{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:10:49Z","timestamp":1793578249877,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008644","name":"McGill University Faculty of Medicine and Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008644","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008582","name":"McGill University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014131","name":"McGill University Health Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Quebec Health Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ajt.2026.01.007","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:23:48Z","timestamp":1770337428000},"page":"1110-1120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Feasibility, safety, and effectiveness of prehabilitation programs in patients awaiting liver transplantation: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0540-8636","authenticated-orcid":false,"given":"Ikram","family":"Abow-Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-613X","authenticated-orcid":false,"given":"Myriam","family":"Martel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-3791","authenticated-orcid":false,"given":"Tania","family":"Janaudis-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0615-5922","authenticated-orcid":false,"given":"Chelsia","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6724-3295","authenticated-orcid":false,"given":"Olivia","family":"Geraci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2657-4558","authenticated-orcid":false,"given":"Farah","family":"Albader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5704-2226","authenticated-orcid":false,"given":"Yen-I","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-7322","authenticated-orcid":false,"given":"Jill","family":"Boruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-8192","authenticated-orcid":false,"given":"Franco","family":"Carli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0486-0174","authenticated-orcid":false,"given":"Puneeta","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-7119","authenticated-orcid":false,"given":"Amal","family":"Bessissow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0202-2276","authenticated-orcid":false,"given":"Amine","family":"Benmassaoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ajt.2026.01.007_bib1","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1111\/ajt.15020","article-title":"Hepatic encephalopathy impacts the predictive value of the Fried Frailty Index","volume":"18","author":"Tapper","year":"2018","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1016\/j.ajt.2026.01.007_bib2","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.cgh.2016.04.040","article-title":"A model to identify sarcopenia in patients with cirrhosis","volume":"14","author":"Tandon","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.ajt.2026.01.007_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ajg.2017.443","article-title":"The liver frailty index improves mortality prediction of the subjective clinician assessment in patients with cirrhosis","volume":"113","author":"Lai","year":"2018","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"10.1016\/j.ajt.2026.01.007_bib4","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1111\/ajt.12762","article-title":"Frailty predicts waitlist mortality in liver transplant candidates","volume":"14","author":"Lai","year":"2014","journal-title":"Am J Transplant"},{"issue":"8","key":"10.1016\/j.ajt.2026.01.007_bib5","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1111\/ajt.14675","article-title":"Physical frailty after liver transplantation","volume":"18","author":"Lai","year":"2018","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1016\/j.ajt.2026.01.007_bib6","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/lt.24506","article-title":"The gap between clinically assessed physical performance and objective physical activity in liver transplant candidates","volume":"22","author":"Dunn","year":"2016","journal-title":"Liver Transpl"},{"issue":"2","key":"10.1016\/j.ajt.2026.01.007_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.amjsurg.2018.11.020","article-title":"Impact of frailty on outcomes in surgical patients: a systematic review and meta-analysis","volume":"218","author":"Panayi","year":"2019","journal-title":"Am J Surg"},{"issue":"2","key":"10.1016\/j.ajt.2026.01.007_bib8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bja.2024.02.035","article-title":"Towards a common definition of surgical prehabilitation: a scoping review of randomised trials","volume":"133","author":"Fleurent-Gr\u00e9goire","year":"2024","journal-title":"Br J Anaesth"},{"issue":"1","key":"10.1016\/j.ajt.2026.01.007_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.anclin.2014.11.002","article-title":"Prehabilitation to enhance perioperative care","volume":"33","author":"Carli","year":"2015","journal-title":"Anesthesiol Clin"},{"key":"10.1016\/j.ajt.2026.01.007_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-081164","article-title":"Relative efficacy of prehabilitation interventions and their components: systematic review with network and component network meta-analyses of randomised controlled trials","volume":"388","author":"McIsaac","year":"2025","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.ajt.2026.01.007_bib11","doi-asserted-by":"crossref","first-page":"e220","DOI":"10.1097\/TP.0000000000002806","article-title":"Exercise for solid organ transplant candidates and recipients: a joint position statement of the Canadian Society of Transplantation and CAN-RESTORE","volume":"103","author":"Janaudis-Ferreira","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.ajt.2026.01.007_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/ti.2023.11564","article-title":"European