{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:03:59Z","timestamp":1789488239266,"version":"build-2803163510"},"reference-count":67,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ajps.2026.101184","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:55:55Z","timestamp":1783922155000},"page":"101184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Janus microneedles enabling orderly vitiligo treatment through spatiotemporal sequential promoting melanogenesis to transfer via PAR2 activation"],"prefix":"10.1016","volume":"21","author":[{"given":"Yan","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhi","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajps.2026.101184_bib0001","article-title":"Pathogenesis and regenerative therapy in vitiligo and alopecia areata: focus on hair follicle","volume":"11","author":"Zhou","year":"2024","journal-title":"Front Med"},{"key":"10.1016\/j.ajps.2026.101184_bib0002","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0022-202X.2004.23528.x","article-title":"Hair follicle pigmentation","volume":"124","author":"Slominski","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajps.2026.101184_bib0003","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1006\/dbio.2000.9856","article-title":"MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair follicles","volume":"225","author":"Jordan","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajps.2026.101184_bib0004","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1755-148X.2011.00855.x","article-title":"Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation","volume":"24","author":"Nishimura","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.ajps.2026.101184_bib0005","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/jid.2014.65","article-title":"Melanocytes as instigators and victims of oxidative stress","volume":"134","author":"Denat","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajps.2026.101184_bib0006","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/14728222.2023.2193329","article-title":"Treatment update for vitiligo based on autoimmune inhibition and melanocyte protection","volume":"27","author":"Xie","year":"2023","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.ajps.2026.101184_bib0007","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.3390\/ijms22094466","article-title":"Melanin transfer in the epidermis: the pursuit of skin pigmentation control mechanisms","volume":"22","author":"Moreiras","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajps.2026.101184_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417306","article-title":"Vitiligo: pathogenesis and new and emerging treatments","volume":"24","author":"Perez-Bootello","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajps.2026.101184_bib0009","article-title":"Candidate approaches for predicting vitiligo recurrence: an effective model and biomarkers","volume":"16","author":"Liu","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajps.2026.101184_bib0010","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.phytochem.2018.05.003","article-title":"Phytochemical profiles, phototoxic and antioxidant properties of eleven Hypericum species \u2013 a comparative study","volume":"152","author":"Napoli","year":"2018","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ajps.2026.101184_bib0011","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.apsb.2025.10.046","article-title":"A systemic immunogenic reactor leveraging modified \u03b3-cyclodextrins for photo-controlled cancer Ca2+ interference via modulating MICU1","volume":"16","author":"Jing","year":"2026","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.ajps.2026.101184_bib0012","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/ptr.6080","article-title":"Astragalus polysaccharides exerts anti-infective activity by inducing human cathelicidin antimicrobial peptide LL-37 in respiratory epithelial cells","volume":"32","author":"Zhao","year":"2018","journal-title":"Phytother Res PTR"},{"key":"10.1016\/j.ajps.2026.101184_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111303","article-title":"Astragalus polysaccharides promote neural stem cells-derived oligodendrogenesis through attenuating CD8+T cell infiltration in experimental autoimmune encephalomyelitis","volume":"126","author":"Zhao","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.ajps.2026.101184_bib0014","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1046\/j.0022-202x.2001.01575.x","article-title":"Protease-activated receptor 2, a receptor involved in melanosome transfer, is upregulated in human skin by ultraviolet irradiation","volume":"117","author":"Scott","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajps.2026.101184_bib0015","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1242\/jcs.113.17.3093","article-title":"The protease-activated receptor-2 upregulates keratinocyte phagocytosis","volume":"113","author":"Sharlow","year":"2000","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajps.2026.101184_bib0016","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.apsb.2023.08.013","article-title":"Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK\/NLRP3\/IL-1\u03b2 and NO\/iNOS signalling","volume":"14","author":"Zhuo","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.ajps.2026.101184_bib0017","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/ar.1092100404","article-title":"The