{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:51:29Z","timestamp":1790394689762,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["GREENL1AB0"],"award-info":[{"award-number":["GREENL1AB0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["MCDYER22AB0"],"award-info":[{"award-number":["MCDYER22AB0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["U01-HL145435"],"award-info":[{"award-number":["U01-HL145435"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL161048"],"award-info":[{"award-number":["R01-HL161048"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL134851"],"award-info":[{"award-number":["R01-HL134851"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","award":["CX002011"],"award-info":[{"award-number":["CX002011"]}],"id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"The Chan Zuckerberg Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ajt.2026.02.002","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:48:15Z","timestamp":1770943695000},"page":"1661-1672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Airway molecular signatures in antibody-mediated lung transplant rejection"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3700-9634","authenticated-orcid":false,"given":"Rashmi Prava","family":"Mohanty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0596-3434","authenticated-orcid":false,"given":"Daniel R.","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9047-5047","authenticated-orcid":false,"given":"Kaveh","family":"Moghbeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-3570","authenticated-orcid":false,"given":"Carlo J.","family":"Iasella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3633-9748","authenticated-orcid":false,"given":"Kaitlyn","family":"Devonshire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8218-9879","authenticated-orcid":false,"given":"Amanda","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6980-5454","authenticated-orcid":false,"given":"Kong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-7472","authenticated-orcid":false,"given":"Jonathan P.","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2887-8451","authenticated-orcid":false,"given":"Steven R.","family":"Hays","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-2524","authenticated-orcid":false,"given":"Lorriana E.","family":"Leard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-1763","authenticated-orcid":false,"given":"Aida Venado","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7927-5522","authenticated-orcid":false,"given":"Rupal J.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-959X","authenticated-orcid":false,"given":"Nicholas A.","family":"Kolaitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Golden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-4646","authenticated-orcid":false,"given":"Charles R.","family":"Langelier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0595-595X","authenticated-orcid":false,"given":"John F.","family":"McDyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-8367","authenticated-orcid":false,"given":"John R.","family":"Greenland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ajt.2026.02.002_bib1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.healun.2016.05.020","article-title":"De-novo donor-specific anti-HLA antibodies 30 days after lung transplantation are associated with a worse outcome","volume":"35","author":"Le Pavec","year":"2016","journal-title":"J Heart Lung Transplant"},{"issue":"11","key":"10.1016\/j.ajt.2026.02.002_bib2","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.1172\/JCI138136","article-title":"Complement activation on endothelium initiates antibody-mediated acute lung injury","volume":"130","author":"Cleary","year":"2020","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.ajt.2026.02.002_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.healun.2016.01.1223","article-title":"Antibody-mediated rejection of the lung: a consensus report of the International Society for Heart and Lung Transplantation","volume":"35","author":"Levine","year":"2016","journal-title":"J Heart Lung Transplant"},{"issue":"10","key":"10.1016\/j.ajt.2026.02.002_bib4","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1681\/ASN.2013111149","article-title":"Molecular microscope strategy to improve risk stratification in early antibody-mediated kidney allograft rejection","volume":"25","author":"Loupy","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"10.1016\/j.ajt.2026.02.002_bib5","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.healun.2019.01.1317","article-title":"Molecular assessment of rejection and injury in lung transplant biopsies","volume":"38","author":"Halloran","year":"2019","journal-title":"J Heart Lung Transplant"},{"issue":"12","key":"10.1016\/j.ajt.2026.02.002_bib6","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/j.ajt.2023.06.003","article-title":"Defining a natural killer cell-enriched molecular rejection-like state in lung transplant transbronchial biopsies","volume":"23","author":"Gauthier","year":"2023","journal-title":"Am J Transplant"},{"issue":"12","key":"10.1016\/j.ajt.2026.02.002_bib7","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.ajt.2023.08.003","article-title":"Theseus and the search for an antibody-mediated rejection molecular state in lung transplant biopsies","volume":"23","author":"Calabrese","year":"2023","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2026.02.002_bib8","doi-asserted-by":"crossref","DOI":"10.1172\/JCI188891","article-title":"Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation","volume":"136","author":"Kulkarni","year":"2025","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.ajt.2026.02.002_bib9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.healun.2023.10.002","article-title":"Assessing the role of phosphorylated S6 ribosomal protein in the pathological diagnosis of pulmonary antibody-mediated rejection","volume":"43","author":"Lunardi","year":"2024","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2026.02.002_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ajt.2022.10.006","article-title":"CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction","volume":"23","author":"Calabrese","year":"2023","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2026.02.002_bib11","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/ajt.16293","article-title":"Chronic