{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:09:05Z","timestamp":1789160945242,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010915","name":"American Society of Transplant Surgeons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008519","name":"University of Arkansas for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008519","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5 T32 AI 125222"],"award-info":[{"award-number":["5 T32 AI 125222"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ajt.2024.09.032","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T18:56:41Z","timestamp":1727549801000},"page":"316-328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gene expression\u2013based molecular scoring of pancreas transplant rejection for a quantitative assessment of rejection severity and resistance to treatment"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-2114","authenticated-orcid":false,"given":"Audrey E.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1494-0429","authenticated-orcid":false,"given":"Yvonne M.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8933-934X","authenticated-orcid":false,"given":"Arya","family":"Zarinsefat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9050-0436","authenticated-orcid":false,"given":"Raphael P.H.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9932-1061","authenticated-orcid":false,"given":"Giulia","family":"Worner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2870-2544","authenticated-orcid":false,"given":"Mehdi","family":"Tavakol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1212-3959","authenticated-orcid":false,"given":"Minnie M.","family":"Sarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-8764","authenticated-orcid":false,"given":"Zoltan G.","family":"Laszik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-0167","authenticated-orcid":false,"given":"Peter G.","family":"Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8448-0328","authenticated-orcid":false,"given":"Tara K.","family":"Sigdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ajt.2024.09.032_bib1","doi-asserted-by":"crossref","first-page":"e289","DOI":"10.1097\/TP.0000000000004133","article-title":"The presence of donor-specific antibodies around the time of pancreas graft biopsy with rejection is associated with an increased risk of graft failure","volume":"106","author":"Parajuli","year":"2022","journal-title":"Transplantation"},{"issue":"suppl 2","key":"10.1016\/j.ajt.2024.09.032_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/ajt.16979","article-title":"OPTN\/SRTR 2020 annual data report: pancreas","volume":"22","author":"Kandaswamy","year":"2022","journal-title":"Am J Transplant."},{"issue":"5","key":"10.1016\/j.ajt.2024.09.032_bib3","first-page":"493","article-title":"The role of percutaneous biopsy in detection of pancreatic transplant rejection","volume":"14","author":"Lee","year":"2000","journal-title":"Clin\u00a0Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2024.09.032_bib4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00007890-200202270-00011","article-title":"Pancreas allograft biopsy: safety of percutaneous biopsy-results of a large experience","volume":"73","author":"Klassen","year":"2002","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.ajt.2024.09.032_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.smim.2011.08.002","article-title":"Functional proteogenomics\u2014embracing complexity","volume":"23","author":"Sarwal","year":"2011","journal-title":"Semin Immunol"},{"issue":"4","key":"10.1016\/j.ajt.2024.09.032_bib6","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/MOT.0b013e32833b9ccb","article-title":"Biomarkers in renal transplantation","volume":"15","author":"Bestard","year":"2010","journal-title":"Curr Opin Organ Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2024.09.032_bib7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1399-0012.2005.00450.x","article-title":"Correlation of genetic markers of rejection with biopsy findings following human pancreas transplant","volume":"20","author":"Cashion","year":"2006","journal-title":"Clin Transplant"},{"issue":"10","key":"10.1016\/j.ajt.2024.09.032_bib8","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1016\/j.transproceed.2006.10.113","article-title":"Serial peripheral blood cytotoxic lymphocyte gene expression measurements for prediction of pancreas transplant rejection","volume":"38","author":"Cashion","year":"2006","journal-title":"Transplant Proc"},{"issue":"2","key":"10.1016\/j.ajt.2024.09.032_bib9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/TP.0b013e31818c8fbf","article-title":"A\u00a0pilot study of gene expression-based categorization of pancreas transplant biopsies","volume":"87","author":"Luan","year":"2009","journal-title":"Transplantation"},{"issue":"10","key":"10.1016\/j.ajt.2024.09.032_bib10","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1080\/14737159.2016.1239530","article-title":"Advances in diagnostics for transplant rejection","volume":"16","author":"Nasr","year":"2016","journal-title":"Expert Rev Mol Diagn"},{"issue":"3","key":"10.1016\/j.ajt.2024.09.032_bib11","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.ekir.2018.01.014","article-title":"Targeted transcriptional profiling of kidney transplant biopsies","volume":"3","author":"Sigdel","year":"2018","journal-title":"Kidney Int Rep"},{"issue":"10","key":"10.1016\/j.ajt.2024.09.032_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205107","article-title":"The common rejection module in chronic rejection post lung transplantation","volume":"13","author":"Sacreas","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ajt.2024.09.032_bib13","article-title":"Use of the tissue common rejection module score in kidney transplant as an objective measure of allograft inflammation","volume":"11","author":"Zarinsefat","year":"2020","journal-title":"Front Immunol"},{"issue":"9","key":"10.1016\/j.ajt.2024.09.032_bib14","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1097\/TP.0000000000000809","article-title":"Transcriptional