influence of the hair cycle on the thickness of mouse skin","volume":"210","author":"Hansen","year":"1984","journal-title":"Anat Rec"},{"key":"10.1016\/j.ajps.2026.101184_bib0018","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.stem.2020.01.012","article-title":"The molecular anatomy of mouse skin during hair growth and rest","volume":"26","author":"Joost","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajps.2026.101184_bib0019","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1038\/s41467-025-59651-z","article-title":"Immunomodulatory multifunctional Janus collagen-based membrane for advanced bone regeneration","volume":"16","author":"Yang","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajps.2026.101184_bib0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-55303-w","article-title":"Surface enzyme-polymerization endows Janus hydrogel tough adhesion and regenerative repair in penetrating orocutaneous fistulas","volume":"15","author":"Ju","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajps.2026.101184_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123090","article-title":"Nano-polymeric platinum activates PAR2 gene editing to suppress tumor metastasis","volume":"317","author":"Jiang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.ajps.2026.101184_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2021.119144","article-title":"PAR2 blockade reverses osimertinib resistance in non-small-cell lung cancer cells via attenuating ERK-mediated EMT and PD-L1 expression","volume":"1869","author":"Jiang","year":"2022","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.ajps.2026.101184_bib0023","article-title":"Bioinspired adaptable indwelling microneedles for treatment of diabetic ulcers","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv Mater"},{"key":"10.1016\/j.ajps.2026.101184_bib0024","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1021\/acsnano.2c08979","article-title":"Reactive oxygen species-responsive gel-based microneedle patches for prolonged and intelligent psoriasis management","volume":"17","author":"Bi","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ajps.2026.101184_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120549","article-title":"Tofacitinib combined with melanocyte protector \u03b1-MSH to treat vitiligo through dextran based hydrogel microneedles","volume":"305","author":"Liang","year":"2023","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.ajps.2026.101184_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120151","article-title":"Reducing neuroinflammation through PKC\u03b3\/p38\/NF-\u03baB signaling pathway: the mechanism of Danzhi Xiaoyaosan in improving post-stroke depression","volume":"352","author":"Zeng","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.ajps.2026.101184_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109892","article-title":"Drug transdermal delivery by electrophonophoresis can increase the concentration of rifampicin in the pleural effusion of patients with tuberculous pleurisy but has no effect on the concentration of rifampicin in plasma","volume":"117","author":"Liu","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.ajps.2026.101184_bib0028","first-page":"61","article-title":"Identification of selected flavonoids extracted from cap and stem of wild and cultivated Ganoderma species (Agaricomycetes) and bioactivities","volume":"27","author":"Liu","year":"2025","journal-title":"Int J Med Mushrooms"},{"key":"10.1016\/j.ajps.2026.101184_bib0029","article-title":"Green tea polyphenol alleviates silica particle-induced lung injury by suppressing IL-17\/NF-\u03baB p65 signaling-driven inflammation","volume":"135","author":"Xu","year":"2024","journal-title":"Phytomedicine Int J Phytother Phytopharm"},{"key":"10.1016\/j.ajps.2026.101184_bib0030","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1080\/14786419.2024.2354860","article-title":"Angeliticin B, a new chromone isolated from Angelica polymorpha Maxim","volume":"39","author":"Yang","year":"2025","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.ajps.2026.101184_bib0031","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jphotobiol.2017.07.007","article-title":"Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo","volume":"174","author":"Doppalapudi","year":"2017","journal-title":"J Photochem Photobiol B"},{"key":"10.1016\/j.ajps.2026.101184_bib0032","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1755-148X.2008.00441.x","article-title":"LIGR, a protease-activated receptor-2-derived peptide, enhances skin pigmentation without inducing inflammatory processes","volume":"21","author":"Lin","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.ajps.2026.101184_bib0033","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1091\/mbc.E19-09-0510","article-title":"Integrin-linked kinase regulates melanosome trafficking and melanin transfer in melanocytes","volume":"31","author":"Crawford","year":"2020","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ajps.2026.101184_bib0034","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/jbm.b.34472","article-title":"Inhibition of melanin synthesis and melanosome transfer by chitosan biomaterials","volume":"108","author":"Chen","year":"2020","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.ajps.2026.101184_bib0035","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/13880209.2022.2163406","article-title":"Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9\/CXCL10 