year":"2024","journal-title":"Adv Sci"},{"key":"10.1016\/j.ajps.2025.101061_bib0076","article-title":"Natural polysaccharid-based smart CXCRR4-targeted nano-system for magnified liver fibrosis therapy","volume":"2024","author":"Sun","year":"2024","journal-title":"Chi Chem Lett"}],"container-title":["Asian Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1818087625000455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1818087625000455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T06:15:04Z","timestamp":1758780904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1818087625000455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1818087625000455"],"URL":"https:\/\/doi.org\/10.1016\/j.ajps.2025.101061","relation":{},"ISSN":["1818-0876"],"issn-type":[{"type":"print","value":"1818-0876"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amphiphilic lipid-peptide engineered placenta-derived mesenchymal stem cells for liver fibrosis treatment","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajps.2025.101061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Shenyang Pharmaceutical University. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101061"}}