{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:04:13Z","timestamp":1789488253463,"version":"build-2803163510"},"reference-count":69,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171336"],"award-info":[{"award-number":["32171336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LHDMY24H300002"],"award-info":[{"award-number":["LHDMY24H300002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ajps.2026.101166","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:34:23Z","timestamp":1780119263000},"page":"101166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydrogel co-delivery of 5-fluorouracil and siRNA attenuates TGF-\u03b21-mediated MMT to prevent postoperative peritoneal metastasis and adhesion in colorectal cancer"],"prefix":"10.1016","volume":"21","author":[{"given":"Jinpeng","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangchuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5620-5470","authenticated-orcid":false,"given":"Yunhe","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanchao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6549-3203","authenticated-orcid":false,"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ajps.2026.101166_bib0001","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.annonc.2020.06.022","article-title":"Localised colon cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"31","author":"Argil\u00e9s","year":"2020","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ajps.2026.101166_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101746","article-title":"Perioperative chemotherapy in colorectal cancer with peritoneal metastases: a global propensity score matched study","volume":"55","author":"Cashin","year":"2023","journal-title":"EClinicalMedicine"},{"issue":"31","key":"10.1016\/j.ajps.2026.101166_bib0003","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202400894","article-title":"Neutrophil extracellular traps-inhibiting and fouling-resistant polysulfoxides potently prevent postoperative adhesion, tumor recurrence, and metastasis","volume":"36","author":"Wang","year":"2024","journal-title":"Adv Mater"},{"issue":"5","key":"10.1016\/j.ajps.2026.101166_bib0004","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/00000658-200005000-00015","article-title":"Survival after resection of multiple bilobar hepatic metastases from colorectal carcinoma","volume":"231","author":"Bolton","year":"2000","journal-title":"Ann Surg"},{"issue":"10","key":"10.1016\/j.ajps.2026.101166_bib0005","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202009431","article-title":"Biodegradable zwitterionic cream gel for effective prevention of postoperative adhesion","volume":"31","author":"Zhang","year":"2021","journal-title":"Adv Funct Mater"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0006","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1038\/s41467-019-12370-8","article-title":"NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis","volume":"10","author":"Ershaid","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajps.2026.101166_bib0007","first-page":"27","article-title":"Bottlebrush inspired injectable hydrogel for rapid prevention of postoperative and recurrent adhesion","volume":"16","author":"Gao","year":"2022","journal-title":"Bioact Mater"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0008","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41584-019-0324-5","article-title":"Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases","volume":"16","author":"Hinz","year":"2020","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"10.1016\/j.ajps.2026.101166_bib0009","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ki.2014.287","article-title":"Origin of myofibroblasts and cellular events triggering fibrosis","volume":"87","author":"Mack","year":"2015","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.ajps.2026.101166_bib0010","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/path.4281","article-title":"Carcinoma-associated fibroblasts derive from mesothelial cells via mesothelial-to-mesenchymal transition in peritoneal metastasis","volume":"231","author":"Sandoval","year":"2013","journal-title":"J Pathol"},{"issue":"2","key":"10.1016\/j.ajps.2026.101166_bib0011","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3390\/cancers12020499","article-title":"Mesothelial-to-mesenchymal transition contributes to the generation of carcinoma-associated fibroblasts in locally advanced primary colorectal carcinomas","volume":"12","author":"Gordillo","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0012","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/path.4695","article-title":"Mesothelial-to-mesenchymal