{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:01:45Z","timestamp":1793044905820,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"German Cancer Aid","doi-asserted-by":"publisher","award":["70115705"],"award-info":[{"award-number":["70115705"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["545913134"],"award-info":[{"award-number":["545913134"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ajt.2025.09.009","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T18:36:12Z","timestamp":1758134172000},"page":"340-348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sustained allogeneic kidney graft operational tolerance despite discontinued conventional immunosuppression after CD19-CAR-T cell therapy for relapsed\/refractory posttransplant lymphoproliferative disorder"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0934-7620","authenticated-orcid":false,"given":"Helena","family":"Hansmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3688-1396","authenticated-orcid":false,"given":"Chiara","family":"Henkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5662-2630","authenticated-orcid":false,"given":"Matthias A.","family":"Fante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-572X","authenticated-orcid":false,"given":"Dennis C.","family":"Harrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7708-5864","authenticated-orcid":false,"given":"Stefanie","family":"Heidemanns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9255-2261","authenticated-orcid":false,"given":"Michael","family":"Oellerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-1363","authenticated-orcid":false,"given":"Julia","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-4870","authenticated-orcid":false,"given":"Ekkehard","family":"Sch\u00fctz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-6387","authenticated-orcid":false,"given":"Verena","family":"Biswenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3464-0722","authenticated-orcid":false,"given":"Markus","family":"Perl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4894-4614","authenticated-orcid":false,"given":"Barbara","family":"Zartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-2533","authenticated-orcid":false,"given":"Matthias","family":"Edinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-3190","authenticated-orcid":false,"given":"Daniel","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3541-6196","authenticated-orcid":false,"given":"Petra","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3991-2256","authenticated-orcid":false,"given":"Wolfgang","family":"Herr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2076-2195","authenticated-orcid":false,"given":"Bernhard","family":"Banas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2123-0310","authenticated-orcid":false,"given":"Daniel","family":"Zecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-0128","authenticated-orcid":false,"given":"Leo","family":"Hansmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 3","key":"10.1016\/j.ajt.2025.09.009_bib1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the care of kidney transplant recipients","volume":"9","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajt.2025.09.009_bib2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-1-4939-7778-9_19","article-title":"A universal droplet digital PCR approach for monitoring of graft health after transplantation using a preselected SNP set","volume":"1768","author":"Beck","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"9","key":"10.1016\/j.ajt.2025.09.009_bib3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41581-021-00428-0","article-title":"Liquid biopsies: donor-derived cell-free DNA for the detection of kidney allograft injury","volume":"17","author":"Oellerich","year":"2021","journal-title":"Nat Rev Nephrol"},{"issue":"11","key":"10.1016\/j.ajt.2025.09.009_bib4","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1111\/ajt.15416","article-title":"Absolute quantification of donor-derived cell-free DNA as a marker of rejection and graft injury in kidney transplantation: results from a prospective observational study","volume":"19","author":"Oellerich","year":"2019","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajt.2025.09.009_bib5","unstructured":"R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing; 2024. http:\/\/www.R-project.org\/. accessed july 4, 2025"},{"issue":"1","key":"10.1016\/j.ajt.2025.09.009_bib6","first-page":"1","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"2","year":"2012","journal-title":"Kidney Int Suppl"},{"issue":"1","key":"10.1016\/j.ajt.2025.09.009_bib7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13063-023-07216-0","article-title":"A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT","volume":"24","author":"Haupenthal","year":"2023","journal-title":"Trials"},{"issue":"3","key":"10.1016\/j.ajt.2025.09.009_bib8","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000001584","article-title":"CAR T-cell therapy for refractory posttransplantation lymphoproliferative disorder in a kidney transplant patient","volume":"10","author":"Guy","year":"2024","journal-title":"Transplant Direct"},{"issue":"4","key":"10.1016\/j.ajt.2025.09.009_bib9","article-title":"CAR-T therapy in solid transplant recipients with post-transplant lymphoproliferative disease: case report and literature review","volume":"69","author":"Hernani","year":"2021","journal-title":"Curr Res Transl Med"},{"issue":"5","key":"10.1016\/j.ajt.2025.09.009_bib10","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/s41409-020-01145-1","article-title":"Anti-CD19 CAR-T therapy for EBV-negative posttransplantation lymphoproliferative disease-a single center case series","volume":"56","author":"Luttwak","year":"2021","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2025.09.009_bib11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/bjh.18828","article-title":"Real-world evidence of the safety and survival with CD19 CAR-T cell therapy for relapsed\/refractory solid organ transplant-related PTLD","volume":"202","author":"McKenna","year":"2023","journal-title":"Br J Haematol"},{"issue":"18","key":"10.1016\/j.ajt.2025.09.009_bib12","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1182\/blood.2020008759","article-title":"Safety of CAR T-cell therapy in kidney transplant recipients","volume":"137","author":"Mamlouk","year":"2021","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ajt.2025.09.009_bib13","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/ajt.16367","article-title":"CAR-T therapy in solid organ transplant recipients with treatment refractory posttransplant lymphoproliferative disorder","volume":"21","author":"Krishnamoorthy","year":"2021","journal-title":"Am J Transplant."