{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:59:00Z","timestamp":1790827140485,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014247","name":"Immune Tolerance Network","doi-asserted-by":"publisher","award":["ITN062ST"],"award-info":[{"award-number":["ITN062ST"]}],"id":[{"id":"10.13039\/100014247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014247","name":"Immune Tolerance Network","doi-asserted-by":"publisher","award":["1U19AI131471-01"],"award-info":[{"award-number":["1U19AI131471-01"]}],"id":[{"id":"10.13039\/100014247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["1U19AI131471-01"],"award-info":[{"award-number":["1U19AI131471-01"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["US FDA IND 17846"],"award-info":[{"award-number":["US FDA IND 17846"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NCT03504241"],"award-info":[{"award-number":["NCT03504241"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1AI109565"],"award-info":[{"award-number":["UM1AI109565"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ajt.2025.05.008","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T19:18:06Z","timestamp":1747077486000},"page":"2114-2126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Donor-specific mesenchymal stem cell infusion in human and nonhuman primate kidney transplantation"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2104-1325","authenticated-orcid":false,"given":"Imran J.","family":"Anwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mulvihill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri","family":"Swan-Nesbit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn A.","family":"Cheatham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam","family":"How","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyha","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Fang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Kurtzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhu","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Bridges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila","family":"Lyakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Breeden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krupa","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Sever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2004-5962","authenticated-orcid":false,"given":"Allan D.","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajt.2025.05.008_bib1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-068769","article-title":"Survival for waitlisted kidney failure patients receiving transplantation versus remaining on waiting list: systematic review and meta-analysis","volume":"376","author":"Chaudhry","year":"2022","journal-title":"BMJ"},{"issue":"23","key":"10.1016\/j.ajt.2025.05.008_bib2","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1056\/NEJM199912023412303","article-title":"Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant","volume":"341","author":"Wolfe","year":"1999","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.ajt.2025.05.008_bib3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.34971","article-title":"Survival benefit of first single-organ deceased donor kidney transplantation compared with long-term dialysis across ages in transplant-eligible patients with kidney failure","volume":"5","author":"Strohmaier","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"5","key":"10.1016\/j.ajt.2025.05.008_bib4","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.transproceed.2015.04.032","article-title":"Kidney Transplantation is superior to hemodialysis and peritoneal dialysis in terms of cognitive function, anxiety, and depression symptoms in chronic kidney disease","volume":"47","author":"Ozcan","year":"2015","journal-title":"Transplant Proc"},{"issue":"1","key":"10.1016\/j.ajt.2025.05.008_bib5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.transproceed.2010.12.015","article-title":"Assessment of health-related quality of life in renal transplant recipients and dialysis patients","volume":"43","author":"Maglakelidze","year":"2011","journal-title":"Transplant Proc"},{"issue":"2","key":"10.1016\/j.ajt.2025.05.008_bib6","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000000974","article-title":"Cost-effectiveness of deceased-donor renal transplant versus dialysis to treat end-stage renal disease: a systematic review","volume":"6","author":"Fu","year":"2020","journal-title":"Transplant Direct"},{"issue":"2S1","key":"10.1016\/j.ajt.2025.05.008_bib7","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.ajt.2024.01.012","article-title":"OPTN\/SRTR 2022 Annual Data Report: kidney","volume":"24","author":"Lentine","year":"2024","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2025.05.008_bib8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0272-6386(00)70348-9","article-title":"Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future","volume":"35","author":"de Mattos","year":"2000","journal-title":"Am J Kidney Dis"},{"issue":"10","key":"10.1016\/j.ajt.2025.05.008_bib9","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1097\/TP.0000000000001756","article-title":"Rapid discontinuation of prednisone in kidney transplant recipients: 15-year outcomes from the University of Minnesota","volume":"101","author":"Serrano","year":"2017","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.ajt.2025.05.008_bib10","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1523-1755.2004.00741.x","article-title":"Risk of malignancy with long-term immunosuppression in renal transplant recipients","volume":"66","author":"Agraharkar","year":"2004","journal-title":"Kidney Int"},{"issue":"5 Pt 1","key":"10.1016\/j.ajt.2025.05.008_bib11","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1600-6143.2006.01259.x","article-title":"A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression","volume":"6","author":"Larsen","year":"2006","journal-title":"Am