transition in the pathogenesis of post-surgical peritoneal adhesions","volume":"239","author":"Sandoval","year":"2016","journal-title":"J Pathol"},{"issue":"2","key":"10.1016\/j.ajps.2026.101166_bib0013","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/path.4889","article-title":"Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer","volume":"242","author":"Rynne-Vidal","year":"2017","journal-title":"J Pathol"},{"key":"10.1016\/j.ajps.2026.101166_bib0014","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.matbio.2016.01.017","article-title":"Pathobiological mechanisms of peritoneal adhesions: the mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-\u03b21 and IL-6 requires activation of Erk1\/2 and Smad2 linker region phosphorylation","volume":"51","author":"Jin","year":"2016","journal-title":"Matrix Biol"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0015","doi-asserted-by":"crossref","first-page":"L115","DOI":"10.1152\/ajplung.90587.2008","article-title":"Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-\u03b21 in vitro","volume":"297","author":"Nasreen","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajps.2026.101166_bib0016","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.2147\/CMAR.S177373","article-title":"SALL4 activatesTGF-\u03b2\/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis","volume":"Volume 10","author":"Zhang","year":"2018","journal-title":"Cancer Manag Res"},{"issue":"20","key":"10.1016\/j.ajps.2026.101166_bib0017","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1038\/onc.2011.429","article-title":"Tissue transglutaminase links TGF-\u03b2, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer","volume":"31","author":"Cao","year":"2012","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0018","first-page":"101","article-title":"Therapeutic siRNA: state of the art","volume":"5","author":"Hu","year":"2020","journal-title":"Sign Transd Targ Ther"},{"key":"10.1016\/j.ajps.2026.101166_bib0019","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s11426-025-3018-0","article-title":"Chemical biology of precise RNA targeting and intervention: advances and perspectives","volume":"69","author":"Wu","year":"2026","journal-title":"Sci China Chem"},{"issue":"5","key":"10.1016\/j.ajps.2026.101166_bib0020","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41576-021-00439-4","article-title":"Drug delivery systems for RNA therapeutics","volume":"23","author":"Paunovska","year":"2022","journal-title":"Nat Rev Genet"},{"issue":"23","key":"10.1016\/j.ajps.2026.101166_bib0021","doi-asserted-by":"crossref","first-page":"17073","DOI":"10.1021\/acs.chemrev.2c00344","article-title":"Zwitterionic biomaterials","volume":"122","author":"Li","year":"2022","journal-title":"Chem Rev"},{"issue":"50","key":"10.1016\/j.ajps.2026.101166_bib0022","doi-asserted-by":"crossref","first-page":"32046","DOI":"10.1073\/pnas.2012491117","article-title":"Fouling-resistant zwitterionic polymers for complete prevention of postoperative adhesion","volume":"117","author":"Zhang","year":"2020","journal-title":"Proc Nat Acad Sci"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0023","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41572-021-00326-6","article-title":"Primary and metastatic peritoneal surface malignancies","volume":"7","author":"Cort\u00e9s-Guiral","year":"2021","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"10.1016\/j.ajps.2026.101166_bib0024","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1158\/0008-5472.CAN-15-1591","article-title":"Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress","volume":"76","author":"Tohme","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajps.2026.101166_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.127096","article-title":"An injectable and antifouling self-fused supramolecular hydrogel for preventing postoperative and recurrent adhesions","volume":"404","author":"Zhao","year":"2021","journal-title":"Chem Eng J"},{"issue":"16","key":"10.1016\/j.ajps.2026.101166_bib0026","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202008395","article-title":"An ultrasoft self-fused supramolecular polymer hydrogel for completely preventing postoperative tissue adhesion","volume":"33","author":"Yu","year":"2021","journal-title":"Adv Mater"},{"key":"10.1016\/j.ajps.2026.101166_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122661","article-title":"An injectable and antifouling hydrogel prevents the development of abdominal adhesions by inhibiting the ccl2\/ccr2 