},{"issue":"5","key":"10.1016\/j.ajt.2025.09.009_bib14","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1053\/j.ajkd.2021.07.012","article-title":"Kidney transplant T cell-mediated rejection occurring after anti-CD19 CAR T-cell therapy for refractory aggressive burkitt-like lymphoma with 11q aberration: a case report","volume":"79","author":"de Nattes","year":"2022","journal-title":"Am J Kidney Dis"},{"issue":"10","key":"10.1016\/j.ajt.2025.09.009_bib15","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.clml.2023.05.007","article-title":"CAR T cell therapy for post-transplant lymphoproliferative disorder after solid organ transplantation: a safe and feasible therapy for an orphan disease","volume":"23","author":"Ibrahim","year":"2023","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"4","key":"10.1016\/j.ajt.2025.09.009_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41409-022-01907-z","article-title":"CD19 CAR-T therapy in solid organ transplant recipients: case report and systematic review","volume":"58","author":"Portuguese","year":"2023","journal-title":"Bone Marrow Transplant"},{"issue":"8","key":"10.1016\/j.ajt.2025.09.009_bib17","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1111\/ajt.15810","article-title":"Torque teno virus for risk stratification of graft rejection and infection in kidney transplant recipients\u2014a prospective observational trial","volume":"20","author":"Doberer","year":"2020","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1016\/j.ajt.2025.09.009_bib18","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.bbmt.2013.07.015","article-title":"CMV-, EBV- and ADV-specific T cell immunity: screening and monitoring of potential third-party donors to improve post-transplantation outcome","volume":"19","author":"Sukdolak","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"issue":"5","key":"10.1016\/j.ajt.2025.09.009_bib19","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1111\/j.1523-1755.2004.05411.x","article-title":"Clinical transplantation tolerance: the promise and challenges","volume":"65","author":"Ansari","year":"2004","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.ajt.2025.09.009_bib20","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1600-6143.2006.01280.x","article-title":"Clinical operational tolerance after kidney transplantation","volume":"6","author":"Roussey-Kesler","year":"2006","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1016\/j.ajt.2025.09.009_bib21","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1038\/s41591-022-02017-5","article-title":"Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus","volume":"28","author":"Mackensen","year":"2022","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.ajt.2025.09.009_bib22","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJMoa2308917","article-title":"CD19 CAR T-cell therapy in autoimmune disease\u2014a case series with follow-up","volume":"390","author":"M\u00fcller","year":"2024","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ajt.2025.09.009_bib23","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1172\/JCI39922","article-title":"Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans","volume":"120","author":"Sagoo","year":"2010","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.ajt.2025.09.009_bib24","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1172\/JCI39933","article-title":"Identification of a B cell signature associated with renal transplant tolerance in humans","volume":"120","author":"Newell","year":"2010","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.ajt.2025.09.009_bib25","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1432-2277.2011.01251.x","article-title":"Identification of a gene expression profile associated with operational tolerance among a selected group of stable kidney transplant patients","volume":"24","author":"Brouard","year":"2011","journal-title":"Transpl Int"},{"issue":"12","key":"10.1016\/j.ajt.2025.09.009_bib26","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1111\/ajt.13932","article-title":"Biomarkers of tolerance in kidney transplantation: are we predicting tolerance or response to immunosuppressive treatment?","volume":"16","author":"Rebollo-Mesa","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajt.2025.09.009_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102899","article-title":"Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy","volume":"58","author":"Christakoudi","year":"2020","journal-title":"EBioMedicine"},{"issue":"8","key":"10.1016\/j.ajt.2025.09.009_bib28","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1097\/00007890-200004270-00005","article-title":"Clinical transplantation tolerance twelve years after prospective withdrawal of immunosuppressive drugs: studies of chimerism and anti-donor reactivity","volume":"69","author":"Strober","year":"2000","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.ajt.2025.09.009_bib29","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJMoa2400763","article-title":"A randomized phase 2 trial of felzartamab in antibody-mediated rejection","volume":"391","author":"Mayer","year":"2024","journal-title":"N Engl J Med"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613525029867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613525029867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:36:01Z","timestamp":1778621761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613525029867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1600613525029867"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2025.09.009","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sustained allogeneic kidney graft operational tolerance despite discontinued conventional immunosuppression after CD19-CAR-T cell therapy for relapsed\/refractory posttransplant lymphoproliferative disorder","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2025.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society of Transplantation & American Society of Transplant Surgeons.","name":"copyright","label":"Copyright"}]}}