{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:32:00Z","timestamp":1793910720572,"version":"4.8.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000762","name":"Imperial College Healthcare NHS Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ajt.2024.12.006","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T17:42:36Z","timestamp":1734284556000},"page":"1021-1029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transfusion-specific alloimmune responses following blood transfusion pre\u2013kidney transplantation"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7062-9766","authenticated-orcid":false,"given":"Katrina J.","family":"Spensley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevda","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0648-6585","authenticated-orcid":false,"given":"David J.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Przybysiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Regan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5678-2799","authenticated-orcid":false,"given":"Colin","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6404-0584","authenticated-orcid":false,"given":"Michelle","family":"Willicombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ajt.2024.12.006_bib1","first-page":"435","article-title":"Blood transfusion effects in kidney transplantation","volume":"63","author":"Carpenter","year":"1990","journal-title":"Yale J Biol Med"},{"issue":"1","key":"10.1016\/j.ajt.2024.12.006_bib2","first-page":"253","article-title":"Effect of blood transfusions on subsequent kidney transplants","volume":"5","author":"Opelz","year":"1973","journal-title":"Transplant Proc"},{"issue":"15","key":"10.1016\/j.ajt.2024.12.006_bib3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJM197810122991503","article-title":"Improvement of kidney-graft survival with increased numbers of blood transfusions","volume":"299","author":"Opelz","year":"1978","journal-title":"N\u00a0Engl J Med"},{"issue":"7882","key":"10.1016\/j.ajt.2024.12.006_bib4","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0140-6736(74)93268-1","article-title":"Poor kidney-transplant survival in recipients with frozen-blood transfusions or no transfusions","volume":"2","author":"Opelz","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.ajt.2024.12.006_bib5","first-page":"287","article-title":"The transfusion effect","author":"Cecka","year":"1987","journal-title":"Clin Transpl"},{"key":"10.1016\/j.ajt.2024.12.006_bib6","first-page":"305","article-title":"Effect of transfusions","author":"Ahmed","year":"1991","journal-title":"Clin Transpl."},{"key":"10.1016\/j.ajt.2024.12.006_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/1471-2369-14-217","article-title":"An update on the impact of pre-transplant transfusions and allosensitization on time to renal transplant and on allograft survival","volume":"14","author":"Scornik","year":"2013","journal-title":"BMC Nephrol"},{"issue":"11","key":"10.1016\/j.ajt.2024.12.006_bib8","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/ndt\/gft362","article-title":"Sensitization from transfusion in patients awaiting primary kidney transplant","volume":"28","author":"Yabu","year":"2013","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2024.12.006_bib9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/TP.0b013e3182419864","article-title":"Allosensitization rate of male patients awaiting first kidney grafts after leuko-depleted blood transfusion","volume":"93","author":"Balasubramaniam","year":"2012","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.ajt.2024.12.006_bib10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/01.tp.0000437435.19980.8f","article-title":"Red blood cell transfusions and the risk of allosensitization in patients awaiting primary kidney transplantation","volume":"97","author":"Leffell","year":"2014","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.ajt.2024.12.006_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00007890-198109000-00002","article-title":"Lymphocytotoxic antibody responses to transfusions in potential kidney transplant recipients","volume":"32","author":"Opelz","year":"1981","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.ajt.2024.12.006_bib12","doi-asserted-by":"crossref","first-page":"852","DOI":"10.2215\/CJN.00020112","article-title":"Effect of red cell transfusions on future kidney transplantation","volume":"8","author":"Obrador","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"issue":"10070","key":"10.1016\/j.ajt.2024.12.006_bib13","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(16)31595-1","article-title":"Post-listing survival for highly sensitised patients on the UK kidney transplant waiting list: a matched cohort analysis","volume":"389","author":"Manook","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ajt.2024.12.006_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.687254","article-title":"Highly sensitized patients are well served by receiving a compatible organ offer based on acceptable mismatches","volume":"12","author":"Heidt","year":"2021","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.ajt.2024.12.006_bib15","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1046\/j.1523-1755.2000.00287.x","article-title":"Effect of waiting time on renal transplant outcome","volume":"58","author":"Meier-Kriesche","year":"2000","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.ajt.2024.12.006_bib16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/00007890-198904000-00011","article-title":"Prevention of transfusion-induced broad sensitization in renal transplant candidates","volume":"47","author":"Scornik","year":"1989","journal-title":"Transplantation"},{"issue":"11","key":"10.1016\/j.ajt.2024.12.006_bib17","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1097\/TP.0b013e318271d776","article-title":"Effects of HLA-matched blood transfusion for patients awaiting renal transplantation","volume":"94","author":"Magee","year":"2012","journal-title":"Transplantation"},{"issue":"6","key":"10.1016\/j.ajt.2024.12.006_bib18","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1111\/ajt.15233","article-title":"Shared alloimmune responses against blood and transplant donors result in adverse clinical outcomes following blood transfusion post-renal transplantation","volume":"19","author":"Hassan","year":"2019","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajt.2024.12.006_bib19","article-title":"Guidelines for the blood transfusion and tissue transplantation services in the UK","year":"2013","journal-title":"Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee"},{"key":"10.1016\/j.ajt.2024.12.006_bib20","unstructured":"Organ donation and transplant. National transplant database HLA conversion chart for organ allocation. NHS Blood and Transplant. Accessed 20\/07\/2024. https:\/\/nhsbtdbe.blob.core.windows.net\/umbraco-assetscorp\/16896\/hla-conversion-chart-for-organ-allocation-sept-2019.pdf."