interaction","volume":"311","author":"Wen","year":"2024","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.ajps.2026.101166_bib0028","doi-asserted-by":"crossref","first-page":"605","DOI":"10.5230\/jgc.2025.25.e46","article-title":"Distinct immunosuppressive tumor microenvironment in gastric cancer with peritoneal metastasis","volume":"25","author":"Kim","year":"2025","journal-title":"J Gastric Cancer"},{"issue":"8","key":"10.1016\/j.ajps.2026.101166_bib0029","doi-asserted-by":"crossref","DOI":"10.1063\/5.0216272","article-title":"A comprehensive electron wavefunction analysis toolbox for chemists, Multiwfn","volume":"161","author":"Lu","year":"2024","journal-title":"J Chem Phys"},{"issue":"5","key":"10.1016\/j.ajps.2026.101166_bib0030","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcc.22885","article-title":"Multiwfn: a multifunctional wavefunction analyzer","volume":"33","author":"Lu","year":"2012","journal-title":"J Comput Chem"},{"key":"10.1016\/j.ajps.2026.101166_bib0031","unstructured":"Tian Lu S. Sobtop: a tool of generating forcefield parameters and GROMACS topology file. Version [1.0(dev5)]. Available online: http:\/\/sobereva.com\/soft\/Sobtop (accessed 1 July 2026)."},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0032","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/wcms.81","article-title":"The ORCA program system","volume":"2","author":"Neese","year":"2012","journal-title":"Wires Comput Mol Sci"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0033","doi-asserted-by":"crossref","DOI":"10.1002\/wcms.1327","article-title":"Software update: the ORCA program system, version 4.0","volume":"8","author":"Neese","year":"2018","journal-title":"Wires Comput Mol Sci"},{"issue":"5","key":"10.1016\/j.ajps.2026.101166_bib0034","doi-asserted-by":"crossref","DOI":"10.1002\/wcms.1606","article-title":"Software update: the ORCA program system\u2014version 5.0","volume":"12","author":"Neese","year":"2022","journal-title":"Wires Comput Mol Sci"},{"issue":"14","key":"10.1016\/j.ajps.2026.101166_bib0035","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1002\/jcc.10318","article-title":"An improvement of the resolution of the identity approximation for the formation of the coulomb matrix","volume":"24","author":"Neese","year":"2003","journal-title":"J Comput Chem"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0036","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.chemphys.2008.10.036","article-title":"Efficient, approximate and parallel Hartree\u2013Fock and hybrid DFT calculations. A \u2018chain-of-spheres\u2019 algorithm for the Hartree\u2013Fock exchange","volume":"356","author":"Neese","year":"2009","journal-title":"Chem Phys"},{"issue":"2","key":"10.1016\/j.ajps.2026.101166_bib0037","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1021\/acs.jctc.6b01041","article-title":"Automatic generation of auxiliary basis sets","volume":"13","author":"Stoychev","year":"2017","journal-title":"J Chem Theory Comput"},{"issue":"20","key":"10.1016\/j.ajps.2026.101166_bib0038","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/jcc.25833","article-title":"Efficient implementation of the analytical second derivatives of Hartree\u2013Fock and hybrid DFT energies within the framework of the conductor-like polarizable continuum model","volume":"40","author":"Garcia-Rat\u00e9s","year":"2019","journal-title":"J Comput Chem"},{"issue":"9","key":"10.1016\/j.ajps.2026.101166_bib0039","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/jcc.26139","article-title":"Effect of the solute cavity on the solvation energy and its derivatives within the framework of the gaussian charge scheme","volume":"41","author":"Garcia-Rat\u00e9s","year":"2020","journal-title":"J Comput Chem"},{"key":"10.1016\/j.ajps.2026.101166_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.softx.2017.11.002","article-title":"Recent developments in LIBXC\u2014a comprehensive electron wavefunction analysis toolbox for chemists, multiwfnA comprehensive library of functionals for density functional theory","volume":"7","author":"Lehtola","year":"2018","journal-title":"SoftwareX"},{"issue":"11","key":"10.1016\/j.ajps.2026.101166_bib0041","doi-asserted-by":"crossref","DOI":"10.1063\/5.0167763","article-title":"Reproducibility of density functional approximations: how new functionals should be reported","volume":"159","author":"Lehtola","year":"2023","journal-title":"J Chem Phys"},{"issue":"10","key":"10.1016\/j.ajps.2026.101166_bib0042","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.cpc.2012.05.007","article-title":"Libxc: a library of exchange and correlation functionals for density functional theory","volume":"183","author":"Marques","year":"2012","journal-title":"Comput Phys Commun"},{"key":"10.1016\/j.ajps.2026.101166_bib0043","unstructured":"Valeev, E.F. Libint: a library for the evaluation of molecular integrals of many-body operators over Gaussian functions (version 2.10.2). Available online: http:\/\/libint.valeyev.net\/ (accessed 1 July 2026)."