{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:04:08Z","timestamp":1793318648678,"version":"4.5.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001922","name":"Efficacy and Mechanism Evaluation Programme","doi-asserted-by":"publisher","award":["13\/94\/55"],"award-info":[{"award-number":["13\/94\/55"]}],"id":[{"id":"10.13039\/501100001922","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P2LAP3_181318"],"award-info":[{"award-number":["P2LAP3_181318"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["Postdoc.Mobility P400PM_194501"],"award-info":[{"award-number":["Postdoc.Mobility P400PM_194501"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI109565"],"award-info":[{"award-number":["UM1AI109565"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014461","name":"NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust\/Institute of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014461","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000764","name":"King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006392","name":"Centre Hospitalier Universitaire Vaudois","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009360","name":"King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ajt.2024.12.002","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T03:08:30Z","timestamp":1734491310000},"page":"1045-1058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1654-0488","authenticated-orcid":false,"given":"Julien","family":"Vionnet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5535-4154","authenticated-orcid":false,"given":"Jorge","family":"Torres-Yaguana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Miquel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan G.","family":"Abraldes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurate","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisavet","family":"Kodela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Jose","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-8802","authenticated-orcid":false,"given":"Pablo","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Navasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Nevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will","family":"Gelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Leithead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1041-9844","authenticated-orcid":false,"given":"Steven","family":"Masson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Jaeckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-2496","authenticated-orcid":false,"given":"Richard","family":"Taubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phaedra","family":"Tachtatzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Eurich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliano","family":"Bonaccorsi-Riani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Quaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Demetris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lesniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Elstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Delord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel","family":"Douiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Rebollo-Mesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Martinez-Llordella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliete A.F.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Markmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8316-3504","authenticated-orcid":false,"given":"Alberto","family":"S\u00e1nchez-Fueyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ajt.2024.12.002_bib1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41575-020-0334-4","article-title":"Understanding, predicting and achieving liver transplant tolerance: from bench to bedside","volume":"17","author":"Thomson","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.ajt.2024.12.002_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1001\/jama.2011.2014","article-title":"Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants","volume":"307","author":"Feng","year":"2012","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.ajt.2024.12.002_bib3","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1002\/hep.26426","article-title":"Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients","volume":"58","author":"Ben\u00edtez","year":"2013","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.ajt.2024.12.002_bib4","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1002\/hep.31520","article-title":"Efficacy and safety of immunosuppression withdrawal in pediatric liver transplant recipients: moving toward personalized management","volume":"73","author":"Feng","year":"2021","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.ajt.2024.12.002_bib5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1172\/JCI59411","article-title":"Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation","volume":"122","author":"Bohne","year":"2012","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"10.1016\/j.ajt.2024.12.002_bib6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1600-6143.2006.01621.x","article-title":"Multiparameter immune profiling of operational tolerance in liver transplantation","volume":"7","author":"Mart\u00ednez-Llordella","year":"2007","journal-title":"Am J Transplant"},{"issue":"8","key":"10.1016\/j.ajt.2024.12.002_bib7","first-page":"2845","article-title":"Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients","volume":"118","author":"Mart\u00ednez-Llordella","year":"2008","journal-title":"J\u00a0Clin Invest"},{"issue":"5","key":"10.1016\/j.ajt.2024.12.002_bib22","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.ajt.2024.10.022","article-title":"Donor-specific immune senescence as a candidate biomarker of operational tolerance following liver transplantation in adults: results of a prospective, multicenter cohort study","volume":"25","author":"Tanimine","year":"2025","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1016\/j.ajt.2024.12.002_bib8","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1111\/ajt.13909","article-title":"2016 Comprehensive update of the Banff Working Group on Liver Allograft Pathology: introduction of antibody-mediated rejection","volume":"16","author":"Demetris","year":"2016","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1016\/j.ajt.2024.12.002_bib9","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/lt.23481","article-title":"Importance of liver biopsy findings in immunosuppression management: biopsy monitoring and working criteria for patients with operational tolerance","volume":"18","author":"Demetris","year":"2012","journal-title":"Liver Transpl"},{"issue":"6","key":"10.1016\/j.ajt.2024.12.002_bib10","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/0016-5085(92)90331-R","article-title":"Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations","volume":"102","author":"Deugnier","year":"1992","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ajt.2024.12.002_bib11","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1038\/s41467-024-47013-0","article-title":"Immunosenescence and vaccine efficacy revealed by immunometabolic analysis of SARS-CoV-2-specific cells in multiple sclerosis patients","volume":"15","author":"De Biasi","year":"2024","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.ajt.2024.12.002_bib12","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.jhep.2021.08.007","article-title":"Non-invasive alloimmune risk stratification of long-term liver transplant recipients","volume":"75","author":"Vionnet","year":"2021","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.ajt.2024.12.002_bib13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/ajt.13488","article-title":"Molecular characterization of acute cellular rejection occurring during intentional immunosuppression withdrawal in liver transplantation","volume":"16","author":"Bonaccorsi-Riani","year":"2016","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2024.12.002_bib14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/hep.32666","article-title":"Next-generation pathology detection of T cell-antigen-presenting cell immune synapses in human liver allografts","volume":"77","author":"Wood-Trageser","year":"2023","journal-title":"Hepatology"},{"issue":"27","key":"10.1016\/j.ajt.2024.12.002_bib15","doi-asserted-by":"crossref","first-page":"7083","DOI":"10.1073\/pnas.1620835114","article-title":"IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors","volume":"114","author":"Whitehouse","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"2","key":"10.1016\/j.ajt.2024.12.002_bib16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/hep.31036","article-title":"Immunosuppression withdrawal in liver transplant recipients on sirolimus","volume":"72","author":"Levitsky","year":"2020","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.ajt.2024.12.002_bib17","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/ajt.13617","article-title":"Hepatic infiltrates in operational tolerant patients after liver transplantation show enrichment of regulatory T\u00a0cells before proinflammatory genes are downregulated","volume":"16","author":"Taubert","year":"2016","journal-title":"Am J Transplant"},{"issue":"242","key":"10.1016\/j.ajt.2024.12.002_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008793","article-title":"HCV-induced immune responses influence the development of operational tolerance after liver transplantation in humans","volume":"6","author":"Bohne","year":"2014","journal-title":"Sci Transl Med"},{"issue":"4","key":"10.1016\/j.ajt.2024.12.002_bib19","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41590-020-0610-z","article-title":"Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis","volume":"21","author":"Moreira-Teixeira","year":"2020","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.ajt.2024.12.002_bib20","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/s41590-022-01152-y","article-title":"Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells","volume":"23","author":"Sumida","year":"2022","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.ajt.2024.12.002_bib21","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/ajt.16835","article-title":"Donor-derived cell-free DNA levels predict graft injury in liver transplant recipients","volume":"22","author":"Levitsky","year":"2022","journal-title":"Am J Transplant"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613524007494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613524007494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:52:05Z","timestamp":1776383525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613524007494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1600613524007494"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2024.12.002","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2024.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of American Society of Transplantation & American Society of Transplant Surgeons.","name":"copyright","label":"Copyright"}]}}