pathway","volume":"61","author":"Peng","year":"2023","journal-title":"Pharm Biol"},{"key":"10.1016\/j.ajps.2026.101184_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntm.2024.100051","article-title":"Phytomedicine meets nanotechnology: a cellular approach to rheumatoid arthritis treatment","volume":"3","author":"Shukla","year":"2024","journal-title":"Nano TransMed"},{"key":"10.1016\/j.ajps.2026.101184_bib0037","article-title":"Exploring the pathophysiological influence of heme oxygenase-1 on neuroinflammation and depression: a study of phytotherapeutic-based modulation","volume":"127","author":"Wang","year":"2024","journal-title":"Phytomedicine Int J Phytother Phytopharm"},{"key":"10.1016\/j.ajps.2026.101184_bib0038","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ijbiomac.2018.11.031","article-title":"Anti-melanogenesis of novel kojic acid derivatives in B16F10 cells and zebrafish","volume":"123","author":"Chen","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.ajps.2026.101184_bib0039","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1021\/acs.jnatprod.2c00527","article-title":"Sesquiterpenoids from Seriphidium transiliense and their melanogenic activity","volume":"85","author":"Wu","year":"2022","journal-title":"J Nat Prod"},{"key":"10.1016\/j.ajps.2026.101184_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101349","article-title":"Epigenetic regulation of melanogenesis","volume":"69","author":"Zhou","year":"2021","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.ajps.2026.101184_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188968","article-title":"Natural tyrosinase enzyme inhibitors: a path from melanin to melanoma and its reported pharmacological activities","volume":"1878","author":"Logesh","year":"2023","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.ajps.2026.101184_bib0042","doi-asserted-by":"crossref","first-page":"7330","DOI":"10.1002\/jcp.27492","article-title":"Ganoderma lucidum polysaccharide inhibits UVB-induced melanogenesis by antagonizing cAMP\/PKA and ROS\/MAPK signaling pathways","volume":"234","author":"Hu","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajps.2026.101184_bib0043","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jep.2012.07.030","article-title":"Alcohol extract from Vernonia anthelmintica (L.) willd seed enhances melanin synthesis through activation of the p38 MAPK signaling pathway in B16F10 cells and primary melanocytes","volume":"143","author":"Zhou","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.ajps.2026.101184_bib0044","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ijpharm.2018.12.022","article-title":"Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model","volume":"556","author":"Bhatnagar","year":"2019","journal-title":"Int J Pharm"},{"key":"10.1016\/j.ajps.2026.101184_bib0045","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1007\/s13346-025-01816-w","article-title":"Application of platelet-rich plasma lysate combined with hyaluronic acid microneedles for the treatment of alopecia","volume":"15","author":"Suo","year":"2025","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.ajps.2026.101184_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126535","article-title":"A review on the impacts of metal\/metal nanoparticles on characteristics of hydrogels: special focus on carbohydrate polymers","volume":"253","author":"Ahmadian","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.ajps.2026.101184_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124915","article-title":"Development of a novel hyaluronic acid\/alginate\/RANKL degradable microneedle patch for accelerating bone remodeling and orthodontic tooth movement through promoting osteoclastogenesis","volume":"669","author":"Shan","year":"2025","journal-title":"Int J Pharm"},{"key":"10.1016\/j.ajps.2026.101184_bib0048","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810631","article-title":"GB83, an agonist of PAR2 with a unique mechanism of action distinct from trypsin and PAR2-AP","volume":"23","author":"Heo","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajps.2026.101184_bib0049","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/tra.12843","article-title":"Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalization","volume":"23","author":"Moreiras","year":"2022","journal-title":"Traffic Cph Den"},{"key":"10.1016\/j.ajps.2026.101184_bib0050","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.jid.2019.11.023","article-title":"The role of autophagy in skin fibroblasts, keratinocytes, melanocytes, and epidermal stem cells","volume":"140","author":"Jeong","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajps.2026.101184_bib0051","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411289","article-title":"Melanin\u2019s journey from melanocytes to keratinocytes: uncovering the molecular mechanisms of melanin transfer and processing","volume":"24","author":"Bento-Lopes","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajps.2026.101184_bib0052","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jid.2019.03.1142","article-title":"Harnessing the power of regenerative therapy for vitiligo and alopecia areata","volume":"140","author":"Barbulescu","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajps.2026.101184_bib0053","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/bjd.14388","article-title":"Ultraviolet