},{"key":"10.1016\/j.ajps.2026.101166_bib0044","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"Gromacs: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.ajps.2026.101166_bib0045","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.micromeso.2015.12.024","article-title":"Controlled synthesis of monodispersed mesoporous silica nanoparticles: particle size tuning and formation mechanism investigation","volume":"225","author":"Lv","year":"2016","journal-title":"Microporous Mesoporous Mater"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0046","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/872035","article-title":"Functionalization of hollow mesoporous silica nanoparticles for improved 5-FU loading","volume":"2015","author":"She","year":"2015","journal-title":"J Nanomater"},{"key":"10.1016\/j.ajps.2026.101166_bib0047","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.actbio.2022.12.025","article-title":"pH-responsive nanocomposite hydrogel for simultaneous prevention of postoperative adhesion and tumor recurrence","volume":"158","author":"Zhou","year":"2023","journal-title":"Acta Biomater"},{"issue":"11","key":"10.1016\/j.ajps.2026.101166_bib0048","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.biomaterials.2013.01.006","article-title":"Injectable intratumoral hydrogel as 5-fluorouracil drug depot","volume":"34","author":"Seo","year":"2013","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.ajps.2026.101166_bib0049","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1021\/acs.langmuir.2c02253","article-title":"Porous hydrogels: present challenges and future opportunities","volume":"39","author":"Foudazi","year":"2023","journal-title":"Langmuir"},{"key":"10.1016\/j.ajps.2026.101166_bib0050","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.actbio.2021.11.036","article-title":"Design and characterization of an in vivo injectable hydrogel with effervescently generated porosity for regenerative medicine applications","volume":"140","author":"Griveau","year":"2022","journal-title":"Acta Biomater"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0051","doi-asserted-by":"crossref","DOI":"10.1080\/23311916.2020.1736407","article-title":"Biocompatible conjugation for biodegradable hydrogels as drug and cell scaffolds","volume":"7","author":"Fan","year":"2020","journal-title":"Cogent Eng"},{"key":"10.1016\/j.ajps.2026.101166_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.146061","article-title":"Carrier-free 5-FU nanoparticle-mediated domestication therapy for scar treatment: a preclinical and first-in-human study","volume":"475","author":"He","year":"2023","journal-title":"Chem Eng J"},{"issue":"8","key":"10.1016\/j.ajps.2026.101166_bib0053","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.1039\/D5RA08269B","article-title":"Hydrogel-based drug delivery systems for enhanced tumor therapy","volume":"16","author":"Tian","year":"2026","journal-title":"RSC Adv"},{"key":"10.1016\/j.ajps.2026.101166_bib0054","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ijbiomac.2022.08.167","article-title":"In-vitro evaluation of the 5-fluorouracil loaded GQDs@Bio-MOF capped with starch biopolymer for improved colon-specific delivery","volume":"221","author":"Hassanpouraghdam","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.ajps.2026.101166_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139513","article-title":"Synergistic topical cancer therapy using dual drug delivery of dexamethasone and 5-fluorouracil via deoxycholic acid micelle-carboxymethyl cellulose hydrogel composites","volume":"300","author":"Rezvanfar","year":"2025","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"10.1016\/j.ajps.2026.101166_bib0056","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s44174-024-00236-7","article-title":"Postoperative adhesions: current research on mechanisms, therapeutics and preventative measures","volume":"3","author":"Morris","year":"2025","journal-title":"Biomed Mater Devices"},{"key":"10.1016\/j.ajps.2026.101166_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.156747","article-title":"Engineering injectable bioadhesives with sealing and anti-fouling properties for postoperative anti-adhesion","volume":"500","author":"Gong","year":"2024","journal-title":"Chem Eng