Society of Organ Transplantation (ESOT) consensus statement on prehabilitation for solid organ transplantation candidates","volume":"36","author":"Annema","year":"2023","journal-title":"Transpl Int"},{"key":"10.1016\/j.ajt.2026.01.007_bib13","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ajt.2026.01.007_bib14","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.ajt.2026.01.007_bib15","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.ajt.2026.01.007_bib16","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.ajt.2026.01.007_bib17","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","year":"2024"},{"issue":"1","key":"10.1016\/j.ajt.2026.01.007_bib18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/TP.0000000000002803","article-title":"An outpatient hospital-based exercise training program for patients with cirrhotic liver disease awaiting transplantation: a feasibility trial","volume":"104","author":"Morkane","year":"2020","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.ajt.2026.01.007_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/TP.0000000000000245","article-title":"Personalized adapted physical activity before liver transplantation: acceptability and results","volume":"99","author":"Debette-Gratien","year":"2015","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.ajt.2026.01.007_bib20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5500\/wjt.v6.i2.429","article-title":"Exercise manual for liver disease patients","volume":"6","author":"Limongi","year":"2016","journal-title":"World J Transplant"},{"issue":"10","key":"10.1016\/j.ajt.2026.01.007_bib21","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1002\/lt.25616","article-title":"Exercise training is safe and feasible in patients awaiting liver transplantation: a pilot randomized controlled trial","volume":"25","author":"Wallen","year":"2019","journal-title":"Liver Transpl"},{"issue":"7","key":"10.1016\/j.ajt.2026.01.007_bib22","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/lt.25442","article-title":"Home-based exercise in patients awaiting liver transplantation: a feasibility study","volume":"25","author":"Williams","year":"2019","journal-title":"Liver Transpl"},{"issue":"11","key":"10.1016\/j.ajt.2026.01.007_bib23","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000601","article-title":"Use of a mobile-assisted telehealth regimen to increase exercise in transplant candidates: a home-based prehabilitation pilot and feasibility trial","volume":"14","author":"Duarte-Rojo","year":"2023","journal-title":"Clin Transl Gastroenterol"},{"issue":"1","key":"10.1016\/j.ajt.2026.01.007_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/LVT.0000000000000198","article-title":"A randomized, controlled, prehabilitation intervention to maximize early recovery (PRIMER) in liver transplantation","volume":"30","author":"Serper","year":"2024","journal-title":"Liver Transpl"},{"issue":"1","key":"10.1016\/j.ajt.2026.01.007_bib25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.23736\/S1973-9087.23.08130-3","article-title":"The influence of prehabilitation in patients with liver cirrhosis before liver transplantation: a randomized clinical trial","volume":"60","author":"Skladan\u00fd","year":"2024","journal-title":"Eur J Phys Rehabil Med"},{"issue":"1","key":"10.1016\/j.ajt.2026.01.007_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1017\/S147895151800024X","article-title":"The feasibility of a group stress management Liver SMART intervention for patients with end-stage liver disease: a pilot study","volume":"17","author":"Jutagir","year":"2019","journal-title":"Palliat Support Care"},{"issue":"1","key":"10.1016\/j.ajt.2026.01.007_bib27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.transproceed.2018.02.206","article-title":"Group psychotherapy could improve depression in cirrhotic patients on the liver transplant waiting list","volume":"51","author":"Febrero","year":"2019","journal-title":"Transplant Proc"},{"issue":"6","key":"10.1016\/j.ajt.2026.01.007_bib28","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.clnu.2017.04.021","article-title":"Effects of continuous use of probiotics before liver transplantation: a randomized, double-blind, placebo-controlled trial","volume":"36","author":"Gr\u0105t","year":"2017","journal-title":"Clin Nutr"},{"issue":"2","key":"10.1016\/j.ajt.2026.01.007_bib29","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.clnu.2004.11.007","article-title":"Pre- and postoperative immunonutrition in patients undergoing liver transplantation: a pilot study of safety and efficacy","volume":"24","author":"Plank","year":"2005","journal-title":"Clin Nutr"},{"key":"10.1016\/j.ajt.2026.01.007_bib30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.clnesp.2017.09.014","article-title":"Customized nutrition intervention and personalized counseling helps achieve nutrition targets in perioperative liver transplant patients","volume":"23","author":"Daphnee","year":"2018","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.ajt.2026.01.007_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2023.112021","article-title":"The effect of \u03b2-hydroxy \u03b2-methylbutyrate (HMB) with nutritional counselling on anthropometric muscle mass markers, strength, functionality, and quality of life in patients on the waiting list for liver transplantation: a double-blind study","volume":"110","author":"Ferreira","year":"2023","journal-title":"Nutrition"},{"issue":"2","key":"10.1016\/j.ajt.2026.01.007_bib32","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/hep.27433","article-title":"Perioperative immunonutrition in patients undergoing liver transplantation: a randomized double-blind