exposure from indoor tanning devices: a systematic review","volume":"174","author":"Nilsen","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ajps.2026.101184_bib0054","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1111\/jocd.16200","article-title":"2-Mercaptonicotinoyl glycine prevents UV-induced skin darkening and delayed tanning in healthy subjects: a randomized controlled clinical study","volume":"23","author":"de Dormael","year":"2024","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.ajps.2026.101184_bib0055","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/BF02254984","article-title":"Melanocyte destruction and repigmentation in vitiligo: a model for nerve cell damage and regrowth","volume":"9","author":"Yu","year":"2002","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.ajps.2026.101184_bib0056","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2174\/1566524022666220621125552","article-title":"Melanocyte adhesion and apoptosis in vitiligo: linking puzzle blocks","volume":"23","author":"Srivastava","year":"2023","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.ajps.2026.101184_bib0057","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/exd.14260","article-title":"Skin pigmentation and its control: from ultraviolet radiation to stem cells","volume":"30","author":"Yardman-Frank","year":"2021","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajps.2026.101184_bib0058","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.fsc.2018.06.003","article-title":"Hair biology: growth and pigmentation","volume":"26","author":"Park","year":"2018","journal-title":"Facial Plast Surg Clin N Am"},{"key":"10.1016\/j.ajps.2026.101184_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112831","article-title":"Study on the chemical constituents of nut oil from Prunus mira Koehne and the mechanism of promoting hair growth","volume":"258","author":"Zhou","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.ajps.2026.101184_bib0060","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1089\/scd.2021.0276","article-title":"Micro-injury induces hair regeneration and vitiligo repigmentation through Wnt\/\u03b2-Catenin pathway","volume":"31","author":"Han","year":"2022","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.ajps.2026.101184_bib0061","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/pcmr.12287","article-title":"Heparin inhibits melanosome uptake and inflammatory response coupled with phagocytosis through blocking PI3k\/Akt and MEK\/ERK signaling pathways in human epidermal keratinocytes","volume":"27","author":"Makino-Okamura","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.ajps.2026.101184_bib0062","doi-asserted-by":"crossref","DOI":"10.1126\/science.ade6289","article-title":"A genome-wide genetic screen uncovers determinants of human pigmentation","volume":"381","author":"Bajpai","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.ajps.2026.101184_bib0063","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jaad.2018.10.010","article-title":"Antioxidant supplements in combination with phototherapy for vitiligo: a systematic review and metaanalysis of randomized controlled trials","volume":"85","author":"Jung","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ajps.2026.101184_bib0064","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3389\/fimmu.2019.00856","article-title":"The emerging epigenetic role of CD8+T cells in autoimmune diseases: a systematic review","volume":"10","author":"Deng","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajps.2026.101184_bib0065","doi-asserted-by":"crossref","DOI":"10.1007\/s10142-024-01506-9","article-title":"Xuanhong Dingchuan Tang suppresses bronchial asthma inflammation via the microRNA-107-3p\/PTGS2\/MAPK axis","volume":"25","author":"Ming","year":"2025","journal-title":"Funct Integr Genomics"},{"key":"10.1016\/j.ajps.2026.101184_bib0066","article-title":"Leptin deficiency in CD8+ T cells ameliorates non-segmental vitiligo by reducing interferon-\u03b3 and Granzyme B","volume":"14","author":"Wu","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajps.2026.101184_bib0067","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/jid.2011.463","article-title":"A mouse model of vitiligo with focused epidermal depigmentation requires IFN-\u03b3 for autoreactive CD8+ T-cell accumulation in the skin","volume":"132","author":"Harris","year":"2012","journal-title":"J Invest Dermatol"}],"container-title":["Asian Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S181808762600070X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S181808762600070X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:19:01Z","timestamp":1789485541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S181808762600070X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S181808762600070X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajps.2026.101184","relation":{},"ISSN":["1818-0876"],"issn-type":[{"value":"1818-0876","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Janus microneedles enabling orderly vitiligo treatment through spatiotemporal sequential promoting melanogenesis to transfer via PAR2 activation","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajps.2026.101184","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Shenyang Pharmaceutical University. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101184"}}