J"},{"key":"10.1016\/j.ajps.2026.101166_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.126536","article-title":"Polysaccharide-based injectable hydrogels for targeted drug delivery: advances and challenges","volume":"690","author":"Liao","year":"2026","journal-title":"Int J Pharm"},{"issue":"4","key":"10.1016\/j.ajps.2026.101166_bib0059","article-title":"Rhein-based pickering emulsion for hepatocellular carcinoma: shaping the metabolic signaling and immunoactivation in transarterial chemoembolization","volume":"5","author":"Liang","year":"2024","journal-title":"Aggregate"},{"issue":"23","key":"10.1016\/j.ajps.2026.101166_bib0060","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400841","article-title":"Enhanced mechanical strength and sustained drug release in carrier-free silver-coordinated anthraquinone natural antibacterial anti-inflammatory hydrogel for infectious wound healing","volume":"13","author":"Liang","year":"2024","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.ajps.2026.101166_bib0061","first-page":"17","article-title":"Hydrogel-based tumor embolization and synergistic therapeutic strategies","volume":"59","author":"Peng","year":"2026","journal-title":"Bioact Mater"},{"key":"10.1016\/j.ajps.2026.101166_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2025.01.088","article-title":"Self-assembling chemodrug fiber-hydrogel for transarterial chemoembolization and radiotherapy-enhanced antitumor immunity","volume":"380","author":"Peng","year":"2025","journal-title":"J Control Release"},{"key":"10.1016\/j.ajps.2026.101166_bib0063","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2020.09.009","article-title":"Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology","volume":"116","author":"Huang","year":"2020","journal-title":"Acta Biomater"},{"issue":"6","key":"10.1016\/j.ajps.2026.101166_bib0064","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1515\/hsz-2021-0120","article-title":"STAT3 promotes peritoneal metastasis of gastric cancer by enhancing mesothelial-mesenchymal transition","volume":"402","author":"Yang","year":"2021","journal-title":"Biol Chem"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0065","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00085-0","article-title":"siRNA delivery using intelligent chitosan-capped mesoporous silica nanoparticles for overcoming multidrug resistance in malignant carcinoma cells","volume":"11","author":"Heidari","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ajps.2026.101166_bib0066","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41598-021-04065-2","article-title":"MiR-29b may suppresses peritoneal metastases through inhibition of the mesothelial-mesenchymal transition (MMT) of human peritoneal mesothelial cells","volume":"12","author":"Kimura","year":"2022","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.ajps.2026.101166_bib0067","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.3390\/ijms21114158","article-title":"Reprogramming of mesothelial-mesenchymal transition in chronic peritoneal diseases by estrogen receptor modulation and TGF-\u03b21 inhibition","volume":"21","author":"Wilson","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajps.2026.101166_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.163134","article-title":"Injectable polyphenol hydrogel prevents peritoneal adhesion intensified by intraperitoneal microbial infection","volume":"513","author":"Wen","year":"2025","journal-title":"Chem Eng J"},{"issue":"10","key":"10.1016\/j.ajps.2026.101166_bib0069","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nrc909","article-title":"VEGF and the quest for tumour angiogenesis factors","volume":"2","author":"Ferrara","year":"2002","journal-title":"Nat Rev Cancer"}],"container-title":["Asian Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1818087626000528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1818087626000528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:20:42Z","timestamp":1789485642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1818087626000528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1818087626000528"],"URL":"https:\/\/doi.org\/10.1016\/j.ajps.2026.101166","relation":{},"ISSN":["1818-0876"],"issn-type":[{"value":"1818-0876","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogel co-delivery of 5-fluorouracil and siRNA attenuates TGF-\u03b21-mediated MMT to prevent postoperative peritoneal metastasis and adhesion in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajps.2026.101166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Shenyang Pharmaceutical University. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101166"}}