perturbations in graft rejection","volume":"99","author":"Vitalone","year":"2015","journal-title":"Transplantation"},{"issue":"11","key":"10.1016\/j.ajt.2024.09.032_bib15","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1084\/jem.20122709","article-title":"A\u00a0common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation","volume":"210","author":"Khatri","year":"2013","journal-title":"J\u00a0Exp Med"},{"issue":"9","key":"10.1016\/j.ajt.2024.09.032_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138133","article-title":"A\u00a0computational gene expression score for predicting immune injury in renal allografts","volume":"10","author":"Sigdel","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ajt.2024.09.032_bib17","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ajt.2023.10.011","article-title":"Banff 2022 pancreas transplantation multidisciplinary report: refinement of guidelines for T cell-mediated rejection, antibody-mediated rejection and islet pathology. Assessment of duodenal cuff biopsies and noninvasive diagnostic methods","volume":"24","author":"Drachenberg","year":"2024","journal-title":"Am J Transplant."},{"issue":"3","key":"10.1016\/j.ajt.2024.09.032_bib18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/ctr.12689","article-title":"Multiplexed color-coded probe-based gene expression assessment for clinical molecular diagnostics in formalin-fixed paraffin-embedded human renal allograft tissue","volume":"30","author":"Adam","year":"2016","journal-title":"Clin Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2024.09.032_bib19","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann Statist"},{"key":"10.1016\/j.ajt.2024.09.032_bib20","author":"Kolde"},{"key":"10.1016\/j.ajt.2024.09.032_bib21","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"issue":"5","key":"10.1016\/j.ajt.2024.09.032_bib22","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"issue":"2","key":"10.1016\/j.ajt.2024.09.032_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1039\/C5MB00663E","article-title":"ReactomePA: an R\/Bioconductor package for reactome pathway analysis and visualization","volume":"12","author":"Yu","year":"2016","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.ajt.2024.09.032_bib24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fmed.2019.00213","article-title":"Assessment of 19 genes and validation of CRM gene panel for quantitative transcriptional analysis of molecular rejection and inflammation in archival kidney transplant biopsies","volume":"6","author":"Sigdel","year":"2019","journal-title":"Front Med (Lausanne)"},{"issue":"7","key":"10.1016\/j.ajt.2024.09.032_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220052","article-title":"A\u00a0urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring","volume":"14","author":"Sigdel","year":"2019","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ajt.2024.09.032_bib26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ni1330","article-title":"Lymphoid organ development: from ontogeny to neogenesis","volume":"7","author":"Drayton","year":"2006","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.ajt.2024.09.032_bib27","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/00007890-200003150-00051","article-title":"Early increased chemokine expression and production in murine allogeneic skin grafts is mediated by natural killer cells","volume":"69","author":"Kondo","year":"2000","journal-title":"Transplantation"},{"issue":"9","key":"10.1016\/j.ajt.2024.09.032_bib28","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1111\/j.1600-6143.2005.00995.x","article-title":"IFN-gamma, produced by NK\u00a0cells that infiltrate liver allografts early after transplantation, links\u00a0the innate and adaptive immune responses","volume":"5","author":"Obara","year":"2005","journal-title":"Am J Transplant"},{"issue":"3","key":"10.1016\/j.ajt.2024.09.032_bib29","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.4049\/jimmunol.169.3.1556","volume":"169","author":"Zhao","year":"2002","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"10.1016\/j.ajt.2024.09.032_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/MOT.0b013e32834ee754","article-title":"Distinctive morphological features of antibody-mediated and T-cell-mediated acute rejection in pancreas allograft biopsies","volume":"17","author":"Papadimitriou","year":"2012","journal-title":"Curr Opin Organ Transplant"},{"issue":"6","key":"10.1016\/j.ajt.2024.09.032_bib31","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1600-6143.2008.02212.x","article-title":"Banff schema for\u00a0grading pancreas allograft rejection: working proposal by a multi-disciplinary international consensus panel","volume":"8","author":"Drachenberg","year":"2008","journal-title":"Am J Transplant"},{"issue":"9","key":"10.1016\/j.ajt.2024.09.032_bib32","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1097\/TP.0000000000002694","article-title":"How should pancreas transplant rejection be treated?","volume":"103","author":"Aziz","year":"2019","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.ajt.2024.09.032_bib33","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/MOT.0000000000000333","article-title":"Biomarkers in pancreas transplant","volume":"21","author":"Burke","year":"2016","journal-title":"Curr Opin Organ Transplant"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613524006014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613524006014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:55:17Z","timestamp":1769907317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613524006014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1600613524006014"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2024.09.032","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression\u2013based molecular scoring of pancreas transplant rejection for a quantitative assessment of rejection severity and resistance to treatment","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2024.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}