{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T13:27:16Z","timestamp":1793453236185,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK132395"],"award-info":[{"award-number":["R01DK132395"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK139240"],"award-info":[{"award-number":["R01DK139240"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01AI152960"],"award-info":[{"award-number":["U01AI152960"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R34AI177209"],"award-info":[{"award-number":["R34AI177209"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K24AI144954"],"award-info":[{"award-number":["K24AI144954"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ajt.2024.11.030","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T12:03:56Z","timestamp":1733141036000},"page":"1226-1234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Balancing equity and human leukocyte antigen matching in deceased-donor kidney allocation with eplet mismatch"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-7408","authenticated-orcid":false,"given":"Michal A.","family":"Mankowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-6518","authenticated-orcid":false,"given":"Loren","family":"Gragert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-3723","authenticated-orcid":false,"given":"Brendan","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-1657","authenticated-orcid":false,"given":"Bonnie E.","family":"Lonze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-4801","authenticated-orcid":false,"given":"Dorry L.","family":"Segev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-4552","authenticated-orcid":false,"given":"Robert","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-8917","authenticated-orcid":false,"given":"Sommer E.","family":"Gentry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5406-4005","authenticated-orcid":false,"given":"Massimo","family":"Mangiola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ajt.2024.11.030_bib1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/TP.0000000000001115","article-title":"The risk of transplant failure with HLA mismatch in first adult kidney allografts from deceased donors","volume":"100","author":"Williams","year":"2016","journal-title":"Transplantation"},{"issue":"11","key":"10.1016\/j.ajt.2024.11.030_bib2","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1111\/j.1600-6143.2012.04226.x","article-title":"Association of HLA mismatch with death with a functioning graft after kidney transplantation: a collaborative transplant study report","volume":"12","author":"Opelz","year":"2012","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2024.11.030_bib3","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/ajt.12643","article-title":"Impact of HLA mismatch at first kidney transplant on lifetime with graft function in young recipients","volume":"14","author":"Foster","year":"2014","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2024.11.030_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1034\/j.1399-0012.1999.130402.x","article-title":"The national impact of the 1995 changes to the UNOS renal allocation system. United Network for Organ Sharing","volume":"13","author":"Leffell","year":"1999","journal-title":"Clin Transplant"},{"issue":"5","key":"10.1016\/j.ajt.2024.11.030_bib5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1053\/j.ajkd.2011.05.023","article-title":"Effect of eliminating priority points for HLA-B matching on racial disparities in kidney transplant rates","volume":"58","author":"Hall","year":"2011","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1016\/j.ajt.2024.11.030_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21926\/obm.transplant.1901041","article-title":"KAS turns four: the state of deceased donor kidney allocation in the U.S","volume":"3","author":"Stewart","year":"2018","journal-title":"OBM Transplant"},{"issue":"3","key":"10.1016\/j.ajt.2024.11.030_bib7","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000001295","article-title":"Time to move on: HLA matching should be reconsidered in modern deceased donor kidney allocation","volume":"8","author":"Gramlick","year":"2022","journal-title":"Transplant Direct"},{"issue":"6","key":"10.1016\/j.ajt.2024.11.030_bib8","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/ajt.13770","article-title":"Changes in deceased donor kidney transplantation one year after KAS implementation","volume":"16","author":"Stewart","year":"2016","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2024.11.030_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ajt.2022.08.001","article-title":"Improving equity in kidney transplant allocation policies through a novel genetic metrics: the matched donor potential","volume":"23","author":"Tambur","year":"2023","journal-title":"Am J Transplant"},{"issue":"suppl 3","key":"10.1016\/j.ajt.2024.11.030_bib10","article-title":"Racial differences in HLA mismatch potential among kidney registrations [abstract]","volume":"22","author":"Robinson","year":"2022","journal-title":"Am J Transplant"},{"issue":"7","key":"10.1016\/j.ajt.2024.11.030_bib11","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1111\/ajt.15258","article-title":"Assessing the utilization of high-resolution 2-field HLA typing in solid organ transplantation","volume":"19","author":"Huang","year":"2019","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2024.11.030_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/tan.13901","article-title":"Rapid high-resolution HLA genotyping by MinION Oxford nanopore sequencing for deceased donor organ allocation","volume":"96","author":"De Santis","year":"2020","journal-title":"HLA"},{"issue":"12","key":"10.1016\/j.ajt.2024.11.030_bib13","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1111\/ajt.12478","article-title":"Class II HLA epitope matching-a strategy to minimize de novo donor-specific antibody development and improve outcomes","volume":"13","author":"Wiebe","year":"2013","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2024.11.030_bib14","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.kint.2019.10.028","article-title":"Epitopes as characterized by antibody-verified eplet mismatches determine risk of kidney transplant loss","volume":"97","author":"Sapir-Pichhadze","year":"2020","journal-title":"Kidney Int"},{"issue":"7","key":"10.1016\/j.ajt.2024.11.030_bib15","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1111\/ajt.13707","article-title":"Alloantibody responses after renal transplant failure can be better predicted by donor-recipient HLA amino acid sequence and physicochemical disparities than conventional HLA matching","volume":"16","author":"Kosmoliaptsis","year":"2016","journal-title":"Am J Transplant"},{"issue":"8","key":"10.1016\/j.ajt.2024.11.030_bib16","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1111\/ajt.16563","article-title":"Preformed T cell alloimmunity and HLA eplet mismatch to guide immunosuppression minimization with tacrolimus monotherapy in kidney transplantation: results of the CELLIMIN