},{"key":"10.1016\/j.ajt.2024.12.006_bib21","unstructured":"Calculators. Kidney calculated reaction frequency tool. NHS Blood and Transplant. Accessed 20\/07\/2024. https:\/\/www.odt.nhs.uk\/transplantation\/tools-policies-and-guidance\/calculators\/."},{"issue":"1","key":"10.1016\/j.ajt.2024.12.006_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/trf.12835","article-title":"Blood donors in England and North Wales: demography and patterns of donation","volume":"55","author":"Lattimore","year":"2015","journal-title":"Transfusion"},{"key":"10.1016\/j.ajt.2024.12.006_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.trim.2022.101680","article-title":"Effects of different sensitization events on HLA alloimmunization in renal transplant cases; a retrospective observation in 1066 cases","volume":"75","author":"Pandey","year":"2022","journal-title":"Transpl Immunol"},{"issue":"10","key":"10.1016\/j.ajt.2024.12.006_bib24","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/ndt\/gfw099","article-title":"The mode of sensitization and its influence on allograft outcomes in highly sensitized kidney transplant recipients","volume":"31","author":"Redfield","year":"2016","journal-title":"Nephrol Dial Transplant"},{"issue":"8","key":"10.1016\/j.ajt.2024.12.006_bib25","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.humimm.2015.06.013","article-title":"Pregnancy-induced HLA antibodies respond more vigorously after renal transplantation than antibodies induced by prior transplantation","volume":"76","author":"Higgins","year":"2015","journal-title":"Hum Immunol"},{"issue":"6","key":"10.1016\/j.ajt.2024.12.006_bib26","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/ki.2014.390","article-title":"Restricted specificity of peripheral alloreactive memory B cells in HLA-sensitized patients awaiting a kidney transplant","volume":"87","author":"Snanoudj","year":"2015","journal-title":"Kidney Int"},{"issue":"3","key":"10.1016\/j.ajt.2024.12.006_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/iji.12493","article-title":"HLA-specific memory B-cell detection in kidney transplantation: insights and future challenges","volume":"47","author":"Wehmeier","year":"2020","journal-title":"Int J Immunogenet"},{"key":"10.1016\/j.ajt.2024.12.006_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1360627","article-title":"Memory B-cell derived\u00a0donor-specific antibodies do not predict outcome in sensitized kidney transplant recipients: a retrospective single-center study","volume":"15","author":"Altulea","year":"2024","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.ajt.2024.12.006_bib29","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/01.ASN.0000115399.80913.B1","article-title":"Leukocyte reduction of red blood cell transfusions does not decrease allosensitization rates in potential kidney transplant candidates","volume":"15","author":"Karpinski","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"10","key":"10.1016\/j.ajt.2024.12.006_bib30","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1007\/s00467-014-2823-6","article-title":"Washing red cells after leucodepletion does not decrease human leukocyte antigen sensitization risk in patients with chronic kidney disease","volume":"29","author":"Aston","year":"2014","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"10.1016\/j.ajt.2024.12.006_bib31","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1432-2277.2005.00085.x","article-title":"Prevalence and significance of anti-HLA and donor-specific antibodies long-term after renal transplantation","volume":"18","author":"Cardarelli","year":"2005","journal-title":"Transpl Int"},{"issue":"9","key":"10.1016\/j.ajt.2024.12.006_bib32","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1681\/ASN.2004121130","article-title":"Frequency and clinical implications of development of donor-specific and non-donor-specific HLA antibodies after kidney transplantation","volume":"16","author":"Hourmant","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.ajt.2024.12.006_bib33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1046\/j.1537-2995.1990.30290162897.x","article-title":"A\u00a0study of HLA (Bg) on red cells and platelets by immunoblotting with monoclonal antibodies","volume":"30","author":"Giles","year":"1990","journal-title":"Transfusion"},{"issue":"1","key":"10.1016\/j.ajt.2024.12.006_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1365-2141.1990.tb02624.x","article-title":"HLA class I expression on erythrocytes and platelets from patients with systemic lupus erythematosus, rheumatoid arthritis and from normal subjects","volume":"75","author":"Botto","year":"1990","journal-title":"Br J Haematol"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613524007548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613524007548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:51:54Z","timestamp":1776383514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613524007548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1600613524007548"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2024.12.006","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transfusion-specific alloimmune responses following blood transfusion pre\u2013kidney transplantation","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2024.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of American Society of Transplantation & American Society of Transplant Surgeons.","name":"copyright","label":"Copyright"}]}}