J Transplant"},{"issue":"11","key":"10.1016\/j.ajt.2025.05.008_bib12","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/15256","article-title":"Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance","volume":"5","author":"Li","year":"1999","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.ajt.2025.05.008_bib13","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/ajt.12712","article-title":"Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors","volume":"14","author":"Kirk","year":"2014","journal-title":"Am J Transplant"},{"issue":"12","key":"10.1016\/j.ajt.2025.05.008_bib14","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1111\/ajt.16121","article-title":"Kidney transplantation using alemtuzumab, belatacept, and sirolimus: five-year follow-up","volume":"20","author":"Schmitz","year":"2020","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2025.05.008_bib15","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/ajt.15688","article-title":"Belatacept-based immunosuppression with simultaneous calcineurin inhibitor avoidance and early corticosteroid withdrawal: a prospective, randomized multicenter trial","volume":"20","author":"Woodle","year":"2020","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2025.05.008_bib16","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/ajt.13100","article-title":"A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation","volume":"15","author":"Lo","year":"2015","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2025.05.008_bib17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1600-6143.2012.04342.x","article-title":"Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion","volume":"13","author":"Lo","year":"2013","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2025.05.008_bib18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/ajt.14625","article-title":"The Banff 2017 Kidney Meeting Report: revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials","volume":"18","author":"Haas","year":"2018","journal-title":"Am J Transplant"},{"issue":"19","key":"10.1016\/j.ajt.2025.05.008_bib19","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"New creatinine- and cystatin C-based equations to estimate GFR without race","volume":"385","author":"Inker","year":"2021","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.ajt.2025.05.008_bib20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5625\/lar.2012.28.3.217","article-title":"Acute gastrointestinal dilation in laboratory rhesus monkeys in the Korea National Primate Research Center","volume":"28","author":"Kim","year":"2012","journal-title":"Lab Anim Res"},{"issue":"9","key":"10.1016\/j.ajt.2025.05.008_bib21","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1111\/ajt.16625","article-title":"Age-related effects on thymic output and homeostatic T cell expansion following depletional induction in renal transplant recipients","volume":"21","author":"Xu","year":"2021","journal-title":"Am J Transplant"},{"issue":"3","key":"10.1016\/j.ajt.2025.05.008_bib22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J Cell Physiol"},{"issue":"12","key":"10.1016\/j.ajt.2025.05.008_bib23","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1097\/TP.0000000000004589","article-title":"Chimerism-based tolerance induction in clinical transplantation: its foundations and mechanisms","volume":"107","author":"Mengrelis","year":"2023","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.ajt.2025.05.008_bib24","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/TP.0b013e3181e7e54f","article-title":"The role of the thymus in tolerance","volume":"90","author":"Griesemer","year":"2010","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.ajt.2025.05.008_bib25","doi-asserted-by":"crossref","first-page":"689","DOI":"10.4049\/jimmunol.168.2.689","article-title":"Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism","volume":"168","author":"Mazzoni","year":"2002","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.ajt.2025.05.008_bib26","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/sj.leu.2403871","article-title":"Mesenchymal stem cells induce apoptosis of activated T cells","volume":"19","author":"Plumas","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.ajt.2025.05.008_bib27","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.3389\/fimmu.2019.01287","article-title":"Mesenchymal stromal cells for transplant tolerance","volume":"10","author":"Podest\u00e0","year":"2019","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.ajt.2025.05.008_bib28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/sctm.19-0185","article-title":"Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration","volume":"9","author":"Casiraghi","year":"2020","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.ajt.2025.05.008_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.trim.2023.101939","article-title":"The potential of mesenchymal stem cells to induce immune tolerance to allogeneic transplants","volume":"81","author":"Yu","year":"2023","journal-title":"Transpl Immunol"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S160061352500262X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S160061352500262X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:35:03Z","timestamp":1790825703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S160061352500262X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S160061352500262X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2025.05.008","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Donor-specific mesenchymal stem cell infusion in human and nonhuman primate kidney transplantation","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2025.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}