{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:53:08Z","timestamp":1789519988394,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL 116273"],"award-info":[{"award-number":["T32 HL 116273"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ajt.2025.11.018","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T16:08:15Z","timestamp":1764346095000},"page":"841-849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact and outcomes after desensitization therapy in highly sensitized heart transplant candidates"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-0091","authenticated-orcid":false,"given":"Rashmi","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2274-5869","authenticated-orcid":false,"given":"Andriana","family":"Nikolova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-2691","authenticated-orcid":false,"given":"Michelle","family":"Kittleson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-2412","authenticated-orcid":false,"given":"Evan P.","family":"Kransdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-0035","authenticated-orcid":false,"given":"David","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9430-321X","authenticated-orcid":false,"given":"Peter","family":"Deckerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-3172","authenticated-orcid":false,"given":"Jon A.","family":"Kobashigawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.ajt.2025.11.018_bib1","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1161\/CIR.0000000000000093","article-title":"Antibody-mediated rejection in cardiac transplantation: emerging knowledge in diagnosis and management: a scientific statement from the American Heart Association","volume":"131","author":"Colvin","year":"2015","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ajt.2025.11.018_bib2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.healun.2017.02.015","article-title":"Calculated panel-reactive antibody predicts outcomes on the heart transplant waiting list","volume":"36","author":"Kransdorf","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.ajt.2025.11.018_bib3","doi-asserted-by":"crossref","unstructured":"Colvin MM, Smith JM, Ahn YS, et al. OPTN\/SRTR 2022 Annual data report: heart. US Department of Health and Human Services. Health Resources and Services Administration. https:\/\/doi.org\/10.1016\/j.ajt.2024.01.016. Accessed date: 3\/5\/25","DOI":"10.1016\/j.ajt.2024.01.016"},{"issue":"5","key":"10.1016\/j.ajt.2025.11.018_bib4","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.athoracsur.2007.05.095","article-title":"Influence of pretransplant panel-reactive antibody on outcomes in 8,160 heart transplant recipients in recent era","volume":"84","author":"Nwakanma","year":"2007","journal-title":"Ann Thorac Surg"},{"issue":"7","key":"10.1016\/j.ajt.2025.11.018_bib5","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1111\/ajt.16420","article-title":"Complement inhibition for prevention of antibody-mediated rejection in immunologically high-risk heart allograft recipients","volume":"21","author":"Patel","year":"2021","journal-title":"Am J Transplant"},{"issue":"8","key":"10.1016\/j.ajt.2025.11.018_bib6","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.34067\/KID.0000000000000509","article-title":"New therapies for highly sensitized patients on the waiting list","volume":"5","author":"Vo","year":"2024","journal-title":"Kidney360"},{"issue":"3","key":"10.1016\/j.ajt.2025.11.018_bib7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/HCO.0000000000000389","article-title":"Desensitization strategies in the patient awaiting heart transplantation","volume":"32","author":"Chang","year":"2017","journal-title":"Curr Opin Cardiol"},{"issue":"4","key":"10.1016\/j.ajt.2025.11.018_bib8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jchf.2023.01.019","article-title":"How to approach HLA sensitization in heart transplant candidates","volume":"11","author":"Rao","year":"2023","journal-title":"JACC Heart Fail"},{"issue":"3","key":"10.1016\/j.ajt.2025.11.018_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.14196","article-title":"Crossing low\/moderate-level donor-specific antibodies during heart transplantation","volume":"35","author":"Setia","year":"2021","journal-title":"Clin Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2025.11.018_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.15165","article-title":"Does bortezomib influence pre-transplant desensitization therapy or benefit post-heart transplant outcomes for highly sensitized patients?","volume":"38","author":"Dhillon","year":"2024","journal-title":"Clin Transplant"},{"issue":"3","key":"10.1016\/j.ajt.2025.11.018_bib11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJMoa0707894","article-title":"Rituximab and intravenous immune globulin for desensitization during renal transplantation","volume":"359","author":"Vo","year":"2008","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.ajt.2025.11.018_bib12","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.healun.2024.05.010","article-title":"International Society for Heart and Lung Transplantation guidelines for the evaluation and care of cardiac transplant