trial","volume":"61","author":"Plank","year":"2015","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.ajt.2026.01.007_bib33","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1097\/00007890-200004150-00026","article-title":"A prospective randomized study of preoperative nutritional supplementation in patients awaiting elective orthotopic liver transplantation","volume":"69","author":"Le Cornu","year":"2000","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.ajt.2026.01.007_bib34","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1097\/HEP.0000000000000840","article-title":"Reversing malnutrition and low muscle strength with targeted enteral feeding in patients awaiting liver transplant: a randomized controlled trial","volume":"80","author":"Chapman","year":"2024","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.ajt.2026.01.007_bib35","article-title":"Effect of immunonutrition on the liver function status of end-stage liver disease patients waiting\/referred for liver transplant: a randomized controlled trial","volume":"15","author":"Beevi Ss","year":"2023","journal-title":"Cureus"},{"issue":"9","key":"10.1016\/j.ajt.2026.01.007_bib36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/hepr.14027","article-title":"Impact of electrical muscle stimulation on serum myostatin level and maintenance of skeletal muscle mass in patients undergoing living-donor liver transplantation: single-center controlled trial","volume":"54","author":"Tsutsui","year":"2024","journal-title":"Hepatol Res"},{"key":"10.1016\/j.ajt.2026.01.007_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/ti.2022.10330","article-title":"Physical effects, safety and feasibility of prehabilitation in patients awaiting orthotopic liver transplantation, a systematic review","volume":"35","author":"Jetten","year":"2022","journal-title":"Transpl Int"},{"issue":"10","key":"10.1016\/j.ajt.2026.01.007_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.14686","article-title":"The role of prehabilitation on short-term outcomes after liver transplantation: a review of the literature and expert panel recommendations","volume":"36","author":"Vinaixa","year":"2022","journal-title":"Clin Transplant"},{"issue":"8","key":"10.1016\/j.ajt.2026.01.007_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.gassur.2025.102119","article-title":"Comparative effectiveness of different prehabilitation strategies in patients undergoing digestive system cancer surgery: a network meta-analysis","volume":"29","author":"Wang","year":"2025","journal-title":"J Gastrointest Surg"},{"issue":"2","key":"10.1016\/j.ajt.2026.01.007_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1139\/apnm-2021-0299","article-title":"Malnutrition modifies the response to multimodal prehabilitation: a pooled analysis of prehabilitation trials","volume":"47","author":"Gillis","year":"2022","journal-title":"Appl Physiol Nutr Metab"},{"issue":"11","key":"10.1016\/j.ajt.2026.01.007_bib41","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/s41430-025-01642-w","article-title":"Exercise and nutrition interventions for sarcopenia in cirrhosis: a systematic review and network meta-analysis of randomized controlled trials","volume":"79","author":"Kittiprachakul","year":"2025","journal-title":"Eur J Clin Nutr"},{"issue":"3","key":"10.1016\/j.ajt.2026.01.007_bib42","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/hep.32049","article-title":"Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 practice guidance by the American Association for the Study of Liver Diseases","volume":"74","author":"Lai","year":"2021","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.ajt.2026.01.007_bib43","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-081362","article-title":"Prehabilitation in patients with cirrhosis awaiting liver transplantation: protocol of a feasibility study","volume":"14","author":"Benmassaoud","year":"2024","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.ajt.2026.01.007_bib44","article-title":"Home-based EXercise and motivAtional programme before and after Liver Transplantation (EXALT): study protocol for phase II two-centre, randomised controlled trial","volume":"11","year":"2024","journal-title":"BMJ Open Gastroenterol"},{"issue":"1","key":"10.1016\/j.ajt.2026.01.007_bib45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41598-017-18320-y","article-title":"Home exercise training improves exercise capacity in cirrhosis patients: role of exercise adherence","volume":"8","author":"Kruger","year":"2018","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.ajt.2026.01.007_bib46","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.jhep.2018.06.017","article-title":"Exercise in cirrhosis: translating evidence and experience to practice","volume":"69","author":"Tandon","year":"2018","journal-title":"J Hepatol"},{"issue":"12","key":"10.1016\/j.ajt.2026.01.007_bib47","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1097\/TP.0000000000003736","article-title":"Recommendations and guidance on nutritional supplementation in the liver transplant setting","volume":"105","author":"Campos-Varela","year":"2021","journal-title":"Transplantation"},{"key":"10.1016\/j.ajt.2026.01.007_bib48","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526000092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526000092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:56:46Z","timestamp":1784717806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613526000092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S1600613526000092"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2026.01.007","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Feasibility, safety, and effectiveness of prehabilitation programs in patients awaiting liver transplantation: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2026.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}