lung allograft dysfunction small airways reveal a lymphocytic inflammation gene signature","volume":"21","author":"Dugger","year":"2021","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2026.02.002_bib12","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1016\/j.healun.2024.02.133","article-title":"Multicenter assessment of the bronchiolar brushing molecular inflammation score, AIS2, to identify incipient CLAD and mortality risk","volume":"43","author":"Mohanty","year":"2024","journal-title":"J Heart Lung Transplant"},{"issue":"11","key":"10.1016\/j.ajt.2026.02.002_bib13","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.healun.2024.07.010","article-title":"Small airway brush gene expression predicts chronic lung allograft dysfunction and mortality","volume":"43","author":"Mohanty","year":"2024","journal-title":"J Heart Lung Transplant"},{"issue":"27","key":"10.1016\/j.ajt.2026.02.002_bib14","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1002\/sim.7036","article-title":"Evaluation of subset matching methods and forms of covariate balance","volume":"35","author":"de los Angeles Resa","year":"2016","journal-title":"Stat Med"},{"issue":"1","key":"10.1016\/j.ajt.2026.02.002_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.ajt.2026.02.002_bib16","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"9","key":"10.1016\/j.ajt.2026.02.002_bib17","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.healun.2025.03.010","article-title":"Persistent and progressive acute lung allograft dysfunction is linked to cell compositional and transcriptional changes in small airways","volume":"44","author":"Brunet-Ratnasingham","year":"2025","journal-title":"J Heart Lung Transplant"},{"issue":"6","key":"10.1016\/j.ajt.2026.02.002_bib18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"issue":"4","key":"10.1016\/j.ajt.2026.02.002_bib19","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1097\/TP.0000000000001586","article-title":"Evidence for CD16a-mediated NK cell stimulation in antibody-mediated kidney transplant rejection","volume":"101","author":"Parkes","year":"2017","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.ajt.2026.02.002_bib20","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1016\/j.healun.2025.09.017","article-title":"Considerations for endpoints in lung transplant clinical trials: an ISHLT consensus statement","volume":"45","author":"Greenland","year":"2025","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.ajt.2026.02.002_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/ti.2023.11710","article-title":"Banff human organ transplant consensus gene panel for the detection of antibody mediated rejection in heart allograft biopsies","volume":"36","author":"Giarraputo","year":"2023","journal-title":"Transpl Int."},{"issue":"4","key":"10.1016\/j.ajt.2026.02.002_bib22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/thoraxjnl-2018-212345","article-title":"Natural killer cells in lung transplantation","volume":"74","author":"Calabrese","year":"2019","journal-title":"Thorax"},{"issue":"10","key":"10.1016\/j.ajt.2026.02.002_bib23","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.healun.2021.06.021","article-title":"Phosphorylated S6 ribosomal protein expression by immunohistochemistry correlates with de novo donor-specific HLA antibodies in lung allograft recipients","volume":"40","author":"Cone","year":"2021","journal-title":"J Heart Lung Transplant"},{"issue":"7","key":"10.1016\/j.ajt.2026.02.002_bib24","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1111\/j.1600-6143.2006.01355.x","article-title":"Phosphorylated S6 ribosomal protein: a novel biomarker of antibody-mediated rejection in heart allografts","volume":"6","author":"Lepin","year":"2006","journal-title":"Am J Transplant"},{"issue":"6","key":"10.1016\/j.ajt.2026.02.002_bib25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1158\/1940-6207.CAPR-08-0174","article-title":"The field of tissue injury in the lung and airway","volume":"1","author":"Steiling","year":"2008","journal-title":"Cancer Prev Res (Phila)"},{"issue":"2","key":"10.1016\/j.ajt.2026.02.002_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.healun.2024.10.019","article-title":"The lung transplant endobronchial biopsy: a forgotten specimen comes of age","volume":"44","author":"Halloran","year":"2025","journal-title":"J Heart Lung Transplant"},{"issue":"12","key":"10.1016\/j.ajt.2026.02.002_bib27","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.healun.2022.08.014","article-title":"The molecular features of chronic lung allograft dysfunction in lung transplant airway mucosa","volume":"41","author":"Halloran","year":"2022","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.ajt.2026.02.002_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.908693","article-title":"Lymphocytic airway inflammation in lung allografts","volume":"13","author":"Santos","year":"2022","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.ajt.2026.02.002_bib29","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/ajt.16895","article-title":"Transcripts associated with chronic lung allograft dysfunction in transbronchial biopsies of lung transplants","volume":"22","author":"Parkes","year":"2022","journal-title":"Am J Transplant"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526000791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526000791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:25:10Z","timestamp":1785882310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613526000791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1600613526000791"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2026.02.002","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Airway molecular signatures in antibody-mediated lung transplant rejection","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2026.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of American Society of Transplantation & American Society of Transplant Surgeons.","name":"copyright","label":"Copyright"}]}}