candidates-2024","volume":"43","author":"Peled","year":"2024","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2025.11.018_bib13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3390\/jcm12020424","article-title":"Tocilizumab evaluation in HLA-desensitization before kidney transplantation as an add-on therapy to apheresis: the TETRA study","volume":"12","author":"Jouve","year":"2023","journal-title":"J Clin Med"},{"issue":"1","key":"10.1016\/j.ajt.2025.11.018_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/ajt.16709","article-title":"Immune responses following tocilizumab therapy to desensitize HLA-sensitized kidney transplant candidates","volume":"22","author":"Jouve","year":"2022","journal-title":"Am J Transplant"},{"issue":"11","key":"10.1016\/j.ajt.2025.11.018_bib15","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1097\/TP.0000000000000741","article-title":"A phase I\/II trial of the interleukin-6 receptor\u2013specific humanized monoclonal (tocilizumab) + intravenous immunoglobulin in difficult to desensitize patients","volume":"99","author":"Vo","year":"2015","journal-title":"Transplantation"},{"issue":"8","key":"10.1016\/j.ajt.2025.11.018_bib16","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1111\/ajt.17060","article-title":"Heart transplantation across preformed donor-specific antibody barriers using a perioperative desensitization protocol","volume":"22","author":"Sommer","year":"2022","journal-title":"Am J Transplant"},{"issue":"11","key":"10.1016\/j.ajt.2025.11.018_bib17","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1016\/j.ekir.2024.08.020","article-title":"Open-label phase 1\/2 study of daratumumab-based desensitization before kidney transplantation","volume":"9","author":"Pilon","year":"2024","journal-title":"Kidney Int Rep"},{"issue":"10","key":"10.1016\/j.ajt.2025.11.018_bib18","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.healun.2021.07.015","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult heart transplantation report \u2014 2021; focus on recipient characteristics","volume":"40","author":"Khush","year":"2021","journal-title":"J Heart Lung Transplant"},{"issue":"5","key":"10.1016\/j.ajt.2025.11.018_bib19","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/ajt.12181","article-title":"Everolimus versus mycophenolate mofetil in heart transplantation: a randomized, multicenter trial","volume":"13","author":"Eisen","year":"2013","journal-title":"Am J Transplant"},{"issue":"4 suppl","key":"10.1016\/j.ajt.2025.11.018_bib20","article-title":"Crossing low level donor-specific antibody at the time of heart transplantation may save lives","volume":"38","author":"Kobashigawa","year":"2019","journal-title":"J Heart Lung Transplant"},{"issue":"4 suppl","key":"10.1016\/j.ajt.2025.11.018_bib21","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.healun.2019.01.113","article-title":"Molecular microscope determinants of graft survival in the INTERHEART study","volume":"38","author":"Reeve","year":"2019","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2025.11.018_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/TP.0000000000004323","article-title":"The molecular microscope diagnostic system: assessment of rejection and injury in heart transplant biopsies","volume":"107","author":"Halloran","year":"2023","journal-title":"Transplantation"},{"issue":"10","key":"10.1016\/j.ajt.2025.11.018_bib23","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.healun.2023.05.005","article-title":"Intermediate-term outcomes of complement inhibition for prevention of antibody-mediated rejection in immunologically high-risk heart allograft recipients","volume":"42","author":"Coutance","year":"2023","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2025.11.018_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1161\/CIRCULATIONAHA.115.019692","article-title":"Elevated angiopoietin-2 level in patients with continuous-flow left ventricular assist devices leads to altered angiogenesis and is associated with higher nonsurgical bleeding","volume":"134","author":"Tabit","year":"2016","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.ajt.2025.11.018_bib25","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.healun.2023.05.001","article-title":"Three year post heart transplant outcomes of desensitized durable mechanical circulatory support patients","volume":"42","author":"Youn","year":"2023","journal-title":"J Heart Lung Transplant"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613525031247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613525031247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:27:43Z","timestamp":1777620463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613525031247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1600613525031247"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2025.11.018","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact and outcomes after desensitization therapy in highly sensitized heart transplant candidates","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2025.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of American Society of Transplantation & American Society of Transplant Surgeons.","name":"copyright","label":"Copyright"}]}}