trial","volume":"21","author":"Bestard","year":"2021","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2024.11.030_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00467-019-04344-1","article-title":"Eplet mismatch analysis and allograft outcome across racially diverse groups in a pediatric transplant cohort: a single-center analysis","volume":"35","author":"Philogene","year":"2020","journal-title":"Pediatr Nephrol"},{"issue":"3","key":"10.1016\/j.ajt.2024.11.030_bib18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.humimm.2021.11.005","article-title":"Role of HLA molecular mismatch in clinical practice","volume":"83","author":"Wiebe","year":"2022","journal-title":"Hum Immunol"},{"issue":"1","key":"10.1016\/j.ajt.2024.11.030_bib19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s42003-021-01989-3","article-title":"High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation","volume":"4","author":"Tran","year":"2021","journal-title":"Commun Biol"},{"issue":"7","key":"10.1016\/j.ajt.2024.11.030_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009248","article-title":"Computational Eurotransplant kidney allocation simulations demonstrate the feasibility and benefit of T-cell epitope matching","volume":"17","author":"Niemann","year":"2021","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.ajt.2024.11.030_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.832488","article-title":"Improving access to HLA-matched kidney transplants for African American patients","volume":"13","author":"Bekbolsynov","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajt.2024.11.030_bib22","unstructured":"Medical Board policies. National Kidney Registry. Accessed June 1, 2023. https:\/\/www.kidneyregistry.org\/for-centers\/medical-board-policies\/."},{"issue":"7","key":"10.1016\/j.ajt.2024.11.030_bib23","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/petr.12815","article-title":"Application of an epitope-based allocation system in pediatric kidney transplantation","volume":"20","author":"Kausman","year":"2016","journal-title":"Pediatr Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2024.11.030_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ajt.2022.11.009","article-title":"Sensitization in Transplantation: assessment of risk 2022 working group meeting report","volume":"23","author":"Tambur","year":"2023","journal-title":"Am J Transplant"},{"issue":"11","key":"10.1016\/j.ajt.2024.11.030_bib25","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.humimm.2018.08.002","article-title":"Mapping molecular HLA typing data to UNOS antigen equivalents","volume":"79","author":"Kaur","year":"2018","journal-title":"Hum Immunol"},{"key":"10.1016\/j.ajt.2024.11.030_bib26","unstructured":"Facilitating living donor transplants. National Kidney Registry. Accessed June 13, 2024. https:\/\/portal.kidneyregistry.org\/hla-tools\/epitope-mismatch."},{"key":"10.1016\/j.ajt.2024.11.030_bib27","article-title":"A comprehensive evaluation of the antibody-verified status of eplets listed in the HLA Epitope Registry","volume":"12","author":"Bezstarosti","year":"2021","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.ajt.2024.11.030_bib28","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1111\/ajt.15177","article-title":"HLA-DR\/DQ molecular mismatch: a prognostic biomarker for primary alloimmunity","volume":"19","author":"Wiebe","year":"2019","journal-title":"Am J Transplant"},{"issue":"11","key":"10.1016\/j.ajt.2024.11.030_bib29","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1681\/ASN.2017030287","article-title":"Class II eplet mismatch modulates tacrolimus trough levels required to prevent donor-specific antibody development","volume":"28","author":"Wiebe","year":"2017","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.ajt.2024.11.030_bib30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/ajt.16290","article-title":"Adequate tacrolimus exposure modulates the impact of HLA class II molecular mismatch: a validation study in an American cohort","volume":"21","author":"Davis","year":"2021","journal-title":"Am J Transplant"},{"issue":"9","key":"10.1016\/j.ajt.2024.11.030_bib31","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1681\/ASN.2020010019","article-title":"Eplet mismatch load and de novo occurrence of donor-specific anti-HLA antibodies, rejection, and graft failure after kidney transplantation: an observational cohort study","volume":"31","author":"Senev","year":"2020","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"10.1016\/j.ajt.2024.11.030_bib32","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.kint.2021.06.026","article-title":"Significance of HLA-DQ in kidney transplantation: time to reevaluate human leukocyte antigen\u2013matching priorities to improve transplant outcomes? An expert review and recommendations","volume":"100","author":"Tambur","year":"2021","journal-title":"Kidney Int"},{"issue":"3","key":"10.1016\/j.ajt.2024.11.030_bib33","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/TP.0000000000004307","article-title":"Can we use eplets (or molecular) mismatch load analysis to improve organ allocation? The hope and the hype","volume":"107","author":"Tambur","year":"2023","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.ajt.2024.11.030_bib34","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.humimm.2021.12.002","article-title":"Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes","volume":"83","author":"Bezstarosti","year":"2022","journal-title":"Hum Immunol."},{"issue":"1","key":"10.1016\/j.ajt.2024.11.030_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/tan.13883","article-title":"HLA-EMMA: a user-friendly tool to analyse HLA class I and class II compatibility on the amino acid level","volume":"96","author":"Kramer","year":"2020","journal-title":"HLA"},{"issue":"1-2","key":"10.1016\/j.ajt.2024.11.030_bib36","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00251-019-01140-x","article-title":"PIRCHE-II: an algorithm to predict indirectly recognizable HLA epitopes in solid organ transplantation","volume":"72","author":"Geneugelijk","year":"2020","journal-title":"Immunogenetics"},{"issue":"8","key":"10.1016\/j.ajt.2024.11.030_bib37","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1097\/TP.0000000000002117","article-title":"A comparison of HLA molecular mismatch methods to determine HLA immunogenicity","volume":"102","author":"Wiebe","year":"2018","journal-title":"Transplantation"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613524007433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613524007433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T01:40:42Z","timestamp":1780278042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613524007433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1600613524007433"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2024.11.030","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.06.13.23290644","asserted-by":"object"}]},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Balancing equity and human leukocyte antigen matching in deceased-donor kidney allocation with eplet mismatch","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2024.11.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}